☆ 4.7 Review

Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery

DRUG DISCOVERY TODAY (2023)

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Review Chemistry, Multidisciplinary

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Adaeze Linda Onugwu et al.

Summary: Diseases affecting the anterior segment of the eye are a major cause of vision impairment and blindness worldwide. Drug delivery to the eye through the topical ocular route is challenging due to structural and physiological constraints. Nanotechnology-based drug delivery systems have been investigated as effective alternatives to conventional ocular delivery systems for treating anterior segment diseases. This review discusses different nanotechnology-based delivery systems and their prospects in clinical use.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Chemistry, Multidisciplinary

Tailoring surface properties of liposomes for dexamethasone intraocular administration

M. D. Al -Amin et al.

Summary: To enhance the delivery of anti-inflammatory drugs to the posterior eye segment, researchers developed liposomes with an engineered surface and found that polyethylene glycol-distearoylphosphatidylethanolamine (PEG(2kDa)-DSPE) reduced the liposomes' zeta potential, restored their diffusivity in the vitreous, and increased their anti-inflammatory effect on retinal cells.

JOURNAL OF CONTROLLED RELEASE (2023)

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Review Pharmacology & Pharmacy

Ocular Drug Delivery: a Comprehensive Review

Sadek Ahmed et al.

Summary: The human eye has complex anatomy and physiology that pose challenges for drug delivery to targeted ophthalmic sites. Overcoming ocular barriers and finding effective routes of administration and dosage forms are important for successful drug delivery. Nanotechnology-based carriers have gained attention due to their ability to entrap drugs, improve ocular permeability, and enhance bioavailability. Different characterization methods help predict the performance of these nanocarriers. This review provides insights into eye anatomy, ocular diseases, obstacles to drug delivery, advantages and drawbacks of different routes of administration and dosage forms, and advancements in ocular delivery.

AAPS PHARMSCITECH (2023)

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Article Pharmacology & Pharmacy

Investigating the effectiveness of Difluprednate-Loaded core-shell lipid-polymeric hybrid nanoparticles for ocular delivery

B. Kaviarasi et al.

Summary: DFB-loaded lipid polymer hybrid nanoparticles were developed to improve the corneal permeation and sustained release of the drug. The nanoparticles showed enhanced permeation and sustained release of DFB, with no damage to the corneal structure and no toxicity for ophthalmic administration.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Chemistry, Physical

Efficient expression of hydrophobin HGFII-his via POT1-mediated 8 integration strategy and its potential in curcumin nanoformulation

Zhongqiang Ma et al.

Summary: In this study, an efficient and eco-friendly expression system for the recombinant hydrophobin HGFII-his was developed. The study also explored the potential of HGFII-his-based curcumin nanoformulations, which showed promising cell uptake profiles and cytotoxic activity against cancer cells.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2023)

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Article Chemistry, Medicinal

Topical Tacrolimus Progylcosomes Nano-Vesicles As a Potential Therapy for Experimental Dry Eye Syndrome

Mohammad et al.

Summary: Topical tacrolimus loaded propylene glycol modified nano-vesicles were found to be more effective than tacrolimus solution in treating experimental dry eye syndrome in rabbits, improving tear production, tear break-up time, ocular surface temperature, and ocular and epithelial damage.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Biophysics

A topical fluorometholone nanoformulation fabricated under aqueous condition for the treatment of dry eye

Tian-zuo Wang et al.

Summary: A transparent FMT nanoformulation was fabricated with increased release rate and enhanced corneal penetration efficiency compared to commercial eye drops, showing more efficient alleviation of dry eye symptoms.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Biophysics

Formulation and development of tacrolimus-gellan gum nanoformulation for treatment of dry eye disease

Deepika Modi et al.

Summary: The study developed and evaluated tacrolimus gellan gum nanoparticles (TGNPs) for the treatment of dry eye disease (DED) and demonstrated their potential for efficient management of DED.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Pharmacology & Pharmacy

Metformin-loaded ethosomes with promoted anti-proliferative activity in melanoma cell line B16, and wound healing aptitude: Development, characterization and in vivo evaluation

Shrouk Magdy et al.

