☆ 4.7 Article

Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer

DRUG RESISTANCE UPDATES (2023)

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Summary: The review discusses the role of natural phytochemicals in modulating ABCB1 gene expression through various signal transduction pathways in MDR cancer cells, suggesting an alternative approach to reversing MDR by downregulating P-glycoprotein expression in tumor tissues.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Multidisciplinary Sciences

Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells

Luping Gao et al.

Summary: This study established a sorafenib-resistant HCC cell line and found that Nrf2 signaling pathway promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant HCC cells.

PLOS ONE (2021)

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Article Food Science & Technology

Lycopene minimizes skin toxicity and oxidative stress in patients treated with panitumumab-containing therapy for metastatic colorectal cancer

Mauro Moroni et al.

Summary: The study revealed the effectiveness of lactolycopene in reducing skin toxicity and protecting tissues from oxidative stress in patients treated with panitumumab. This led to improvements in patient quality of life during anti-EGFR therapy.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Review Biochemistry & Molecular Biology

Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species

Ludwik Gorczyca et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2020)

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Article Pharmacology & Pharmacy

Targeting MDR-1 gene expression, BAX/BCL2, caspase-3, and Ki-67 by nanoencapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity

Alaa E. El-Sisi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

SOX2 upregulates side population cells and enhances their chemoresistant ability by transactivating ABCC1 expression contributing to intrinsic resistance to paclitaxel in melanoma

Xiaoqiang Si et al.

MOLECULAR CARCINOGENESIS (2020)

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Review Cell Biology

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Ufuk Degirmenci et al.

CELLS (2020)

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Review Pharmacology & Pharmacy

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Amit S. Choudhari et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Impact of novel N-aryl substituted piperamide on NF-kappa B translocation as a potent anti-neuroinflammatory agent

Sajad Shahbazi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma

Valerie Le Morvan et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

Chemosensitization by 4-hydroxyphenyl retinamide-induced NF-κB inhibition in acute myeloid leukemia cells

Hui Zhang et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2020)

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Article Chemistry, Medicinal

Indole Curcumin Reverses Muttidrug Resistance by Reducing the Expression of ABCB1 and COX2 in Induced Multidrug Resistant Human Lung Cancer Cells

Sankar Pajaniradje et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2020)

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Article Biochemistry & Molecular Biology

Oroxylin A reverses hypoxia-induced cisplatin resistance through inhibiting HIF-1α mediated XPC transcription

Yunyao Liu et al.

ONCOGENE (2020)

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Article Oncology

The Hedgehog signaling pathway promotes chemotherapy resistance via multidrug resistance protein 1 in ovarian cancer

Hong Zhang et al.

ONCOLOGY REPORTS (2020)

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Review Cell Biology

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Rui Liu et al.

CELL DEATH & DISEASE (2020)

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Review Cell Biology

Notch Signaling in Breast Cancer: A Role in Drug Resistance

McKenna BeLow et al.

CELLS (2020)

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Article Oncology

Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AML

Xiaoxuan Yu et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Article Pharmacology & Pharmacy

Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway

Dongya Chai et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2020)

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Article Plant Sciences

A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo

Rui-Ming Liu et al.

PHYTOMEDICINE (2020)

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Review Oncology

Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

Jiun- Lai et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Medicine, Research & Experimental

N6-methyladenosine-induced ERR. triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming

Zhuojia Chen et al.

THERANOSTICS (2020)

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Article Nutrition & Dietetics

The phytoestrogens daidzein and equol inhibit the drug transporter BCRP/ABCG2 in breast cancer cells: potential chemosensitizing effect

Juan Pablo Rigalli et al.

EUROPEAN JOURNAL OF NUTRITION (2019)

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Article Biochemistry & Molecular Biology

Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells

Yaxun Li et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

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Article Plant Sciences

Vielanin P enhances the cytotoxicity of doxorubicin via the inhibition of PI3K/Nrf2-stimulated MRP1 expression in MCF-7 and K562 DOX-resistant cell lines

Gao Hong-Liang et al.

PHYTOMEDICINE (2019)

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Review Oncology

Epigenetic Enzyme Mutations: Role in Tumorigenesis and Molecular Inhibitors

Mei Han et al.

