☆ 4.6 Review

Anti-TNF Agents and New Biological Agents (Vedolizumab and Ustekinumab) in the Prevention and Treatment of Postoperative Recurrence After Surgery in Crohn's Disease

DRUGS (2023)

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Article Gastroenterology & Hepatology

Early Biological Therapy in Operated Crohn's Disease Patients Is Associated With a Lower Rate of Endoscopic Recurrence and Improved Long-term Outcomes: A Single-center Experience

Ferdinando D'Amico et al.

Summary: This study aimed to investigate the impact of postoperative biological therapy on the incidence of endoscopic recurrence and long-term outcomes in Crohn's disease patients. The results showed that early treatment with biologics decreased the rates of endoscopic recurrence and hospitalization/surgery.

INFLAMMATORY BOWEL DISEASES (2023)

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Article Gastroenterology & Hepatology

Retreatment with anti-tumor necrosis factor therapy in combination with an immunomodulator for recurrence of Crohn's disease after ileocecal resection results in prolonged continuation as compared to anti-tumor necrosis factor monotherapy

Sebastiaan Ten Bokkel Huinink et al.

Summary: This study assessed the effectiveness of retreatment with anti-TNF therapy in patients with postoperative recurrence of Crohn's disease. The results showed that retreatment with anti-TNF therapy is a valid strategy for treating postoperative Crohn's disease recurrence, and combination therapy is associated with a lower risk of treatment failure.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

OP14 Prevention of postoperative recurrence of Crohn's disease with vedolizumab: First results of the prospective placebo-controlled randomised trial REPREVIO

G D'Haens et al.

Journal of Crohns & Colitis (2023)

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Article Gastroenterology & Hepatology

Ustekinumab and vedolizumab for the prevention of postoperative recurrence of Crohn's disease: Results from the ENEIDA registry

Miriam Manosa et al.

Summary: This study found that ustekinumab and vedolizumab are effective in preventing postoperative recurrence in high-risk Crohn's disease patients. However, further controlled trials comparing these drugs with conventional therapies are needed.

DIGESTIVE AND LIVER DISEASE (2023)

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Article Gastroenterology & Hepatology

Prevention of post-operative recurrence of Crohn's disease among patients with prior anti-TNFα failure: A retrospective multicenter study

Guillaume Le Cosquer et al.

Summary: This study compared the efficacy of anti-TNF-α with other biologics and immunosuppressants in preventing postoperative recurrence of Crohn's disease. The results showed that patients treated with anti-TNF-α had a lower recurrence rate.

DIGESTIVE AND LIVER DISEASE (2023)

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Article Gastroenterology & Hepatology

Benefit of Risk-stratified Prophylactic Treatment on Clinical Outcome in Postoperative Crohn's Disease

Vincent Joustra et al.

Summary: Immediate prophylactic treatment can reduce endoscopic postoperative recurrence rates in high-risk patients within 1 year, but the effect is not significant in low-risk patients. There is no significant difference in clinical postoperative recurrence within 3 years between prophylactic and endoscopy-driven treatment in both high-risk and low-risk patients, but there may be a cumulative effect in high-risk patients with multiple risk factors.

JOURNAL OF CROHNS & COLITIS (2023)

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Article Gastroenterology & Hepatology

Prophylactic Medication for the Prevention of Endoscopic Recurrence in Crohn's Disease: a Prospective Study Based on Clinical Risk Stratification

Jeanine H. C. Arkenbosch et al.

Summary: This study aimed to evaluate the effectiveness of a clinical management algorithm in preventing recurrence after ileocolonic resection in Crohn's disease and determine the predictive value of clinical and histological risk factors. The results showed that prophylactic medication can effectively reduce endoscopic recurrence in both low-risk and high-risk patients. Clinical risk stratification has a certain predictive value in predicting patient recurrence but further improvements are needed.

JOURNAL OF CROHNS & COLITIS (2023)

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Article Gastroenterology & Hepatology

Comparison of two strategies for the management of postoperative recurrence in Crohn's disease patients with one clinical risk factor: A multicentre IG-IBD study

Gabriele Dragoni et al.

Summary: Immediate immunoprophylaxis does not decrease the rate of early clinical and endoscopic recurrence in Crohn's disease patients with only one risk factor for postoperative recurrence.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2023)

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Article Gastroenterology & Hepatology

18th Congress of the European Crohn's and Colitis Organisation

Rob Brierley

Lancet Gastroenterology & Hepatology (2023)

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Article Gastroenterology & Hepatology

Factors associated with anti-tumor necrosis factor effectiveness to prevent postoperative recurrence in Crohn's disease

Anthony Buisson et al.

Summary: Anti-TNF therapy was found to be the most effective medication in preventing endoscopic and clinical postoperative recurrence (POR) in Crohn's disease (CD). Combination therapy with anti-TNF agents and immunosuppressive drugs should be considered for patients previously exposed to anti-TNF before surgery.

INTESTINAL RESEARCH (2022)

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Review Gastroenterology & Hepatology

Risk Prediction and Comparative Efficacy of Anti-TNF vs Thiopurines, for Preventing Postoperative Recurrence in Crohn's Disease: A Pooled Analysis of 6 Trials

Evelien M. J. Beelen et al.

