Electrochemical measurement of naproxen in the presence of diclofenac and ascorbic acid using Gr/ZnFe2O4/CPE

In this project, a carbon paste electrode (CPE) modified with graphene and ZnFe2O4 spinel nanoparticles, Gr/ ZnFe2O4/CPE, was used to measure the drug naproxen. Various electrochemical methods such as cyclic vol-tammetry (CV), electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), chro-noamperometry, and chronocoulometry were used to investigate the behavior of naproxen. The electrochemical behavior of naproxen on the modified electrode with graphene and ZnFe2O4 and the unmodified electrode was investigated. Parameters such as the amount of graphene and ZnFe2O4 nanoparticles at the stage of making the electrode, pH of the environment, and instrument parameters were optimized. The relationship between peak current, Ip, and concentration of naproxen in the DPV method is linear in the two ranges of 0.05 to 3.00 mu M and 3.00 to 50.00 mu M, and the detection limit was 0.222 nM. The selectivity of the method was evaluated by examining the interference effect of different species in the measurement of naproxen. The amount of naproxen in real samples was measured using the modified electrode. Finally, Gr/ZnFe2O4/CPE was used to measure naproxen in the presence of diclofenac and ascorbic acid.

Automated summary

In this project, a carbon paste electrode modified with graphene and ZnFe2O4 spinel nanoparticles (Gr/ZnFe2O4/CPE) was used to measure naproxen, and various electrochemical methods were used to investigate its behavior. By optimizing the parameters, good measurement results were obtained.