Summary: This study develops metformin-loaded ethosomes for localized treatment of melanoma and wound healing. The optimized ethosomal formulation exhibits efficient skin permeation and shows good efficacy in inhibiting melanoma cells and promoting wound healing.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system

Saman Yasamineh et al.

Summary: Niosomes, formed by the accumulation of nonionic surfactants in water, play a critical role in medication delivery systems. They enable controlled release and targeted distribution, making them suitable for treating cancer, infectious illnesses, and other disorders. Niosomes can also be injected through ocular and transdermal routes. Furthermore, they offer exciting opportunities for manufacturing biotechnology goods and novel vaccines.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of apocynin

Yaru Li et al.

Summary: The study demonstrates the potential feasibility of APO-VA64 nano-ophthalmic solution as a new treatment for ocular inflammatory diseases. The solution, fabricated via a simple process, exhibits valuable characteristics such as good ocular tolerance and improved drug permeation ability. It shows significant efficacy in treating ocular damage induced by benzalkonium chloride.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Fabrication of anti-oxidant curcumin loaded ceria nanoclusters for the novel delivery system to prevention of selenite-induced cataract therapy in alleviating diabetic cataract

Yanzhang Liu et al.

Summary: Diabetic cataract is a major cause of visual impairment for diabetic patients. Current drug delivery approaches and pharmacologic interventions for controlling diabetic cataract progression are limited, especially non-invasive strategies involving eye drops. This study developed a novel nanoformulation using antioxidant curcumin and cerium oxide nanoparticles to treat diabetic cataract complications by improving redox and anti-glycation potential. The nanoformulation exhibited effective antioxidant and anti-glycation properties in protecting lens epithelial cells and showed no toxicity in vivo.

PROCESS BIOCHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evaluation in rabbits

Asmaa Ashraf Nemr et al.

Summary: This study formulated AGO into bilosomal vesicles for the treatment of glaucoma. The optimal bilosomal formula showed high entrapment efficiency, controlled drug release, good stability, and safety for ocular use. Moreover, the bilosomes demonstrated superiority in in vivo pharmacodynamics parameters over the AGO solution, suggesting improved ocular delivery and bioavailability of agomelatine.

DRUG DELIVERY (2022)

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Article Pharmacology & Pharmacy

Preparation and Evaluation of Modified Chitosan Nanoparticles Using Anionic Sodium Alginate Polymer for Treatment of Ocular Disease

Vaishnavi A. Bhosale et al.

Summary: In this research, mucoadhesive nanoparticles were modified to mucous-penetrating nanoparticles by coating them with anionic polymer. The modified nanoparticles showed the potential to effectively penetrate the corneal epithelium, highlighting their potential in the treatment of fungal keratitis.

PHARMACEUTICS (2022)

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Article Medicine, Research & Experimental

Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/b-catenin signaling pathway

Nesrine Ebrahim et al.

Summary: The study indicated that BM-MSCs-Ex reduced oxidative stress, inflammation, and angiogenesis in diabetic retinas by inhibiting the Wnt/β-catenin signaling pathway, ultimately improving DR features.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Pharmacology & Pharmacy

Spanlastic nanovesicles for enhanced ocular delivery of vanillic acid: design, in vitro characterization, and in vivo anti-inflammatory evaluation

Shaimaa S. Ibrahim et al.

Summary: This study aimed to enhance the delivery of vanillic acid (VA) for the treatment of ocular inflammation using novel surfactant-based elastic vesicular nanocarriers called Spanlastics. The formulation composed of Span 60 and Tween 80 displayed the smallest particle size and good physical stability. In vivo experiments showed that the VA-loaded Spanlastic formulation significantly reduced inflammation compared to the drug suspension.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Role of extracellular vesicles in mitochondrial eye diseases

Sushma Anand et al.

Summary: Extracellular vesicles (EVs) play a significant role in eye health and disease, with potential for monitoring disease phenotypes and therapeutic outcomes. The relationship between EVs and mitochondria dysfunction could contribute to various eye disorders. EVs are gaining attention as potential therapeutics and drug-delivery vehicles for treating eye diseases.

IUBMB LIFE (2022)

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Article Chemistry, Multidisciplinary

Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery

Roman V. Moiseev et al.

