Encapsulation of polyphenols in protein-based nanoparticles: Preparation, properties, and applications

Polyphenols have a variety of physiological activities, including antioxidant, antimicrobial, and anti-inflammatory properties. However, their applications are often limited because due to the instability of polyphenols. Encapsulation technologies can be employed to overcome these problems and increase the utilization of polyphenols. In this article, the utilization of protein-based nanoparticles for encapsulating polyphenols is reviewed due to their good biocompatibility, biodegradability, and functional attributes. Initially, the various kinds of animal and plant proteins available for forming protein nanoparticles are discussed, as well as the fabrication methods that can be used to assemble these nanoparticles. The molecular interaction mechanisms between proteins and polyphenols are then summarized. Applications of protein-based nanoparticles for encapsulating polyphenols are then discussed, including as nutrient delivery systems, in food packaging materials, and in the creation of functional foods. Finally, areas where further research is need on the development, characterization, and application of protein-based polyphenol-loaded nanoparticles are highlighted.

Automated summary

Polyphenols have various physiological activities, but their applications are often limited due to their instability. Encapsulation technologies can overcome these problems and increase polyphenol utilization. This article reviews the use of protein-based nanoparticles for encapsulating polyphenols, highlighting their biocompatibility, biodegradability, and functional attributes. The various types of animal and plant proteins and fabrication methods for protein nanoparticles are discussed, followed by the molecular interaction mechanisms between proteins and polyphenols. Applications of protein-based nanoparticles for encapsulating polyphenols in nutrient delivery systems, food packaging materials, and functional foods are discussed. Finally, areas for further research on the development, characterization, and application of protein-based polyphenol-loaded nanoparticles are highlighted.