☆ 4.8 Review

Assays for alkaline phosphatase that use L-ascorbic acid 2-phosphate as a substrate

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Chemistry, Physical

A novel S-scheme heterojunction of Cd0.5Zn0.5S/BiOCl with oxygen defects for antibiotic norfloxacin photodegradation: Performance, mechanism, and intermediates toxicity evaluation

Mingjie Cai et al.

Summary: In this study, an integrative S-scheme heterojunction photocatalyst composed of Cd0.5Zn0.5S nanoparticles and BiOCl microflowers was developed for efficient degradation of PPCPs. The Cd0.5Zn0.5S/BiOCl showed significantly enhanced photo-activity and stability compared to pristine Cd0.5Zn0.5S or BiOCl, and it also demonstrated good resistance to various contaminants. The ability of Cd0.5Zn0.5S/BiOCl for PPCPs de-toxicity was verified through the evaluation of toxicity of norfloxacin and its degradation intermediate.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Article Chemistry, Physical

Self-deposited ultrasmall Ru nanoparticles on carbon nitride with high peroxidase-mimicking activity for the colorimetric detection of alkaline phosphatase

Zhenyu Ding et al.

Summary: This study successfully embeds highly dispersed ultrasmall Ru nanoparticles onto carbon nitride (C3N4) nanosheets through a spontaneous redox reaction, forming Ru-C3N4 nanocomposites. The Ru-C3N4 exhibits excellent peroxidase-like activity, which can be regulated by adjusting the loading of Ru nanoparticles. A colorimetric sensing method for alkaline phosphatase (ALP) detection is developed based on the inhibitory effect of ascorbic acid on the color development reaction of Ru-C3N4. The sensor shows a wide linear range and low detection limit for ALP sensing, and satisfactory results are obtained in detecting ALP in human serum.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Article Biochemistry & Molecular Biology

ALP-Based Biosensors Employing Electrodes Modified with Carbon Nanomaterials for Pesticides Detection

Stefano Gianvittorio et al.

Summary: The development of fast and reliable detection methods for pesticides is needed due to their increasing presence in the environment and food. This paper describes the development of an electrochemical biosensor using alkaline phosphatase as the recognition element and a chemically modified glassy carbon electrode as the transducer. The biosensor showed promising results in detecting pesticides and demonstrated re-usability through a washing procedure.

MOLECULES (2023)

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Article Chemistry, Multidisciplinary

Regulating the N Coordination Environment of Co Single-Atom Nanozymes for Highly Efficient Oxidase Mimics

Zhe Li et al.

Summary: This study demonstrates that the oxidase-like activity of single-atom Co catalysts greatly depends on their local N coordination around the Co catalytic sites. We synthesized a series of Co single-atom catalysts with different nitrogen coordination numbers (Co-Nx(C), x = 2, 3, and 4) and demonstrated that the oxidase-like activity of single-atom Co catalysts could be effectively tailored by fine-tuning the N coordination. Among the studied single-atom Co catalysts, the Co-N3(C) with three-coordinate N atoms shows the optimum oxygen adsorption structure and robust reactive oxygen species (ROS) generation, thus presenting the preferable oxidase-like catalytic activity. This work facilitates the future development of rational nanozyme designs for targeting reactions at the atomic level.

NANO LETTERS (2023)

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Article Chemistry, Multidisciplinary

Ultrasensitive electrochemical immunoassay for screening the influenza A (H1N1) virus based on atomically Ru-dispersed nitrogen-doped carbon

Jiancheng Lin et al.

Summary: In this study, a versatile electrochemical immunoassay was developed for sensitive and specific screening of low-abundance influenza A (H1N1) virus using a Ru-CN modified disposable SPCE. The immunoassay generated ascorbic acid, which was then detected using differential pulse voltammetry. The proposed sensing system showed good reproducibility, high specificity, and acceptable stability, and was comparable to the commercial ELISA method in detecting H1N1 virus in clinical samples. This study demonstrates the potential of atomic-level dispersed metals in developing highly sensitive electrochemical immunoassays for early detection of epidemic viruses.

NEW JOURNAL OF CHEMISTRY (2023)

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Article Chemistry, Analytical

Construction of a dual-mode biosensor for electrochemiluminescent and electrochemical sensing of alkaline phosphatase

Lin Cui et al.

Summary: A dual-mode biosensor based on fully-pi conjugated covalent organic framework (COF) and cobalt oxyhydroxide (CoOOH) nanoflakes is demonstrated for electrochemiluminescent (ECL) and electrochemical sensing of alkaline phosphatase (ALP). This dual-mode biosensor can efficiently eliminate errors and provide more reliability and accuracy than a single-mode biosensor.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Materials Science, Biomaterials

A redox reaction-induced ratiometric fluorescence platform for the specific detection of ascorbic acid based on Ag2S quantum dots and multifunctional CoOOH nanoflakes

Haoyu Chen et al.

Summary: A ratiometric fluorescent nanoplatform based on Ag2S quantum dots and multifunctional hydroxyl cobalt oxide nanoflakes was constructed for the detection of ascorbic acid (AA). The platform effectively quenches the NIR fluorescence emission of Ag2S QDs at 680 nm through the inner filter effect, and catalyzes the oxidation of o-Phenylenediamine (OPD) into 2,3-diaminophenazine (DAP) with an emission peak at 575 nm. The addition of AA leads to the decline in the OXD-like activity of CoOOH NFs, resulting in the recovery of red fluorescence from the released Ag2S QDs. The ratiometric fluorescence sensor enables the quantification of AA in real samples with a linear range of 0.2 μM-20 mM and a detection limit of 0.014 μM.

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Article Nanoscience & Nanotechnology

DNA-Programmed Tuning of the Growth and Enzyme-Like Activity of a Bimetallic Nanozyme and Its Biosensing Applications

Mengchao Cai et al.

Summary: This study reports a DNA-programming seed-growth strategy to control the growth of platinum nanoparticles (PtNPs) on gold bipyramids (AuBPs), resulting in the synthesis of a bimetallic nanozyme. By encoding a polyT sequence, it was found that bimetallic nanohybrids with significantly enhanced peroxidase-like activity could be successfully formed. The morphologies and optical properties of the resulting Au/T15/Pt nanostructures were observed to change over time, and the nanozyme activity could be tuned by controlling the experimental conditions. This work provides a new approach for the rational design of bimetallic nanozymes for biosensing applications.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Biophysics

Near-infrared light-induced photoelectrochemical biosensor based on plasmon-enhanced upconversion nanocomposites for microRNA-155 detection with cascade amplifications

Pei Miao et al.

Summary: In this study, a novel near-infrared light-driven photoelectrochemical biosensor based on NaYF4:Yb3+, Er3+@Bi2MoO6@Bi nanocomposites was developed for highly sensitive detection of microRNA-155 (miRNA-155). The biosensor achieved signal enhancement through the use of coupled plasmonic bismuth nanoparticles as an energy relay to facilitate energy transfer, ultimately enabling efficient separation of electron-hole pairs. A cascade signal amplification process was triggered upon addition of the target miRNA, resulting in accurate detection within a wide range and a low detection limit. The proposed biosensor offers a promising platform for monitoring tumor biomarkers in clinical diagnostics.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Chemistry, Applied

Gold nanoclusters-manganese dioxide composite-based fluorescence immunoassay for sensitive monitoring of fenitrothion degradation in Chinese cabbage

Ting Lv et al.

Summary: In this study, a sensitive fluorescence immunoassay (FIA) was designed for detecting the residues and degradation of organophosphorus pesticides (OPs) in crops. The FIA utilized nanobody-linked alkaline phosphatase (Nb-ALP) and gold nanoclusters anchored manganese dioxide (AuNCs-MnO2) composite. The developed FIA exhibited high detection sensitivity and was successfully applied for monitoring the degradation of fenitrothion (FNT) in Chinese cabbage, paving the way for determining pesticide residues in real food samples.

FOOD CHEMISTRY (2023)

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Article Agriculture, Multidisciplinary

Ratiometric Fluorescence Immunoassay Based on MnO2 Nanoflakes for Sensitive and Accurate Detection of Tricaine

Hong-Wei Liang et al.

Summary: In this study, a RF-ELISA method was successfully developed for the detection of tricaine. The detection limits of this method in tilapia and shrimp were determined to be 5.6 and 2.8 ng/g, respectively. The validation data from LC-MS/MS confirmed the accuracy, precision, and reliability of RF-ELISA. This method opens up new avenues for the analysis of tricaine and other targets in food safety detection.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Chemistry, Analytical

Fluorescence ratio immunoassay for fumonisin B1 based on the oxidase characteristics of the growth of monodispersed 2-D MnO2 nanosheet on an individual gold nanoparticle (AuNP@MnO2)

Yao Yu et al.

Summary: A sensitive fluorescence ratio immunoassay was developed for the detection of the mycotoxin fumonisin B1 (FB1) in maize samples. The assay utilizes the growth of monodispersed 2-D MnO2 nanosheets on gold nanoparticles (AuNP@MnO2) and the competitive binding of FB1 with the coated FB1-BSA to the FB1 monoclonal antibody. The content of FB1 can be determined by the fluorescence ratio of blue/yellow.

MICROCHIMICA ACTA (2023)

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Article Chemistry, Analytical

Fluorescent nanoswitch based on redox-controlled reversible sulfhydryl functionalized carbon dots for highly sensitive detection of ochratoxin A

Yuanjin Zhan et al.

Summary: In this study, sulfhydryl functionalized carbon dots (SH-CDs) were synthesized for the first time using a two-step hydrothermal method. The sulfhydryl group in SH-CDs can be efficiently and reversibly converted under redox conditions. By combining ochratoxin A (OTA) induced amplification and enzymatic hydrolysis, ascorbic acid (AA) is produced. AA reduces the aggregated SH-CDs, allowing for rapid quantitative analysis of OTA concentration through changes in fluorescence intensity and absorbance. The proposed sensor has a good linear relationship with OTA concentration in the range of 2.0-5.0 nM, with a lowest detection limit of 2.0 nM. The visual color change of the solution improves the simplicity and accuracy of semi-quantitative detection of OTA with the naked eye. In summary, this method offers advantages of rapidity, sensitivity, reversibility, and visualization.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

A dual-mode system based on molybdophosphoric heteropoly acid and fluorescent microspheres for the reliable and ultrasensitive detection of alkaline phosphatase

Qiannan Li et al.

