Study protocol for a multicenter randomized controlled trial to compare radiofrequency ablation with surgical resection for treatment of pancreatic insulinoma

Article Gastroenterology & Hepatology

Endoscopic Ultrasound-guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma

Stefano Francesco Crino et al.

Summary: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a safe and effective treatment for pancreatic insulinoma (PI), outperforming surgical resection in terms of safety and clinical efficacy.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Review Medicine, General & Internal

Efficacy and Safety of Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Neuroendocrine Tumors: A Systematic Review and Metanalysis

Elia Armellini et al.

Summary: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a safe and effective minimally invasive technique for the treatment of pancreatic neuroendocrine tumors (Pan-NETs), especially for low-grade NF- or F-Pan-NETs patients who are not eligible or have a high risk for surgery.

MEDICINA-LITHUANIA (2023)

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Article Gastroenterology & Hepatology

Novel classification for adverse events in GI endoscopy: the AGREE classification

Karlijn J. Nass et al.

Summary: This article introduces a new classification system called AGREE for adverse events in GI endoscopy, which provides a standardized and reproducible approach to assessing these events. Through surveys and questionnaires involving endoscopists, endoscopy nurses, and patients, the acceptability and effectiveness of the AGREE classification were demonstrated.

GASTROINTESTINAL ENDOSCOPY (2022)

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Article Endocrinology & Metabolism

Development of a quality of life questionnaire for patients with pancreatic neuroendocrine tumours (the PANNET module)

John K. Ramage et al.

Summary: This study developed a module of questions based on EORTC guidelines to assess the quality of life of patients with pancreatic neuroendocrine tumors. The module was validated in an international study, resulting in a provisional module.

JOURNAL OF NEUROENDOCRINOLOGY (2022)

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Article Gastroenterology & Hepatology

EUS-guided radiofrequency ablation of pancreatic/peripancreatic tumors and oligometastatic disease: an observational prospective multicenter study

Mariana Figueiredo Ferreira et al.

Summary: This study aimed to evaluate the feasibility, safety, and efficacy of EUS-RFA for pancreatic and peripancreatic tumors. The results showed that EUS-RFA is a feasible, safe, and effective treatment option for these tumors. The majority of patients had varying degrees of tumor response at 6-month and 12-month follow-up. In addition, EUS-RFA demonstrated good outcomes for symptomatic insulinomas.

ENDOSCOPY INTERNATIONAL OPEN (2022)

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Review Gastroenterology & Hepatology

Contrast-enhanced EUS for the characterization of mural nodules within pancreatic cystic neoplasms: systematic review and meta-analysis

Andrea Lisotti et al.

Summary: The study provided robust evidence on the value of CE-EUS for the characterization of mural nodules within PCNs. CH-EUS offered an increased diagnostic yield in the identification and characterization of malignant mural nodules.

GASTROINTESTINAL ENDOSCOPY (2021)

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Review Medicine, General & Internal

Diagnostic and Interventional Role of Endoscopic Ultrasonography for the Management of Pancreatic Neuroendocrine Neoplasms

Giuseppinella Melita et al.

Summary: Pancreatic neuroendocrine neoplasms (PanNENs) are rare but their incidence has increased significantly. Endoscopic ultrasound (EUS) is crucial for diagnosis and prognostic stratification, with a well-demonstrated correlation between Ki-67 proliferation index values and tumor grading on EUS and surgical specimens according to the WHO 2017 classification. EUS also serves as a guide for preoperative sampling and interventions, with the possibility of locoregional ablative treatments in selected patients unfit for surgery.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Gastroenterology & Hepatology

Endoscopic ultrasound-guided ethanol and radiofrequency ablation of pancreatic insulinomas: a systematic literature review

Ghassan El Sayed et al.

Summary: The systematic review of EUS-guided ablations for insulinomas demonstrated a high clinical success rate of 98.5%, indicating that it is a safe and effective treatment option. Most patients experienced a significant increase in blood glucose levels post-treatment, and there were no peri-procedural deaths reported.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology