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Biochemistry & Molecular Biology
Chen Chen et al.
Summary: This study investigates the role of FAT10 in cardiac fibrosis after myocardial ischemic injury and its underlying mechanism. The results show that FAT10 deficiency in mice leads to excessive cardiac fibrosis and deteriorated cardiac function after myocardial ischemic injury, while restoration of FAT10 suppresses fibrosis and improves cardiac function. In vitro experiments demonstrate that FAT10 overexpression protects cardiac fibroblasts against proliferation, migration, and differentiation induced by TGF-beta 1. The study also suggests that FAT10 may mediate the degradation of Smad3, a critical factor in cardiac fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hee-Young Jeon et al.
Summary: Overexpression of androgen receptor (AR) is the primary cause of castration-resistant prostate cancer, and this study reveals that SMAD3 plays a crucial role in upregulating AR expression by binding to intron 3 of the AR gene. Targeting SMAD3 binding sites can reduce AR levels and inhibit AR target gene expression. SMAD3 may also cooperate with or co-activate AR for AR target expression. These findings suggest that SMAD3 could be a potential target for inhibiting AR in prostate cancer.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Jihao Tu et al.
Summary: This study analyzed immune infiltration in osteosarcoma and identified the major immune cell population. It was found that 1q positive tumor-associated macrophages were the main immune cells in osteosarcoma and were associated with better prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Guowei Gong et al.
Summary: Osteosarcoma is a common malignant bone tumor with high metastatic properties and no effective treatment. In this study, the efficacy of ononin on osteosarcoma cell migration, invasion, and the underlying mechanisms was investigated. The dose-dependent treatment of ononin increased apoptosis and inhibited cell proliferation in MG-63 and U2OS osteosarcoma cell lines through the EGFR-Erk1/2 signaling pathways. The in vivo anti-tumorigenic and anti-migratory efficacy of ononin was confirmed using the MG-63-xenograft mice model. These findings suggest that ononin could be a potentially effective agent against osteosarcoma metastasis.
Article
Pharmacology & Pharmacy
Sunny Li-Yun Chang et al.
Summary: Despite low survival rates of metastatic osteosarcoma (OS) with surgery and chemotherapy, new therapeutic approaches are needed. Epigenetic changes like histone H3 methylation play crucial roles in various cancers including OS, although the underlying mechanisms are unclear. Treating OS cells with the histone lysine demethylase inhibitor IOX-1 increased histone H3 methylation, suppressed migration and invasion, reversed epithelial-to-mesenchymal transition, and reduced stemness properties.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ya Han et al.
Summary: TISCH2 is a resource of single-cell RNA-seq data from tumors, providing comprehensive analysis of gene expression in the tumor microenvironment. With added features, users can better utilize the large-scale datasets for analysis and visualization.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Endocrinology & Metabolism
Isidora Panez-Toro et al.
Summary: This article provides an overview of recent developments in the treatment of osteosarcoma, including targeting signaling pathways, immune checkpoint inhibitors, drug delivery strategies, and identification of new therapeutic targets.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Oncology
Jun Wang et al.
Summary: We evaluated the relationship between circulating serum exosomal PD-L1 level at initial diagnosis and oncologic outcome during the follow-up in newly diagnosed osteosarcoma patients. Results showed that high levels of circulating exosomal PD-L1 were positively associated with clinicopathologic disease markers and poor prognosis. Liquid biopsy of circulating exosomal PD-L1 at initial diagnosis can be used as a robust means of predicting prognosis for newly diagnosed osteosarcoma patients.
CLINICAL CANCER RESEARCH
(2023)
Review
Cell & Tissue Engineering
Hailong Tian et al.
Summary: Osteosarcoma, the most common primary bone cancer in adolescents, has a poor survival rate after metastasis. Existing therapeutic strategies are insufficient, and immunotherapy has shown advantages in inhibiting metastasis. Managing the immune microenvironment in osteosarcoma can provide valuable insights into the disease's heterogeneity and progression. Nanomedicine offers advanced platforms for enhanced osteosarcoma immunotherapy. This review discusses the classification, characteristics, and functions of the immune microenvironment in osteosarcoma, as well as the application, progress, and prospects of osteosarcoma immunotherapy.
Review
Oncology
Antoinette van Weverwijk et al.
