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Article
Chemistry, Multidisciplinary
Lukas Schneider et al.
Summary: This article reports six novel and easily accessible BODIPY-based agents for cancer treatment that exhibit both photodynamic and photothermal activities, and do not rely on the generation of reactive oxygen species for cytotoxicity. These agents demonstrate high photocytotoxicity and low dark toxicity in different cancer cell lines. Under hypoxic conditions, they exhibit oxygen-independent photothermal mechanisms, making them potential candidates for overcoming limitations in current cancer therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biophysics
Zhongtang Wang et al.
Summary: This article reviews the recent progress of photothermal detection, including the main types of photothermal nanomaterials and the generation principle of the photothermal effect, as well as their applications in designing sensing strategies. It aims to provide researchers with a reference for synthesizing nanomaterials with stable and high photothermal conversion efficiency and developing more effective and sensitive detection methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Zuping Xiong et al.
Summary: This study re-examined the classic heavy-atom effect from a completely fresh perspective and proposed a universal heavy-atom-induced fluorescence enhancement principle suited for most AIEgens.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Wonseok Choi et al.
Summary: Photoacoustic imaging (PAI) has been investigated for decades as a niche biomedical imaging modality. Despite its desirable contrast and resolution, PAI faces limitations such as low signal-to-noise ratio, diminished image contrast, and spatial resolution constraints in deep tissue. Practical limitations, including insufficient targeting and difficulties in developing clinically translatable agents, have also been identified. This review discusses recent research efforts in addressing these challenges and proposes future directions for contrast-enhanced PAI.
Review
Chemistry, Inorganic & Nuclear
Zhiqiang Mao et al.
Summary: In recent years, BODIPY-based theranostics have been increasingly utilized in cancer therapy with remarkable success. By modifying the chemical structure, the optical imaging and phototherapy properties of BODIPY-based dyes can be well-balanced and tailored. Additionally, molecular/nanoparticle engineering allows versatile functionalities and improved tumor-targeting ability, enhancing the therapeutic efficacy and minimizing side effects. This review focuses on the applications of BODIPY-based theranostics in tumor therapy, including fluorescence-guided chemotherapy, photodynamic therapy, photothermal therapy, and multi-modal imaging-guided therapies.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Tianfu Zhang et al.
Summary: Phototheranostic agents, integrating sensitive in situ fluorescence imaging and effective multi-model synergistic therapy, have emerged as promising tools for cancer theranostics. However, balancing the competitive radiative and nonradiative processes in photon energy transfer remains challenging. In this study, three simple molecules with electron donating-accepting structures were developed. The introduction of an acridinium unit as an electron acceptor led to the formation of TPEDCAc with aggregation-induced second near-infrared emission, high reactive oxygen species generation capability, and excellent photothermal conversion efficiency. The key factors for achieving NIR-II emission and balanced photodynamic/photothermal conversion were found to be large torsional angle and strong electron-withdrawing ability of the acridinium unit. Impressively, TPEDCAc exhibited mitochondria-targeting capability and high performance in in vivo multi-modal cancer theranostics under NIR laser irradiation. This work not only provides a single NIR-II AIE-based multi-modal cancer theranostic system but also inspires new insights into the development of theranostic platforms in the future.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hong-Bo Cheng et al.
Summary: This article introduces a novel supramolecular theranostic system that combines biomarker protein activation and a host-guest strategy. The authors demonstrate the design of a nanoparticulate theranostic agent that can detect albumin and treat cancer. The system also exhibits enhanced biocompatibility and photothermal conversion efficiency, making it a promising strategy for photodynamic and photothermal immunotherapy.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chenzhi Yao et al.
Summary: A new aza-boron-dipyrromethene (aza-BODIPY) brush macromolecular probe (FBP 912) with high brightness and renal clearance efficiency has been developed for non-invasive diagnosis of kidney diseases. This probe shows superior performance compared to traditional fluorophores in passive targeted imaging of tumors and active targeted imaging of renal cell carcinoma.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Yuewen Yu et al.
