Ultrasound-assisted Synthesis of Nitrogen and Oxygen Containing Heterocycles

Ultrasound is well explored in the preparation of several heterocycles as it is an eco-friendly, safer and cheaper technique compared to the previous conventional synthetic approach. Ultrasonication offers a great deal of interest for chemists as it not only lowers the reaction time but also markedly reduces the use of hazardous chemicals and enhances the purity of synthesized compounds. Since the application of ultrasound waves acts as a non-polluting energy source, therefore, it is an area of great importance in the field of green and sustainable chemistry. Also, nitrogen and oxygen-based pharmaceuticals have been found to be a beneficial tool for modifying solubility, lipophilicity, polarity and other important pharmacokinetic parameters which aid in optimizing ADMET characteristics of drug candidates. Further, nitrogen and oxygen-containing compounds have been reported to exhibit antibacterial, antiviral, anti-inflammatory, anticancer, analgesic, antihyperglycemic action etc. Therefore, the review focues to coveron covering the latest applications of ultrasonication in the preparation of oxygen and nitrogen nitrogen-containing heterocycles holding immense importance in therapeutically active molecules, which will aid new researchers in their ongoingnd future research.

Automated summary

Ultrasound is an eco-friendly and cost-effective technique that has attracted interest from chemists for its ability to reduce reaction time and the use of hazardous chemicals, and enhance compound purity. The application of ultrasound waves as a non-polluting energy source has great importance in the field of green and sustainable chemistry. This review focuses on the latest applications of ultrasonication in the preparation of oxygen and nitrogen-containing heterocycles, which play an important role in therapeutically active molecules and will assist new researchers in their ongoing and future research.