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Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

DRUG DISCOVERY TODAY (2024)

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Article Polymer Science

Galactose engineered nanocarriers: Hopes and hypes in cancer therapy

Mahak Fatima et al.

Summary: Adequate knowledge about the cancer tissue environment, cancer cell pathology, and available methods of targeting is crucial for specific cancer cell targeting. Cancer cells express certain receptors that distinguish them from non-cancerous cells. Galactose, a ligand with high affinity towards asialoglycoprotein receptors expressed by hepatic cells, is being investigated as a means of targeting cancer cells. Nano-carriers modified with galactose show promise for specific targeting and delivery of therapeutic agents to tumor cells.

EUROPEAN POLYMER JOURNAL (2023)

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Article Polymer Science

CD44 and CD133 aptamer directed nanocarriers for cancer stem cells targeting

Rakshita Grover et al.

Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.

EUROPEAN POLYMER JOURNAL (2023)

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Article Polymer Science

Immunoliposomes as an emerging nanocarrier for breast cancer therapy

Neha Parveen et al.

Summary: Breast cancer is the most common non-cutaneous carcinoma in women and the second most prevalent tumour-related condition. Innovative nanotechnologies have shown promise in treating or targeting breast cancer. Recent research focuses on developing components that include drugs and target the site of illness. This article complements existing reviews on liposomal drug delivery by emphasizing immunoliposome tumour targeting and summarizing various experiments on therapeutic potential, liposomal parameters, and target site needs. Immunoliposomes are suggested as a promising therapeutic delivery device for breast cancer therapy, combining distinct target-cell associations and cytotoxic drugs.

EUROPEAN POLYMER JOURNAL (2023)

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Article Biochemistry & Molecular Biology

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Leli Zeng et al.

Molecular Cancer (2023)

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Article Biochemistry & Molecular Biology

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer

Zhe Liu et al.

Molecular Cancer (2023)

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Review Pharmacology & Pharmacy

Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Chaithanya Ganji et al.

Summary: Mitochondria, as the powerhouses of cells, play important roles in cellular survival through regulating essential metabolic functions. Dysregulation of mitochondrial pathways, such as oxidative phosphorylation or production of reactive oxygen species (ROS), has been identified in cancer growth and development, making them attractive targets against cancer. Recent advances in nanotechnology have provided innovative solutions for delivering antitumor agents to mitochondria. This review explores the importance of mitochondria in neoplastic development, discusses the latest smart designs of nano-based systems for targeting mitochondria, and highlights key mitochondrial pathways in cancer cells.

DRUG DISCOVERY TODAY (2023)

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Review Environmental Sciences

Targeted therapy of breast tumor by PLGA-based nanostructures: The versatile function in doxorubicin delivery

Tenzin Sonam Dongsar et al.

Summary: Breast carcinoma is a diverse disease and one of the most prevalent malignancies in females worldwide. Chemotherapy is widely used for its treatment, but it has limitations. Nanoparticulate systems, particularly PLGA-based nano systems, are being explored as a promising strategy for improving breast carcinoma treatment. This review focuses on the effectiveness of DOX-encapsulated PLGA nanoparticles as a feasible option for breast cancer treatment.

ENVIRONMENTAL RESEARCH (2023)

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Article Polymer Science

Self-nanoemulsifying drug delivery system for pancreatic cancer

Neha Parveen et al.

Summary: Pancreatic cancer is the fourth leading cause of death worldwide, with low survival rates. The difficulties in early detection and the unique characteristics of pancreatic cancer contribute to ineffective therapies and widespread metastasis. Novel approaches, such as combining nanotechnology with cancer targeting, have shown potential in improving treatment efficacy and reducing cytotoxic effects.

EUROPEAN POLYMER JOURNAL (2023)

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Article Polymer Science

Emerging application of magnetic nanoparticles for breast cancer therapy

Tenzin Tsering Dongsar et al.

Summary: Breast carcinoma is a highly prevalent and deadly cancer in females, causing a significant number of mortalities and incidences. Conventional cancer treatments have limitations in terms of side effects and efficacy. Nanotechnology, specifically magnetic nanoparticles (MNPs), has emerged as an innovative approach for cancer management and detection. This article summarizes the applications of MNPs in cancer therapy, focusing on the potential of MNPs in treating breast cancer.

