Epigenetic Effects of Psychoactive Drugs

Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies heritable alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgenerationally. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses. This review aims to look at the epigenetic modifications brought forth by psychoactive drug abuse.

Automated summary

The world is currently facing a severe epidemic of psychoactive drug abuse, resulting in significant loss of life. Recent research has shown that long-term use of these drugs can cause heritable changes in gene expression, which may be passed down to future generations. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses.