期刊
DIAGNOSTIC CYTOPATHOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/dc.25213
关键词
cytology; foamy cells; lipids; malignant mesothelioma; pleural effusion
We described uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. The cells exhibited abundant cytoplasmic vacuolization and eccentric nuclei. A glossy spherical material was observed in some cells, which tested positive in Sudan III stain. Immunocytochemical analysis showed positive expression of calretinin, podoplanin, epithelial membrane antigen, and methylthioadenosine phosphorylase in tumor cells, while negative expression of BRCA1-associated protein 1, CD68, and desmin. The intracytoplasmic vacuoles were positive for adipophilin expression.
In this brief report, we described some uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. The tumor cells exhibited abundant cytoplasmic vacuolization, with presence of single or multiple eccentric nuclei in several cells. In the Giemsa-stained smear, we observed a glossy spherical material in some cells, which tested positive in Sudan III stain. In immunocytochemical analysis, tumor cells were positive for calretinin, podoplanin, epithelial membrane antigen, and methylthioadenosine phosphorylase; tumor cells were negative for BRCA1-associated protein 1, CD68, and desmin. The intracytoplasmic vacuoles were positive for adipophilin expression.
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