期刊
CURRENT ORGANIC CHEMISTRY
卷 26, 期 20, 页码 1827-1847出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666221229104724
关键词
1; 4-Benzodiazepines; palladium; C-N coupling; pyrrole; pyrazole; triazole
In this review, Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds are discussed. Different synthetic strategies, such as C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling, are included. The domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool to synthesize functionalized benzodiazepines. The article primarily focuses on synthesizing a 1,4-benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.
In this review, we have focused our attention on Pd-catalyzed amination and arylation reactions for the construction of various benzodiazepine scaffolds. It includes numerous types of synthetic strategies like C-H arylation, Pd-catalyzed carbonylation, and Buchwald Hartwig coupling. To synthesize different functionalized benzodiazepines, the domino processes as intra- or intermolecular reactions are developed as an eco-friendly and effective tool. Benzodiazepines exhibit several biological activities and play a valuable role in medicinal and pharmaceutical chemistry. This review article mainly focuses on synthesizing a 1,4-benzodiazepine nucleus fused with 5-membered carbo- and heterocycles in the presence of palladium catalysts.
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