Summary: This meta-analysis found that anti-TNF-alpha treatment is superior to thiopurine prophylaxis for preventing endoscopic and clinical recurrence of Crohn's disease after ileocolonic resection. This advantage was confirmed in subgroup analysis and after risk stratification.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Vedolizumab may be an effective option for the treatment of postoperative recurrence of Crohn's disease

Fabio Salvatore Macaluso et al.

Summary: The study assessed the effectiveness of Vedolizumab (VDZ) in the treatment of postoperative recurrence of Crohn's disease (CD). The results suggest that VDZ may be an effective option for treating CD postoperative recurrence.

DIGESTIVE AND LIVER DISEASE (2022)

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Review Gastroenterology & Hepatology

Vedolizumab as the first line of biologic therapy for ulcerative colitis and Crohn's disease - a systematic review with meta-analysis

Mohamed Attauabi et al.

Summary: A meta-analysis showed that vedolizumab as first line of biological therapy has favorable efficacy and safety profile in bio-naive patients with ulcerative colitis (UC) and Crohn's disease (CD).

DIGESTIVE AND LIVER DISEASE (2022)

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Article Gastroenterology & Hepatology

Indications, Postoperative Management, and Long-term Prognosis of Crohn's Disease After Ileocecal Resection: A Multicenter Study Comparing the East and West

Jeanine H. C. Arkenbosch et al.

Summary: This study compares the indications, postoperative management, and long-term prognosis of patients with ileocecal resection (ICR) for Crohn's disease (CD) in Hong Kong and the Netherlands. The study finds that there are differences in the main indications and postoperative management between the two regions, but the long-term prognosis after ICR is similar.

INFLAMMATORY BOWEL DISEASES (2022)

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Article Gastroenterology & Hepatology

Rate and risk factors of postoperative endoscopic recurrence of moderate- to high-risk Crohn's disease patients - A real-world experience from a Middle Eastern cohort

Nahla Azzam et al.

Saudi Journal of Gastroenterology (2022)

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Review Gastroenterology & Hepatology

Advances in the Comprehensive Management of Postoperative Crohn's Disease

Robert Battat et al.

Summary: Patients with postoperative Crohn's disease are challenging to manage due to the severity of their condition, multiple confounding symptoms, and poor sensitivity of symptomatic remission. Novel noninvasive testing and endoscopy-based disease activity assessment are helpful, but more research is needed to determine the efficacy of therapies in this setting.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Effectiveness and Safety of Ustekinumab in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Sailish Honap et al.

Summary: In this comprehensive systematic review and meta-analysis, ustekinumab has been shown to be effective and safe in the real-world treatment of inflammatory bowel disease (IBD), with sustained efficacy for both Crohn's disease (CD) and ulcerative colitis (UC).

DIGESTIVE DISEASES AND SCIENCES (2022)

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Review Gastroenterology & Hepatology

What's New in the Postoperative Management of Crohn's Disease?

Sonya S. Dasharathy et al.

Summary: Patients with Crohn's disease often require surgical resection due to complications or refractory disease. Postoperative management involves assessing risk factors for recurrence, advances in endoscopic evaluation, prophylactic therapy, noninvasive assessment methods, and novel surgical techniques. Studies suggest postoperative anti-TNF therapy reduces endoscopic recurrence, but optimal prophylaxis in biologic-experienced patients requires further exploration. Preliminary data also indicates new surgical modalities like the Kono-S anastomosis may decrease postoperative recurrence.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Article Gastroenterology & Hepatology

Continued Postoperative Use of Tumor Necrosis Factor-α Inhibitors for the Prevention of Crohn's Disease Recurrence

Jongwook Yu et al.

Summary: This retrospective study evaluated the impact of continuing TNF-alpha inhibitors postoperatively on the recurrence of Crohn's disease in patients who were previously treated with TNF-alpha inhibitors. The results showed that postoperative use of TNF-alpha inhibitors significantly reduced the rate of clinical recurrence, suggesting that continuing TNF-alpha inhibitors after surgery could be beneficial for CD patients who received TNF-alpha inhibitors preoperatively.

GUT AND LIVER (2022)

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Article Gastroenterology & Hepatology

Endoscopic Postoperative Recurrence in Crohn's Disease After Curative Ileocecal Resection with Early Prophylaxis by Anti-TNF,Vedolizumab or Ustekinumab: A Real-World Multicentre European Study

Henit Yanai et al.

Summary: This study aimed to evaluate the effectiveness of early prophylaxis with biologics in preventing endoscopic-post-operative-recurrence (ePOR) in Crohn's disease (CD) after ileocecal resection (ICR). The study compared the effectiveness of anti-tumour necrosis factor (anti-TNF) therapy with vedolizumab (VDZ) and ustekinumab (UST). The results showed that 60% of patients successfully prevented ePOR within 1 year after surgery. Patients treated with VDZ or UST were more difficult to treat. After controlling for confounders, there were no differences in ePOR risk between anti-TNF prophylaxis and other treatment groups.

JOURNAL OF CROHNS & COLITIS (2022)

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Review Medicine, General & Internal

Contemporary Management of Postoperative Crohn's Disease after Ileocolonic Resection

Jurij Hanzel et al.

