A super-fast response fluorescent probe for detecting endogenous H2S in living cells

Article Spectroscopy

An ESIPT-based fluorescent probe with fast-response for detection of hydrogen sulfide in mitochondria

Yuting Du et al.

Summary: The designed fluorescent probe HBTP-H2S based on ESIPT effect showed fast response time, good selectivity and a large Stokes shift towards H2S, and was successfully employed to monitor mitochondrial H2S in HepG2 cells.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Spectroscopy

Novel near-infrared spectroscopic probe for visualizing hydrogen sulfide in lysosomes

Chang Liu et al.

Summary: A novel H2S probe, SHCy-H2S, with high selectivity and sensitivity for specific detection of H2S in lysosome has been designed and synthesized in this study. It exhibits marked color changes in naked-eye and fluorescence, providing a potential tool for exploring the function of H2S at subcellular level.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Biochemical Research Methods

Mitochondrion-targeting near-infrared fluorescent probe for detecting intracellular nanomolar level hydrogen sulfide with high recognition rate

Kaiquan Zhang et al.

Summary: In this study, a new fluorescent probe QcyCHO was developed for rapid and accurate detection of physiological levels of H2S, with the ability to target and measure H2S levels in cells. The probe showed high recognition specificity and potential for shedding light on the biology of H2S and therapeutic development in H2S-associated diseases.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Nitric oxide and hydrogen sulfide: Sibling rivalry in the family of epigenetic regulators

Hannah Petraitis Kuschman et al.

Summary: Nitric oxide (NO) and hydrogen sulfide (H2S) are now recognized as potent gaseous messenger molecules that rapidly transduce cellular signals and regulate various physiological functions. They often work synergistically and competitively to modulate each other's activity through chemical reactions and modifications to protein targets. In addition to their canonical modes of action, increasing evidence has shown that they also share the signaling mechanism of epigenetic regulation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul et al.

Summary: Hydrogen sulfide (H2S) was once thought to be only toxic, but is now known to also act as an endogenous signaling molecule. The effects of H2S on cellular physiology are dose-dependent, with lower concentrations being beneficial and higher concentrations being cytotoxic. In particular, H2S has contrasting effects on mitochondrial function, inhibiting the electron transport chain at higher concentrations and stimulating bioenergetics at lower concentrations.

REDOX BIOLOGY (2021)

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Article Chemistry, Analytical

A bifunctional probe reveals increased viscosity and hydrogen sulfide in zebra fish model of Parkinson's disease

Wei Shen et al.

Summary: A new dual-function fluorescent probe DF was designed and synthesized to analyze intracellular viscosity and hydrogen sulfide levels in Parkinson's disease. The probe, with improved photostability and large Stokes shift, revealed increased viscosity and hydrogen sulfide in a zebrafish model of PD for the first time.

TALANTA (2021)

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Article Chemistry, Analytical

Two-photon ratiometric fluorescent probe based on NBD-amine functionalized semiconducting polymer nanoparticles for real-time imaging of hydrogen sulfide in living cells and zebrafish

Dongmei Wang et al.

Summary: The thiolysis of NBD-A enables specific detection of H2S and real-time imaging in living organisms. The NBD@PFO probes, constructed with ratiometric mode and two-photon excitation, show high selectivity, fast response, and are successfully applied for monitoring H2S concentration in living cells and zebrafish. This work demonstrates the potential of polymer nanoparticles to enhance the imaging capability of an organic small molecular probe.

TALANTA (2021)

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Review Biochemistry & Molecular Biology

Spatiotemporal regulation of hydrogen sulfide signaling in the kidney

Maurits Roorda et al.

Summary: Hydrogen sulfide (H2S), previously known as a putrid, toxic gas, is now recognized as the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. H2S plays a critical role in regulating vascular and cellular function in the kidneys, impacting blood flow, glomerular filtration rate, and the renin-angiotensin axis. Furthermore, H2S offers protection against acute kidney injury (AKI) by enhancing ATP production and preventing damage due to free radicals during hypoxia or ischemia-reperfusion injury. Understanding the (sub)cellular signaling mechanisms of H2S can lead to novel therapeutic targets for preventing kidney injury.

REDOX BIOLOGY (2021)

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Review Chemistry, Multidisciplinary

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

Chenyang Jiang et al.

Summary: The review focuses on NBD-based synthetic probes as advanced chemical tools for biomolecular sensing, discussing detection mechanisms, selectivity, design strategies, and biological applications of these important constructs, as well as highlighting self-assembled NBD-based probes and outlining future directions for NBD-based chemosensors. The comprehensive review aims to facilitate the development of future probes for investigating and understanding different biological processes and aid the development of potential theranostic agents.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Inorganic & Nuclear

A cancer cell-specific benzoxadiazole-based fluorescent probe for hydrogen sulfide detection in mitochondria

Maxine Mambo Fortibui et al.

