期刊
DYES AND PIGMENTS
卷 215, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2023.111271
关键词
Iridium(III) complex; Multi -photon; FLIM; PDT
In this study, a novel cyclometallated iridium(III) complex (Ir-OH) with aggregation-induced emission (AIE) properties was developed for FLIM imaging-guided photodynamic therapy. The results showed that Ir-OH exhibited excellent fluorescence response to mitochondrial viscosity and had satisfactory multiphoton absorption properties in the near-infrared region. Changes in mitochondrial viscosity during photodynamic processes could be quantified in real-time by FLIM.
Cyclometallated iridium(III) complexes have unique photophysical properties that turn them into promising photosensitizers and potential fluorescence lifetime imaging probes. Herein, we developed a novel cyclo-metallated iridium(III) complex (Ir-OH) with aggregation-induced emission (AIE) properties for FLIM imaging -guided photodynamic therapy. Studies on photophysical properties show that Ir-OH exhibits excellent fluo-rescence response to in situ mitochondrial viscosity with varied lifetime. In addition, Ir-OH shows satisfactory multiphoton absorption properties in the near-infrared region (Two-photon: 700-800 nm; Three-photon: 1150-1450 nm). More importantly, changes in mitochondrial viscosity during photodynamic processes can be quantified in real-time by FLIM. Thus, our work illustrates that cyclometallated iridium(III) complexes can simultaneously induce and precisely detect microenvironmental changes at the subcellular level using FLIM, leading to self-reporting PDT outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据