Summary: Surgery remains an important treatment modality in the management of Crohn's disease. Recent advances in postoperative CD management include refined endoscopic scoring indices and noninvasive monitoring methods.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Medicine, General & Internal

Real-World Evidence of the Effectiveness and Safety of Ustekinumab for the Treatment of Crohn's Disease: Systematic Review and Meta-Analysis of Observational Studies

Cristina Rubin de Celix et al.

Summary: The study found that ustekinumab had good effectiveness and safety in Crohn's disease patients, but 18% of patients lost response during follow-up. Nearly one-third of the patients needed dose optimization, and it was effective in most cases.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Gastroenterology & Hepatology

Post-operative prevention and monitoring of Crohn's disease recurrence

Kate E. Lee et al.

Summary: Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. Although surgery can cure ulcerative colitis, it is rarely curative for Crohn's disease. Research has identified risk factors for post-operative Crohn's disease recurrence, allowing for patient risk stratification and preventive treatment.

GASTROENTEROLOGY REPORT (2022)

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Review Medicine, General & Internal

Efficacy and safety of vedolizumab for inflammatory bowel diseases: A systematic review and meta-analysis of randomized controlled trials

Bo Qiu et al.

Summary: This study evaluated the efficacy and safety of vedolizumab in the treatment of inflammatory bowel disease. The meta-analysis results showed that vedolizumab was more effective than placebo in inducing and maintaining clinical response, clinical remission, and mucosal healing. Vedolizumab was also found to be safe and did not increase the risk of serious adverse reactions.

MEDICINE (2022)

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Article Surgery

Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease

Bryan P. Kline et al.

Summary: This study evaluated factors associated with time to surgical recurrence after Crohn's ileocolectomy, finding that ileocolonic involvement and the rs2066844 SNP in NOD2 were associated with shorter time to recurrent surgery. Initiating postoperative biologics in naive patients was linked to a reduced incidence of recurrence over time.

ANNALS OF SURGERY (2021)

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Article Gastroenterology & Hepatology

Rates of Postoperative Recurrence of Crohn's Disease and Effects of Immunosuppressive and Biologic Therapies

Pauline Riviere et al.

Summary: This study investigated the rates of clinical and surgical recurrence of Crohn's disease after surgery, and found that therapy modification based on post-operative endoscopic findings can impact disease recurrence rates. However, while initiating immunosuppressant or biological therapy after endoscopy showed a modest decrease in risk of clinical recurrence for patients with Rutgeerts scores of i3 or i4, this effect was not observed for patients with scores of i2.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Ileocolonic End-to-End Anastomoses in Crohn's Disease Increase the Risk of Early Post-operative Endoscopic Recurrence in Those Undergoing an Emergency Resection

Lena W. Y. Thin et al.

Summary: The study compared the risk of early post-operative endoscopic recurrence in Crohn's disease patients undergoing end-to-end anastomosis (ETEA) versus side-to-side anastomosis (STSA). The results showed that in emergency surgeries, ETEA was associated with a higher risk of EPER, while early initiation of biologics and/or immunosuppressants and smoking cessation were crucial for this high-risk group of patients.

JOURNAL OF GASTROINTESTINAL SURGERY (2021)

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Letter Gastroenterology & Hepatology

Ustekinumab for prevention of postoperative recurrence: Our clinical experience

Samia Hallouch Toutouh et al.

GASTROENTEROLOGIA Y HEPATOLOGIA (2021)

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Review Gastroenterology & Hepatology

Therapeutic Drug Monitoring of Tumor Necrosis Factor Antagonists in Crohn Disease: A Theoretical Construct to Apply Pharmacokinetics and Guidelines to Clinical Practice

Niels Vande Casteele et al.

Summary: TDM for CD patients focuses on optimizing TNF antagonist therapy, with reactive TDM for treatment failure and proactive TDM for regular monitoring to achieve treatment optimization. Data for TDM in CD patients mainly relate to a few antagonists such as infliximab, with more support for reactive TDM and further research needed for proactive TDM.

INFLAMMATORY BOWEL DISEASES (2021)

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Article Medicine, General & Internal

Characterization of Crohn's disease patients in Egypt: Risk factors for postoperative recurrence (A cohort study)

Shimaa Kamel et al.

Summary: The aim of this study was to identify the characterizations of Crohn's disease in Egyptian patients and its predictors for postoperative recurrence. Age at diagnosis, age at operation, and ileal location of Crohn's disease were found to significantly predict postoperative recurrence. Additionally, postoperative biological therapy significantly decreased the incidence of postoperative recurrence.

ANNALS OF MEDICINE AND SURGERY (2021)

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Review Gastroenterology & Hepatology

Does anti-tumor necrosis factor alpha prevent the recurrence of Crohn's disease? Systematic review and meta-analysis

Motoi Uchino et al.

Summary: Anti-TNF therapy is effective at preventing endoscopic recurrence for 1-2 years after surgery for Crohn's disease, without increasing adverse events. However, the reduction in clinical recurrence is not significant. Efficacy of postoperative anti-TNF therapy may vary in terms of outcomes such as long-term prevention and cost-effectiveness.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Contemporary Risk of Surgery in Patients With Ulcerative Colitis and Crohn's Disease: A Meta-Analysis of Population-Based Cohorts

Lester Tsai et al.