Summary: In this study, a cationization molecular engineering strategy was used to enhance the generation of reactive oxygen species (ROS) for efficient photodynamic therapy (PDT). The cationization process improved the aggregation-induced emission (AIE) feature, promoted intersystem crossing (ISC) processes, and increased charge transfer and separation ability, leading to the efficient production of ROS, particularly hydroxyl and superoxide radicals. Additionally, the cationic AIE photosensitizers also exhibited specific cancer cell mitochondrial targeting capability, which further improved the efficacy of PDT.
Article
Chemistry, Physical
Li Yang et al.
Summary: This study successfully improved the photodynamic therapy (PDT) efficacy of indocyanine green (ICG) by assembling free ICG molecules with free oxygen nanobubbles (NBs-O-2), and evaluated its therapeutic efficacy in the treatment of oral cancer in vivo. The results demonstrated that ICG-NBs-O-2 showed excellent tumor ablation and has great potential for clinical application.
Article
Chemistry, Multidisciplinary
Peihong Xiao et al.
Summary: A series of near-infrared anion-pi(+) photosensitizers with aggregation-induced emission were designed and developed for broad-spectrum MDR bacteria eradication, achieving up to 99% photodynamic killing efficacy against MRSA and MDR E. coli. Due to enhanced ROS generation capability, these AIE-PSs exhibited excellent therapeutic performance under white light irradiation.
Review
Oncology
Nafiseh Behranvand et al.
Summary: Chemotherapy is a well-known and effective treatment for cancers, but its efficiency in eradicating all cancer cells falls short of expectations. Research suggests that alterations in the tumor microenvironment's physiological conditions may contribute to this. Using mild anti-inflammatory drugs during chemotherapy could potentially lead to more successful clinical outcomes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Lina Feng et al.
Summary: A strategy of acceptor planarization and donor rotation was proposed to design type I photosensitizers (PSs) and photothermal reagents for tumor therapy. Experimental results showed that nanoparticles with the most rotors exhibited the highest photothermal conversion efficiency, making them suitable for NIR fluorescence imaging-guided synergistic therapy.
Review
Chemistry, Multidisciplinary
Yanyan Wang et al.
Summary: This review comprehensively summarizes the recent development of ring-fused aza-BODIPY dyes since 2002, with a focus on the design, synthesis, and potential applications in the near-infrared (NIR) region.
CHINESE CHEMICAL LETTERS
(2022)
Article
Engineering, Biomedical
Tingyu Shi et al.
Summary: This article discusses the application of non-invasive optical imaging and phototherapy in tumor diagnosis and treatment, focusing on the research methods of aggregation-induced emission organic nanomaterials in the near-infrared second region. It also reviews the recent progress in tumor imaging and phototherapy using near-infrared second region organic nanomaterials, and provides an outlook for future research.
Review
Chemistry, Inorganic & Nuclear
Chen Chen et al.
Summary: Photodynamic therapy (PDT) has proved its significance in cancer treatment, but its therapeutic effect is limited by the low penetration of light source, tumor microenvironment (TME) hypoxia, and tumor cell metastasis and recurrence. This review presents the design of PDT platforms and discusses the latest studies on combinatorial cancer therapy strategies using PDT, aiming to evaluate its potential in future clinical cancer treatments. The latest progress mainly focuses on three aspects: combining with drugs or gases to overcome TME hypoxia, employing advanced light sources to increase penetration depth, and combining with immunotherapy to inhibit tumor metastasis. The integration of diagnosis and treatment using an imaging-guided therapeutic nanoplatform has brought more optimized treatment effects to PDT.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Meijiao Zhao et al.
Summary: This study introduces an intelligent nanoagent, BDP-Oxide nanoparticles, which can initiate optimal tumor treatment based on localized oxygen levels, achieving photodynamic/photothermal complementary therapy and significantly suppressing solid tumor growth.
Article
Chemistry, Multidisciplinary
Debabrata Dutta et al.
Summary: This study presents the use of covalent organic framework (COF) nanoparticles loaded with the near-infrared (NIR) dye cypate for oxygen-independent generation of singlet oxygen (O-1(2)), allowing for concurrent photothermal therapy (PTT) and photodynamic therapy (PDT) under NIR irradiation. The COF nanoparticles protect cypate from photodegradation and improve its photostability and photothermal conversion efficiency. Upon NIR irradiation, the COF nanoparticles release the stored O-1(2) and induce ablation of tumors through oxygen-independent concurrent PTT/PDT.
