期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 188, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2023.104061
关键词
Folate; Folic acid; Chemotherapy; Toxicity; Cancer
A systematic literature review indicates that folate and folic acid have an impact on the treatment tolerance of cancer patients. In studies on antifolate treatments, a deficient folate status and lower intake were associated with a higher risk of toxicities. In studies on fluoropyrimidine treatments, a higher folate status and intake were associated with a higher risk of toxicities.
Folate metabolism is a target for various chemotherapeutic drugs. Folate and its synthetic variant folic acid are B-vitamins. To what extent these vitamins impact treatment tolerance in patients with cancer remains unclear. A systematic literature review was conducted on intake and status of folate and folic acid in relation to chemotherapy-induced toxicities in children and adults with cancer. A total of 6231 publications were identified, of which 40 publications met the inclusion criteria. In 12 out of 22 studies focusing on antifolates, a deficient folate status and lower folate and folic acid intake were associated with a higher risk of toxicities. In 8 out of 14 studies focusing on fluoropyrimidine treatments, a higher folate status and intake were associated with a higher risk of toxicities. These findings might explain interindividual differences in treatment tolerance and highlight the importance of evaluating nutritional status in oncology care.
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