4.5 Review

Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Single-cell profiling identifies ACE plus granuloma macrophages as a nonpermissive niche for intracellular bacteria during persistent Salmonella infection

Trung H. M. Pham et al.

Summary: Macrophages play both a crucial role in antimicrobial responses against intracellular bacterial pathogens and a permissive role in allowing these pathogens to persist in infected tissues. Through single-cell transcriptomics, we identify determinants of macrophage heterogeneity during persistent infection and describe distinct populations with different functions and spatial localization. We find that angiotensin-converting enzyme (ACE) defines a macrophage population in granulomas that is nonpermissive for intracellular bacteria, and disruption of pathogen control is linked to preferential depletion of ACE+ macrophages.

SCIENCE ADVANCES (2023)

Review Microbiology

Ready, STAT3, Go! Bacteria in the race for M2 macrophage polarisation

Ioanna Panagi et al.

Summary: Despite being important for host defences, some intracellular bacteria are able to infect, survive, replicate, and persist in macrophages. This may be due to the heterogeneity of macrophages, which can be divided into pro-inflammatory M1 subset and anti-inflammatory M2 subset. Recent findings suggest that intracellular pathogens can manipulate host cells by activating the STAT3 transcription factor through various mechanisms.

CURRENT OPINION IN MICROBIOLOGY (2023)

Review Microbiology

One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections

Benjamin X. Wang et al.

Summary: Salmonella enterica is a widely spread bacterial pathogen causing millions of infections and thousands of deaths annually. It can be classified into nontyphoidal and typhoidal Salmonella, which differ in disease manifestation and host tropism. While nontyphoidal strains cause gastroenteritis in various hosts, typhoidal strains are restricted to humans and cause a systemic disease called typhoid fever with a high mortality rate. Understanding the molecular details underlying these infections, especially in typhoidal Salmonella, is crucial for eradicating these dangerous pathogens.

CURRENT OPINION IN MICROBIOLOGY (2023)

Review Immunology

The Tuberculous Granuloma and Preexisting Immunity

Sara B. Cohen et al.

Summary: Pulmonary granulomas are the epicenters of immune response to Mycobacterium tuberculosis, but the impact of preexisting immunity on granuloma structure and immune response is still unclear.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets

Ravi Pal et al.

Summary: Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, has evolved highly sophisticated secretion systems and secretory proteins to modulate host immune responses, making it a formidable pathogen. These secretory proteins are crucial for the virulence and immune evasion of M. tuberculosis, hijacking host machineries through various functions and localization within cellular organelles. The study of these secretory proteins and their functions may provide insights for the development of effective anti-tuberculosis therapeutics.

FEBS JOURNAL (2022)

Review Immunology

Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance

Katherine M. Sheu et al.

Summary: This review discusses the importance and functions of macrophages in the immune system. The effector and sentinel functions of healthy macrophages rely on response specificity, context dependence, and stimulus memory. Impairment of these hallmark properties may lead to immune dysregulation.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

Article Immunology

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

Hannah P. Gideon et al.

Summary: This study focuses on tuberculosis lung infection and its complex multicellular structure, the granuloma. Through various techniques, the study identifies factors that influence bacterial control in granulomas. It shows that granulomas with bacterial persistence are enriched with different cell types that communicate through immune and wound-healing pathways. On the other hand, granulomas that drive bacterial control are characterized by diverse cell populations engaged in pro-inflammatory signaling networks. The study also finds that granulomas that arise later in infection display characteristics of restrictive granulomas and are more effective at killing Mycobacterium tuberculosis.

IMMUNITY (2022)

Review Biochemistry & Molecular Biology

Macrophages in health and disease

Matthew D. Park et al.

Summary: The heterogeneity of tissue macrophages in health and disease is increasingly apparent. Understanding their origins and functions requires a conceptual framework that takes into account their ontogeny and the influence of various signals on homeostasis and disease progression.
Article Immunology

A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella

Dotan Hoffman et al.

Summary: The study identified two phases of bacterial control in the spleen during early systemic Salmonella Typhimurium infection in mice, with tissue-resident red-pulp macrophages and CD9-expressing macrophages playing key roles. CD9(+) macrophages induce pathways for detoxicating oxidized lipids that may benefit intracellular S.Tm.

IMMUNITY (2021)

Review Immunology

Origins, Biology, and Diseases of Tissue Macrophages

Nehemiah Cox et al.

Summary: This review discusses the developmental biology of tissue-resident macrophages from an evolutionary perspective, emphasizing on their functional attributes. A framework for investigating macrophage functions in vivo is proposed, along with discussions on how genetic and somatic mutations contribute to macrophage roles in diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Article Biochemistry & Molecular Biology

A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

Mark R. Cronan et al.