Summary: The patient-level risks of surgery in patients with ulcerative colitis and Crohn's disease have significantly decreased over time, with a 5-year cumulative risk of surgery of 7.0% in ulcerative colitis and 18.0% in Crohn's disease in contemporary cohorts. This decrease may be related to early detection and/or better treatment.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Medicine, General & Internal

Primary Failure to an Anti-TNF Agent in Inflammatory Bowel Disease: Switch (to a Second Anti-TNF Agent) or Swap (for Another Mechanism of Action)?

Javier P. Gisbert et al.

Summary: For patients with primary non-response to anti-TNF therapy in inflammatory bowel disease, switching to a second anti-TNF or swapping to vedolizumab/ustekinumab are the two main strategies. However, the efficacy of a second anti-TNF is lower in cases of primary failure, while vedolizumab and ustekinumab have generally shown less effectiveness in anti-TNF exposed patients. More randomized trials are needed to compare these strategies and improve treatment outcomes for patients with primary non-response.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Therapeutic Drug Monitoring of Biologics in IBD: Essentials for the Surgical Patient

Rodrigo Bremer Nones et al.

Summary: Despite the development in pharmacological treatment of IBD, the impact of biologics in perioperative period needs further investigation. Studies show no increased risk of postoperative complications with biologics, with potential benefits in reducing colectomy rates and improving fistula healing after surgery. Therapeutic drug monitoring is a valuable tool in guiding clinical decisions during the perioperative setting.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Ustekinumab is more effective than azathioprine to prevent endoscopic postoperative recurrence in Crohn's disease

Anthony Buisson et al.

Summary: This study compared the efficacy of ustekinumab versus azathioprine in preventing postoperative recurrence in Crohn's disease patients. Results showed that ustekinumab was more effective in reducing endoscopic postoperative recurrence rates compared to azathioprine at 6 months.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2021)

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Article Biotechnology & Applied Microbiology

Anti -TNF alpha agents in preventing the postoperative recurrence of Crohn's disease: Do they still play a role in the biological era?

Caiguang Liu et al.

Summary: The results of this meta-analysis demonstrate that biologics are more effective than non-biological treatments in preventing postoperative recurrence in patients with Crohn's disease, with anti-TNFα agents showing superiority in preventing endoscopic recurrence. Additionally, infliximab and adalimumab have similar efficacy in preventing postoperative recurrence.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Article Gastroenterology & Hepatology

Quantifying the rate of recurrence of postoperative Crohn's disease with biological therapy. A meta-analysis

Sneha R. Jain et al.

Summary: The use of anti-TNF-alpha agents is effective in preventing postoperative recurrence of Crohn's disease, with different rates observed at various time points. However, the type of biological agent and timing of treatment initiation after surgery have minimal impact on recurrence rates. Infliximab and adalimumab demonstrate similar efficacy in preventing postoperative recurrence.

JOURNAL OF DIGESTIVE DISEASES (2021)

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Article Medicine, General & Internal

Management and outcomes of surgical patients with intestinal Behcet's disease and Crohn's disease in southwest China

Li Zeng et al.

Summary: Gastrointestinal involvement in Behcet's disease (GIBD) and Crohn's disease (CD) share similarities but GIBD surgical patients require more emergency surgeries, are more susceptible to postoperative complications and recurrence, and often need aggressive postoperative treatments compared to CD surgical patients.

WORLD JOURNAL OF CLINICAL CASES (2021)

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Review Gastroenterology & Hepatology

Medical therapies for postoperative Crohn's disease

Ravi S. Shah et al.

Summary: Postoperative recurrence of Crohn's disease is common and requires multidisciplinary approach involving surgeons and gastroenterologists. Endoscopic monitoring is crucial for guiding postoperative management, along with risk stratification of patients and follow-up endoscopic monitoring for therapy intensification. This review summarizes evidence on recurrence rates, disease monitoring techniques, and postoperative management strategies guided by endoscopic monitoring.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Rate of Reoperation Decreased Significantly After Year 2002 in Patients With Crohn's Disease

Takahide Shinagawa et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Perioperative and Postoperative Management of Patients With Crohn's Disease and Ulcerative Colitis

Edward L. Barne et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Review Pharmacology & Pharmacy

Pharmacological Prevention of Postoperative Recurrence in Crohn's Disease

Lucine Vuitton et al.

DRUGS (2020)

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Review Gastroenterology & Hepatology

Postoperative Crohn's disease management

Edward L. Barnes

CURRENT OPINION IN GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

The prevention and management of Crohn's disease postoperative recurrence: results from the Y-ECCO/ClinCom 2019 Survey

Gabriele Dragoni et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

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Letter Gastroenterology & Hepatology

Serum Adalimumab Concentration after Surgery is Correlated with Postoperative Endoscopic Recurrence in Crohn's Disease Patients: One Step before Proactive Therapeutic Drug Monitoring

Lucile Boivineau et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Gastroenterology & Hepatology

Real-World Experience with AGA Guidelines in the Management of Crohn's Disease following Ileocolonic Resection: A Retrospective Cohort Study

Shasha Tang et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2020)

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Article Gastroenterology & Hepatology

Antitumor Necrosis Factor Agents to Treat Endoscopic Postoperative Recurrence of Crohn's Disease: A Nationwide Study With Propensity-Matched Score Analysis

Fiorella Cañete et al.

Clinical and Translational Gastroenterology (2020)

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Article Gastroenterology & Hepatology

Delays in Initiating Post-operative Prophylactic Biologic Therapy Are Common Among Crohn's Disease Patients

Shirley Cohen-Mekelburg et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

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Review Gastroenterology & Hepatology

Comparative Efficacy of Anti-TNF Therapies For The Prevention of Postoperative Recurrence of Crohn's Disease A Systematic Review and Network Meta-Analysis of Prospective Trials

Ziad Bakouny et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2019)

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Editorial Material Gastroenterology & Hepatology

Medical Prophylaxis of Post-Surgical Crohn's Disease Recurrence: Towards Timely Anti-TNF Therapy

Adam C. Fields et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

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Article Gastroenterology & Hepatology

Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry

Fiorella Canete et al.

INFLAMMATORY BOWEL DISEASES (2019)

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Article Surgery

Penetrating Crohn Disease Is Not Associated With a Higher Risk of Recurrence After Surgery A Prospective Nationwide Cohort Conducted by the Getaid Chirurgie Group

Leon Maggiori et al.

ANNALS OF SURGERY (2019)

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Review Gastroenterology & Hepatology

Anti-TNFα agents are the best choice in preventing postoperative Crohn's disease: A meta-analysis

Adrienn Eros et al.

DIGESTIVE AND LIVER DISEASE (2019)

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Article Gastroenterology & Hepatology

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

Christopher Andrew Lamb et al.

GUT (2019)

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Review Gastroenterology & Hepatology

Systematic Review and Network Meta-Analysis of Medical Therapies to Prevent Recurrence of Post-Operative Crohn's Disease

Nicholas E. Burr et al.

JOURNAL OF CROHNS & COLITIS (2019)

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Review Medicine, General & Internal

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease

Teuta Gjuladin-Hellon et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2019)

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Review Gastroenterology & Hepatology

European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal ['Exit Strategies'] in Inflammatory Bowel Disease

Glen Doherty et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Article Gastroenterology & Hepatology

Postoperative Morbidity Risks Following Ileocolic Resection for Crohn's Disease Treated With Anti-TNF Alpha Therapy: A Retrospective Study of 360 Patients

Ingrid Jouvin et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Article Gastroenterology & Hepatology

Is the Pharmacokinetic Profile of a First Anti-TNF Predictive of the Clinical Outcome and Pharmacokinetics of a Second Anti-TNF?

Xavier Roblin et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Article Gastroenterology & Hepatology

The Use of Vedolizumab in Preventing Postoperative Recurrence of Crohn's Disease

Akihiro Yamada et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Article Gastroenterology & Hepatology

Anti-TNF Therapeutic Drug Monitoring in Postoperative Crohn's Disease

Emily K. Wright et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Article Surgery

Postoperative adalimumab maintenance therapy for Japanese patients with Crohn's disease: a single-center, single-arm phase II trial (CCOG-1107 study)

Takahiro Asada et al.

SURGERY TODAY (2018)

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Article Surgery

Postoperative therapy with infliximab for Crohn's disease: a 2-year prospective randomized multicenter study in Japan

Kouhei Fukushima et al.

SURGERY TODAY (2018)

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Article Gastroenterology & Hepatology

Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease

Karen van Hoeve et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Article Gastroenterology & Hepatology

Short and long-term effectiveness and safety of vedolizumab in inflammatory bowel disease: results from the ENEIDA registry

Maria Chaparro et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

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Review Biotechnology & Applied Microbiology

A Meta-Analysis of Efficacy and Safety of Infliximab for Prevention of Postoperative Recurrence in Patients with Crohn's Disease

He Huang et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Gastroenterology & Hepatology

Efficacy of restarting anti-tumor necrosis factor α agents after surgery in patients with Crohn's disease

Sakiko Hiraoka et al.

INTESTINAL RESEARCH (2018)

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Article Gastroenterology & Hepatology

Knowledge Gaps in the Management of Postoperative Crohn's Disease: A US National Survey

Vu Q. Nguyen et al.

DIGESTIVE DISEASES AND SCIENCES (2018)

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Article Gastroenterology & Hepatology

Male gender, active smoking and previous intestinal resection are risk factors for post-operative endoscopic recurrence in Crohn's disease: results from a prospective cohort study

Claire Auzolle et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

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Article Gastroenterology & Hepatology

Submucosal Plexitis as a Predictive Factor for Postoperative Endoscopic Recurrence in Patients with Crohn's Disease Undergoing a Resection with Ileocolonic Anastomosis: Results from a Prospective Single-centre Study

Bart Lemmens et al.

JOURNAL OF CROHNS & COLITIS (2017)

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Article Gastroenterology & Hepatology

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 2: Surgical Management and Special Situations

Paolo Gionchetti et al.

JOURNAL OF CROHNS & COLITIS (2017)

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Editorial Material Gastroenterology & Hepatology

American Gastroenterological Association Institute Guideline on the Management of Crohn's Disease After Surgical Resection

Geoffrey C. Nguyen et al.

GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Anti-TNFα Treatment After Surgical Resection for Crohn's Disease Is Effective Despite Previous Pharmacodynamic Failure

Amit Assa et al.

