期刊
DRUG DISCOVERY TODAY
卷 28, 期 8, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2023.103667
关键词
bacteria; surface modi fi cation; genetic engineering; drug delivery; gastrointestinal disease; cancer
Therapeutics based on living organisms provide a roadmap for next-generation biomedicine, and bacteria play a crucial role in the development, regulation, and treatment of gastrointestinal disease and cancer through similar mechanisms. However, primitive bacteria lack stability to overcome complex drug delivery barriers and their multifunctionality is limited. Artificially engineered bacteria (ArtBac) with modified surfaces and genetic functions show promise in addressing these issues.
Therapeutics based on living organisms provide a roadmap for next-generation biomedicine. Bacteria have an essential role in the development, regulation, and treatment of gastrointestinal disease and cancer through similar mechanisms. However, primitive bacteria lack the stability to overcome complex drug delivery barriers, and their multifunctionality in reinforcing both conventional and emerging therapeutics is limited. Artificially engineered bacteria (ArtBac) with modified surfaces and genetic functions show promise for tackling these problems. Herein, we discuss recent applications of ArtBac as living biomedicine for the treatment of gastrointestinal diseases and tumors. Future perspectives are given to guide the rational design of ArtBac toward safe multifunctional medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据