期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 75, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2023.102401
关键词
Epigenetics; Chromatin; DNA replication; Histone modifications; Histone variants; Arabidopsis
This study summarizes recent discoveries in plants regarding the role of H3.1 in chromatin replication, genomic stability, epigenetic inheritance, and its interaction with DNA polymerase epsilon.
The replication-dependent histone H3.1 variant, ubiquitous in multicellular eukaryotes, has been proposed to play key roles during chromatin replication due to its unique expression pattern restricted to the S phase of the cell cycle. Here, we describe recent discoveries in plants regarding molecular mechanisms and cellular pathways involving H3.1 that contribute to the maintenance of genomic and epigenomic in-formation. First, we highlight new advances concerning the contribution of the histone chaperone CAF-1 and the TSK-H3.1 DNA repair pathway in preventing genomic instability during replication. We then summarize the evidence connect-ing H3.1 to specific roles required for the mitotic inheritance of epigenetic states. Finally, we discuss the recent identification of a specific interaction between H3.1 and DNA polymerase epsilon and its functional implications.
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