期刊
DRUG DISCOVERY TODAY
卷 28, 期 10, 页码 1-8出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2023.103695
关键词
miRNAs; cardiac biomarkers; early diagnostic; prognosis; myocardial infarction; molecular signaling
Current research focuses on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. The pathology of myocardial infarction and the alterations in miRNAs for their specificity, stability, and prognostic value at the early stage of acute myocardial infarction (AMI) are thoroughly examined. The study concludes that novel biomarkers, including miRNA-1, miRNA-208a/b, and miRNA-499, could be used to predict the emergence of AMI at an early stage.
Current investigations focus on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. We thoroughly scrutinize the leading pathology of myocardial infarction and contemporary alterations in miRNAs for their specificity, stability and significant prognostic value at the early stage of acute myocardial infarction (AMI). Based on secondary data analysis, we explore common biomarkers and further investigate included miRNA biomarkers for their specificity, stability and area under the curve (AUC) values. We conclude that a group of novel biomarkers, including miRNA-1, miRNA-208a/b and miRNA-499, could help predict the emergence of AMI at an early stage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据