期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 189, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2023.104083
关键词
Hepatocellular carcinoma (HCC); Portal vein tumor thrombosis (PVTT); Adjuvant therapy; Radiotherapy; Network meta-analysis
This study compared the oncological prognosis of different perioperative locoregional adjuvant treatments for HCC with PVTT. The results showed that adjuvant therapy with radiotherapy had the lowest hazard ratio for both overall survival (OS) and recurrence-free survival (RFS). It was concluded that perioperative locoregional adjuvant therapy, especially radiotherapy, provides survival benefits and reduces the risk of recurrence for HCC patients with PVTT.
Background: To identify the optimal strategy for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) by comparing the oncological prognosis of different perioperative locoregional adjuvant treatments. Methods: Electronic database were searched for relevant studies. Overall survival (OS) and recurrence-free survival (RFS) were pooled by pairwise and network meta-analysis. Results: Fourteen eligible trials with 1927 patients and covering four adjuvant treatments were included. All adjuvant therapies in combination with surgery were shown to be superior to surgery alone. Adjuvant therapy with radiotherapy had the lowest hazard ratio (HR) for both OS (HR: 0.38, 95% CrI: 0.25-0.57) and RFS (HR: 0.27, 95% CrI: 0.11-0.65) compared with other combination treatments, with estimated surface under the cumulative ranking of 93.2% and 82.7%, respectively. Conclusions: Perioperative locoregional adjuvant therapy provides OS benefits and reduces the risk of recurrence for patients suffering from HCC with PVTT. Radiotherapy is likely to be the most effective adjuvant regimen.
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