☆ 4.7 Review

Astaxanthin impact on brain: health potential and market perspective

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Neurosciences

Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights

Najmeh Oliyaei et al.

Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with complex pathology. Natural products such as fucoxanthin and astaxanthin found in algae have shown promising potential in preventing and slowing down the progression of AD. These carotenoids exhibit neuroprotective properties through antioxidant and anti-inflammatory effects, as well as modulation of various targets involved in AD.

BRAIN RESEARCH BULLETIN (2023)

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Review Medicine, Research & Experimental

Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Zeynab Kohandel et al.

Summary: This study summarizes the anti-inflammatory efficacy of astaxanthin in various chronic and acute disorders, as well as the pathways through which it mediates its effects. Further experimental and clinical studies are needed to confirm the anti-inflammatory and protective effects of astaxanthin in humans. The review suggests that astaxanthin, with its demonstrated anti-inflammatory properties, may be a suitable candidate for drug design with novel technology.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Food Science & Technology

Bioactive peptides derived from marine sources: Biological and functional properties

Sara Alexandra Cunha et al.

Summary: Bioactive peptides derived from marine sources have valuable potential in pharmaceutical, food, and cosmetic industries due to their various biological activities and functional properties. Enzymatic hydrolysis is the most commonly used method for peptide production. Encapsulation is an interesting approach to enhance peptide protection and their effectiveness in pharmaceuticals, food, or cosmetics.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Neurosciences

The effect of astaxanthin treatment on the rat model of fetal alcohol spectrum disorders (FASD)

Mu-Hsuan Chen et al.

Summary: The study provides evidence that treatment with astaxanthin can improve morphological changes and cognitive impairment in FASD rats by reducing oxidative stress and neuroinflammation in the brain.

BRAIN RESEARCH BULLETIN (2022)

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Article Chemistry, Medicinal

Astaxanthin Confers a Significant Attenuation of Hippocampal Neuronal Loss Induced by Severe Ischemia-Reperfusion Injury in Gerbils by Reducing Oxidative Stress

Joon Ha Park et al.

Summary: Astaxanthin has been shown to have neuroprotective effects in transient ischemic brain injury, reducing neuronal death and oxidative damage. It also increases the expression of antioxidant enzymes.

MARINE DRUGS (2022)

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Article Biochemistry & Molecular Biology

Bioactive Hydrolysates from Chlorella vulgaris: Optimal Process and Bioactive Properties

Sara A. Cunha et al.

Summary: This study focused on the production of protein/peptide-rich hydrolysates from microalgae C. vulgaris and investigated their bioactive properties. The hydrolysates showed antioxidant, antihypertensive, and antidiabetic potential, making them promising functional ingredients for food, nutraceuticals, and cosmetics.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Dose-Dependent Effects of Astaxanthin on Ischemia/Reperfusion Induced Brain Injury in MCAO Model Rat

Forough Taheri et al.

Summary: Astaxanthin has significant effects in reducing complications caused by acute cerebral stroke, including reducing stroke volume, neurological deficits, and lipid peroxidation. It can restore oxidative status, antioxidant enzyme activity, and gene expression.

NEUROCHEMICAL RESEARCH (2022)

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Review Biotechnology & Applied Microbiology

Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies

Mostafa Basiony et al.

Summary: The demand for natural astaxanthin in the global market is increasing rapidly, and producing it through native producers is facing challenges of limited yield and high cost. Using nonnative microbial cell factories is a promising strategy to overcome these limitations.

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?

Fleur L. Meulmeester et al.

Summary: Oxidative stress is a major contributor to lifestyle- and age-related diseases. Antioxidant supplementation has been proposed as a method to delay and improve these diseases, but clinical trials have failed to provide evidence for its benefits. This review discusses recent developments and research techniques in clarifying the controversy surrounding antioxidant supplementation in health and disease.

