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Closed-Loop from Diagnosis of Type 1 Diabetes in Children and Young People

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Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes A Randomized Clinical Trial

Jennifer McVean et al.

Summary: The study aimed to determine the effectiveness of intensive diabetes management to achieve near normalization of glucose levels on preservation of pancreatic beta cell function in youth with newly diagnosed type 1 diabetes. The results showed that although the intensive management group achieved excellent glucose control, it did not affect the decline in pancreatic C-peptide secretion at 52 weeks.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

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Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes

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Summary: In youths with new-onset type 1 diabetes, intensive glucose control for 24 months did not appear to prevent the decline in residual C-peptide secretion.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Adolescents' and their parents' experiences of using a closed-loop system to manage type 1 diabetes in everyday life: qualitative study

D. Rankin et al.

Summary: The closed-loop system has life-enhancing consequences for both adolescents and parents, reducing the burden of diabetes management and allowing adolescents to have more control over their condition. Some concerns about visibility of components were raised, but overall, the technology was reported to have minimal disruptions and helped to keep adolescents safe.

CHRONIC ILLNESS (2022)

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User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics

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The Beneficial Effects of Earlier Versus Later Implementation of Intensive Therapy in Type 1 Diabetes

John M. Lachin et al.

Summary: In patients with type 1 diabetes, earlier implementation of intensive therapy compared to later implementation is associated with a greater reduction in the risks of kidney and cardiovascular complications.

DIABETES CARE (2021)