Summary: Liposomes with different modifications were formulated and their physicochemical characteristics and retention on ex vivo eye tissues were evaluated. The maleimide-decorated liposomes showed the best retention performance on bovine conjunctiva compared to other liposomal formulations.

LANGMUIR (2022)

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Editorial Material Medicine, General & Internal

Ethosomes: A novel drug carrier

Neha Chauhan et al.

ANNALS OF MEDICINE AND SURGERY (2022)

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Article Polymer Science

Formulation and Evaluation of Moxifloxacin Loaded Bilosomes In-Situ Gel: Optimization to Antibacterial Evaluation

Ameeduzzafar Zafar et al.

Summary: In this study, a moxifloxacin-loaded bilosome in situ gel was developed to improve ocular residence time. The optimized formulation (MX-BSop-Ig4) exhibited desirable viscosity, sustained release, bio-adhesiveness, and antimicrobial properties. It showed no toxicity to the tested tissue and demonstrated significantly higher antimicrobial activity compared to pure moxifloxacin.

GELS (2022)

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Review Pharmacology & Pharmacy

Emerging potential of niosomes in ocular delivery

Amit Verma et al.

Summary: Niosomes have emerged as a promising tool for site-specific drug delivery, particularly in ophthalmology. They overcome limitations of traditional liposomes and enhance drug adhesion at the ocular site. Niosomes accommodate a variety of drugs and are widely used in ocular drug delivery.

EXPERT OPINION ON DRUG DELIVERY (2021)

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Article Pharmacology & Pharmacy

Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment

Rofida Albash et al.

Summary: This study focused on enhancing the topical antifungal activity of FTN using PEGylated cerosomes. By designing different formulations and studying their physicochemical properties, the optimal formulation PC6 was identified, showing high drug concentration and safety in dermatokinetic and histopathological studies.

DRUG DELIVERY (2021)

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Article Chemistry, Physical

Investigations on the role of edge activator upon structural transitions in Span vesicles

Sachin Rathod et al.

Summary: In this study, the microstructural characteristics of Span 80 vesicles were successfully modulated by using Tween 80 as an edge activator, through adjusting the EA-VB ratio and total surfactant concentration. The formation of large vesicles was observed as the proportion of EA decreased and the total surfactant concentration increased. Shifting towards higher surfactant concentration led to profound microstructural changes in the vesicles.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Article Ophthalmology

Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway

Qiqi Li et al.

Summary: Corneal alkali burns are a serious ophthalmic emergency that require novel treatment options. This study explored the use of dipotassium glycyrrhizinate as a nanocarrier encapsulating rebamipide to create a strengthened ophthalmic solution for treating corneal alkali burns. The results demonstrated the ease of preparation and the potential of DG-RBM to regulate HMGB1 signaling and effectively treat corneal alkali burns.

EXPERIMENTAL EYE RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

Dawin Khiev et al.

Summary: Nanotechnology plays a crucial role in treating ocular diseases by providing advantages such as sustained drug release and specific tissue targeting, as well as overcoming the blood-retinal barrier to increase drug bioavailability.

NANOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Study the Antifungal and Ocular Permeation of Ketoconazole from Ophthalmic Formulations Containing Trans-Ethosomes Nanoparticles

Tarek A. Ahmed et al.

Summary: Optimized trans-ethosomal vesicles loaded with ketoconazole were developed in this study to enhance ocular permeation, antifungal activity, and eliminate quickly. The optimized vesicles showed improved characteristics and significantly enhanced antifungal activity of ketoconazole. The in situ gel formulation loaded with these trans-ethosomes vesicles represents a promising ocular delivery system for deep fungal eye infections treatment.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

An updated review on exosomes: biosynthesis to clinical applications

Sheela Modani et al.

Summary: Exosomes are naturally released membrane-based extracellular vesicles that have a nano size range and unique properties, making them suitable for drug delivery systems and as delivery carriers. This review outlines the composition, biogenesis, isolation and characterization methods, biological and clinical applications, and biopharmaceutical features of exosomes, and also elaborates on potential future clinical directions for their use as drug delivery platforms.

JOURNAL OF DRUG TARGETING (2021)

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Article Chemistry, Medicinal

Amelioration of Endotoxin-Induced Uveitis in Rabbit by Topical Administration of Tacrolimus Proglycosome Nano-Vesicles

Vaidehi Garg et al.