ANTIOXIDANTS (2022)

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Review Food Science & Technology

Bioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review

P. A. Aneesh et al.

Summary: This review focuses on the biomedical advantages of natural astaxanthin and its various biological activities. Natural astaxanthin is more biologically active than its synthetic counterpart and has the potential for widespread use in the food and pharmaceutical industries.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Psychiatry

Cognitive deficits in children with autism spectrum disorders: Toward an integrative approach combining social and non-social cognition

Melek Hajri et al.

Summary: Autism spectrum disorder is associated with neurocognitive impairment, and cognitive remediation is a behavioral training-based intervention aiming to improve cognitive processes. Studies have shown that integrated cognitive remediation programs can effectively improve cognitive domains and functional outcomes in individuals with autism spectrum disorder.

FRONTIERS IN PSYCHIATRY (2022)

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Review Chemistry, Medicinal

Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin

Apurva D. Patil et al.

Summary: Astaxanthin is a powerful antioxidant and potential therapeutic compound found in marine ecosystems. It has been observed to have significant bioactivities against chronic diseases such as cardiovascular diseases, cancer, and diabetes. It also possesses various potencies including anti-inflammatory, anti-proliferative, anti-aging, and antiviral effects, making it valuable for the prevention and treatment of common diseases.

NATURAL PRODUCTS AND BIOPROSPECTING (2022)

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Article Biochemistry & Molecular Biology

Diet supplementation of astaxanthin mitigates cadmium induced negative effects on oxidative, inflammatory and non-specific immune responses, and the intestinal morphology in Trachinotus ovatus

HaoHang Fang et al.

Summary: This study investigated the effects of astaxanthin supplemented diet on hepatic Cd deposition, oxidative, inflammatory and non-specific immune responses, and intestinal morphology of Trachinotus ovatus exposed to dietary Cd treatment. The results showed that astaxanthin could mitigate the inhibitory effects of Cd on the oxidative, inflammatory and non-specific immune responses, and intestinal morphology of T. ovatus while not reduce the hepatic Cd deposition.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

Geir Bjorklund et al.

Summary: This review provides an analysis of the sources of astaxanthin (ASX) and its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid naturally synthesized by microalgae, yeasts, and bacteria. It has been found to be a more significant antioxidant agent than other antioxidants, and has important nutraceutical applications and health benefits, especially in healthy aging processes. However, further research is needed to understand the mechanisms through which ASX exerts its effects.

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Detection of astaxanthin at different regions of the brain in rats treated with astaxanthin nanoemulsion

Mazzura Wan Chik et al.

Summary: This study quantified the distribution of Ast nanoemulsion in different regions of the rat brain using high-performance liquid chromatography. It was found that the nanoemulsion was able to cross the blood-brain barrier and may provide protective benefits.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2022)

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Review Biotechnology & Applied Microbiology

Bioprocess Strategy of Haematococcus lacustris for Biomass and Astaxanthin Production Keys to Commercialization: Perspective and Future Direction

Siti Nur Hazwani Oslan et al.

Summary: Haematococcus lacustris is considered the most promising microalgae for producing natural astaxanthin, with high antioxidant activity and economic potential. Although synthetic astaxanthin currently dominates the market, extracting it from this microalga remains expensive due to bioprocess difficulties and high cultivation costs.

FERMENTATION-BASEL (2022)

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Article Neurosciences

Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR7/SNCA axis

Dong-Fang Shen et al.

Summary: In this study, astaxanthin was shown to protect against Parkinson's disease-induced neuron damage by targeting the miR-7/SNCA axis and suppressing ER stress. These findings suggest that astaxanthin may be a potential therapeutic agent for PD.

NEUROSCIENCE RESEARCH (2021)

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Article

Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19

Ali-Reza Ahmadi et al.

Iranian Journal of Microbiology (2021)

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Article Pharmacology & Pharmacy

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

Xiang-Sheng Zhang et al.

Summary: The study showed that astaxanthin significantly reduced oxidative stress and neuronal apoptosis after traumatic brain injury. Astaxanthin improved neurological functions through the SIRT1/Nrf2/Prx2/ASK1/p38 signaling pathway, suggesting it as a potential candidate for alleviating traumatic brain injury.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Beta-Carotene derivatives as novel therapy for the prevention and treatment of autistic symptoms

Yosefa Avraham et al.

Summary: Autistic Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by impaired social interaction and communication, with no effective treatment available currently. Oxytocin and CD38 may play a role in ASD, while all-trans retinoic acid and beta-carotene derivatives have shown potential in ameliorating ASD symptoms.

BIOORGANIC CHEMISTRY (2021)

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Article Environmental Sciences

Microalgae for high-value products: A way towards green nutraceutical and pharmaceutical compounds

Sanjeet Mehariya et al.

Summary: Microalgae, a renewable bioresource with potential to replace conventional industrial production, shows promise in applications for food supplements and bioactive compounds. However, challenges in production efficiency and lack of economic analysis hinder the commercialization of the microalgal industry at present stage.

CHEMOSPHERE (2021)

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Article Cell Biology

Ameliorative effects of astaxanthin on brain tissues of alzheimer's disease-like model: cross talk between neuronal-specific microRNA-124 and related pathways

Hala A. Hafez et al.

Summary: This study demonstrated that astaxanthin (ATX) has a promising therapeutic effect on Alzheimer's disease by improving cognitive function, suppressing amyloid accumulation, regulating enzyme and protein expressions, and targeting different pathogenic pathways.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Article Green & Sustainable Science & Technology

Sustainable aquaculture and animal feed from microalgae-Nutritive value and techno-functional components

Dillirani Nagarajan et al.

Summary: Microalgae are promoted as a sustainable feed option with high nutritional quality, utilized in biofuel production and bioremediation. They offer advantages of protein, carbohydrates, fats, vitamins, and minerals, but quality assessments such as digestibility, bioavailability, and toxicity must be considered. Their utilization in animal husbandry and aquaculture sectors, along with potential future research prospects, are highlighted.

RENEWABLE & SUSTAINABLE ENERGY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Neuroprotective Effect of Ultrasound Triggered Astaxanthin Release Nanoparticles on Early Brain Injury After Subarachnoid Hemorrhage

Wei Cai et al.

Summary: Subarachnoid hemorrhage (SAH) is a fatal disease that results in the destruction of the blood-brain barrier (BBB) and nerve cell responses such as autophagy, apoptosis, and oxidative stress. Antioxidation is essential for SAH treatment, and Astaxanthin (ATX) has been shown to induce antioxidant behaviors in cells. ATX is mainly encapsulated in stimulus-responsive nanocarriers to improve stability and efficiently enter lesion tissue.

FRONTIERS IN CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

Andrea Donoso et al.

Summary: Astaxanthin is a natural antioxidant with various health benefits, such as neuroprotection, cardioprotection, anti-tumoral properties, and promotion of skin and eye health. Studies have shown that astaxanthin has higher antioxidant and free radical inhibitory activity compared to other antioxidants, suggesting its significant potential for disease prevention.

PHARMACOLOGICAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

The potential antiepileptic activity of astaxanthin in epileptic rats treated with valproic acid

Yussra Ata Yaseen Abdulqader et al.

Summary: The study demonstrates that ASTA has antiepileptic and anti-inflammatory effects by reducing the generation of reactive oxygen species. Compared to VPA alone, the combination therapy of VPA/ASTA has a synergistic effect in treating epilepsy and could potentially minimize recurrence and/or exacerbation of seizures.

SAUDI PHARMACEUTICAL JOURNAL (2021)

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Review Biotechnology & Applied Microbiology

Astaxanthin as a microalgal metabolite for aquaculture: A review on the synthetic mechanisms, production techniques, and practical application

Qian Lu et al.

Summary: Astaxanthin, an important metabolite with anti-oxidative property, has been discovered in fish, shrimp, and microorganisms. Microalgal astaxanthin, with great advantages in sustainability and safety, has gained increasing attention. Researchers have isolated microalgal species, explored synthesis pathways, and optimized culture conditions for astaxanthin production. This paper reviews progress in microalgal astaxanthin production and discusses challenges and prospects for its application.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2021)

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Article Biochemistry & Molecular Biology

Nutritional cognitive neuroscience of aging: Focus on carotenoids and cognitive frailty

M. Cristina Polidori et al.

Summary: Nutritional cognitive neuroscience is a newly established field that focuses on the impact of nutrition on cognition and brain health, especially in individuals with cognitive frailty. Carotenoids have been shown to play a crucial role in improving cognitive function in this population. Further research is needed to integrate carotenoid interventions into multidomain, personalized lifestyle strategies.

REDOX BIOLOGY (2021)

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Article Medicine, Research & Experimental

Astaxanthin attenuates acute cerebral infarction via Nrf-2/HO-1 pathway in rats

Bin-bin Yang et al.

Summary: This study demonstrated that pretreatment with ATX can significantly improve neurological function, reduce brain edema, infarct area, and brain cell apoptosis in acute cerebral infarction in rats. Additionally, ATX also showed anti-inflammatory effects by decreasing the levels of inflammatory factors.

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE (2021)

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Article Agriculture, Dairy & Animal Science

Assessment of Response to Moderate and High Dose Supplementation of Astaxanthin in Laying Hens

Dieudonne M. Dansou et al.

Summary: The study evaluated the effects of moderate and high dose dietary supplementation of astaxanthin on egg quality and laying hens' health status. It was found that moderate dose supplementation efficiently improved egg yolk color and laying hens' health status, while high dose supplementation showed positive effects but with decreased efficacy compared to moderate doses. Astaxanthin had no adverse effects on laying hens' performance and health status but may not be valuable for egg fortification at high doses.

ANIMALS (2021)

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Article Neurosciences

The effects of astaxanthin treatment on a rat model of Alzheimer's disease

Mu-Hsuan Chen et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss and dementia, potentially caused by abnormalities in cortical milieu and protein aggregation. Results indicate that astaxanthin may help slow the progression of the disease by reducing neuroinflammation, restoring neuronal fibers, and improving hippocampal neuron morphology.

BRAIN RESEARCH BULLETIN (2021)

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Review Veterinary Sciences

Beneficial effects and health benefits of Astaxanthin molecules on animal production: A review

Sayed Haidar Abbas Raza et al.

Summary: Astaxanthin is a high-quality keto-carotenoid pigment with various biological actions such as antihypertensive, antioxidant, anti-obesity, and anti-carcinogenic properties, as well as being a popular immunomodulator. Despite its wide use in medical sciences and aquatic species nutrition, its applications in broader animal nutrition are currently restricted.

RESEARCH IN VETERINARY SCIENCE (2021)

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Review Medicine, Research & Experimental

Antioxidant and anti-inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review)

Carolina Parga Martins Pereira et al.

Summary: Astaxanthin, a carotenoid compound with antioxidant and anti-inflammatory properties, shows potential beneficial effects on cardiovascular health and can be used as a treatment or preventive measure for cardiovascular diseases.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Cell Biology

Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins

Ning Liu et al.

Summary: Astaxanthin can regulate the expression of synaptic proteins in the hippocampus of mice, leading to improvements in learning, cognitive, and memory abilities.

NEURAL REGENERATION RESEARCH (2021)

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Article Biochemical Research Methods

Favorable Effects of Astaxanthin on Brain Damage due to Ischemia-Reperfusion Injury

Esra Cakir et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2020)

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Article Agronomy

Astaxanthin production byXanthophyllomyces dendrorhousgrowing on a low cost substrate

Teresa Gervasi et al.

AGROFORESTRY SYSTEMS (2020)

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Article Pharmacology & Pharmacy

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

Yuting Ke et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Cell Biology

Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3 beta/Nrf2 signalling pathway in vitro

Jie Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Chemistry, Medicinal

Recent Advances in Astaxanthin Micro/Nanoencapsulation to Improve Its Stability and Functionality as a Food Ingredient

Oscar Martinez-Alvarez et al.

MARINE DRUGS (2020)

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Article Chemistry, Medicinal

Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

Shohei Tsuji et al.

MARINE DRUGS (2020)

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Article Clinical Neurology

Cognitive Effects of Astaxanthin Pretreatment on Recovery From Traumatic Brain Injury

Chen Fleischmann et al.