EUROPEAN POLYMER JOURNAL (2023)

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Article Engineering, Biomedical

Formulation and evaluation of a two-stage targeted liposome coated with hyaluronic acid for improving lung cancer chemotherapy and overcoming multidrug resistance

Xuelian Wang et al.

Summary: Multidrug resistance is a major challenge in chemotherapy for non-small cell lung cancer. Mitochondria have been identified as a promising target for overcoming drug resistance. A two-stage targeted liposome was successfully developed, with paclitaxel-loaded cationic liposome formulated and further coated with hyaluronic acid. The encapsulated paclitaxel showed improved stability and safety, and the liposomes enhanced cellular uptake and accumulation of paclitaxel in mitochondria, leading to disrupted mitochondrial function, increased apoptosis, and stronger anticancer efficacy.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2023)

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Review Biochemistry & Molecular Biology

Gold nanoparticles and gold nanorods in the landscape of cancer therapy

Prashant Kesharwani et al.

Summary: Cancer is a devastating disease, and more efficient, non-invasive therapies with minimal side effects are needed. Gold nanoparticles with impressive optical properties have been at the forefront of bioengineered cancer therapy. This review discusses the optical features of gold nanoparticles and highlights the recent research on their application, especially gold nanorods, in combating various cancers such as breast, lung, colon, oral, prostate, and pancreatic cancer.

MOLECULAR CANCER (2023)

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Review Biochemistry & Molecular Biology

New opportunities for RGD-engineered metal nanoparticles in cancer

Wei Qin et al.

Summary: The use of nanotechnology in bioimaging has opened up new opportunities, especially with the use of metal nanoparticles such as gold, silver, iron, and copper. These nanoparticles have broad optical characteristics, are easy to manufacture, and can be easily modified. The arginine-glycine-aspartate (RGD) peptide has shown great potential for targeting tumour cells and can be used with metal nanoparticles for non-invasive cancer imaging.

MOLECULAR CANCER (2023)

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Review Pharmacology & Pharmacy

Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy

Yinping Sun et al.

Summary: This review highlights the recent designs of smart systems that promote efficient lysosomal release and/or escape of anticancer agents and biotherapeutics, thereby boosting cancer therapy and immunotherapy. Lysosomal-mediated drug release presents an appealing approach to develop innovative cancer therapeutics and immunotherapeutics.

ADVANCED DRUG DELIVERY REVIEWS (2023)

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Review Biochemistry & Molecular Biology

Mitochondria and cell death-associated inflammation

Esmee Vringer et al.

Summary: Mitochondria can initiate inflammation during cell death through the release of mitochondrial-derived damage-associated molecular patterns (DAMPs) and activation of similar inflammatory pathways as cytosol-invading bacteria. Understanding the role of mitochondrial inflammation in cell death has important implications for clinical therapeutics.

CELL DEATH AND DIFFERENTIATION (2023)

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Review Environmental Sciences

Hyaluronic acid-functionalized lipoplexes and polyplexes as emerging nanocarriers for receptor-targeted cancer therapy

Jyoti Chandra et al.

Summary: Cancer is a complex disease that develops in response to a combination of hereditary and environmental risk factors, resulting in genomic changes. CD44, a transmembrane glycoprotein, serves as a potential biomarker and therapeutic target for cancer stem cells. Hyaluronic acid, a polysaccharide, shows affinity for the CD44 receptor, making it a promising candidate for selectively targeting CD44-positive cancer cells.

ENVIRONMENTAL RESEARCH (2023)

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Review Environmental Sciences

Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer

Nazeer Hasan et al.

Summary: Non-melanoma skin cancer is a common malignancy worldwide, and current treatment therapies are limited by drug resistance. Nanoparticles can potentially overcome this limitation and enhance therapeutic efficacy. In this study, a combined therapy of 5-fluorouracil (5-FU) and cannabidiol (CBD)-loaded nanostructured lipid carrier gel was developed and evaluated for the treatment of skin cancer.

ENVIRONMENTAL RESEARCH (2023)

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Review Polymer Science

Recent advances in nanoparticle-based approaches for the treatment of brain tumors: Opportunities and challenges

Jisan Ahamed et al.

