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Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery

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DRUG DISCOVERY TODAY
卷 28, 期 8, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2023.103647

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ocular drug delivery; ultradeformable; elastic vesicles; ophthalmic delivery; extravesicles

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Elastic vesicles serve as effective ocular drug delivery vehicles due to their unique squeezability and deformability, allowing them to overcome ocular barriers and achieve reliable delivery to the eye.
Ocular drug delivery is enigmatic on account of various physiological precorneal barriers that ultimately hinder efficient drug penetration and corneal ionic surfactants, edge activators and vesicular builders that provide enormous elasticity and deformability. The elastic vesicles can cross the ocular barriers owing to their peculiar squeezability and distorting ability and, thus, establish an infallible shot for ocular delivery. This review provides an overview of the recent advancements and updates of elastic vesicles as effective ocular drug delivery vehicles.

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