Summary: A novel dual-mode sensing system based on molybdophosphoric heteropoly acid (PMA) and fluorescent microspheres (FMs) was developed for monitoring alkaline phosphatase (ALP) activity. The system utilized the catalytic hydrolysis of l-ascorbic acid-2-phosphate (AAP) by ALP to generate a colorimetric signal and reduce PMA to phosphorus molybdenum blue (PMB). Additionally, the fluorescence of FMs was quenched through the inner-filter effect, enabling simultaneous fluorescence detection. The system showed high sensitivity with a limit of detection of 0.27 U L-1 and 0.11 U L-1, and demonstrated good analytical performance in biological samples. A portable test kit for visual detection of ALP in serum samples was also developed using a smartphone as a visual detection platform.

ANALYST (2023)

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Article Chemistry, Analytical

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal-Organic Frameworks by Phosphate

Wei Wang et al.

Summary: Alkaline phosphatase (ALP) is a widely present and important biomarker in the human body. Researchers synthesized a core-shell metal-organic framework sensor that can be used for sensitive and accurate ALP detection. By self-triggered control of phosphate ions (Pi), the sensor avoids the potential inaccuracy caused by using ascorbic acid (AA) as the reducing component. The developed strategy has shown linear response to ALP concentrations ranging from 0.1 to 150 mU/mL with a detection limit of 0.03 mU/mL.

ANALYTICAL CHEMISTRY (2023)

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Article Biophysics

Antibody-free photoelectrochemical strategy for simultaneous detection of methylated RNA, METTL3/METTL14 protein and MazF protein based on enhanced photoactivity of MoSe2-BiOI nanocomposite

Xiaoting Cui et al.

Summary: A novel photoelectrochemical biosensor was constructed for simultaneous detection of RNA methylation, METTL3/METTL14 proteins, and MazF proteins using MoSe2-BiOI nanocomposite as a photoactive material. The detection ranges for methylated RNA, METTL3/METTL14 protein, and MazF protein were 0.001-50 nM, 0.001-25 ng/μL, and 0.001-10 U/mL, respectively. The developed method was also applicable for drug screening and preliminary exploration of pollutant effects on protein activity.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Biophysics

CRISPR/Cas12a-based magnetic relaxation switching biosensor for nucleic acid amplification-free and ultrasensitive detection of methicillin-resistant Staphylococcus aureus

Luyu Wei et al.

Summary: In this study, a CRISPR/Cas12a-based magnetic relaxation switching (C-MRS) biosensor was developed for ultrasensitive and nucleic acid amplification-free detection of methicillin-resistant Staphylococcus aureus (MRSA) in food. The biosensor utilizes CRISPR-RNA to recognize the mecA gene in MRSA, activating the trans-cleavage activity of Cas12a and releasing alkaline phosphatase (ALP). The released ALP hydrolyzes a substrate to produce ascorbic acid, triggering a click reaction between magnetic probes. The transverse relaxation time of the unbound magnetic probes is then measured for signal readout.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Chemistry, Applied

Ultrasensitive alkaline phosphatase activity assay based on controllable signal probe production coupled with the cathodic photoelectrochemical analysis

Ying-zhuo Shen et al.

Summary: A highly sensitive and selective split-type perovskite-based photoelectrochemical (PEC) platform was developed to measure alkaline phosphatase (ALP) activity in milk and serum samples. The PEC used a CTAB@CH3NH3PbI3 film as the cathode to monitor the controlled AA production. With excellent sensitivity and selectivity, the platform has great potential for use in food and biomedical analysis.

FOOD CHEMISTRY (2023)

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Article Chemistry, Physical

Photothermal visual sensing of alkaline phosphatase based on the etching of Au@MnO2 core-shell nanoparticles

Jin Li et al.

Summary: A novel photothermal quantitative method based on the etching of MnO2-coated gold nanoparticles was developed for the determination of alkaline phosphatase (ALP) activity using a household thermometer as a visual readout. The photothermal effect of the nanoparticles was significantly enhanced by the MnO2 shell, and the etching of the nanoparticles caused a gradual decrease in the temperature increment of the solution. The method showed a wide linear range and a low detection limit, and could potentially be applied for screening enzyme inhibitors.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Article Biophysics

Dual enzyme induced colorimetric sensor for simultaneous identifying multiple pathogens

Weiwei Chen et al.

Summary: A colorimetric sensor using double-enzyme-induced colorimetry was developed in this study for detecting multiple bacteria. The method identifies bacteria based on the decomposition of L-ascorbic acid 2-magnesium phosphate salt hydrate and the oxidation of TMB by MnO2 NFs. By analyzing the color changes and plasmon resonance wavelength signals produced, bacteria with varying ALP levels can be accurately identified. The method achieved 99.57% accuracy in identifying multiple bacteria and can be used in diverse environments for the rapid and simple identification of foodborne illnesses.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Chemistry, Multidisciplinary

Integrating resonance energy transfer with enzyme-triggered hydrolysis for ultrasensitive electrochemiluminescence detection of exosomes

Yuanyuan Wang et al.

Summary: We developed an electrochemiluminescence (ECL) sensor by combining resonance energy transfer (RET) and enzyme-triggered hydrolysis reaction. The sensor exhibited high sensitivity toward A549 cell-derived exosomes with a detection limit of 1.22 x 10(3) particles mL(-1) due to efficient RET, signal amplification by DNA competitive reaction, and quick response of alkaline phosphatase (ALP)-triggered hydrolysis reaction. It performed well on biosamples from lung cancer patients and healthy individuals, indicating its potential application in cancer diagnosis.

CHEMICAL COMMUNICATIONS (2023)

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Article Nanoscience & Nanotechnology

High-Performance Broadband Photoelectrochemical Photodetectors Based on Ultrathin Bi2O2S Nanosheets

Xuxuan Yang et al.

Summary: In this study, ultrathin 2D Bi2O2S nanosheets were successfully synthesized and used to fabricate PEC photodetectors with excellent performance. The photodetectors exhibited a broad photoresponse spectrum, high responsivity, fast response times, and good long-term stability, and could function as self-powered broadband photodetectors.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Hydrogel-Involved Colorimetric Platforms Based on Layered Double Oxide Nanozymes for Point-of-Care Detection of Liver-Related Biomarkers

Xiaoxue Liu et al.

Summary: We designed a novel colorimetric point-of-care platform that can conveniently and inexpensively monitor liver status and detect liver-related biomarkers with high sensitivity and quantitative analysis capability. The platform utilizes nanozymes and different reaction substances to generate colorimetric signals, which are converted into hue values for analysis using a smartphone.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Biochemical Research Methods

Directed self-assembly of Ag+-deposited MoS2 quantum dots for colorimetric, fluorescent and fluorescence-lifetime sensing of alkaline phosphatase

Manivannan Madhu et al.

Summary: A triple-readout probe has been developed for the colorimetric, fluorescent, and fluorescence-lifetime sensing of alkaline phosphatase (ALP) using silver nanoparticles (AgNPs) formed on molybdenum disulfide quantum dots (MoS2 QDs). The probe shows high sensitivity and selectivity for the detection of target proteins in clinical samples.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Midas Touch: Engineering Activity of Metal-Organic Frameworks via Coordination for Biosensing

Chao Peng et al.

Summary: The study proposes a strategy to endow inert metal-organic frameworks (MOFs) with enzyme mimicking activity by introducing Cu2+, resulting in the preparation of Zr-MOF-Cu with unparalleled catalytic ability. Details on the coordination environment of Cu active sites in Zr-MOF-Cu are disclosed through electron paramagnetic resonance and synchrotron-radiation-based X-ray absorption fine structure analyses. The material enables 8-fold signal amplification and successfully constructs a universal fluorescent system for the quantitative measurement of alkaline phosphatase (ALP) activity and enzyme-linked immunosorbent assay related to ALP.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

A Target-Driven Self-Feedback Paper-Based Photoelectrochemical Sensing Platform for Ultrasensitive Detection of Ochratoxin A with an In2S3/WO3 Heterojunction Structure

Xiaoran Tan et al.

Summary: In this study, a paper-based photoelectrochemical (PEC) sensor was developed for ultrasensitive detection of OTA. By using polyvinylpyrrolidone-treated In2S3/WO3 functionalized paper as a signal transducer and employing the Exo III-assisted cycling process and PECCC redox cycling strategy, the sensor achieved high sensitivity in OTA detection.

ANALYTICAL CHEMISTRY (2022)

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Article Biophysics

A membraneless self-powered photoelectrochemical biosensor based on Bi2S3/BiPO4 heterojunction photoanode coupling with redox cycling signal amplification strategy

Jun-Tao Cao et al.

Summary: An ingenious visible light-induced membraneless self-powered PEC biosensing platform was developed in this study, which showed excellent performance with a wide linear range and low detection limit. The proposed system incorporated a redox cycling strategy for ultrasensitive split-type PEC bioanalysis, providing an effective approach for clinical diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Chemistry, Multidisciplinary

Activatable fluorescent probes for in situ imaging of enzymes

Xiaofeng Wu et al.

Summary: This article summarizes the methods for in situ imaging of enzymes using activatable fluorescent probes, and proposes that fluorescent probes with both activatable and in situ properties will facilitate high-resolution studies of enzymes in living systems.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Agriculture, Dairy & Animal Science

I2/I--mediated fluorescence quenching of an Ag+-doped gold nanocluster-based immunoassay for sensitive detection of Escherichia coli O157:H7 in milk

Bolong Fang et al.

Summary: In this study, stable Ag+-doped gold nanoclusters (Ag-AuNC) were synthesized and used for detecting Escherichia coli O157:H7 in the field of food safety. The combination of I2 and I- was applied to quench the enhanced fluorescence of Ag-AuNC and improve the sensitivity of detection. The proposed immunoassay exhibited excellent sensitivity, specificity, recovery, and accuracy for quantitative detection of Escherichia coli O157:H7 in food safety.

JOURNAL OF DAIRY SCIENCE (2022)

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Article Chemistry, Analytical

A ratiometric electrochemical biosensor via alkaline phosphatase mediated dissolution of nano-MnO2 and Ru(III) redox recycling for the determination of dimethoate

Li Hou et al.

Summary: A sensitive and ratiometric electrochemical biosensor was developed for the determination of dimethoate via alkaline phosphatase (ALP) mediated dissolution of nano-MnO2 and [Ru(NH3)(6)](3+)(Ru(III)) redox recycling. The biosensor showed good performance in detecting dimethoate with high sensitivity and a detection limit of 6.3 pg mL(-1).

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Chemistry, Analytical

Fluorescent assay of alkaline phosphatase activity via atom transfer radical polymerization

Jing Lu et al.