Summary: Malignant brain tumors have a poor prognosis and low survival rate due to the challenges in drug delivery, including crossing the blood-brain barrier, achieving optimal drug distribution within the tumor, and minimizing damage to healthy cells. Nanotechnology has emerged as a promising approach for brain tumor treatment by using nanoparticles to overcome these obstacles.

EUROPEAN POLYMER JOURNAL (2023)

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Review Engineering, Biomedical

Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

Mahavir Narwade et al.

Summary: The lack of specificity in standard anticancer therapies has negative consequences in clinical treatment. The use of cutting-edge ligands can achieve therapeutic specificity. Small synthetic oligonucleotide-ligands selected through SELEX are innovative as aptamers, also known as chemical antibodies. These aptamers have excellent specificity and affinity for target molecules and can be used as medicines to directly suppress tumor cell growth. The creation of aptamer-conjugated nanoconstructs has opened up new possibilities for more effective cancer therapy with minimal toxicity to healthy tissues. This review focuses on describing the most capable classes of aptamer-tethered nanocarriers for precise cancer cell recognition, with significant development in proficiency, selectivity, and targetability for cancer therapy. Existing theranostic applications, challenges, and future directions are also discussed.

BIOMATERIALS RESEARCH (2023)

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Article Materials Science, Biomaterials

Targeting drug delivery and efficient lysosomal escape for chemo-photodynamic cancer therapy by a peptide/DNA nanocomplex

Qiusheng Wang et al.

Summary: A peptide/DNA nanocomplex was developed for targeted delivery of chemotherapeutics and photosensitizers to cancer cells for efficient combination therapy. The complex demonstrated high affinity and specificity in targeting cancer cells, leading to efficient uptake and lysosomal escape for effective treatment outcomes. The combination of chemotherapy drug and photosensitizer induced cell death, showcasing the potential of this nanoplatform for advanced cancer therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Editorial Material Pharmacology & Pharmacy

Mitochondria-Targeted Drug Delivery

Joanna Kopecka

PHARMACEUTICS (2022)

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Review Materials Science, Biomaterials

A Comprehensive Review on Novel Liposomal Methodologies, Commercial Formulations, Clinical Trials and Patents

Veera Venkata Satya Naga Lakshmi Andra et al.

Summary: This review focuses on the scalable techniques for liposome preparation and discusses the strengths and limitations in industrial applicability. It also provides updates on recent advancements in biomedical applications, including commercially available formulations, clinical trials, and patents.

BIONANOSCIENCE (2022)

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Review Engineering, Biomedical

Microparticulate and nanotechnology mediated drug delivery system for the delivery of herbal extracts

Sunil Kumar Dubey et al.

Summary: There is a growing interest in exploring the potential of phytoconstituents, herbal or plant-based ingredients, due to their various beneficial activities. However, these constituents are sensitive to environmental and physiological factors. Therefore, a drug delivery system is needed to protect the phytoconstituents. A microparticulate drug delivery system, with its small size and ability to protect the active constituents, is considered an ideal choice for sustained and targeted drug delivery, minimizing side effects.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2022)

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Article Chemistry, Multidisciplinary

Recent Advancements in Mitochondria-Targeted Nanoparticle Drug Delivery for Cancer Therapy

Jiangsheng Xu et al.

Summary: Mitochondria are critical organelles for producing energy in cells and can be targeted for cancer therapy. Mitochondria-targeting nanotechnologies have shown high efficacy for cancer treatment both in vitro and in vivo, and can be intelligently designed based on the characteristics of the tumor microenvironment.

NANOMATERIALS (2022)

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Article Oncology

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Md Sanower Hossain et al.

Summary: Colorectal cancer (CRC) is a highly lethal disease with increasing incidence and mortality worldwide. Early detection and treatment are essential for survival, but recurrence and drug resistance pose significant challenges. This comprehensive review addresses the development, risk factors, and management strategies of CRC. In addition, natural products as potential therapeutics are also discussed. Public awareness is crucial for improving CRC management, especially in developing countries where access to diagnosis and treatment resources is limited.

CANCERS (2022)

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Review Cell Biology

Mitochondria Related Cell Death Modalities and Disease

Chuwen Tian et al.

