Typhoid fever due to laboratory-acquired Salmonella Typhi, confirmed by core genome multi-locus sequence typing

We present a case of laboratory-acquired Salmonella Typhi, resulting in hospitalization of a technician. Blood and stool cultures revealed a S. Typhi strain, identical to the strain with which the employee had recently worked, confirmed using core-genome multilocus sequence typing. The incident occurred despite working in a biosafety cabinet.& COPY; 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Automated summary

We present a case of a laboratory-acquired Salmonella Typhi infection, resulting in hospitalization of a technician. The strain of S. Typhi isolated from blood and stool cultures was found to be identical to the strain the employee had recently worked with, confirmed through core-genome multilocus sequence typing. Despite working in a biosafety cabinet, the incident still occurred.