期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 108, 期 2, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2023.116118
关键词
(1-3)-beta-D-glucan; Diagnosis; Candidemia; Fungal infection
This study compared the clinical characteristics of Fungitell and Dynamiker Fungus assays for diagnosing candidemia. The results showed that the DFA assay performed excellently, with high consistency with the FA assay and superior diagnostic performance.
(1-3)-Beta-D Glucan (BDG) detection has shown to be a highly effective tool to diagnose invasive fungal infections. Therefore, this study aimed to compare clinical characteristics of the Fungitell (FA) and Dynamiker Fungus (1-3)-beta-D-Glucan assay (DFA) for the diagnosis of candidemia.Using DFA and FA, the BDG levels of 57 serum samples from case and control groups were determined. The kappa coefficient (kappa) and Spearman's rank correlation (rs) were used to examine the consistency of assays on a quantitative and qualitative level, respectively.The sensitivity, specificity, and accuracy were 94.6 %, 65.0 %, and 87.7% for DFA, and 94.6 %, 75.0 %, and 89.4 % for FA, respectively. The performance of the DFA for the diagnosis of candidemia was highly consistent with that of the FA, both quantitatively (rs: 0.9) and qualitatively (kappa = 0.78).Collectively, the DFA assay performed excellently in comparison to the FA for the diagnosis of candidemia.
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