FRONTIERS IN ONCOLOGY (2019)

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Meeting Abstract Oncology

A phase I open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung cancer.

Khashayar Esfahani et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Medicine, General & Internal

HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1

Yanan Lu et al.

EBIOMEDICINE (2019)

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Article Oncology

Increase Paclitaxel Sensitivity to Better Suppress Serous Epithelial Ovarian Cancer via Ablating Androgen Receptor/Aryl Hydrocarbon Receptor-ABCG2 Axis

Wei-Min Chung et al.

CANCERS (2019)

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Review Oncology

Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy?

Wasundara Fernando et al.

CANCER LETTERS (2019)

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Article Oncology

Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death

Ping Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Genetics & Heredity

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

Silvia Pietrobono et al.

FRONTIERS IN GENETICS (2019)

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Review Chemistry, Medicinal

Natural products as multidrug resistance modulators in cancer

Amit Kumar et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer

Seong-Hun Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Meeting Abstract Hematology

Progressive Down Regulation of JAK-STAT, Cell Cycle, and ABC Transporter Genes in CD34+/Lin- Cells of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients at Diagnosis Vs. 12 Months of Nilotinib Treatment Vs. Healthy Subjects

Alessandra Trojani et al.

BLOOD (2019)

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Article Medicine, Research & Experimental

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

Jakub Hofman et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery

Jeffrey A. van Santen et al.

ACS CENTRAL SCIENCE (2019)

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Article Medicine, General & Internal

Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer

Ming Zhan et al.

EBIOMEDICINE (2019)

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Review Oncology

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

Cornelia Braicu et al.

CANCERS (2019)

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Article Biochemistry & Molecular Biology

Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-kappa B signaling pathway

Ganesan Muthusamy et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2019)

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Article Oncology

Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation

Zong-Lin Zhang et al.

BREAST CANCER (2018)

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Article Biochemistry & Molecular Biology

Pregnane X receptor mediates sorafenib resistance in advanced hepatocellular carcinoma

Fan Feng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

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Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

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Article Biochemistry & Molecular Biology

Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1α

Ke Wang et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

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Article Oncology

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene

Gabriela Antonio-Andres et al.

LEUKEMIA & LYMPHOMA (2018)

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Article Biochemistry & Molecular Biology

Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice

Tae Hwan Kim et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

GlcNAc-l-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation

Jiho Yoo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Article Plant Sciences

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells

Zhaolin Chen et al.

PHYTOMEDICINE (2018)

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Article Biochemistry & Molecular Biology

GlcNAc-l-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation

Jiho Yoo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Article

miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2

Zeinab Mohamed et al.

Oncotarget (2018)

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Article Immunology

Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway

Kaili Qin et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

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Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Medicine, General & Internal

miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression

Minjiang Chen et al.

EBIOMEDICINE (2018)

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Article Nutrition & Dietetics

Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3/-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells

Jeong Yong Moon et al.

NUTRIENTS (2018)

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Article Oncology

LINE- 1 ORF- 1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells

Yan Chen et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

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Article Pharmacology & Pharmacy

Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells

Peng-Cheng Li et al.

DRUG METABOLISM AND DISPOSITION (2018)

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Article Chemistry, Multidisciplinary

Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis

Li Chen et al.

RSC ADVANCES (2018)

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Review Medicine, Research & Experimental

The role of the Hedgehog signaling pathway in cancer: A comprehensive review

Ana Marija Skoda et al.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK-HIF-1α

Yue Pan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

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Article Medicine, Research & Experimental

Tetrandrine prevents multidrug resistance in the osteosarcoma cell line, U-2OS, by preventing Pgp overexpression through the inhibition of NF-B signaling

Yandong Lu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway

Yu-Tsai Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell

Chi-Ming Liu et al.

MOLECULES (2017)

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Article Biochemistry & Molecular Biology

MraY-antibiotic complex reveals details of tunicamycin mode of action

Jonna K. Hakulinen et al.

NATURE CHEMICAL BIOLOGY (2017)

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Article Pathology

Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells

Chun Li et al.