FRONTIERS IN NEUROLOGY (2020)

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Review Food Science & Technology

Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications

Seyede Nazanin Zarneshan et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Food Science & Technology

Therapeutic potentials of crocin in medication of neurological disorders

Salman Ahmed et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Nutrition & Dietetics

Central Nervous System Migration of Astaxanthin and Adonixanthin Following Their Oral Administration in Cynomolgus Monkeys

Shinsuke Nakamura et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2020)

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Article Food Science & Technology

Safety of astaxanthin for its use as a novel food in food supplements

Dominique Turck et al.

EFSA JOURNAL (2020)

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Review Biology

Microalgae metabolites: A rich source for food and medicine

Ramaraj Sathasivam et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Medicine, Research & Experimental

Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease

Syed Obaidur Rahman et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Neurosciences

Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress

Md Mamun Al-Amin et al.

BRAIN RESEARCH (2019)

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Review Agricultural Engineering

Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis

Kuan Shiong Khoo et al.

BIORESOURCE TECHNOLOGY (2019)

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Article Cell Biology

Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function

Yanbin Wang et al.

ACTA HISTOCHEMICA (2019)

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Article Biotechnology & Applied Microbiology

Essential and toxic elements in commercial microalgal food supplements

Piotr Rzymski et al.

JOURNAL OF APPLIED PHYCOLOGY (2019)

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Review Chemistry, Medicinal

Astaxanthin: How much is too much? A safety review

Thomas Brendler et al.

PHYTOTHERAPY RESEARCH (2019)

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Article Food Science & Technology

Effect of Astaxanthin supplementation on psychophysiological heart-brain axis dynamics in healthy subjects

Shawn Talbott et al.

FUNCTIONAL FOODS IN HEALTH AND DISEASE (2019)

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Article Toxicology

Protective effect of astaxanthin on acute cerebral infarction in rats

Yu Nai et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2018)

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Article Agricultural Engineering

Rapid selection of astaxanthin-hyperproducing Haematococcus mutant via azide-based colorimetric assay combined with oil-based astaxanthin extraction

Min Eui Hong et al.

BIORESOURCE TECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Dietary astaxanthin can accumulate in the brain of rats

Yuki Manabe et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2018)

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Article Agriculture, Multidisciplinary

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice

Hongxia Che et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Neurosciences

Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

Naoki Ito et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Biotechnology & Applied Microbiology

Extraction of astaxanthin from microalga Haematococcus pluvialis in red phase by using generally recognized as safe solvents and accelerated extraction

Antonio Molino et al.

JOURNAL OF BIOTECHNOLOGY (2018)

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Article Nutrition & Dietetics

Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals

Masahiro Hayashi et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2018)

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Article Nutrition & Dietetics

Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study

Ayano Imai et al.

NUTRIENTS (2018)

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Article Pharmacology & Pharmacy

The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats

Yonghao Feng et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Neurosciences

Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury

Sajad Fakhri et al.

BRAIN RESEARCH BULLETIN (2018)

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Review Pharmacology & Pharmacy

Astaxanthin: A mechanistic review on its biological activities and health benefits

Sajad Fakhri et al.

PHARMACOLOGICAL RESEARCH (2018)

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Article Medicine, Legal

Safety assessment of astaxanthin derived from engineered Escherichia coli K-12 using a 13-week repeated dose oral toxicity study and a prenatal developmental toxicity study in rats

Yin-Ju Lin et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)

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Article Oncology

The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

Xi Jiang et al.

ONCOTARGET (2017)

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Article

Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen et al.

Oncotarget (2017)

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Article Neurosciences

Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway

Mingkun Zhang et al.

BMC NEUROSCIENCE (2017)

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Article Neurosciences

The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion

Yan Xue et al.

BRAIN RESEARCH BULLETIN (2017)

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Article Neurosciences

Preventive treatment of astaxanthin provides neuroprotection through suppression of reactive oxygen species and activation of antioxidant defense pathway after stroke in rats

Lei Pan et al.

