期刊
DIGESTIVE DISEASES AND SCIENCES
卷 68, 期 9, 页码 3774-3780出版社
SPRINGER
DOI: 10.1007/s10620-023-08019-8
关键词
Endoscopic ultrasound; Liver biopsy; Endohepatology; Liver fibrosis; Cirrhosis
This study aims to evaluate if EUS-bx can effectively and safely obtain adequate specimen and accurately predict hepatic fibrosis compared to P-bx. The outcomes of EUS-bx versus P-bx were assessed by success rate, performance, and safety profile. The results showed that EUS-bx can be safely performed and accurately predict liver fibrosis stage.
BackgroundPercutaneous liver biopsy (P-bx) is the gold standard for diagnosing advanced fibrosis. Despite the proven technical feasibility of EUS-guided liver bx (EUS-bx) as a novel alternative way of liver biopsy, the clinical applicability remains to be determined.AimsThe primary aim of this study is to evaluate if EUS-bx, compared to P-bx, can effectively and safely obtain adequate specimen and accurately predict hepatic fibrosis.MethodsThis is a single center, retrospective chart review among patients with liver diseases at a tertiary endoscopy center from February 2011 to March 2020. We assessed the EUS-bx versus P-bx outcomes by success rate, performance, and safety profile. The primary outcome was the association between EUS-bx clinical variables and the presence of histologic liver fibrosis stage & GE; 3. The secondary outcomes were the associations between EUS-bx and variables indicative of fibrosis.ResultsFifty-nine patients underwent EUS-bx; and 59, P-bx. All EUS-bx procedures were successfully completed. All 56/56 (100%) of EUS-bx vs. 50/52 (96.2%) P-bx were considered adequate samples. Tissue lengths were significantly longer in the EUS-bx cohort (p < 0.0001) with a trend towards a greater number of portal tracts. 46/56 (82.1%) cases of EUS-bx vs. 32/52 (61.5%) of P-bx had > 10 portal tracts; 21/56 (37.5%) cases of EUS-bx vs. 14/52 (26.9%) of P-bx had > 15 portal tracts. There were 6 (10.2%) EUS-bx vs. 1 (1.7%) P-bx related complication leading to a phone call (p = 0.061).ConclusionsEUS-bx can safely performed and accurately predict liver fibrosis stage as the standard P-bx without being influenced by procedure-related factors.
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