PATHOLOGY RESEARCH AND PRACTICE (2017)

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Article Pharmacology & Pharmacy

Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells

Sami Hamdoun et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Article Integrative & Complementary Medicine

Solanum nigrum Unripe fruit fraction attenuates Adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway

Sankar Jagadeeshan et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

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Review Oncology

Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of MEK

Erika Martinelli et al.

CANCER TREATMENT REVIEWS (2017)

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Article Cell Biology

Parthenolide prevents resistance of MDA-MB231 cells to doxorubicin and mitoxantrone: the role of Nrf2

Daniela Carlisi et al.

CELL DEATH DISCOVERY (2017)

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Article Oncology

Hypoxia regulates ABCG(2) activity through the activivation of ERK1/2/HIF-1 alpha and contributes to chemoresistance in pancreatic cancer cells

Xiaodan He et al.

CANCER BIOLOGY & THERAPY (2016)

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Review Cell Biology

Mechanisms of Hippo pathway regulation

Zhipeng Meng et al.

GENES & DEVELOPMENT (2016)

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Article Oncology

Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway

Jie-Ru Chen et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Evodiamine Suppresses ABCG2 Mediated Drug Resistance by Inhibiting p50/p65 NF-κB Pathway in Colorectal Cancer

Hua Sui et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

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Review Biochemistry & Molecular Biology

Advances in plant-based inhibitors of P-glycoprotein

Jun Yu et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

Dietary extra virgin olive oil attenuates kidney injury in pristane-induced SLE model via activation of HO-1/Nrf-2 antioxidant pathway and suppression of JAK/STAT, NF-kappa B and MAPK activation

Marina Aparicio-Soto et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)

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Article Biochemistry & Molecular Biology

A high definition look at the NF-Y regulome reveals genome-wide associations with selected transcription factors

Diletta Dolfini et al.

NUCLEIC ACIDS RESEARCH (2016)

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Article Oncology

Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1α in vitro

Wen-Jing Wang et al.

ONCOLOGY REPORTS (2016)

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Article Oncology

Asclepiasterol, a novel C21 steroidal glycoside derived from Asclepias curassavica, reverses tumor multidrug resistance by down-regulating P-glycoprotein expression

Wei-Qi Yuan et al.

ONCOTARGET (2016)

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Article Oncology

Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer

Randall F Holcombe et al.

Cancer Management and Research (2016)

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Review Chemistry, Medicinal

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

Vanessa Lopes-Rodrigues et al.

PHARMACEUTICALS (2016)

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Article Oncology

Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance

Dong-Yu Wang et al.

CHINESE JOURNAL OF CANCER (2016)

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Article Biochemistry & Molecular Biology

Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway

Kazuhiro Katayama et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer

Swati Dhar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

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Article Multidisciplinary Sciences

Structural integration in hypoxia-inducible factors

Dalei Wu et al.

NATURE (2015)

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Article Oncology

Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-κB signaling and suppressing cAMP-responsive element transcriptional activity

Ziyuan Wang et al.

TUMOR BIOLOGY (2015)

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Article Biotechnology & Applied Microbiology

Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer

Yingqian Lv et al.

ONCOTARGETS AND THERAPY (2015)

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Article Multidisciplinary Sciences

Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells

Yinsong Zhu et al.

SCIENTIFIC REPORTS (2015)

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Review Pharmacology & Pharmacy

HIF-1α pathway: role, regulation and intervention for cancer therapy

Georgina N. Masoud et al.

ACTA PHARMACEUTICA SINICA B (2015)

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Review Multidisciplinary Sciences

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

Hossam M. Abdallah et al.

JOURNAL OF ADVANCED RESEARCH (2015)

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Review Biochemistry & Molecular Biology

The mammalian Hippo pathway: regulation and function of YAP1 and TAZ

Manami Kodaka et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Article Pharmacology & Pharmacy

Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells

Qiuxia Chen et al.

DRUG METABOLISM AND PHARMACOKINETICS (2014)

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Article Biochemistry & Molecular Biology

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

Jurian Schuijers et al.

EMBO JOURNAL (2014)

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Article Oncology

Feroniellin A- induced autophagy causes apoptosis in multidrug- resistant human A549 lung cancer cells

Chutima Kaewpiboon et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Plant Sciences

Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells

Yan Fang Sun et al.