Summary: A novel fluorescence assay for alkaline phosphatase (ALP) activity detection is proposed using the activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) strategy. The method exhibited excellent performance in the detection of fluorescence signals.

MICROCHIMICA ACTA (2022)

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Article Chemistry, Analytical

A signal-off photoelectrochemical aptasensor for ultrasensitive 17β-estradiol detection based on rose-like CdS@C nanostructure and enzymatic amplification

Lian-Hong Tu et al.

Summary: Carbon-coated cadmium sulfide rose-like nanostructures were prepared as a photoelectrochemical sensing platform for the integration of functional biomolecules. A novel signal-off photoelectrochemical aptasensor mediated by enzymatic amplification was proposed for the detection of 17 beta-estradiol with high sensitivity and selectivity.

MICROCHIMICA ACTA (2022)

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Article Chemistry, Physical

Single-atom Pd catalysts as oxidase mimics with maximum atom utilization for colorimetric analysis

Zhe Li et al.

Summary: This study demonstrates the utilization of single-atom Pd catalysts as efficient enzyme mimics, with significantly enhanced catalytic efficiency and excellent analytical performance. These nanozymes can be applied in antioxidant capacity determination and logic gate construction.

NANO RESEARCH (2022)

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Article Spectroscopy

A colorimetric and ratiometric photometric sequential assay for ascorbic acid and alkaline phosphatase in serum based on valence states modulation

Min Huang et al.

Summary: The photometric method is widely used in clinical tests due to its simplicity and cost-effectiveness. Novel colorimetric and ratiometric assays are important for accurately quantifying targets, with the challenge lying in designing chromophores with significant spectral shifts before and after binding. The established sensing system has a low limit of detection for ALP and can be applied for detecting ALP in complex clinical samples.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Multidisciplinary

Accelerated Mimetic Oxidase Activity of Polydopamine-Dressed PdCu Nanozyme for the Detection of Ascorbic Acid Related Bioenzymes

Chenghui Zhang et al.

Summary: Polydopamine-dressed PdCu alloy (PDA-PdCu) nanozymes with nanochain networks were successfully prepared by combining surface modification and nonprecious metal doping strategies. The synthesized PDA-PdCu samples exhibited considerably enhanced oxidase mimetic activity compared to PDA-Pd and PdCu nanozymes, and a sensitive colorimetric biosensing strategy for ascorbic acid (AA)-related bioenzyme activity was developed.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2022)

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Article Chemistry, Analytical

Brightness Analysis per Moving Particle: In Situ Analysis of Alkaline Phosphatase in Living Cells

Luoyu Ding et al.

Summary: In this paper, a novel in situ measurement strategy using resonance light scattering (RLS) was proposed to detect alkaline phosphatase (ALP) activity within single living cells. The method involves the measurement of the resonance light scattering brightness ratio (SBR) per moving nanoparticle that forms in an ALP-related chemical reaction. The results showed a linear relationship between the SBR and ALP activity, and the method was successfully used to in situ measure ALP activity within living cells.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Redox-Responsive Breakup of a Nucleic Acids@CoOOH Nanocomplex Triggering Cascade Recycling Amplification for Sensitive Sensing of Alkaline Phosphatase

Shuo Li et al.

Summary: In this study, a highly sensitive and label-free fluorescence biosensing strategy for the determination of alkaline phosphatase (ALP) activity was introduced using cobalt oxyhydroxide (CoOOH) nanoflakes and nonenzymatic cascade recycling amplification (CRA). The method exhibits excellent specificity and a low detection limit, making it suitable for evaluating ALP activity in complex human serum samples.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Efficient Biocatalytic System for Biosensing by Combining Metal- Organic Framework (MOF)-Based Nanozymes and G-Quadruplex (G4)-DNAzymes

Xuanxiang Mao et al.

Summary: In this study, a combination of metal-organic framework nanozymes and G-quadruplex-based catalytic system was developed for biosensing applications. The resulting biosensor showed high catalytic efficiency, robust chemical structure, and low detection limit for ALP, a marker of bone diseases and cancers, in human plasma samples.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Single-Molecule Biosensing of Alkaline Phosphatase in Cells andSerum Based on Dephosphorylation-Triggered Catalytic Assemblyand Disassembly of the Fluorescent DNA Chain

Fei Ma et al.

Summary: This study reports a new single-molecule fluorescent biosensor for the simple and ultrasensitive detection of alkaline phosphatase (ALP). The biosensor enables efficient amplification and transduction of the target ALP signal through enzyme-free assembly and disassembly processes, significantly simplifying the experimental procedure and improving the assay accuracy.

ANALYTICAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Generation of a nanobody-alkaline phosphatase heptamer fusion for ratiometric fluorescence immunodetection of trace alpha fetoprotein in serum

Benchao Su et al.

Summary: In this study, a ratiometric fluorescence enzyme immunoassay (RFEIA) was developed using nanobody-alkaline phosphatase (Nb-AP) heptamer and Mn-Fe layered double hydroxides nanoflakes (Mn-Fe LDH) for ultrasensitive detection of alpha fetoprotein (AFP). The RFEIA showed a limit of detection of 0.013 ng/mL with good selectivity, accuracy and precision, and the results were well confirmed by the automated chemiluminescence immunoassay analyzer. This work demonstrates the potential of the developed RFEIA as a promising tool for the diagnosis of hepatocellular carcinoma (HCC).

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Chemistry, Analytical

A catalyst-free co-reaction system of long-lasting and intensive chemiluminescence applied to the detection of alkaline phosphatase

Xin Jie Wu et al.

Summary: A catalyst-free co-reaction luminol-H2O2-K2S2O8 chemiluminescence (CL) system was developed, which exhibited long-life and high-intensity emission lasting for 6 hours. The mechanism of persistent and intense emission was discussed based on CL spectra, cyclic voltammetry, electron spin resonance (ESR), and the effects of radical scavengers. A CL-based method for the detection of ALP was established with good linearity and a low limit of detection. This method was successfully applied to detect ALP in human serum samples.

MICROCHIMICA ACTA (2022)

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Article Chemistry, Analytical

Alkaline phosphatase-triggered dual-signal immunoassay for colorimetric and electrochemical detection of zearalenone in cornmeal

Cuiling Shang et al.

Summary: A dual-signal immunoassay utilizing alkaline phosphatase was developed to detect Zearalenone (ZEN) in cornmeal. The method combines colorimetric and electrochemical detection, generating Prussian blue nanoparticles and multicolor changes. The results demonstrate a high sensitivity for ZEN detection in corn samples through UV-vis spectrometry and differential pulse voltammetry.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Applied

A high-resolution colorimetric immunoassay for tyramine detection based on enzyme-enabled growth of gold nanostar coupled with smartphone readout

Lin Luo et al.

Summary: In this work, a specific monoclonal antibody against tyramine was produced using a new hapten design. A high-resolution multicolor colorimetric immunoassay for tyramine was developed by integrating enzyme-induced multicolor generation with smartphone-assisted signal readout. The immunoassay showed a limit of detection of 19.7 mg/kg or L in beef, pork, and yogurt, and the results were reliable.

FOOD CHEMISTRY (2022)

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Article Agriculture, Multidisciplinary

Optical Biosensor for Ochratoxin A Detection in Grains Using an Enzyme-Mediated Click Reaction and Polystyrene Nanoparticles

Luyu Wei et al.

Summary: Researchers have developed an optical biosensor for highly sensitive and facile detection of ochratoxin A (OTA). The biosensor utilizes an enzyme-mediated click reaction for signal amplification and polystyrene nanoparticles (PNPs) for signal readout. The biosensor demonstrates improved sensitivity and simplified procedures, making it a promising tool for mycotoxin screening.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Chemistry, Analytical

A portable multicolor aptasensor for MUC1 detection based on enzyme-mediated cascade reaction

Jin-Hong Sui et al.

Summary: MUC1 is an important tumor biomarker with significant implications in clinical diagnostics, prognosis assessment, and therapy monitoring. This study developed a visual multicolor aptasensor for MUC1 detection using an alkaline phosphatase-triggered cascade reaction. The proposed aptasensor allows naked eye detection of MUC1 with a low detection limit, providing a new approach for MUC1 detection in resource-limited settings.

MICROCHEMICAL JOURNAL (2022)

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Article Nanoscience & Nanotechnology

Gold Nanostar@Polyaniline Theranostic Agent with High Photothermal Conversion Efficiency for Photoacoustic Imaging-Guided Anticancer Phototherapy at a Low Dosage

Yuanzheng Wang et al.

Summary: An efficient photothermal theranostic agent based on a gold nanostar@polyaniline core-shell nanocomposite with high photothermal conversion efficiency is developed for photoacoustic imaging-guided photothermal therapy. The nanocomposite shows outstanding photothermal performance and can also act as a targeted probe for tumors. It exhibits excellent therapeutic effects in vitro and in vivo, effectively suppressing tumor growth.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Analytical

In situ encapsulation of SQDs by zinc ion-induced ZIF-8 growth strategy for fluorescent and colorimetric dual-signal detection of alkaline phosphatase

Xiao-Xue Jiang et al.

Summary: Sulfur quantum dots (SQDs) were successfully encapsulated into metal-organic frameworks (ZIF-8) using a surface bound zinc ion-induced growth strategy, resulting in SQDs@ZIF-8 for alkaline phosphatase (ALP) detection. This new synthesis procedure significantly improved the luminous efficiency of SQDs. The detection of ALP was achieved by pH-triggered fluorescence quenching of SQDs@ZIF-8, and an extended detection range was obtained by complexing free SQDs with Fe2+. SQDs@ZIF-8 exhibited excellent stability in water and showed potential for fluorescence and colorimetric detection of ALP in human serum.

ANALYTICA CHIMICA ACTA (2022)

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Review Chemistry, Inorganic & Nuclear

A comprehensive overview on alkaline phosphatase targeting and reporting assays

Samy M. Shaban et al.

Summary: This review provides a comprehensive overview of recent advances in ALP assays and immunoassay strategies. It discusses the different techniques and their comparison, offering a convenient route for developing more advanced ALP sensors.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Spectroscopy

In situ reaction-based ratiometric fluorescent assay for alkaline phosphatase activity and bioimaging

Yu Ding et al.

Summary: In this study, a reaction-based ratiometric fluorescence assay was proposed for the detection of alkaline phosphatase (ALP). The method demonstrated high sensitivity, good selectivity, cost efficiency, and easy operation.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Food Science & Technology

Multicolorimetric and fluorometric dual-modal immunosensor for histamine via enzyme-enabled metallization of gold nanorods and inner filter effect of carbon dots

Shuang-Zi Luo et al.