INFLAMMATORY BOWEL DISEASES (2017)

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Article Gastroenterology & Hepatology

Cost-utility Analysis: Thiopurines Plus Endoscopy-guided Biological Step-up Therapy is the Optimal Management of Postoperative Crohn's Disease

Roberto Candia et al.

INFLAMMATORY BOWEL DISEASES (2017)

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Article Gastroenterology & Hepatology

The Association Between Drug Levels and Endoscopic Recurrence in Postoperative Patients with Crohn's Disease Treated with Tumor Necrosis Factor Inhibitors

Shmuel Fay et al.

INFLAMMATORY BOWEL DISEASES (2017)

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Article Gastroenterology & Hepatology

The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effector T Cells In Vivo

Sebastian Zundler et al.

INFLAMMATORY BOWEL DISEASES (2017)

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Article Gastroenterology & Hepatology

Risk factors associated with postoperative recurrence and repeat surgery in Japanese patients with Crohn's disease

Jun Kusaka et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2017)

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Article Gastroenterology & Hepatology

Adalimumab vs Azathioprine in the Prevention of Postoperative Crohn's Disease Recurrence. A GETECCU Randomised Trial

Antonio Lopez-Sanroman et al.

JOURNAL OF CROHNS & COLITIS (2017)

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Article Gastroenterology & Hepatology

Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease

Kwan Mo Yang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Review Gastroenterology & Hepatology

Strategies for Preventing Endoscopic Recurrence of Crohn's Disease 1 Year after Surgery: A Network Meta-Analysis

Jin-shan Feng et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2017)

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Review Gastroenterology & Hepatology

Perioperative use of immunosuppressive medications in patients with Crohn's disease in the new biological era

Amy L. Lightner et al.

GASTROENTEROLOGY REPORT (2017)

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Meeting Abstract Gastroenterology & Hepatology

A Prospective Validation of Deep Learning for Polyp Auto-detection during Colonoscopy

Pu Wang et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Effectiveness of Mesalazine, Thiopurines and Tumour Necrosis Factor Antagonists in Preventing Post-Operative Crohn's Disease Recurrence in a Real-Life Setting

Mariangela Allocca et al.

DIGESTION (2017)

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Article Gastroenterology & Hepatology

Risk factors for recurrence of Crohn's disease requiring surgery in patients receiving post-operative anti-tumor necrosis factor maintenance therapy

Toshimitsu Araki et al.

JOURNAL OF THE ANUS RECTUM AND COLON (2017)

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Review Surgery

Current trends and challenges in the postoperative medical management of Crohn's disease: A systematic review

Andrew T. Schlussel et al.

AMERICAN JOURNAL OF SURGERY (2017)

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Article Gastroenterology & Hepatology

Postoperative prophylaxis in Crohn's disease after intestinal resection: a retrospective analysis

Anthony O'Connor et al.

FRONTLINE GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study

I. F. de Barcelos et al.

COLORECTAL DISEASE (2017)

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Article Gastroenterology & Hepatology

The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study

Andres J. Yarur et al.

GUT (2016)

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Article Gastroenterology & Hepatology

Clinical efficacy of adalimumab in Crohn's disease: a real practice observational study in Japan

Fuminao Takeshima et al.

BMC GASTROENTEROLOGY (2016)

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Editorial Material Gastroenterology & Hepatology

Is an Ounce of Prevention Worth a Pound of Cure: Postoperative Recurrence of Crohn's Disease?

Subrata Ghosh et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection

Miguel Regueiro et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Postoperative Use of Anti-TNF-α Agents in Patients with Crohn's Disease and Risk of Reoperation-A Nationwide Cohort Study

Jens Kjeldsen et al.

INFLAMMATORY BOWEL DISEASES (2016)

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Article Gastroenterology & Hepatology

Comparable outcomes of the consistent use versus switched use of anti- tumor necrosis factor agents in postoperative recurrent Crohn's disease following ileocolonic resection

Yi Li et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2016)

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Review Medicine, General & Internal

Aminosalicylates for induction of remission or response in Crohn's disease

Wee-Chian Lim et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2016)

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Article Gastroenterology & Hepatology

Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial

Craig Mowat et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Efficacy of thiopurines and adalimumab in preventing Crohn's disease recurrence in high-risk patients - a POCER study analysis

P. De Cruz et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2015)

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Review Gastroenterology & Hepatology

Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed

J. P. Gisbert et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2015)

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Article Gastroenterology & Hepatology

Combination Therapy with Infliximab and Thiopurine Compared to Infliximab Monotherapy in Maintaining Remission of Postoperative Crohn's Disease

Atsushi Sakuraba et al.

DIGESTION (2015)

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Article Gastroenterology & Hepatology

Prevention and treatment of postoperative Crohn's disease recurrence with anti-TNF therapy: A meta-analysis of controlled trials

Amelie Carla-Moreau et al.

DIGESTIVE AND LIVER DISEASE (2015)

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Article Gastroenterology & Hepatology

Postsurgical Prophylaxis in Crohn's Disease: Which Patients, Which Agents?

Pierre Michetti

DIGESTIVE DISEASES (2015)

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Article Gastroenterology & Hepatology

Vedolizumab in the treatment of Crohn's disease

Javier P. Gisbert et al.