Summary: Mitochondria play a key role in cell death, not only generating ATP but also controlling cell death through various mechanisms. These mitochondria-associated modes of cell death are related to various diseases, and mitochondria-based treatments have shown effectiveness.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biology

Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems: Therapeutics for Mitochondrial Disorders

Sakshi Buchke et al.

Summary: In addition to ATP generation, mitochondria play important roles in various functions and their dysfunction is implicated in the pathophysiology of several diseases. Nanoparticles provide promising strategies for targeted drug delivery to mitochondria, overcoming challenges such as low solubility and poor bioavailability. This review evaluates different nanoparticle-based drug delivery systems and discusses their potential as treatments for mitochondrial disorders.

LIFE-BASEL (2022)

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Review Multidisciplinary Sciences

Liposomes: structure, composition, types, and clinical applications

Hamdi Nsairat et al.

Summary: Liposomes are widely used nanocarriers for drug delivery due to their high biocompatibility, biodegradability, and low immunogenicity. They enhance drug solubility and controlled release, as well as allowing for surface modifications for targeted and sustained release. Liposomes have been clinically approved for treating various diseases and show promising potential in clinical trials.

HELIYON (2022)

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Article Biotechnology & Applied Microbiology

Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy

Liwei Gu et al.

Summary: This study successfully improved the anti-tumor efficacy of artemisinin drugs by preparing liposomes that target tumor cells and mitochondria, providing new research strategies for the development of new anti-tumor drugs.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Medicinal

Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment

Tianyu Chen et al.

Summary: In this study, KLA-modified liposomes co-loaded with 5-fluorouracil and paclitaxel were developed and demonstrated to have enhanced anticancer activity against triple-negative breast cancer (TNBC). The liposomes showed improved drug delivery to mitochondria and induced mitochondria-mediated apoptosis. In a mouse model, the liposomes also exhibited favorable antitumor activity with targeted tumor and mitochondria delivery, without obvious systemic toxicity.

PHARMACEUTICALS (2022)

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Review Medicine, Research & Experimental

Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy

Susanta Kumar Rout et al.

Summary: This article provides an in-depth analysis of cancer treatment targeting the mitochondrial genome at the molecular level. It discusses the use of nanomedicine techniques and theranostic nanomedicine for mitochondrial targeting, as well as the conceptual information on mitochondrial biomarkers for cancer treatment. The article also addresses the major drawbacks and challenges related to mitochondrial targeting for advanced cancer therapy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Materials Science, Multidisciplinary

Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials

Xiaofei Qin et al.

Summary: This review discusses the applications and future directions of nuclear targeting strategies in the study of nuclear entry mechanisms, aiming to promote the clinical translation of nuclear targeting nanotherapeutics.

MATERIALS & DESIGN (2022)

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Review Oncology

Breast cancer: an up-to-date review and future perspectives

Ruoxi Hong et al.

Summary: Breast cancer is the most common cancer worldwide, and treatment strategies vary by molecular features. Early-stage breast cancer can be cured with local-regional therapies, while advanced breast cancer is considered incurable. Innovative technologies of precision medicine may guide individualized treatment strategies in the future.

CANCER COMMUNICATIONS (2022)

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Review Oncology

Mitochondrial DNA is a major source of driver mutations in cancer

Minsoo Kim et al.

Summary: This article discusses the role of mitochondrial DNA mutations in tumors, emphasizing their direct impact on metabolic homeostasis. The contentious nature of this impact has been clarified by recent studies, revealing the importance of mutations in cancer initiation and progression.

TRENDS IN CANCER (2022)

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Article Nanoscience & Nanotechnology

Antitumor Effect of Hyperoside Loaded in Charge Reversed and Mitochondria-Targeted Liposomes

Yufei Feng et al.

Summary: The novel dual-functional liposome system possessing both extracellular charge reversal and mitochondrial targeting properties significantly enhances drug accumulation in mitochondria and triggers apoptosis of cancer cells. The results demonstrate that the charge reversed and mitochondria-targeted liposomes facilitate cellular internalization and mitochondrial accumulation for enhanced antitumor effect. Therefore, this liposome system represents a promising anticancer drug delivery system for improved therapeutic efficacy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

Zeng Zeng et al.