Summary: This study reveals that in tuberculosis infection, type 2 immune signals mediated by stat6 are crucial for macrophage epithelialization and granuloma formation, working in conjunction with type 1 immune responses to impact the structure of granulomas.
Article Immunology

Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung

Davide Pisu et al.

Summary: This study presents a novel approach that combines bacterial fitness fluorescent reporter strains with single-cell RNA sequencing to acquire host transcriptome, surface marker expression, and bacterial phenotype for each infected cell, allowing for the dissection of functional heterogeneity of M. tuberculosis-infected alveolar and interstitial macrophages in vivo. The main macrophage populations in the lungs show epigenetic constraints in their response to infection, and inter-species comparison reveals conservation of most alveolar macrophage subsets between mice and humans. This conceptual approach has the potential to enhance understanding of the roles different host cell populations play during infection.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

The cellular architecture of the antimicrobial response network in human leprosy granulomas

Feiyang Ma et al.

Summary: The study identified a set of genes involved in antimicrobial responses that are differentially expressed in reversal reactions (RRs) lesions compared to lepromatous leprosy (L-lep) lesions, regulated by interferon-gamma and interleukin-1 beta. By integrating spatial coordinates of key cell types and antimicrobial gene expression, a map depicting the organized architecture of granulomas in RR and T-lep lesions was constructed, showing compositional and functional layers contributing to the antimicrobial response. Modlin and colleagues utilized single-cell RNA sequencing with cellular spatial mapping to examine the architecture of granulomas in leprosy lesions, providing insights from localized disease (tuberculoid leprosy, reversal reaction) to progressive infection (lepromatous leprosy).

NATURE IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections

Sarika Rana et al.

Summary: Non-typhoidal Salmonella infections can lead to chronic infections, where the bacteria utilize complex strategies to reprogram macrophages and create a suitable replicative niche. The upregulation of histone H3-lysine 27 trimethylation-specific demethylase KDM6B plays a crucial role in Salmonella infection, affecting gene targets like PPAR delta and leading to pathogen load reduction in chronic infection models through epigenetic reprogramming.

GUT MICROBES (2021)

Article Immunology

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

Subhankar Mukhopadhyay et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Immunology

Determinants of Resident Tissue Macrophage Identity and Function

Camille Bleriot et al.

IMMUNITY (2020)

Article Respiratory System

IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages

Anil Pooran et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Microbiology

Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis

Mohlopheni J. Marakalala et al.

FRONTIERS IN MICROBIOLOGY (2018)

Article Multidisciplinary Sciences

Salmonella persisters undermine host immune defenses during antibiotic treatment

Daphne A. C. Stapels et al.

SCIENCE (2018)

Article Microbiology

Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella

Antoine-Emmanuel Saliba et al.

NATURE MICROBIOLOGY (2017)

Article Immunology

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Alexander V. Misharin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

STAT3 Represses Nitric Oxide Synthesis in Human Macrophages upon Mycobacterium tuberculosis Infection

Christophe J. Queval et al.

SCIENTIFIC REPORTS (2016)

Article Microbiology

Chronic Bacterial Pathogens: Mechanisms of Persistence

Mariana X. Byndloss et al.

MICROBIOLOGY SPECTRUM (2016)

Review Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

Sky W. Brubaker et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Review Medicine, Research & Experimental

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

John J. O'Shea et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Review Immunology

Macrophage defense mechanisms against intracellular bacteria

Guenter Weiss et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Immunology

Bacterial recognition pathways that lead to inflammasome activation

Kelly M. Storek et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Immunology

Functions and development of red pulp macrophages

Daisuke Kurotaki et al.

MICROBIOLOGY AND IMMUNOLOGY (2015)

Review Immunology

Molecular and epigenetic basis of macrophage polarized activation

Chiara Porta et al.

SEMINARS IN IMMUNOLOGY (2015)

Article Cell Biology

TNF Counterbalances the Emergence of M2 Tumor Macrophages

Franz Kratochvill et al.

CELL REPORTS (2015)

Review Immunology

The Macrophage Paradox

Jordan V. Price et al.

IMMUNITY (2014)

Review Immunology

Epigenomics of macrophages

David Gosselin et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Microbiology

IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium

Kyoung-Sun Lee et al.

JOURNAL OF MICROBIOLOGY (2011)

Review Immunology

The role of IL-10 in immune regulation during M. tuberculosis infection

P. S. Redford et al.

MUCOSAL IMMUNOLOGY (2011)

Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon et al.

IMMUNITY (2010)

Article Biochemistry & Molecular Biology

Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

Joseph E. Qualls et al.

SCIENCE SIGNALING (2010)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation

Ulrich A. Maus et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

STAT3 activation in macrophages following infection with Salmonella

T Lin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Immunology

M-1/M-2 macrophages and the Th1/Th2 paradigm

CD Mills et al.

JOURNAL OF IMMUNOLOGY (2000)