Summary: A multicolorimetric and fluorometric dual-readout immunosensor has been developed for accurate and convenient detection of histamine. The sensor shows high sensitivity and reliability, making it suitable for laboratory and on-site detection.

FOOD CONTROL (2022)

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Article Engineering, Environmental

Thermal-controlled active sensor module using enzyme-regulated UiO-66-NH2/MnO2 fluorescence probe for total organophosphorus pesticide determination

Lei Yuan et al.

Summary: An enzyme-regulated UiO-66-NH2/MnO2 fluorescence sensor was developed for cost-effective determination of organophosphorus pesticides (OPs). This sensor exhibited superior OPs affinity and fluorescence quenching behavior compared to other nanomaterials. The analytical advantages were amplified by an active sensor module with automatic regulation of enzyme activity. The method showed uniform and log-linear responses to common OPs species in laboratory and real samples.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Engineering, Environmental

A colorimetric smartphone-based platform for pesticides detection using Fe-N/C single-atom nanozyme as oxidase mimetics

Jia Ge et al.

Summary: In this study, a novel highly sensitive colorimetric platform based on FeN/C SAzyme was designed for malathion assay. The synthesized SAzyme could directly oxidize 3,3,' 5,5 '-tetramethylbenzidine (TMB) to generate oxidized TMB, which exhibited a blue color. The addition of malathion hindered the ACP activity and restored the catalytic activity of single-atom nanozyme, enabling the quantitative detection of malathion.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Chemistry, Analytical

Paper-based multicolor sensor for on-site quantitative detection of 2,4-dichlorophenoxyacetic acid based on alkaline phosphatase-mediated gold nanobipyramids growth and colorimeter-assisted method for quantifying color

Xingyan Ye et al.

Summary: In this study, a paper-based multicolor AuNBPs sensor was developed for quantitative detection of 2,4-D. The sensor improved stability of AuNBPs and the detection sensitivity by using a paper-based analytical device and a handheld colorimeter. By combining this sensor with an alkaline phosphatase-mediated AuNBPs growth method, 2,4-D could be quantified with a detection limit of 18 ng mL(-1) by a colorimeter. The sensor showed good recovery rates and a low relative standard deviation when applied to detect 2,4-D in spiked rice and apple samples.

TALANTA (2022)

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Article Nanoscience & Nanotechnology

Detection of Organophosphorus Pesticides Using Silver-Coated Gold Nanoparticles

Siyi Liu et al.

Summary: This study presents a versatile sensing strategy for the triple-mode detection of organophosphorus pesticides. By depositing silver ions and carbon dots on gold nanoparticles, the system can detect light absorption, fluorescence, and Rayleigh scattering signals. The detection system can be used for the determination of organophosphorus pesticides in vegetables.

ACS APPLIED NANO MATERIALS (2022)

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Article Chemistry, Analytical

Stable and sensitive sensor for alkaline phosphatase based on target-triggered wavelength tuning of fluorescent copper nanoclusters

Ting Zhu et al.

Summary: This study presents a novel and stable fluorescent sensor based on the wavelength shift of copper nanoclusters (CuNCs) as signal readout. By introducing manganese ion (Mn2+), the fluorescence wavelength of CuNCs could be precisely tuned, and it is demonstrated that wavelength readout is more stable than intensity readout. A stable sensor for sensitive alkaline phosphatase (ALP) detection is constructed based on this principle, and consistent results with clinical test data are obtained in real serum samples.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Analytical

In situ fluorogenic reaction for ratiometric fluorescent detection of alkaline phosphatase activity

Jialin Wen et al.

Summary: In this study, a novel ratiometric fluorescent probe based on in situ fluorogenic reaction was developed for alkaline phosphatase (ALP) activity sensing. The probe showed high sensitivity for ALP activity with a detection limit of 0.08 U/L.

ANALYTICA CHIMICA ACTA (2022)

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Article Biochemical Research Methods

A ratiometric fluorescence method based on nitrogen-doped carbon quantum dots for the determination of the activity of alkaline phosphatase

Yuntai Lv et al.

Summary: A simple and sensitive ratiometric fluorescence sensing platform was developed to detect ALP activity using yellow fluorescent nitrogen-doped carbon quantum dots (YNCDs) and the blue fluorescent quinoxaline derivative QXD as reference and report signals, respectively.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Review Chemistry, Inorganic & Nuclear

Advances in quantum dot-based biosensors for DNA-modifying enzymes assay

Qian Zhang et al.

Summary: DNA-modifying enzymes play crucial roles in genetic functions and their malfunction can lead to various human diseases. Detection of DNA-modifying enzymes is essential for fundamental research, drug discovery, and clinical diagnosis.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Chemistry, Applied

Enzyme-modulated photothermal immunoassay of chloramphenicol residues in milk and egg using a self-calibrated thermal imager

Luyu Wei et al.

Summary: A highly sensitive and accurate enzyme-modulated photothermal immunosensor utilizing a self-calibrated thermal imaging system (SCTIS) was developed for the detection of chloramphenicol. The immunosensor used alkaline phosphatase as a modulator of the photothermal conversion and employed SCTIS for real-time self-calibration of temperature. It achieved a LOD of 9 pg/mL for chloramphenicol detection in 2 hours, with low relative standard deviations and good average recoveries in milk and egg samples.

FOOD CHEMISTRY (2022)

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Article Chemistry, Physical

Ultrathin porous Pd metallene as highly efficient oxidase mimics for colorimetric analysis

Xiaoxue Zhao et al.

Summary: The study demonstrated the use of ultrathin Pd metallene as efficient oxidase mimics with abundant accessible active sites. The Pd metallene was successfully applied in colorimetric-based analysis, showing its potential in detecting the activity of commercial beverages and vitamin C chewable pieces.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Analytical

MOFs-functionalized regenerable SERS sensor based on electrochemistry for pretreatment-free detection of serum alkaline phosphatase activity

Cheng-Ye Xi et al.

Summary: In this study, a reusable surface-enhanced Raman scattering (SERS) sensor was designed for detecting the activity of alkaline phosphatase (ALP) in the human body. The sensor was constructed by electrochemically self-assembling gold nanoparticles (AuNPs) and zinc-based metal organic frameworks (Zn-MOFs) on anodic aluminum oxide (AAO) membrane. The sensor exhibited strong anti-interference performance and a wide detection range, allowing for the direct detection of ALP activity in serum without any pretreatment.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

CRISPR/Cas12a-based photoelectrochemical sensing of microRNA on reduced graphene oxide-anchored Bi2WO6 coupling with catalytic hairpin assembly

Hexiang Gong et al.

Summary: An innovative and generic CRISPR/Cas12a-driven photoelectrochemical biosensing platform was developed for screening microRNA-21. The platform utilizes target-triggered catalytic hairpin assembly and reduced graphene oxide-anchored Bi2WO6 as the photoactive material. The system displayed satisfying photocurrent responses and a low limit of detection, making it suitable for clinical cancer diagnostics and biomolecular research.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Enzyme-controllable just-in-time production system of copper hexacyanoferrate nanoparticles with oxidase-mimicking activity for highly sensitive colorimetric immunoassay

Wenqiang Lai et al.

Summary: This study reports on a just-in-time production system for the rapid synthesis of copper hexacyanoferrate nanoparticles with oxidase-like activity. The system is coupled with alkaline phosphatase to create an enzyme-controllable just-in-time production system, which is used for the detection of aflatoxin B1 in peanut samples. The developed method enables sensitive detection with a low detection limit.

TALANTA (2022)

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Article Chemistry, Analytical

Dual-product synergistically enhanced ratiometric fluorescence assay for alkaline phosphatase activity using core-shell lanthanide-based nanoprobe

Tian-Tian Cai et al.

Summary: A new core-shell ratiometric fluorescent nanoprobe was developed for the detection of alkaline phosphatase (ALP) activity in human serum. The nanoprobe exhibited dual emission characteristics, and the luminescence signals changed upon the specific cleavage of an ALP substrate, enabling quantitative measurement of ALP activity and screening of ALP inhibitors. Additionally, a smartphone-assisted paper-based sensing platform was designed for on-site analysis of ALP activity.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Analytical

Signal-On Near-Infrared Photoelectrochemical Aptasensors for Sensing VEGF165 Based on Ionic Liquid-Functionalized Nd-MOF Nanorods and In-Site Formation of Gold Nanoparticles

Yingying Zhong et al.

Summary: In this study, a photoelectrochemical immunosensing system utilizing near-infrared light was constructed. The absorption wavelength of the metal-organic frameworks was regulated by adjusting the metal ions and the conjugation degree of the ligands. The system showed a low detection limit and good accuracy in the detection of VEGF165.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

A novel metal-organic framework of Co-hemin for portable and visual colorimetric detection of 2,4-dichlorophenoxyacetic acid

Jintao Yi et al.

Summary: In this study, a novel metal-organic framework (MOF) of Co-hemin was synthesized and used for on-site colorimetric monitoring of 2,4-dichlorophenoxyacetic acid (2,4-D). The Co-hemin biosensor exhibited good oxidase-like activity and showed good selectivity, specificity, and low detection limit. Additionally, a smartphone-based RGB analysis system was developed for sensitive detection of 2,4-D. This study not only provided a portable and visual platform for on-site monitoring of 2,4-D, but also expanded application prospects in the field of complex biological analysis.

ANALYTICAL METHODS (2022)

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Review Chemistry, Inorganic & Nuclear

Multi-enzyme activity nanozymes for biosensing and disease treatment

Li Su et al.

Summary: This review summarizes the research developments of multi-enzyme activity nanozymes, including classification, catalytic mechanisms, regulation strategies, and applications. It provides guidance for the design and biomedical applications of multi-enzyme activity nanozymes.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

An electrochemiluminescence dual turn-on strategy for alkaline phosphatase detection using a dual quenching Ru(bpy)32+ encapsulated zeolite imidazole metal organic framework

Chengpei Du et al.

Summary: An electrochemiluminescence dual turn-on strategy is developed for detecting alkaline phosphatase. The strategy utilizes a dual quenching and releasing mechanism of Ru(bpy)(3)(2+)@ZIF-90 to control the luminescence.

CHEMICAL COMMUNICATIONS (2022)

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Article Materials Science, Biomaterials

Three-in-one nanocomposites as multifunctional nanozymes for ultrasensitive ratiometric fluorescence detection of alkaline phosphatase

Xuemei Li et al.