Summary: The study indicated that PNVs were more effective in treating uveitis compared to tacrolimus. PNV therapy not only alleviated clinical symptoms, but also prevented the breakdown of blood aqueous barrier. The research demonstrates the potential of PNVs as a new topical treatment for uveitis.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Implementing Spanlastics for Improving the Ocular Delivery of Clotrimazole: In vitro Characterization, Ex vivo Permeability, Microbiological Assessment and In vivo Safety Study

Manar Adel Abdelbari et al.

Summary: This study aimed to encapsulate the antifungal drug clotrimazole (CLT) into spanlastics (SPs) to provide controlled ocular delivery. The optimal formulation S1 showed high encapsulation efficiency, elastic vesicles, sustained release profile, and superior inhibition of Candida albicans development compared to CLT suspension. In vivo histopathological examination confirmed the safety of S1 for ophthalmic application in rabbits, demonstrating the efficacy of SPs for ocular delivery of CLT.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

3D printed ocusert laden with ultra-fluidic glycerosomes of ganciclovir for the management of ocular cytomegalovirus retinitis

Marianne J. Naguib et al.

Summary: The study aimed to develop a non-invasive delivery system for GCV in the treatment of CMV retinitis. The results demonstrated that the newly formulated ocusert showed excellent drug release properties and penetration capabilities.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Effect of glycerol plasticizer loading on the physical, mechanical, thermal, and barrier properties of arrowroot (Maranta arundinacea) starch biopolymers

J. Tarique et al.

Summary: This study investigated the development of arrowroot starch films with glycerol as a plasticizer, showing improvements in physical, mechanical, thermal, and barrier properties of the films. Increasing glycerol concentration resulted in higher film thickness and moisture content, while reducing tensile strength and modulus. The findings provide valuable insights into the potential for biodegradable food packaging.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Anti-inflammatory effects of a topical emulsion containing Helianthus annuus oil, glycerin, and vitamin B3 in mice

Leandro Mendes Freitas et al.

Summary: The study confirmed the stability and anti-inflammatory activities of the emulsion containing sunflower oil, glycerin, and vitamin B3. Treatment effectively reversed inflammatory parameters induced by croton oil, providing a new strategy for the treatment of inflammatory skin conditions.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

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Review Pharmacology & Pharmacy

Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale

Raquel Fernandez-Garcia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Chemistry, Multidisciplinary

Invasome: A Novel Nanocarrier for Transdermal Drug Delivery

Soraya Babaie et al.

NANOMATERIALS (2020)

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Article Education, Scientific Disciplines

Development of Natamycin Loaded Glycerosomes-A Novel Approach to Defend Ophthalmic Keratitis

Priya Gupta et al.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

Sandra Buratta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Phospholipid Vesicles for Dermal/Transdermal and Nasal Administration of Active Molecules: The Effect of Surfactants and Alcohols on the Fluidity of Their Lipid Bilayers and Penetration Enhancement Properties

Hiba Natsheh et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles Mediate Anti-Oxidative Response-In Vitro Study in the Ocular Drainage System

Natalie Lerner et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery

Shakthi Apsara Thejani Opatha et al.

PHARMACEUTICS (2020)

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Review Nanoscience & Nanotechnology

Roles of Exosomes in Ocular Diseases

Jia Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Pharmacology & Pharmacy

The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

Simon Drescher et al.

PHARMACEUTICS (2020)

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Review Pharmacology & Pharmacy

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Sopan Nangare et al.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Pharmacology & Pharmacy

Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment

Fatma A. Aboali et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Pharmacology & Pharmacy

Glycerosomes: Advanced Liposomal Drug Delivery System

Priya Gupta et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Review Pharmacology & Pharmacy

Proniosomes: the effective and efficient drug-carrier system

Swati Mittal et al.