GASTROENTEROLOGIA Y HEPATOLOGIA (2015)

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Article Gastroenterology & Hepatology

Comparative Efficacy of Pharmacologic Interventions in Preventing Relapse of Crohn's Disease After Surgery: A Systematic Review and Network Meta-analysis

Siddharth Singh et al.

GASTROENTEROLOGY (2015)

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Review Gastroenterology & Hepatology

Systematic Review with Meta-analysis of Prospective Studies: Anti-tumour Necrosis Factor for Prevention of Postoperative Crohn's Disease Recurrence

Yun Qiu et al.

JOURNAL OF CROHNS & COLITIS (2015)

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Article Gastroenterology & Hepatology

Direct Retrospective Comparison of Adalimumab and Infliximab in Preventing Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease: Results from the MULTIPER Database

Paulo Gustavo Kotze et al.

JOURNAL OF CROHNS & COLITIS (2015)

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Article Medicine, General & Internal

Crohn's disease management after intestinal resection: a randomised trial

Peter De Cruz et al.

LANCET (2015)

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Article Multidisciplinary Sciences

Low Dose Infliximab for Prevention of Postoperative Recurrence of Crohn's Disease: Long Term Follow-Up and Impact of Infliximab Trough Levels and Antibodies to Infliximab

Dario Sorrentino et al.

PLOS ONE (2015)

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Review Gastroenterology & Hepatology

Biologics for the prevention of postoperative Crohn's disease recurrence: A systematic review and meta-analysis

Ye Zhao et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2015)

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Article Pediatrics

Anti-TNF-α treatment for post-anastomotic ulcers and inflammatory bowel disease with Crohn's-like pathologic changes following intestinal surgery in pediatric patients

Jennifer J. Freeman et al.

PEDIATRIC SURGERY INTERNATIONAL (2015)

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Review Gastroenterology & Hepatology

Systematic review: the use of thiopurines or anti-TNF in post-operative Crohn's disease maintenance-progress and prospects

G. R. Jones et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2014)

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Editorial Material Gastroenterology & Hepatology

Anti-Tumor Necrosis Factor Therapy to Prevent Crohn's Disease Recurrence After Surgery

Hans H. Herfarth

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Postoperative Therapy With Infliximab Prevents Long-term Crohn's Disease Recurrence

Miguel Regueiro et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Low serum trough levels are associated with post-surgical recurrence in Crohn's disease patients undergoing prophylaxis with adalimumab

Giorgia Bodini et al.

DIGESTIVE AND LIVER DISEASE (2014)

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Article Gastroenterology & Hepatology

Antitumor necrosis factor a is more effective than conventional medical therapy for the prevention of postoperative recurrence of Crohn's disease: a meta-analysis

Douglas L. Nguyen et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis

Remo Panaccione et al.

GASTROENTEROLOGY (2014)

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Article Biochemistry & Molecular Biology

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

Raja Atreya et al.

NATURE MEDICINE (2014)

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Article Surgery

The impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn's disease: a single-center paired case-control study

Toshimitsu Araki et al.

SURGERY TODAY (2014)

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Article Gastroenterology & Hepatology

Comparison of the effectiveness of infliximab and adalimumab in preventing postoperative recurrence in patients with Crohn's disease: an open-label, pilot study

A. Tursi et al.

TECHNIQUES IN COLOPROCTOLOGY (2014)

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Article Surgery

A network meta-analysis on the efficacy of 5-aminosalicylates, immunomodulators and biologics for the prevention of postoperative recurrence in Crohn's disease

Zhiping Yang et al.

INTERNATIONAL JOURNAL OF SURGERY (2014)

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Review Gastroenterology & Hepatology

Cumulative Incidence of Second Intestinal Resection in Crohn's Disease: A Systematic Review and Meta-Analysis of Population-Based Studies

Alexandra D. Frolkis et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Adalimumab Is More Effective Than Azathioprine and Mesalamine at Preventing Postoperative Recurrence of Crohn's Disease: A Randomized Controlled Trial

Edoardo Savarino et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

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Review Gastroenterology & Hepatology

Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies

Alexandra D. Frolkis et al.

GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn's disease: An open-label pilot study

Alessandro Armuzzi et al.

Journal of Crohns & Colitis (2013)

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Article Gastroenterology & Hepatology

Infliximab versus azathioprine to prevent postoperative recurrence in Crohn's disease: are all controversial issues defined?

Paulo Gustavo Kotze et al.

Journal of Crohns & Colitis (2013)

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Review Gastroenterology & Hepatology

Surgery for Crohn's disease and anti-TNF agents: the changing scenario

Dario Sorrentino et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2013)

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Article Gastroenterology & Hepatology

The impact of early endoscopic lesions on the clinical course of patients following ileocolonic resection for Crohn's disease: A 5-year prospective cohort study

Takayuki Yamamoto et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2013)

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Review Gastroenterology & Hepatology

Review article: the natural history of postoperative Crohn's disease recurrence

A. Buisson et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2012)

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Review Gastroenterology & Hepatology

Diagnosis, prevention and treatment of postoperative Crohn's disease recurrence

Anthony Buisson et al.