Summary: Mitochondria are essential organelles in cells that produce ATP and regulate apoptotic pathways in cancer cells. Nanocarriers combined with mitochondria have shown great potential in various cancer treatments, promoting efficient cancer therapies. This review discusses how mitochondria-targeted nanocarriers can enhance cancer treatment in different modalities and their challenges and prospects in clinical cancer treatment.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Lei Jiang et al.

Summary: Mitochondria are key targets for photothermal and photodynamic treatment for cancer, but delivery of therapeutics to these organelles remains a challenge. In this study, authors developed a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting moiety and demonstrated its targeting and antitumour efficacy in a mouse model of breast cancer.

NATURE COMMUNICATIONS (2021)

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Review Oncology

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Tomasz Sawicki et al.

Summary: Colorectal cancer is one of the most common malignant tumors, with increasing incidence and mortality rates each year. Genetic and environmental factors, as well as lifestyle choices, play a significant role in its development. Studying the epidemiology and diagnosis of colorectal cancer is crucial for informing future strategies in disease prevention and control.

CANCERS (2021)

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Review Nanoscience & Nanotechnology

Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Yongjia Huang et al.

Summary: The article discusses the challenges of delivering therapeutic agents specifically to dysfunctional mitochondria in tumor progression and presents a variety of pathways to achieve smart stimuli-responsive and mitochondria-targeted drug delivery systems. These systems not only target the mitochondria with precision but also respond to internal and external stimuli to increase efficacy and reduce side effects, showing promise as a potential precision medicine for cancer treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Nanoscience & Nanotechnology

Hyaluronic Acid Coated Liposomes Co-Delivery of Natural Cyclic Peptide RA-XII and Mitochondrial Targeted Photosensitizer for Highly Selective Precise Combined Treatment of Colon Cancer

Yanqing Xu et al.

Summary: This study successfully designed a new cancer-targeted nanomedicine platform for the collaborative treatment of colon cancer, showing significant therapeutic effects in vitro and in vivo. The platform can achieve targeted continuous release of multiple therapeutic drugs and efficiently inhibit tumor growth in colon cancer cells.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Medicine, Research & Experimental

Nanotherapeutic approaches to target mitochondria in cancer

Shalini Mani et al.

Summary: Nanotechnology-based approaches offer incredible potential in cancer therapeutics due to their higher target specificity, demonstrating a potential and efficient way to target mitochondria of cancer cells for improved survival rates of cancer patients.

LIFE SCIENCES (2021)

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Article Chemistry, Medicinal

Dual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer

Kamel S. Ahmed et al.

Summary: The study developed a multifunctional nano-structured liposomal system for co-delivery of doxorubicin and celecoxib to overcome doxorubicin resistance in breast cancer, showing remarkable treatment efficacy. The peptide-modified targeted liposomes exhibited strong cellular entry ability and mitochondrial-targeting effect, effectively inhibiting P-glycoprotein efflux activity.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

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Review Biotechnology & Applied Microbiology

Mitochondria-Targeted Nanomedicine for Enhanced Efficacy of Cancer Therapy

Yan Gao et al.

Summary: Nanomedicines have been developed to deliver anticancer drugs selectively to tumor sites, with a focus on targeting mitochondria for cancer treatment. Various strategies are used to damage mitochondria and enhance cancer therapeutic modalities.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

An understanding of mitochondria and its role in targeting nanocarriers for diagnosis and treatment of cancer

Devendra Choudhary et al.

Summary: Nanotechnology has shown tremendous potential in cancer therapy by targeting mitochondria, the powerhouse of the cell, and different nanoparticulate systems have been explored for improving the treatment of cancer by targeting mitochondria.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Updates on the use of liposomes for active tumor targeting in cancer therapy

Wei Yan et al.

NANOMEDICINE (2020)

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Article Biotechnology & Applied Microbiology

X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system

Xuefan Gu et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy

Ang Gao et al.

ACTA PHARMACOLOGICA SINICA (2019)

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Article Medicine, Research & Experimental

New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety

Somayeh Handali et al.

LIFE SCIENCES (2019)

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Article Biophysics

Folate receptor-targeted liposomal nanocomplex for effective synergistic photothermal-chemotherapy of breast cancer in vivo

Van Du Nguyen et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Materials Science, Biomaterials

Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics

Yuehua Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Chemistry, Multidisciplinary

Recent progress on mitochondrial targeted cancer therapy based on inorganic nanomaterials

Z. Xu et al.

MATERIALS TODAY CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Lysosomal targeting strategies for design and delivery of bioactive for therapeutic interventions

Ankur Sharma et al.