Summary: This study develops a simple hydrothermal method to prepare flower-like Fe3O4 nanocomposites with tetra-enzyme-like activities. Based on the excellent catalytic oxidation and fluorescence quenching abilities, a ratiometric fluorescence strategy is established for label-free and ultrasensitive alkaline phosphatase detection.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Multidisciplinary

A target-induced inner-filter effect-based ratiometric sensing platform by fluorescence modulation of persistent luminescent nanoparticles and 2,3-diaminophenazine

Guiqun Zhang et al.

Summary: A ratiometric fluorescent sensing platform with smartphones was developed for the highly sensitive detection of GSH, AA, and ALP activity. The platform utilized the inner filter effect between persistent luminescent nanoparticles and 2,3-diaminophenazine to modulate the fluorescence signals. By measuring the ratio of the fluorescence intensity of DAP and PLNPs, a simple and highly sensitive detection method was achieved.

NEW JOURNAL OF CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Etching reaction of carbon quantum dot-functionalized MnO2 nanosheets with an enzymatic product for photoelectrochemical immunoassay of alpha-fetoprotein

Junshan Lin et al.

Summary: An etching reaction-based photoelectrochemical immunoassay was developed for the detection of alpha-fetoprotein (AFP). The method utilized carbon quantum dot-functionalized MnO2 nanosheets and a sandwiched immunoreaction mode to achieve AFP detection. The assay showed high sensitivity and accuracy.

NEW JOURNAL OF CHEMISTRY (2022)

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Article Chemistry, Analytical

A highly sensitive colorimetric sensing platform based on silver nanocomposites for alkaline phosphatase

Wei-Feng Wang et al.

Summary: In this study, a facile and sensitive sensing platform based on CQD-silver nanocomposites was developed for colorimetric detection of alkaline phosphatase. The method allows for visual and fast evaluation of ALP activity and can be used to screen ALP inhibitors.

ANALYTICAL METHODS (2022)

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Article Chemistry, Analytical

Enzyme-triggered click chemistry combined with surface-enhanced Raman spectroscopy for the simple and sensitive detection of alkaline phosphatase activity from complex biological samples

Fanghao Cao et al.

Summary: In this study, a method combining enzyme-triggered click chemistry and surface-enhanced Raman spectroscopy (SERS) was developed for the highly sensitive detection of alkaline phosphatase (ALP) activity in complex biological samples. The proposed method demonstrated high sensitivity, selectivity, and repeatability, and showed potential for medical diagnosis.

ANALYST (2022)

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Article Chemistry, Inorganic & Nuclear

In situ construction of a C3N5 nanosheet/Bi2WO6 nanodot S-scheme heterojunction with enhanced structural defects for the efficient photocatalytic removal of tetracycline and Cr(vi)

Shijie Li et al.

Summary: This study investigates the performance of C3N5/Bi2WO6 photocatalyst with S-scheme heterojunction in water decontamination, and finds that it exhibits higher activity and more structural defects than single C3N5 and Bi2WO6, leading to improved charge separation and generation of more active species.

INORGANIC CHEMISTRY FRONTIERS (2022)

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Review Chemistry, Multidisciplinary

2D graphdiyne: an emerging carbon material

Yan Fang et al.

Summary: Graphdiyne (GDY), as a new member of carbon allotropes, possesses unique chemical and electronic structures and has found applications in energy, catalysis, environmental science, and electronic devices. It has been recognized for its scientific value and development potential.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Magnetic beads-based multicolor colorimetric immunoassay for ultrasensitive detection of aflatoxin B1

Shan He et al.

Summary: A novel magnetic beads multicolor colorimetric immunoassay (MBMCIA) based on Au@Ag nanorods was proposed for the visual detection of ultralow concentration of Aflatoxin B-1 (AFB(1)). The method exhibited good sensitivity and specificity, making it suitable for applications in food safety inspection and environmental monitoring.

CHINESE CHEMICAL LETTERS (2021)

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Review Chemistry, Multidisciplinary

Recent advances in fluorescence imaging of alkaline phosphatase

Meng Li et al.

Summary: Phosphatase is crucial in many biological functions, with alkaline phosphatase (ALP) serving as a key prognostic indicator for various diseases, though current detection methods are limited to in vitro colorimetric techniques. Fluorescence imaging provides a reliable way to monitor real-time changes in ALP levels, with research focusing mainly on ALP imaging probes grouped by their luminescence mechanisms. Challenges and future prospects for phosphatase probes were also discussed.

CHINESE CHEMICAL LETTERS (2021)

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Article Nanoscience & Nanotechnology

Lysozyme-Functionalized 5-Methyl-2-thiouracil Gold/Silver Nanoclusters for Luminescence Assay of Alkaline Phosphatase

Mengjun Wang et al.

Summary: Here, lysozyme-functionalized 5-methyl-2-thiouracil gold/silver nanoclusters were successfully synthesized, showing improved chemical properties. By integrating these nanoclusters with a graphene nanozyme, a sensitive fluorescent probe for monitoring alkaline phosphatase (ALP) was constructed, exhibiting excellent performance and a low detection limit of 0.193 U L-1. This biosensor also showed satisfactory results for quantifying ALP in human serum.

ACS APPLIED NANO MATERIALS (2021)

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Article Chemistry, Analytical

Multicolor and photothermal dual-mode assay of alkaline phosphatase based on the UV light-assisted etching of gold nanorods

Tianran Lin et al.

Summary: A multicolor and photothermal dual-mode assay for sensitive ALP determination was developed based on the TMB-induced etching of AuNRs, providing linear range of 1.0-8.0 mU/mL with detection limits of 0.34 mU/mL for multicolor assay and 0.11 mU/mL for photothermal assay. This method was successfully applied to ALP determination in serum samples.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Multidisciplinary

Dual-readout test strips platform for portable and highly sensitive detection of alkaline phosphatase in human serum samples

Juanzu Liu et al.

Summary: A simple dual-readout lateral flow test strip platform was developed for sensitive detection of alkaline phosphatase (ALP) based on a portable device. The method utilizes colorimetric and fluorescent signals to quantitatively detect trace amounts of ALP, showing great potential for clinical diagnosis.

CHINESE CHEMICAL LETTERS (2021)

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Article Chemistry, Analytical

An enzyme linked aptamer photoelectrochemical biosensor for Tau-381 protein using AuNPs/MoSe2 as sensing material

Xu Hun et al.

Summary: An in situ enzyme catalysis generating electron donor photoelectrochemical biosensor has been developed for Tau-381 protein detection, with a wide detection range and low limit of detection. This versatile sensing protocol can be easily adapted to detect various targets.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Review Chemistry, Analytical

Fluorescent probes for the detection of alkaline phosphatase in biological systems: Recent advances and future prospects

Kai Wang et al.

Summary: This review summarizes the characteristics and research progress of ALP fluorescent probes, introduces the importance of ALP in physiological and pathological events, and highlights the advantages of fluorescent probes in ALP detection, providing an important reference for related research.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Rational Design of Dual-Emission Lanthanide Metal-Organic Framework for Visual Alkaline Phosphatase Activity Assay

Long Yu et al.

Summary: This study presents a reasonable design strategy for dual-emission Ln-MOFs based on theoretical calculations, combining various theories to reveal the luminescence law of Ln-MOFs. The developed dual-emission Tb-MOF fluorescent probe shows ultrasensitive and selective response to ALP, suitable for point-of-care visual detection. The research also includes the development of a portable enzyme activity assay kit and a logical decoder for intelligent ALP activity detection equipment.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Dual-Modal Immunosensor with Functionalized Gold Nanoparticles for Ultrasensitive Detection of Chloroacetamide Herbicides

Yonghong Zha et al.

Summary: This paper presents a dual-modal immunosensor for detecting chloroacetamide herbicides using a gold nanoparticle probe and multiple reactions, which shows low detection limits and good recovery rates, indicating promising application prospects.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

Enzyme-induced Cu2+/Cu+ conversion as the electrochemical signal for sensitive detection of ethyl carbamate

Long Wu et al.

Summary: By developing an electrochemical immunoassay method based on enzyme-induced Cu2+/Cu+ conversion, the sensitivity for detecting ethyl carbamate was improved, combining the advantages of electrochemistry and ELISA, showing good selectivity and high sensitivity in wine samples.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

Fluorescence and visual immunoassay of HIV-1 p24 antigen in clinical samples via multiple selective recognitions of CdTe QDs

Zhuoyun Tang et al.

Summary: The newly developed method for detecting HIV-1 p24 antigen demonstrates high sensitivity and selectivity, allowing for the detection of as low as 1 pg/mL of antigen by naked eyes. The analysis of clinical samples using this method shows good consistency with clinical data, and the method can accurately distinguish HIV infection from other viruses and infections.

MICROCHIMICA ACTA (2021)

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Article Spectroscopy

Generation of a nanobody-alkaline phosphatase fusion and its application in an enzyme cascade-amplified immunoassay for colorimetric detection of alpha fetoprotein in human serum

Benchao Su et al.

Summary: The study developed an enzyme cascade-amplified immunoassay (ECAIA) based on Nb-ALP and MnO2 for detecting AFP, which showed high sensitivity and selectivity. The method had good recovery rate and linear correlation for AFP detection, providing a reference for analysis of other macromolecule biomarkers.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Chemistry, Analytical

A novel split-type photoelectrochemical immunosensor based on chemical redox cycling amplification for sensitive detection of cardiac troponin I

Xiao-Jing Liao et al.

Summary: The split-type PEC immunosensor developed in this study utilizes the cosensitized structure of Ag2S/ZnO nanocomposites as photoelectrode and the photogenerated hole-induced chemical redox cycling amplification strategy, demonstrating high sensitivity for cardiac troponin I (cTnI) detection. By integrating immunoreaction on 96-well plates with chemical redox cycling amplification on the photoelectrode, the immunosensor achieves a detection limit of 3.0 x 10(-15) g mL(-1) and a detection range of 1.0 x 10(-14) g mL(-1) to 1.0 x 10(-9) g mL(-1) for cTnI, showing potential for sensitive biosensing and bioanalysis.

TALANTA (2021)

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Article Chemistry, Analytical

Direct Transverse Relaxation Time Biosensing Strategy for Detecting Foodborne Pathogens through Enzyme-Mediated Sol-Gel Transition of Hydrogels

Luyu Wei et al.