BRAIN RESEARCH BULLETIN (2017)

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Article Neurosciences

Astaxanthin improves cognitive performance in mice following mild traumatic brain injury

Xinran Ji et al.

BRAIN RESEARCH (2017)

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Article Neurosciences

Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice

Xiao-yan Zhou et al.

BRAIN RESEARCH (2017)

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Article Ecology

The potential of carbon dioxide capture and sequestration with algae

David Dah-Wei Tsai et al.

ECOLOGICAL ENGINEERING (2017)

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Article Agriculture, Multidisciplinary

The effect of astaxanthin on the aging ratbrain: gender-related differences inmodulating inflammation

Marta Balietti et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2016)

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Article Neurosciences

Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice

Mingkun Zhang et al.

BMC NEUROSCIENCE (2016)

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Article Neurosciences

Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice

Xi Jiang et al.

BRAIN RESEARCH (2016)

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Article Pharmacology & Pharmacy

Astaxanthin ameliorates aluminum chloride-induced spatial memory impairment and neuronal oxidative stress in mice

Md Mamun Al-Amin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Food Science & Technology

Chemical and Physical Stability of Astaxanthin-Enriched Emulsion-Based Delivery Systems

Xiaojuan Liu et al.

FOOD BIOPHYSICS (2016)

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Review Geriatrics & Gerontology

Healthy brain ageing and cognition: Nutritional factors

M. Vandewoude et al.

EUROPEAN GERIATRIC MEDICINE (2016)

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Article Chemistry, Multidisciplinary

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

Prakash Chandra Bhatt et al.

RSC ADVANCES (2016)

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Article Behavioral Sciences

Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism

Md. Mamun Al-Amin et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

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Article Neurosciences

Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats

Xiang-Sheng Zhang et al.

BRAIN RESEARCH (2015)

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Article Chemistry, Medicinal

Redox Status and Neuro Inflammation Indexes in Cerebellum and Motor Cortex of Wistar Rats Supplemented with Natural Sources of Omega-3 Fatty Acids and Astaxanthin: Fish Oil, Krill Oil, and Algal Biomass

Tatiana G. Polotow et al.

MARINE DRUGS (2015)

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Article Endocrinology & Metabolism

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

Md. Mamun Al-Amin et al.

METABOLIC BRAIN DISEASE (2015)

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Article Biotechnology & Applied Microbiology

Advanced methods for genetic engineering of Haematococcus pluvialis (Chlorophyceae, Volvocales)

Revital Sharon-Gojman et al.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2015)

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Article Surgery

Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage

Xiang-Sheng Zhang et al.

JOURNAL OF SURGICAL RESEARCH (2014)

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Article Chemistry, Medicinal

Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling

Xiang-Sheng Zhang et al.

MARINE DRUGS (2014)

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Article Chemistry, Medicinal

Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury

Qi Wu et al.

MARINE DRUGS (2014)

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Article Clinical Neurology

Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study

Danilo Zanotta et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2014)

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Article Food Science & Technology

In vivo bioavailability and antioxidant activity of carotenoids from microalgal biomass - A repeated dose study

A. Ranga Rao et al.

FOOD RESEARCH INTERNATIONAL (2013)

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Article Nutrition & Dietetics

Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study

Mikiyuki Katagiri et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2012)

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Article Multidisciplinary Sciences

Amyloid β Levels in Human Red Blood Cells

Takehiro Kiko et al.

PLOS ONE (2012)

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Article Nutrition & Dietetics

Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes

Kiyotaka Nakagawa et al.

BRITISH JOURNAL OF NUTRITION (2011)

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Article Neurosciences

Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

Ya-Peng Lu et al.

BRAIN RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Astaxanthin reduces ischemic brain injury in adult rats

Hui Shen et al.

FASEB JOURNAL (2009)

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Article Nutrition & Dietetics

Preliminary Clinical Evaluation of Toxicity and Efficacy of A New Astaxanthin-rich Haematococcus pluvialis Extract

Akira Satoh et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2009)

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Article Pharmacology & Pharmacy

Combined cancer therapy by micellar-encapsulated drug and ultrasound

N Rapoport

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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