PHYTOMEDICINE (2014)

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Article Multidisciplinary Sciences

YAP/TEAD Co-Activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells

Yan Xia et al.

PLOS ONE (2014)

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Article Oncology

Effect of pregnane X receptor expression on drug resistance in breast cancer

En-Qi Qiao et al.

ONCOLOGY LETTERS (2014)

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Article Oncology

Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer

Armina A. Kazi et al.

BREAST CANCER RESEARCH (2014)

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Article Cell Biology

Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells

Ki-Hwan Eum et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)

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Article Oncology

Tunicamycin Potentiates Cisplatin Anticancer Efficacy through the DPAGT1/Akt/ABCG2 Pathway in Mouse Xenograft Models of Human Hepatocellular Carcinoma

Helei Hou et al.

MOLECULAR CANCER THERAPEUTICS (2013)

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Review Food Science & Technology

Curcumin as a regulator of epigenetic events

Marie-Helene Teiten et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2013)

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Article Biochemistry & Molecular Biology

Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype

Wook-Jin Yang et al.

MOLECULES AND CELLS (2013)

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Article Multidisciplinary Sciences

Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells

Sascha Venturelli et al.

PLoS One (2013)

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Article Toxicology

Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest

Litao Zhu et al.

TOXICOLOGY LETTERS (2013)

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Article Chemistry, Medicinal

Tropolones As Lead-Like Natural Products: The Development of Potent and Selective Histone Deacetylase Inhibitors

Sophia N. Ononye et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

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Article Biochemistry & Molecular Biology

Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

Trinidad Mata Balaguer et al.

BMC MOLECULAR BIOLOGY (2012)

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Article Oncology

Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition

Lv Li et al.

CANCER CELL INTERNATIONAL (2012)

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Article Oncology

Genistein inhibits the sternness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway

Linlin Zhang et al.

CANCER LETTERS (2012)

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Article Oncology

Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression

Bin Bao et al.

CANCER RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors in Physiology and Medicine

Gregg L. Semenza

CELL (2012)

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Article Chemistry, Medicinal

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

Cheng-Ling Liu et al.

MARINE DRUGS (2012)

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Article Oncology

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

Chii-Wen Chou et al.

NEURO-ONCOLOGY (2012)

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Effects of Baicalein on the Pharmacokinetics of Tamoxifen and its Main Metabolite, 4-Hydroxytamoxifen, in Rats: Possible Role of Cytochrome P450 3A4 and P-glycoprotein inhibition by Baicalein

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HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: Implication for chemosensitization

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Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line

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ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma

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Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo

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Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells

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Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells

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Review Biochemistry & Molecular Biology

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

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Tetrandrine prevents acquired drug resistance of K562 cells through inhibition of mdr1 gene transcription

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JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

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(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line

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Orphan Nuclear Receptors as Targets for Drug Development

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Inhibition of P-Glycoprotein by Wogonin Is Involved with the Potentiation of Etoposide-Induced Apoptosis in Cancer Cells

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Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

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Elucidating the 'Jekyll and Hyde' Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

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Pregnane X Receptor and its Potential Role in Drug Resistance in Cancer Treatment

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RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2009)

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Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

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ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)

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STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

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Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells

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Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells

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Tumor suppressor LATS1 is a negative regulator of oncogene YAP

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Elucidation of a universal size-control mechanism in Drosophila and mammals

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The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model

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Structural basis for depletion of heat shock protein 90 client proteins by deguelin

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Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180

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Chrysin inhibits expression of hypoxia-inducible factor-1 alpha through reducing hypoxia-inducible factor-1 alpha stability and inhibiting its protein synthesis

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Transporters on demand: Intracellular reservoirs and cycling of bile canalicular ABC transporters

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Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176)

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Transcriptional repression of protein kinase Cα via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation

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Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines

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The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

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Transcriptional regulation of ABC drug transporters

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Multidrug resistance genes and P-glycoprotein in the testis of the rat, mouse, guinea pig, and human

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Multidrug resistance in cancer: Role of ATP-dependent transporters

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Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1

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Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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