THERAPEUTIC DELIVERY (2020)

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Review Chemistry, Multidisciplinary

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Olivier G. de Jong et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Pharmacology & Pharmacy

Cationized hyaluronic acid coated spanlastics for cyclosporine A ocular delivery: Prolonged ocular retention, enhanced corneal permeation and improved tear production

Yang Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Immunology

Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide

Jessica Hoppstaedter et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Pharmacology & Pharmacy

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Shuo Chen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Review Nanoscience & Nanotechnology

Exosome function in aerodigestive mucosa

Sarina K. Mueller et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Article Multidisciplinary Sciences

Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air-water interface

Xinxing Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Biochemistry & Molecular Biology

Extracellular vesicles: translational challenges and opportunities

Hannah Clemmens et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

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Article Agricultural Engineering

Production of medium-chain carboxylic acids by anaerobic fermentation of glycerol using a bioaugmented open culture

Rosemeri I. Dams et al.

BIOMASS & BIOENERGY (2018)

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Review Chemistry, Multidisciplinary

Extracellular vesicles: intelligent delivery strategies for therapeutic applications

Alice Pinheiro et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Pharmacology & Pharmacy

Recent advances on extracellular vesicles in therapeutic delivery: Challenges, solutions, and opportunities

Mei Lu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Review Nanoscience & Nanotechnology

Elastic liposomes as novel carriers: recent advances in drug delivery

Afzal Hussain et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Review Ophthalmology

Roles of exosomes in the normal and diseased eye

Mikael Klingeborn et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2017)

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Article Biophysics

Proglycosomes: A novel nano-vesicle for ocular delivery of tacrolimus

Vaidehi Garg et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

CELL (2016)

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Article Pharmacology & Pharmacy

Fabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: In vitro characterization, ex vivo permeation and in vivo safety assessment

Aly A. Abdelbary et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Review Nanoscience & Nanotechnology

Safety and toxicity of nanomaterials for ocular drug delivery applications

Neelesh K. Mehra et al.

NANOTOXICOLOGY (2016)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Article Pharmacology & Pharmacy

Proniosome-derived niosomes for tacrolimus topical ocular delivery: In vitro cornea permeation, ocular irritation, and in vivo anti-allograft rejection

Qi Li et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Article Chemistry, Multidisciplinary

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

Roy van der Meel et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Pharmacology & Pharmacy

Skin permeation behavior of elastic liposomes: role of formulation ingredients

Jun Chen et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

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Article Pharmacology & Pharmacy

Glycerosomes: A new tool for effective dermal and transdermal drug delivery

Maria Letizia Manca et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Engineering, Environmental

Preparation and Properties of Propylene Glycol Plasticized Wheat Protein Isolate Novel Green Films

Dani Jagadeesh et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2013)

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Article Biotechnology & Applied Microbiology

Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

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Article Pharmacology & Pharmacy

Menthosomes, Novel Ultradeformable Vesicles for Transdermal Drug Delivery: Optimization and Characterization

Sureewan Duangjit et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)

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Article Pharmacology & Pharmacy

Niosomes and discomes for ocular delivery of naltrexone hydrochloride: Morphological, rheological, spreading properties and photo-protective effects

Hamdy Abdelkader et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Ophthalmology

Development and Evaluation of Novel Surfactant-Based Elastic Vesicular System for Ocular Delivery of Fluconazole

Indu Pal Kaur et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2012)

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Proceedings Paper Physics, Applied

Influence of Cholesterol on the Elastic Properties of Lipid Membranes

J. Genova et al.

17TH INTERNATIONAL SCHOOL ON CONDENSED MATTER PHYSICS (ISCMP): OPEN PROBLEMS IN CONDENSED MATTER PHYSICS, BIOMEDICAL PHYSICS AND THEIR APPLICATIONS (2012)

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Article Pharmacology & Pharmacy

Spanlastics-A novel nanovesicular carrier system for ocular delivery

Shilpa Kakkar et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Review Pharmacology & Pharmacy

Nonionic surfactant vesicular systems for effective drug delivery-an overview

Gannu P. Kumar et al.

ACTA PHARMACEUTICA SINICA B (2011)

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Article Pharmacology & Pharmacy

Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery

Ghada M. El Zaafarany et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Engineering, Biomedical

Effect of edge activators on the formation and transfection efficiency of ultradeformable liposomes

EH Lee et al.

BIOMATERIALS (2005)

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Review Pharmacology & Pharmacy

Vesicular systems in ocular drug delivery: an overview

IP Kaur et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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