Summary: Tumours exhibit a wide range of variations in the distribution, composition, and activation state of immune cells, which affect their progression and response to immunotherapy. Understanding the mechanisms that regulate the diversity and function of immune cells in the tumour microenvironment will lead to the development of more targeted immunomodulatory strategies for the benefit of cancer patients.
NATURE REVIEWS CANCER
(2023)
Article
Biochemistry & Molecular Biology
Hui Lin et al.
Summary: This paper explores the functional role and molecular mechanism of long noncoding RNA CASC15 in ovarian cancer. In vitro and in vivo experiments validate CASC15 as an oncogenic gene that enhances metastasis in ovarian cancer. It is shown that miR-23b-3p and miR-24-3p directly target CASC15 and CASC15 regulates SMAD3 expression through these microRNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Boren Tian et al.
Summary: Osteosarcoma, an increasingly common malignancy in adolescents, is associated with the presence of osteosarcoma stem cells (OSCs) that contribute to malignant progression and therapy resistance. The unique properties of OSCs, such as self-renewal, multilineage differentiation, and metastatic potential, are closely regulated by the tumor microenvironment. Novel strategies targeting OSC plasticity and modulation of the tumor microenvironment are being explored for the treatment of osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Guang-Yu Lian et al.
Summary: This study developed a novel therapeutic strategy for lung carcinoma by developing a specific inhibitor of Smad3 (SIS3) into a self-carried nanodrug (SCND-SIS3). SCND-SIS3 demonstrated better anti-cancer effects in an animal model and achieved comparable efficacy with just one-fifth of the dose of unmodified-SIS3.
Article
Cell Biology
Eun-Jun Kim et al.
Summary: JAG1 intracellular domain (JICD1) induces cancer stem cell properties and tumorigenicity by forming a transcriptional complex with DDX17, SMAD3, and TGIF2 to increase SOX2 expression.
Article
Cell Biology
Shan Song et al.
Summary: The study found that Sestrin2 is low-expressed in diabetic kidney disease and can alleviate podocyte injury by modulating the activity of TSP-1/TGF-beta 1/Smad3 pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Feng Xie et al.
Summary: Understanding the factors that hinder immune therapy in breast cancer is crucial for improving patient response rate. This study demonstrates that breast cancer cells transfer active TGF-beta type II receptors to CD8 + T cells, leading to T cell exhaustion and suppression of the anti-tumor immune response.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sarah Morice et al.
Summary: Our study demonstrates the significant role of YAP in lung metastasis development in OS, with the crucial involvement of the TGF-beta signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dengwei He et al.
Summary: RepSox effectively inhibited the proliferation, migration, and invasion of OS cells, reduced levels of E-cadherin and other associated proteins, and inhibited the JNK/Smad3 signaling pathway to promote apoptosis in OS cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Bo Yu et al.
Summary: This study reveals a KAT6A acetylation-dependent regulatory mechanism governing SMAD3 oncogenic function and provides insight into how targeting an epigenetic factor with immunotherapies enhances the antimetastasis efficacy.
Article
Biotechnology & Applied Microbiology
He-Wei Zhang et al.
Summary: The study found that high expression of three members of SMADs (SMAD1, SMAD2, SMAD4) is associated with favorable overall survival of gastric cancer patients, while the expression level of SMAD3 indicates highly differentiated cancer. Surgical treatment is associated with high expression levels of SMAD1 and SMAD2, and the effect of Her2 on gastric cancer is not significant. Furthermore, inhibition of SMAD3 expression suppressed the proliferation and migration ability of gastric cancer cells through inducing apoptosis.
Review
Biochemistry & Molecular Biology
Ingrid Lilienthal et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Zhijian Gu et al.
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xiubo Jiang et al.
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Yang Sun et al.
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Oncology
Souvik Chakraborty et al.
BRITISH JOURNAL OF CANCER
(2018)
Article
Oncology
Lucia Fernandez et al.
CLINICAL CANCER RESEARCH
(2017)
Review
Oncology
Mark J. Smyth et al.
NATURE REVIEWS CLINICAL ONCOLOGY
(2016)
Article
Oncology
Soo Youn Cho et al.
Article
Biochemistry & Molecular Biology
M. Petersen et al.