Summary: In this study, a direct T-2 biosensing strategy was developed for detecting foodborne pathogens using the alkaline phosphatase-mediated sol-gel transition of hydrogels. This biosensor demonstrated high sensitivity for detecting Salmonella enteritidis within 2 hours, offering a novel and sensitive platform for pathogen detection by modulating water molecules directly.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

In Situ Fluorogenic Reaction Generated via Ascorbic Acid for the Construction of Universal Sensing Platform

Yongchao Fan et al.

Summary: The study revealed a highly fluorescent emission reaction between PTA and AA controlled by reaction temperature, leading to the development of a sensitive and selective platform integrated with ALP-triggered transformation. The fluorescent reaction without nanomaterial catalysis provided a direct strategy for early clinical diagnosis coupled with ALP-related catalysis.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

2D Co-MOF nanosheet-based nanozyme with ultrahigh peroxidase catalytic activity for detection of biomolecules in human serum samples

Huimin Wan et al.

Summary: A two-dimensional Co-MOF nanosheet-based nanozyme was developed for colorimetric detection of ascorbic acid and alkaline phosphatase. The nanozyme exhibited high catalytic activity and was successfully used for clinical sample detection.

MICROCHIMICA ACTA (2021)

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Article Chemistry, Analytical

MnO2 shell-isolated SERS nanoprobe for the quantitative detection of ALP activity in trace serum: Relying on the enzyme-triggered etching of MnO2 shell to regulate the signal

Xin Dai et al.

Summary: A stable and reliable SERS nanoprobe, named AMAM, has been developed for quantitative detection of ALP in trace serum, demonstrating high stability, reproducibility, and reliability for SERS quantification of ALP. The nanoprobe exhibits good performance in colorimetric and SERS dual-readout detection, with a wide linear dynamic range and low detection limit, making it suitable for direct SERS analysis in trace undiluted human serum.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Nanoscience & Nanotechnology

Aptamer-Functionalized DNA-Silver Nanocluster Nanofilm for Visual Detection and Elimination of Bacteria

Min Yang et al.

Summary: The combination of DNA-AgNCs with bacterial aptamers has led to a novel approach for visual detection and effective elimination of bacteria. The capture of aptamers not only facilitates visual monitoring of bacteria but also enhances antibacterial effects. Additionally, a fluorescent nanofilm with excellent selectivity and antibacterial activity for detecting and eliminating S. aureus has been developed based on the DNA-AgNCs.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Cathode-Anode Spatial Division Photoelectrochemical Platform Based on a One-Step DNA Walker for Monitoring of miRNA-21

Chuan Huang et al.

Summary: The novel cathode-anode spatial division PEC platform enhances photocurrent response and anti-interference ability through a two-electrode synergistic enhancement strategy. The platform integrates a photoanode and photocathode in the same circuit, utilizing nanoparticles for signal amplification and spatial separation of the two electrodes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

Near-Infrared Light-Initiated Photoelectrochemical Biosensor Based on Upconversion Nanorods for Immobilization-Free miRNA Detection with Double Signal Amplification

Mengjiao Hao et al.

Summary: A NIR-initiated PEC biosensor was developed for sensitive detection of AMI-related miRNA-133a in an immobilization-free format, showing high detection sensitivity and linear selectivity.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

ICP-MS and Photothermal Dual-Readout Assay for Ultrasensitive and Point-of-Care Detection of Pancreatic Cancer Exosomes

Yingzhi Zhang et al.

Summary: Pancreatic cancer is difficult to detect early due to its location, but exosomes from cancer cells may offer a liquid biopsy option. A new dual-readout platform using ICP-MS and photothermal methods has been developed to detect pancreatic cancer exosomes with high sensitivity and point-of-care capabilities.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Alkaline Phosphatase-Triggered Etching of Au@FeOOH Nanoparticles for Enzyme Level Assay under Dark-Field Microscopy

Hui Wang et al.

Summary: A simple and sensitive plasmonic probe (Au@FeOOH) was synthesized and used for alkaline phosphatase level detection, showing excellent linear range and detection limit. By using ΔR/G value as the analytical signal, the method effectively suppressed errors and exhibited excellent selectivity in complex biological serum samples, promising for early diagnosis of clinical diseases in the future.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization

Ruo-Chen Guo et al.

Summary: A novel in vivo self-assembly strategy is developed to induce phase separation of cell membrane, improving the internalization of therapeutic peptides and enhancing drug delivery efficacy, particularly in cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Analytical

Machine learning: Assisted multivariate detection and visual image matching to build broad-specificity immunosensor

Aori Qileng et al.

Summary: A machine learning approach based on image matching is presented for constructing a broad-specificity immunosensor for detecting multiple ochratoxins. The method combines colorimetry, photoelectrochemistry, and fluorescence signals for multi-signal detection, showing great potential in predicting multiple ochratoxins. This study highlights the capability of machine learning in combining multi-signal and multi-target detection in immunosensors.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Alkaline phosphatase-regulated in situ formation of chromogenic probes for multicolor visual sensing of biomarkers

Yun-Yun Wei et al.

Summary: This study introduces a strategy for ALP activity detection based on Prussian blue nanoparticles and polychromatic superposition effect, achieving sensitive multicolor ALP activity assay by simply blending commercially available reagents. The combination of ALP-regulated multicolor system with aptasensor allows for the construction of magnetic sandwich and competitive sensing platforms for multiple biomarkers detection.

TALANTA (2021)

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Article Chemistry, Multidisciplinary

Distance-Based Paper Device for a Naked-Eye Albumin-to-Alkaline Phosphatase Ratio Assay

Kamonchanok Phoonsawat et al.

Summary: The paper presents a dual-color distance-based paper device for detecting albumin and alkaline phosphatase to evaluate the cancer prognostic index AAPR. The method is simple, fast, and accurate, suitable for assessing lung cancer risk.

ACS SENSORS (2021)

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Article Chemistry, Multidisciplinary

CDs-MnO2-TPPS Ternary System for Ratiometric Fluorescence Detection of Ascorbic Acid and Alkaline Phosphatase

Hongzhi Lu et al.

Summary: This study introduced a fluorescence sensor based on MnO2 nanosheets with the involvement of Mn2+ in the detection process for detecting ascorbic acid. The sensor design utilized a ternary system of carbon dots, MnO2 nanosheets, and TPPS, achieving fluorescence intensity recovery and quenching after the addition of ascorbic acid.

ACS OMEGA (2021)

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Article Chemistry, Multidisciplinary

Highly sensitive fluorescence detection of tobacco mosaic virus RNA based on disodium 4,4′-diazidostilbene-2,2′-disulfonate tetrahydrate in situ reaction

Wenbin Wang et al.

Summary: A highly sensitive fluorescence detection method for TMV RNA based on in situ reaction of DES was developed for the first time, showing good linear relationship and a low detection limit. The method demonstrated excellent selectivity and reproducibility, highlighting its potential application in the qualitative and quantitative analysis of tRNA.

NEW JOURNAL OF CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Enzyme cascade-amplified immunoassay based on the nanobody-alkaline phosphatase fusion and MnO2 nanosheets for the detection of ochratoxin A in coffee

Zeling Zhang et al.

Summary: A novel enzyme cascade-amplified immunoassay (ECAIA) was developed for the detection of Ochratoxin A (OTA) in coffee, showing high selectivity, good recovery rates, and low detection limits. The method can be completed in a relatively short time with a wide linear range.

RSC ADVANCES (2021)

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Article Chemistry, Multidisciplinary

Digital counting of single semiconducting polymer nanoparticles for the detection of alkaline phosphatase

Shumin Wang et al.

Summary: The proposed method accurately quantifies ALP by suppressing the fluorescence of SPNs with a PDA layer, achieving a linear range from 0.031 to 12.4 mu U mL(-1) and a detection limit of 0.01 mu U mL(-1). The spiked recoveries for ALP determination in human serum samples are between 90% and 108% with an RSD less than 3.1%, indicating promising prospects for ALP detection in complex biological matrices.

NANOSCALE (2021)

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Article Chemistry, Analytical

Fe-N-C single-atom nanozymes with peroxidase-like activity for the detection of alkaline phosphatase

Xiaolei Xie et al.

Summary: A colorimetric strategy based on Fe-N-C single-atom nanozymes was established for the detection of alkaline phosphatase activity, providing a wide linear range and low detection limit. Fe/NC-SAs showed high stability under harsh conditions and were successfully validated in human serum samples for ALP determination.

ANALYST (2021)

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Article Chemistry, Analytical

A redox modulated fluorescence nanoplatform for the detection of alkaline phosphatase activity with fluorescent polydopamine nanoparticles

Jing-Xuan Tian et al.

Summary: By constructing a novel nanoplatform using PDA NPs as an effective signal reporter, the method demonstrated high sensitivity and desirable selectivity for the detection of ALP. This approach not only could be used to screen inhibitors of ALP, but also successfully detect ALP activity in human serum samples.

ANALYTICAL METHODS (2021)

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Article Engineering, Environmental

Facile one-pot synthesis of novel hierarchical Bi2O3/Bi2S3 nanoflower photocatalyst with intrinsic p-n junction for efficient photocatalytic removals of RhB and Cr(VI)

Yan Sang et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Chemistry, Analytical

Electrochemiluminescence resonance energy transfer immunoassay for alkaline phosphatase using p-nitrophenyl phosphate as substrate

Wenjing Qi et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

A novel ratiometric fluorescent sensing method based on MnO2 nanosheet for sensitive detection of alkaline phosphatase in serum

Qi Zuo et al.

TALANTA (2020)

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Review Chemistry, Multidisciplinary

Synthesis, Structure, Properties, and Applications of Bimetallic Nanoparticles of Noble Metals

Kateryna Loza et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Analytical

Upconversion nanoparticles with bright red luminescence for highly sensitive quantifying alkaline phosphatase activity based on target-triggered fusing reaction

Hongyu Chen et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

DNA Nanofirecrackers Assembled through Hybridization Chain Reaction for Ultrasensitive SERS Immunoassay of Prostate Specific Antigen

Jia Ru Wang et al.

ANALYTICAL CHEMISTRY (2020)

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Review Biophysics

Recent progress and prospects of alkaline phosphatase biosensor based on fluorescence strategy

Yangxia Han et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Biophysics

Inkjet-printed electrochemically reduced graphene oxide microelectrode as a platform for HT-2 mycotoxin immunoenzymatic biosensing

Jiri Kudr et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Food Science & Technology

Alkaline Phosphatase-Triggered Immunoassay Based on Fluorogenic Reaction for Sensitive Detection of Acetochlor, Metolachlor, and Propisochlor

Yonghong Zha et al.