Summary: This study described the design and biological applications of a novel probe for hydrosulfide detection, showing high selectivity and rapid detection of endogenous H2S, which is higher in cancer cells than in normal cells. The probe targets mitochondria specifically, allowing for safe and rapid detection of H2S to distinguish cancer cells from normal cells.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Physical

A quaternary ammonium modified fluorescent probe for hydrogen sulfide detection in living cells

Zhengkun Liu et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2020)

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Article Chemistry, Analytical

Turn-on visible and ratiometric near-infrared fluorescent probes for distinction endogenous esterases and chymotrypsins in live cells

Jiemin Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Environmental Sciences

A dicyanoisophorone-based highly sensitive and selective near-infrared fluorescent probe for sensing thiophenol in water samples and living cells

Yintang Zhang et al.

ENVIRONMENTAL POLLUTION (2020)

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Article Chemistry, Analytical

A ratiometric fluorescent probe for imaging enzyme dependent hydrogen sulfide variation in the mitochondria and in living mice

Yuming Zhang et al.

ANALYST (2020)

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Article Chemistry, Multidisciplinary

Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

Mingwang Yang et al.

CHEMICAL SCIENCE (2020)

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Article Materials Science, Biomaterials

A new strategy to improve the water solubility of an organic fluorescent probe using silicon nanodots and fabricate two-photon SiND-ANPA-N3 for visualizing hydrogen sulfide in living cells and onion tissues

Yu-Jia Fu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

Rational modulation of coumarin-hemicyanine platform based on OH substitution for higher selective detection of hypochlorite

Jin-Shuai Lan et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Analytical

A fluorescent probe for the dicriminatory detecion of Cys/Hcy, GSH and H2S in living cells and zebrafish

Fengpei Qi et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Applied

A dual-sites fluorescent probe based on symmetric structure of naphthalimide derivative to detect H2S

Xurong Shi et al.

DYES AND PIGMENTS (2019)

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Article Chemistry, Applied

A near-infrared fluorescent probe based on nucleophilic substitution-cyclization for selective detection of hydrogen sulfide and bioimaging

Jinxia Men et al.

DYES AND PIGMENTS (2018)

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Review Cell Biology

Glutathione metabolism in cancer progression and treatment resistance

Ankita Bansal et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

Tuoyi Li et al.

NATURE COMMUNICATIONS (2018)

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Article Biochemical Research Methods

Synthesis of an ultrasensitive BODIPY-derived fluorescent probe for detecting HOCI in live cells

Hao Zhu et al.

NATURE PROTOCOLS (2018)

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Review Biochemistry & Molecular Biology

Plant peroxisomes: A nitro-oxidative cocktail

Francisco J. Corpas et al.

REDOX BIOLOGY (2017)

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Article Chemistry, Multidisciplinary

Two-Photon Near Infrared Fluorescent Turn-On Probe Toward Cysteine and Its Imaging Applications

Junfeng Wang et al.

ACS SENSORS (2016)

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Article Chemistry, Multidisciplinary

Mechanistic Insights into the H2S-Mediated Reduction of Aryl Azides Commonly Used in H2S Detection

Hillary A. Henthorn et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Chemistry, Analytical

Design of a Simultaneous Target and Location-Activatable Fluorescent Probe for Visualizing Hydrogen Sulfide in Lysosomes

Sheng Yang et al.

ANALYTICAL CHEMISTRY (2014)

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Article Chemistry, Organic

A Chemosensor Bearing Sulfonyl Azide Moieties for Selective Chromo-Fluorogenic Hydrogen Sulfide Recognition in Aqueous Media and in Living Cells

Luis E. Santos-Figueroa et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2014)

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Article Chemistry, Organic

A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus

Ling Zhang et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

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Article Chemistry, Organic

NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide

Chao Wei et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

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Article Chemistry, Multidisciplinary

In vivo monitoring of hydrogen sulfide using a cresyl violet-based ratiometric fluorescence probe

Qiongqiong Wan et al.

CHEMICAL COMMUNICATIONS (2013)

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Article Chemistry, Multidisciplinary

Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite

Yuan-Qiang Sun et al.

CHEMICAL COMMUNICATIONS (2013)

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Article Chemistry, Applied

A near-infrared fluorescent probe for hydrogen sulfide in living cells

Yi Zheng et al.

DYES AND PIGMENTS (2013)

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Article Chemistry, Organic

Development of Selective Colorimetric Probes for Hydrogen Sulfide Based on Nucleophilic Aromatic Substitution

Leticia A. Montoya et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

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Article Chemistry, Multidisciplinary

A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H2S Production in Parkinson's Disease Gene Knockout Astrocytes

Sung Keun Bae et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Multidisciplinary Sciences

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

Csaba Szabo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Multidisciplinary Sciences

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya et al.

NATURE COMMUNICATIONS (2013)

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Article Chemistry, Multidisciplinary

A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood

Hanjing Peng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Review Multidisciplinary Sciences

The case against climate regulation via oceanic phytoplankton sulphur emissions

P. K. Quinn et al.

NATURE (2011)

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Article Biochemistry & Molecular Biology

Making and working with hydrogen sulfide The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: A review

Martin N. Hughes et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

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Review Biotechnology & Applied Microbiology

Hydrogen sulphide and its therapeutic potential

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2007)

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Article Biochemical Research Methods

Hydrogen sulfide consumption measured at low steady state concentrations using a sulfidostat

DG Searcy et al.

ANALYTICAL BIOCHEMISTRY (2004)

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A super-fast response fluorescent probe for detecting endogenous H2S in living cells

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