Article
Chemistry, Multidisciplinary
Ruohan Xu et al.
Summary: This study presents deep-red AIE nanocrystals with high photoluminescence quantum yield and reactive oxygen species generation efficiency. Moreover, these nanocrystals can target both lysosomes and the nucleus, enhancing the effectiveness of photodynamic therapy for cancer treatment.
Review
Chemistry, Inorganic & Nuclear
Jun Wang et al.
Summary: Aza-BODIPY is an important class of heteroatom-containing BODIPY analogue that can be modified to extend its absorption and emission wavelengths, making it promising for the development of near infrared chromophores and fluorophores.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Natalia A. Bumagina et al.
Summary: The review discusses research on the synthesis and photophysical properties of BODIPY conducted by scientists from different countries. The study focuses on the modification of BODIPY structure by substituting various components and its impact on the spectral properties and practical applications. The findings demonstrate that these modifications can significantly alter the absorption and fluorescence bands of BODIPY, affecting its photophysical properties and suitability for different applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Yuqiu Shi et al.
Summary: The design of novel nanomaterials and nanoprobes has shown great potential in biomedical fields, particularly in the development of advanced imaging and therapy techniques for tumors. Aggregate-induced emission luminous (AIEgens)-based nanoprobes and nanomaterials have attracted attention and demonstrated a wide range of applications in photoacoustic imaging and photodynamic/photothermal therapy. This review focuses on the advances in the rational design and synthesis of functional AIEgens for photoacoustic imaging and phototherapy applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Yinqian Yang et al.
Summary: The study focuses on establishing the in vitro-in vivo correlation of solid dosage forms in terms of dissolution of active pharmaceutical ingredients. In vivo dissolution of a poorly water-soluble drug, fenofibrate, was investigated using fluorescence bioimaging, showing promise for reliable quantification and determination of dissolution. The study validates the newly established IVIVC through correlating in vitro and in vivo dissolution with in vivo absorption fractions obtained from pharmacokinetic data.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Dingbowen Wang et al.
Summary: Optical waveguide-mediated phototherapy shows promising potential for precise administration in fighting against a variety of infectious pathogens. Despite high therapeutic potential, further research is needed to optimize materials, fabrication designs, and exact mechanisms.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Dingyuan Yan et al.
Summary: The study successfully constructed highly stable NIR-II AIEgen DPBTA-DPTQ nanoparticles using benzo[c]thiophene as an electron-rich and bulky donor/π-bridge, achieving acceptable fluorescence quantum yield and excellent photothermal conversion efficiency. DPBTA-DPTQ showed good biocompatibility and efficient photothermal therapeutic effects in in vitro tests, demonstrating potential for photothermal eradication of tumors in mouse models.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Jinya Du et al.
Summary: The emergence of photoacoustic imaging (PAI) has greatly expanded the application of biomolecules bioimaging, especially in near-infrared (NIR) PAI which shows great potential in biomedical applications. Comparing different imaging modalities and focusing on the strategies used to improve contrast and performance in NIR-PAI are essential for enhancing imaging accuracy. Challenges and prospects in accelerating the development of PAI are identified to attract more researchers in this field.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Multidisciplinary
Thanh Chung Pham et al.
Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.
Article
Chemistry, Multidisciplinary
Xiangyu Deng et al.
Summary: Phototherapy, such as photothermal therapy and photodynamic therapy, has shown great potential in cancer treatment, but there are still many challenges that need to be addressed. Scientists are designing different systems to overcome the drawbacks associated with phototherapy, aiming to make it a more effective cancer treatment approach in clinical practice. This article discusses the problems and solutions in phototherapy research, providing insights for future advancements in the field.
Article
Chemistry, Multidisciplinary
Zengming Yang et al.
Summary: This study successfully utilized precise molecular engineering to develop organic fluorophores with multimodal imaging-guided synergistic therapy functions, and designed a high-performance phototheranostic agent MeTIC, providing potential clinical design principles for cancer treatment.
Article
Chemistry, Multidisciplinary
Hui Bian et al.