FOOD ANALYTICAL METHODS (2020)

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Article Chemistry, Analytical

Redox-modulated colorimetric detection of ascorbic acid and alkaline phosphatase activity with gold nanoparticles

Liping Lin et al.

LUMINESCENCE (2020)

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Article Chemistry, Analytical

Colorimetric determination of the activity of alkaline phosphatase by exploiting the oxidase-like activity of palladium cube@CeO2 core-shell nanoparticles

Jiawei Wang et al.

MICROCHIMICA ACTA (2020)

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Article Chemistry, Analytical

Ratiometric fluorescence and colorimetry dual-mode assay based on manganese dioxide nanosheets for visual detection of alkaline phosphatase activity

Qian Yang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

A dual-mode fluorescent and colorimetric immunoassay based on in situ ascorbic acid-induced signal generation from metal-organic frameworks

Wenyue Xie et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

Dual-colored carbon dots-based ratiometric fluorescent sensor for high-precision detection of alkaline phosphatase activity

Kang Shao et al.

TALANTA (2020)

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Article Chemistry, Analytical

A turn-on fluorescence assay of alkaline phosphatase activity based on an enzyme-triggered conformational switch of G-quadruplex

Xi Zhou et al.

TALANTA (2020)

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Article Chemistry, Analytical

A portable photoacoustic device for facile and sensitive detection of serum alkaline phosphatase activity

Ya-Jie Zhang et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Plasmonic Enhanced Gold Nanoclusters-Based Photoelectrochemical Biosensor for Sensitive Alkaline Phosphatase Activity Analysis

Chun-Qin Zhao et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision

Haidong Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Analytical

o-Phenylenediamine/gold nanocluster-based nanoplatform for ratiometric fluorescence detection of alkaline phosphatase activity

Xue Han et al.

TALANTA (2020)

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Article Chemistry, Multidisciplinary

Determining Alkaline Phosphatase Based on Core-Shell Gold@silver Nanocubes by Single-Particle Dark-Field Images

Yanan Li et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

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Article Chemistry, Applied

Multicolor colorimetric detection of ochratoxin A via structure-switching aptamer and enzyme-induced metallization of gold nanorods

Fengyu Tian et al.

FOOD CHEMISTRY (2020)

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Article Chemistry, Analytical

An Enzyme-Induced Metallization-Based Electrochemical Signal Amplification Strategy for Ultrahigh Sensitive Alkaline Phosphatase Detection at Attomolar Concentrations

Chuan-Hua Zhou et al.

JOURNAL OF ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Fluorescence sensor for organophosphorus pesticide detection based on the alkaline phosphatase-triggered reaction

Jingjiao Dong et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Smartphone-Assisted Robust Sensing Platform for On-Site Quantitation of 2,4-Dichlorophenoxyacetic Acid Using Red Emissive Carbon Dots

Dandan Su et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

In Situ Controllable Generation of Copper Nanoclusters Confined in a Poly-L-Cysteine Porous Film with Enhanced Electrochemiluminescence for Alkaline Phosphatase Detection

Mei-Chen Pan et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Gold Nanocluster-catalyzed Luminol Chemiluminescent Sensing Method for Sensitive and Selective Detection of Alkaline Phosphatase

Ying Li et al.

ANALYTICAL SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Planar and Twisted Molecular Structure Leads to the High Brightness of Semiconducting Polymer Nanoparticles for NIR-IIa Fluorescence Imaging

Shunjie Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Analytical

Highly sensitive detection of salbutamol by ALP-mediated plasmonic ELISA based on controlled growth of AgNPs

Hongwei He et al.

MICROCHEMICAL JOURNAL (2020)

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Article Chemistry, Physical

Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

Xuan-Hung Pham et al.

NANO RESEARCH (2020)

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Article Chemistry, Analytical

Wireless label-free electrochemical detection of cancer cells by MnO2-Decorated polymer dots

Hyun Jeong Won et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Multidisciplinary

A dual-mode resonance Rayleigh scattering and colorimetric alkaline phosphatase assay based onin situascorbic acid-induced signal generation from manganese dioxide nanosheets

Shiyu Liu et al.

RSC ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Dual Enzyme-Induced Au-Ag Alloy Nanorods as Colorful Chromogenic Substrates for Sensitive Detection of Staphylococcus aureus

Jing Zhou et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A simple thermometer-based photothermometric assay for alkaline phosphatase activity based on target-induced nanoprobe generation

Honghong Rao et al.

NEW JOURNAL OF CHEMISTRY (2020)

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Article Chemistry, Analytical

A simple enzyme-catalyzed reaction induced switch type fluorescence biosensor based on carbon nitride nanosheets for the assay of alkaline phosphatase activity

Xi Zhu et al.

ANALYST (2020)

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Article Chemistry, Multidisciplinary

Ratiometric sensing of alkaline phosphatase based on the catalytical activity from Mn-Fe layered double hydroxide nanosheets

Chao Peng et al.

NANOSCALE (2020)

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Article Chemistry, Multidisciplinary

Enzyme activity-modulated etching of gold nanobipyramids@MnO2 nanoparticles for ALP assay using surface-enhanced Raman spectroscopy

Hua Liu et al.

NANOSCALE (2020)

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Article Materials Science, Multidisciplinary

Multi-emitting fluorescence sensor of MnO2-OPD-QD for the multiplex and visual detection of ascorbic acid and alkaline phosphatase

Qian Yang et al.

JOURNAL OF MATERIALS CHEMISTRY C (2020)

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Article Nanoscience & Nanotechnology

Ag-Ion-Modified Au Nanoclusters for Fluorometric Analysis of Alkaline Phosphatase

Mengke Wang et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Multicolor Colorimetric Sensor for Detection of Omethoate Based on the Inhibition of the Enzyme-Induced Metallization of Gold Nanorods

Qingtong Zhang et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Chemistry, Analytical

Plasmonic Colorimetric Biosensor for Sensitive Exosome Detection via Enzyme-Induced Etching of Gold Nanobipyramid@MnO2 Nanosheet Nanostructures

Yingzhi Zhang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Fluorescence Immunoassay Based on the Alkaline Phosphatase Triggered in Situ Fluorogenic Reaction of o-Phenylenediamine and Ascorbic Acid

Dan Zhao et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Ru(NH3)63+/Ru(NH3)62+-Mediated Redox Cycling: Toward Enhanced Triple Signal Amplification for Photoelectrochemical Immunoassay

Bing Wang et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Fluorescent enzyme-linked immunoassay strategy based on enzyme-triggered in-situ synthesis of fluorescent copper nanoclusters

Ruiying Li et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Analytical

Switchable fluorescence immunoassay using gold nanoclusters anchored cobalt oxyhydroxide composite for sensitive detection of imidacloprid

Hongxia Li et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Analytical

A ratiometric fluorescent strategy for alkaline phosphatase activity assay based on g-C3N4/CoOOH nanohybrid via target-triggered competitive redox reaction

Shi Gang Liu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Analytical

Self-assembled gold nanoclusters for fluorescence turn-on and colorimetric dual-readout detection of alkaline phosphatase activity via DCIP-mediated fluorescence resonance energy transfer

Xue Han et al.

TALANTA (2019)

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Review Chemistry, Analytical

Recent trends in nanomaterial-modified electrodes for electroanalytical applications

Nadeem Baig et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Single-Particle Enzyme Activity Assay with Spectral-Resolved Dark-Field Optical Microscopy

Fuyan Wang et al.

ANALYTICAL CHEMISTRY (2019)

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Article Biophysics

Photoelectrochemical platform for MicroRNA let-7a detection based on graphdiyne loaded with AuNPs modified electrode coupled with alkaline phosphatase

Yanxin Li et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Chemistry, Physical

Ultrasensitive photoelectrochemical immunosensor based on Cu-doped TiO2 and carbon nitride for detection of carcinoembryonic antigen

Yaoguang Wang et al.

CARBON (2019)

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Article Chemistry, Analytical

Fluorometric and colorimetric dual-readout alkaline phosphatase activityassay based on enzymatically induced formation of colored Au@Ag nanoparticles and an inner filter effect

Chuanxia Chen et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

Development of a fluorescence immunoassay for highly sensitive detection of amantadine using the nanoassembly of carbon dots and MnO2 nanosheets as the signal probe

Baolei Dong et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Review Chemistry, Analytical

Assays for alkaline phosphatase activity: Progress and prospects

Zhenwei Tang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Point-of-Care Assay of Alkaline Phosphatase Enzymatic Activity Using a Thermometer or Temperature Discoloration Sticker as Readout

Xiaofeng Liu et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

MnO2 nanosheets as oxidase mimics for colorimetric detection of alkaline phosphatase activity

Fengyu Tian et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

Fluorometric and resonance Rayleigh scattering dual-mode bioprobe for determination ofthe activity of alkaline phosphatasebased on the use ofCoOOH nanoflakes and cobalt(II)-dependent DNAzyme-assisted amplification

Jiao Zhou et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

A novel photoelectrochemical sensing platform based on Fe2O3@Bi2S3 heterojunction for an enzymatic process and enzyme activity inhibition reaction

Feng Xia Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Analytical

A novel fluorescence immunoassay based on AgNCs and ALP for ultrasensitive detection of sulfamethazine (SMZ) in environmental and biological samples

Nuanfei Zhu et al.

TALANTA (2019)

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Article Multidisciplinary Sciences

Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression

Cheng Jin et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Ratiometric Sensing for Alkaline Phosphatase Based on Two Independent Signals from in Situ Formed Nanohybrids of Semiconducting Polymer Nanoparticles and MnO2 Nanosheets

Jiajia He et al.

ACS OMEGA (2019)

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Article Chemistry, Analytical

Nitrogen-doped carbon dots-V2O5 nanobelts sensing platform for sensitive detection of ascorbic acid and alkaline phosphatase activity

Ruifeng Zhu et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Biophysics

Photoelectrochemical biosensor of HIV-1 based on cascaded photoactive materials and triple-helix molecular switch

Shaopeng Wang et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Chemistry, Analytical

Colorimetric detection of ascorbic acid and alkaline phosphatase activity based on the novel oxidase mimetic of Fe-Co bimetallic alloy encapsulated porous carbon nanocages

Tengteng Wu et al.

