Transformation of colitis and colorectal cancer: a tale of gut microbiota

Intestinal inflammation modifies host physiology to promote the occurrence of colorectal cancer (CRC), as seen in colitis-associated CRC. Gut microbiota is crucial in cancer progression, primarily by inducing intestinal chronic inflammatory microenvironment, leading to DNA damage, chromosomal mutation, and alterations in specific metabolite production. Therefore, there is an increasing interest in microbiota-based prevention and treatment strategies, such as probiotics, prebiotics, microbiota-derived metabolites, and fecal microbiota transplantation. This review aims to provide valuable insights into the potential correlations between gut microbiota and colitis-associated CRC, as well as the promising microbiota-based strategies for colitis-associated CRC.

Automated summary

Intestinal inflammation caused by gut microbiota plays a crucial role in promoting colorectal cancer, particularly in colitis-associated CRC. This review focuses on exploring the potential correlations between gut microbiota and colitis-associated CRC, as well as discussing promising microbiota-based strategies such as probiotics, prebiotics, microbiota-derived metabolites, and fecal microbiota transplantation.