JOURNAL OF DRUG TARGETING (2018)

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Review Biochemistry & Molecular Biology

Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review

Muhammad Kashif Riaz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells

Eskandar Moghimipour et al.

LIFE SCIENCES (2018)

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Article Chemistry, Medicinal

Overcoming drug-resistant lung cancer by paclitaxel-loaded hyaluronic acid-coated liposomes targeted to mitochondria

Yongfeng Tian et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2018)

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Article Nanoscience & Nanotechnology

Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction

Cancheng Liao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Review Oncology

Encapsulation of Nutraceutical Ingredients in Liposomes and Their Potential for Cancer Treatment

Sayantani Dutta et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

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Article Biotechnology & Applied Microbiology

The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis

Xin Jin et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

Ultrasound triggered drug delivery for mitochondria targeted sonodynamic therapy

MengJia Chen et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2017)

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Article Chemistry, Multidisciplinary

Mitochondria-targeting near-infrared light-triggered thermosensitive liposomes for localized photothermal and photodynamic ablation of tumors combined with chemotherapy

Caixia Yue et al.

NANOSCALE (2017)

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Article Chemistry, Multidisciplinary

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

Daniel A. Richards et al.

CHEMICAL SCIENCE (2017)

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Review Oncology

The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities

Kate L. Hertweck et al.

FRONTIERS IN ONCOLOGY (2017)

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Review Pharmacology & Pharmacy

Liposomal Formulations in Clinical Use: An Updated Review

Upendra Bulbake et al.

PHARMACEUTICS (2017)

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Article Biochemistry & Molecular Biology

The role of mitochondria in metabolism and cell death

Helin Vakifahmetoglu-Norberg et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Pharmacology & Pharmacy

Mitochondria-targeted drug delivery system for cancer treatment

Zhi-Peng Chen et al.

JOURNAL OF DRUG TARGETING (2016)

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Article Materials Science, Biomaterials

Development of a novel berberine-mediated mitochondria-targeting nano-platform for drug-resistant cancer therapy

Jue Tuo et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Biotechnology & Applied Microbiology

Application of liposomes in medicine and drug delivery

Hadis Daraee et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)

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Review Oncology

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors

Md Maksudul Alam et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2016)

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Article Engineering, Biomedical

Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response

Lei Jiang et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment

Assogba G. Assanhou et al.

BIOMATERIALS (2015)

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Article Nanoscience & Nanotechnology

A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer

Ji-Feng Shi et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

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Review Biotechnology & Applied Microbiology

Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers

Alessandro Parodi et al.

NANOMEDICINE (2015)

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Review Pharmacology & Pharmacy

Advances and Challenges of Liposome Assisted Drug Delivery

Lisa Sercombe et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Article Engineering, Biomedical

Liposomes, modified with PTDHIV-1 peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer

Rui-Jun Ju et al.

BIOMATERIALS (2014)

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Article Chemistry, Multidisciplinary

Nucleus-Targeted Drug Delivery: Theoretical Optimization of Nanoparticles Decoration for Enhanced Intracellular Active Transport

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NANO LETTERS (2014)

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The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer

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Article Engineering, Biomedical

Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes

Xu Ma et al.

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Current trends in the use of liposomes for tumor targeting

Pranali P. Deshpande et al.

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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NANOSCALE RESEARCH LETTERS (2013)

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Article Engineering, Biomedical

Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma

Yang Yu et al.

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Review Chemistry, Multidisciplinary

Doxil® - The first FDA-approved nano-drug: Lessons learned

Yechezkel (Chezy) Barenholz

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Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

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Article Oncology

Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

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ANTI-CANCER DRUGS (2011)

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Article Engineering, Biomedical

The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells

Xiao-Xing Wang et al.

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Article Biochemistry & Molecular Biology

Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol

Niravkumar R. Patel et al.

JOURNAL OF LIPOSOME RESEARCH (2010)

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The Role of Mitochondria in Apoptosis

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Review Biotechnology & Applied Microbiology

Recent advances with liposomes as pharmaceutical carriers

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