4.5 Review

Palladium-Catalyzed C-N Coupling in the Synthesis of 1,4-Benzodiazepines Fused with 5-Membered Carbo- and Heterocycles

期刊

CURRENT ORGANIC CHEMISTRY
卷 26, 期 20, 页码 1827-1847

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666221229104724

关键词

1; 4-Benzodiazepines; palladium; C-N coupling; pyrrole; pyrazole; triazole

向作者/读者索取更多资源

In this review, Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds are discussed. Different synthetic strategies, such as C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling, are included. The domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool to synthesize functionalized benzodiazepines. The article primarily focuses on synthesizing a 1,4-benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.
In this review, we have focused our attention on Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds. It includes numerous types of synthetic strategies like C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling. To synthesize different functionalized benzodiazepines, the domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool. Benzodiazepines exhibit several biological activities and play a valuable role in medicinal and pharmaceutical chemistry. This review article mainly focuses on synthesizing a 1,4-benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据