Summary: In this study, five novel NIR-II dyes were successfully developed with intense absorption ranging from 890 to 1206 nm, strong singlet oxygen generation capability, and fluorescence imaging ability triggered by a single NIR-II light. Among them, BH 1024 showed the best performance in singlet oxygen generation, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Encapsulating BH 1024 into folate-functionalized polymer demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. This is the first attempt to explore and design small molecular dyes for NIR-II PDT or NIR-II PDT/PTT.
Article
Engineering, Biomedical
Kai Deng et al.
Summary: This study introduces a dual-step light irradiation strategy to enhance the efficacy of cancer photodynamic therapy, which significantly improves the generation of singlet oxygen and leads to more efficient cancer therapeutic effects compared to single-step irradiation with the same total irradiation time.
Review
Chemistry, Multidisciplinary
Hanming Dai et al.
Summary: Precision oncotherapy can effectively remove tumors without harming normal tissues.NIR-II organic nanotheranostics show good biocompatibility and safety, holding great potential for clinical tumor treatment.
Review
Chemistry, Multidisciplinary
Dapeng Chen et al.
Summary: Photodynamic therapy (PDT) has great potential for tumor treatment, with type I PDT showing superiority over type II PDT in treating hypoxic tumors. Recent research focuses on developing highly effective type I photosensitizers and addressing key challenges in clinical translations of these photosensitizers.
Article
Engineering, Biomedical
Weijing Huang et al.
Summary: This study successfully developed CCNU-1060 nanoparticles with NIR-II fluorescence-guided phototherapeutic properties using a molecular design strategy. This approach enabled high-spatial vessel imaging and effective tumor ablation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zuping Xiong et al.
Summary: The study reveals that classic heavy-atom effect has a minimal impact on the fluorescence of silole-based AIEgens, while weak intermolecular interactions and heavy-atom-induced vibration restriction collaboratively contribute to the emission enhancement of these AIEgens. The breaking of classic heavy-atom effect not only proves its limited scope on through-bond conjugated dyes, but also offers an effective and simple strategy to significantly improve the emission efficiency of AIEgens.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jongjit Treekoon et al.
Summary: Polymeric nanoparticles loaded with aza-BODIPY were successfully prepared for targeted nanodelivery, exhibiting monodisperse spherical morphology. These nanoparticles showed significant therapeutic effects on breast cancer cells and demonstrated tumor growth inhibition in vivo.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Xiaozhen Li et al.
Summary: The synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT) shows superior clinical application prospects compared to single PDT or PTT. By designing and synthesizing a near-infrared (NIR) small molecule (ETTC), multiple functions such as NIR-II fluorescence imaging, photoacoustic imaging, PTT, and PDT were successfully achieved and optimized. This work provides a novel perspective for the development of efficient and versatile biomedical applications in a single molecule.
NANOSCALE HORIZONS
(2021)
Article
Chemistry, Multidisciplinary
Chao Chen et al.
ADVANCED MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Dapeng Chen et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Chemistry, Inorganic & Nuclear
P. Chinna Ayya Swamy et al.
COORDINATION CHEMISTRY REVIEWS
(2020)
Review
Materials Science, Multidisciplinary
Haixiang Liu et al.
ADVANCED OPTICAL MATERIALS
(2020)
Review
Pharmacology & Pharmacy
Jun Fang et al.
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Zhijun Zhang et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Physical
Dapeng Chen et al.
Article
Nanoscience & Nanotechnology
Ning Liu et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Chemistry, Multidisciplinary
Chunyan Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Materials Science, Multidisciplinary
Jing-Jing Hu et al.
PROGRESS IN MATERIALS SCIENCE
(2020)
Review
Chemistry, Multidisciplinary
Zhenxiong Shi et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Christopher J. J. Reinhardt et al.
Article
Chemistry, Multidisciplinary
Jianjian Zhang et al.
Review
Engineering, Biomedical
Minhuan Lan et al.
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Medicine, Research & Experimental
Duyang Gao et al.
Review
Pharmacology & Pharmacy
Jianhong Zhao et al.
ACTA PHARMACEUTICA SINICA B
(2018)
Article
Engineering, Biomedical
Wanyue Xiao et al.
Article
Nanoscience & Nanotechnology
Jianhua Zou et al.
ACS APPLIED MATERIALS & INTERFACES
(2017)
Review
Chemistry, Multidisciplinary
Eun-Kyung Lim et al.
