Osteopontin levels correlate with severity of diabetic cardiomyopathy in early stage of diabetes

Diabetic cardiomyopathy (DbCM) is characterized by restrictive pattern and consistent risk of overt heart failure. We here focused osteopontin (OPN), which was tested independently associated with left ventricular diastolic dysfunction (LVDD). Overall, OPN increased with DbCM severity according with the presence of left atrial dilatation, LV hypertrophy and LVDD.

Automated summary

Diabetic cardiomyopathy is characterized by restrictive pattern and the risk of heart failure. The osteopontin (OPN) was independently associated with left ventricular diastolic dysfunction and increased with the severity of DbCM.