Antiobesity pathways of pterostilbene and resveratrol: a comprehensive insight

It may not always be possible for obese individuals to limit energy intake or to provide and/or maintain greater energy expenditure through exercise and physical activity. Therefore, the search for effective methods for obesity continues. Recently, the anti-obesity effect of stilbenes has attracted attention. In this review, aim was evaluating the effect of pterostilbene and resveratrol against obesity and the possible mechanisms in this effect. Dietary phytochemicals can induce body weight loss by increasing basal metabolic rate and thermogenesis and/or altering lipid metabolism. Stilbenes are products of the plant phenylpropanoid pathway. Very important mechanisms for the anti-obesity impact belonging to resveratrol as well as pterostilbene include thermogenic activation in brown adipose tissue alongside the browning of white adipose tissue. Considering nutrition and dietary habits, which have an important place in lifestyle changes for both the prevention and the treatment of obesity, pterostilbene and resveratrol, which are polyphenols and stilbenes, are seen as promising. However, optimal dose, duration, mechanism, long-term safety, side effects, combination, elucidation of genomic interactions, and lifestyle modifications should be considered.

Automated summary

It may not always be possible for obese individuals to limit energy intake or increase energy expenditure through exercise. For this reason, the search for effective methods to combat obesity continues. The anti-obesity effects of stilbenes, such as pterostilbene and resveratrol, have recently been highlighted. These dietary phytochemicals can promote weight loss by increasing metabolic rate and altering lipid metabolism. Stilbenes have shown promising potential in activating thermogenesis in brown adipose tissue and promoting the browning of white adipose tissue, making them attractive candidates in the prevention and treatment of obesity. However, further research is needed to determine optimal dosage, safety, and potential side effects.