DIGESTIVE AND LIVER DISEASE (2012)

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Article Gastroenterology & Hepatology

Early Diagnosis and Treatment of Postoperative Endoscopic Recurrence of Crohn's Disease: Partial Benefit by Infliximab-A Pilot Study

Dario Sorrentino et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

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Article Gastroenterology & Hepatology

Scheduled infliximab monotherapy to prevent recurrence of Crohn's disease following ileocolic or ileal resection: A 3-year prospective randomized open trial

Koji Yoshida et al.

INFLAMMATORY BOWEL DISEASES (2012)

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Article Gastroenterology & Hepatology

Comparative cost-effectiveness of strategies to prevent postoperative clinical recurrence of Crohn's disease

Glen A. Doherty et al.

INFLAMMATORY BOWEL DISEASES (2012)

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Article Gastroenterology & Hepatology

The use of infliximab in the prevention of postsurgical recurrence in polysurgery Crohn's disease patients: a pilot open-labeled prospective study

Atsushi Sakuraba et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2012)

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Article Gastroenterology & Hepatology

Adalimumab for the prevention and/or treatment of post-operative recurrence of Crohn's disease: A prospective, two-year, single center, pilot study

Konstantinos Papamichael et al.

JOURNAL OF CROHNS & COLITIS (2012)

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Review Gastroenterology & Hepatology

Prevention of postoperative recurrence of Crohn's disease

E. S. van Loo et al.

JOURNAL OF CROHNS & COLITIS (2012)

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Article Medicine, General & Internal

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Gastroenterology & Hepatology

Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients

Mariam Aguas et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

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Review Gastroenterology & Hepatology

5-Aminosalicylates Prevent Relapse of Crohn's Disease After Surgically Induced Remission: Systematic Review and Meta-Analysis

Alexander C. Ford et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)

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Article Gastroenterology & Hepatology

Strategies for the Prevention of Postoperative Recurrence in Crohn's Disease: Results of a Decision Analysis

Ashwin N. Ananthakrishnan et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)

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Article Gastroenterology & Hepatology

Postoperative Infliximab Is Not Associated with An Increase in Adverse Events in Crohn's Disease

Miguel Regueiro et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

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Article Surgery

Recurrence and Impact of Postoperative Prophylaxis in Laparoscopically Treated Primary Ileocolic Crohn Disease

Kishore Malireddy et al.

ARCHIVES OF SURGERY (2010)

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Article Gastroenterology & Hepatology

Low-Dose Maintenance Therapy With Infliximab Prevents Postsurgical Recurrence of Crohn's Disease

Dario Sorrentino et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2010)

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Review Pharmacology & Pharmacy

Anti-TNF's for Postoperative Recurrence in Crohn's Disease: The If's and How's

D. Sorrentino et al.

CURRENT DRUG TARGETS (2010)

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Article Gastroenterology & Hepatology

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects

Matthieu Allez et al.

JOURNAL OF CROHNS & COLITIS (2010)

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Article Medicine, General & Internal

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease.

Jean Frederic Colombel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Editorial Material Gastroenterology & Hepatology

Prevention of recurrence after surgery for Crohn's disease: Efficacy of infliximab

Takayuki Yamamoto

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

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Review Gastroenterology & Hepatology

Azathioprine and 6-Mercaptopurine for the Prevention of Postoperative Recurrence in Crohn's Disease: A Meta-Analysis

Laurent Peyrin-Biroulet et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

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Article Gastroenterology & Hepatology

Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection

Miguel Regueiro et al.

GASTROENTEROLOGY (2009)

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Article Gastroenterology & Hepatology

Impact of Infliximab Therapy After Early Endoscopic Recurrence Following Ileocolonic Resection of Crohn's Disease: A Prospective Pilot Study

Takayuki Yamamoto et al.

INFLAMMATORY BOWEL DISEASES (2009)

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Review Medicine, General & Internal

Interventions for prevention of post-operative recurrence of Crohn's disease

Glen Doherty et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)

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Review Gastroenterology & Hepatology

A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating Versus nonperforating Crohn's disease

Constantinos Simillis et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

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Article Gastroenterology & Hepatology

Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: A controlled randomized trial

Geert R. D'Haens et al.

GASTROENTEROLOGY (2008)

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Article Gastroenterology & Hepatology

The effect of smoking after surgery for Crohn's disease: a meta-analysis of observational studies

George E. Reese et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2008)

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Article Gastroenterology & Hepatology

Postoperative Crohn's disease recurrence:: A practical approach

Pilar Nos et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

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Letter Medicine, General & Internal

Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease

Dario Sorrentino et al.

ARCHIVES OF INTERNAL MEDICINE (2007)

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Article Gastroenterology & Hepatology

Prevention of postoperative recurrence of Crohn's disease by infliximab

Dario Sorrentino et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2006)

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Article Gastroenterology & Hepatology

Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease

S Ardizzone et al.

GASTROENTEROLOGY (2004)

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Article Gastroenterology & Hepatology

Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease

B Meresse et al.

GUT (2002)

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Letter Gastroenterology & Hepatology

Mesalamine and relapse prevention in Crohn's disease

M Cottone et al.

GASTROENTEROLOGY (2000)

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Article Surgery

Risk factors for surgery and postoperative recurrence in Crohn's disease

O Bernell et al.

ANNALS OF SURGERY (2000)

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