TALANTA (2019)

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Article Nanoscience & Nanotechnology

Fluorescent-Magnetic-Catalytic Nanospheres for Dual-Modality Detection of H9N2 Avian Influenza Virus

Xiaolun Peng et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

A Colorimetric Immunoassay Based on Coordination Polymer Composite for the Detection of Carcinoembryonic Antigen

Sixuan Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biochemical Research Methods

Ratiometric detection of alkaline phosphatase based on aggregation-induced emission enhancement

Fei Qu et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

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Article Biophysics

A ratiometric multicolor fluorescence biosensor for visual detection of alkaline phosphatase activity via a smartphone

Li Hou et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Biophysics

A novel photoelectrochemical strategy based on an integrative photoactive heterojunction nanomaterial and a redox cycling amplification system for ultrasensitive determination of microRNA in cells

Weijing Yi et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Chemistry, Analytical

Etching reaction-based photoelectrochemical immunoassay of aflatoxin B1 in foodstuff using cobalt oxyhydroxide nanosheets-coating cadmium sulfide nanoparticles as the signal tags

Lingshan Su et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Biochemical Research Methods

A novel switchable fluorescent sensor for facile and highly sensitive detection of alkaline phosphatase activity in a water environment with gold/silver nanoclusters

Xiaoyan Wang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Chemical Redox-Cycling for Improving the Sensitivity of Colorimetric Enzyme-Linked Immunosorbent Assay

Zhaopeng Chen et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Plasmonic and Photothermal Immunoassay via Enzyme-Triggered Crystal Growth on Gold Nanostars

Yahua Liu et al.

ANALYTICAL CHEMISTRY (2019)

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Article Biophysics

An ultrasensitive electrochemical biosensor for detection of microRNA-21 based on redox reaction of ascorbic acid/iodine and duplex-specific nuclease assisted target recycling

Jin Wang et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Article Biophysics

A dual signal-on photoelectrochemical immunosensor for sensitively detecting target avian viruses based on AuNPs/g-C3N4 coupling with CdTe quantum dots and in situ enzymatic generation of electron donor

Bing Sun et al.

BIOSENSORS & BIOELECTRONICS (2019)

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Review Chemistry, Analytical

A review on emerging principles and strategies for colorimetric and fluorescent detection of alkaline phosphatase activity

Xiangheng Niu et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Chemistry, Analytical

Amplified Magnetic Resonance Sensing via Enzyme-Mediated Click Chemistry and Magnetic Separation

Long Wu et al.

ANALYTICAL CHEMISTRY (2019)

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Article Chemistry, Analytical

Determination of alkaline phosphatase activity and of carcinoembryonic antigen by using a multicolor liquid crystal biosensor based on the controlled growth of silver nanoparticles

Chuan-Hua Zhou et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

Photoelectrochemical determination of the activity of alkaline phosphatase by using a CdS@graphene conjugate coupled to CoOOH nanosheets for signal amplification

Weisu Kong et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

Colorimetric determination of ascorbic acid and the activity of alkaline phosphatase based on the inhibition of the peroxidase-like activity of citric acid-capped Prussian Blue nanocubes

Tengteng Wu et al.

MICROCHIMICA ACTA (2019)

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Article Chemistry, Analytical

A simple electrochemical immunosensor platform for detection of Apolipoprotein A1 (Apo-A1) as a bladder cancer biomarker in urine

Seong-Eun Kim et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Chemistry, Analytical

Molecular structure regulation and enzyme cascade signal amplification strategy for upconversion ratiometric luminescent and colorimetric alkaline phosphatase detection

Hongyu Chen et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Chemistry, Multidisciplinary

Sensitive Multicolor Visual Detection of Exosomes via Dual Signal Amplification Strategy of Enzyme-Catalyzed Metallization of Au Nanorods and Hybridization Chain Reaction

Yingzhi Zhang et al.

ACS SENSORS (2019)

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Article Chemistry, Analytical

A catalytic reaction-based colorimetric assay of alkaline phosphatase activity based on oxidase-like MnO2 microspheres

Linjie Wang et al.

ANALYTICAL METHODS (2019)

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Article Chemistry, Analytical

Rapid and simple detection of ascorbic acid and alkaline phosphatase via controlled generation of silver nanoparticles and selective recognition

Piaopiao Chen et al.

ANALYST (2019)

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Article Chemistry, Analytical

Phage based electrochemical detection of Escherichia coli in drinking water using affinity reporter probes

Danhui Wang et al.

ANALYST (2019)

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Article Materials Science, Biomaterials

Facile colorimetric detection of alkaline phosphatase activity based on the target-induced valence state regulation of oxidase-mimicking Ce-based nanorods

Hongwei Song et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Chemistry, Multidisciplinary

Rapid and sensitive colorimetric detection of pathogens based on silver-urease interactions

Pargat Singh et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Analytical

A novel alkaline phosphatase assay based on the specific chromogenic interaction between Fe3+ and ascorbic acid 2-phosphate

Linjie Wang et al.

ANALYTICAL METHODS (2019)

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Article Chemistry, Multidisciplinary

A nanozyme-based cascade colorimetric aptasensor for amplified detection of ochratoxin A

Fengyu Tian et al.

NANOSCALE (2019)

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Article Chemistry, Analytical

Amplified photoelectrochemical DNA biosensor based on a CdS quantum dot/WS2 nanosheet heterojunction and hybridization chain reaction-mediated enzymatic hydrolysis

Yun Ju et al.

ANALYTICAL METHODS (2019)

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Article Chemistry, Analytical

Enzyme-triggered in situ formation of Ag nanoparticles with oxidase-mimicking activity for amplified detection of alkaline phosphatase activity

Hongwei Song et al.

ANALYST (2019)

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Article Chemistry, Analytical

Photoelectrochemical immunoassay of aflatoxin B1 in foodstuff based on amorphous TiO2 and CsPbBr3 perovskite nanocrystals

Lingshan Su et al.

ANALYST (2019)

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Article Chemistry, Multidisciplinary

Ligase amplification reaction-catalyzed assembly of a single quantum dot-based nanosensor for sensitive detection of alkaline phosphatase

Fei Ma et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Inorganic & Nuclear

A turn-on sensor based on MnO2 coated UCNPs for detection of alkaline phosphatase and ascorbic acid

Mei-yu Liang et al.

DALTON TRANSACTIONS (2019)

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Article Nanoscience & Nanotechnology

FRET Effect between Fluorescent Polydopamine Nanoparticles and MnO2 Nanosheets and Its Application for Sensitive Sensing of Alkaline Phosphatase

Ting Xiao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Analytical

A novel signal-on photoelectrochemical sensor for ultrasensitive detection of alkaline phosphatase activity based on a TiO2/g-C3N4 heterojunction

Feng Xia Wang et al.

ANALYST (2018)

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Article Chemistry, Analytical

A high-resolution colorimetric immunoassay platform realized by coupling enzymatic multicolor generation with smartphone readout

Wenyue Xie et al.

ANALYST (2018)

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Article Chemistry, Analytical

A new photoelectrochemical biosensor for ultrasensitive determination of nucleic acids based on a three-stage cascade signal amplification strategy

Erhu Xiong et al.

ANALYST (2018)

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Article Chemistry, Analytical

Near-Infrared Light-Excited Core-Core-Shell UCNP@Au@CdS Upconversion Nanospheres for Ultrasensitive Photoelectrochemical Enzyme Immunoassay

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Cascade Reaction-Mediated Assembly of Magnetic/Silver Nanoparticles for Amplified Magnetic Biosensing

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ANALYTICAL CHEMISTRY (2018)

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Dual-Modal Split-Type Immunosensor for Sensitive Detection of Microcystin-LR: Enzyme-Induced Photoelectrochemistry and Colorimetry

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Metal-to-Ligand Charge-Transfer-based Visual Detection of Alkaline Phosphatase Activity

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ANALYTICAL SCIENCES (2018)

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Article Biophysics

Liposome-amplified photoelectrochemical immunoassay for highly sensitive monitoring of disease biomarkers based on a split-type strategy

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Ultrasensitive electrochemical sensing of Hg2+ based on thymine-Hg2+-thymine interaction and signal amplification of alkaline phosphatase catalyzed silver deposition

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Ultrasensitive photoelectrochemical biosensor for the detection of HTLV-I DNA: A cascade signal amplification strategy integrating lambda-exonuclease aided target recycling with hybridization chain reaction and enzyme catalysis

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Article Electrochemistry

Ascorbic acid-sensitized Au nanorods-functionalized nanostructured TiO2 transparent electrodes for photoelectrochemical genosensing

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ELECTROCHIMICA ACTA (2018)

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Article Electrochemistry

Gold Nanoparticle-Decorated Single-Walled Carbon Nanotubes as a Catalytic Amplification Platform for the Electrochemical Detection of Alkaline Phosphatase Activity

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INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2018)

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Ultrasensitive immunoassay of proteins based on in-situ enzymatic formation of quantum dots and microliter-droplet anodic stripping voltammetry

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JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Analytical

Polydopamine nanodots are viable probes for fluorometric determination of the activity of alkaline phosphatase via the in situ regulation of a redox reaction triggered by the enzyme

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MICROCHIMICA ACTA (2018)

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Article Chemistry, Analytical

Determination of the activity of alkaline phosphatase by using nanoclusters composed of flower-like cobalt oxyhydroxide and copper nanoclusters as fluorescent probes

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MICROCHIMICA ACTA (2018)

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A surface expressed alkaline phosphatase biosensor modified with flower shaped ZnO for the detection of chlorpyrifos

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SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Tuning surface states to achieve the modulated fluorescence of carbon dots for probing the activity of alkaline phosphatase and immunoassay of α-fetoprotein

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SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Colorimetric and fluorescent dual-mode sensing of alkaline phosphatase activity in L-02 cells and its application in living cell imaging based on in-situ growth of silver nanoparticles on graphene quantum dots

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Metal ion chelation-based color generation for alkaline phosphatase-linked high-performance visual immunoassays

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SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Fluorescence quenching based alkaline phosphatase activity detection

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TALANTA (2018)

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Prereduction-promoted enhanced growth of silver nanoparticles for ultrasensitive colorimetric detection of alkaline phosphatase and carbohydrate antigen 125

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TALANTA (2018)

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The chemical redox modulated switch-on fluorescence of carbon dots for probing alkaline phosphatase and its application in an immunoassay

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RSC ADVANCES (2018)

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Article Multidisciplinary Sciences

Enzyme-catalyzed Ag Growth on Au Nanoparticle-assembled Structure for Highly Sensitive Colorimetric Immunoassay

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SCIENTIFIC REPORTS (2018)

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A fluorescence and colorimetric dual-mode assay of alkaline phosphatase activity via destroying oxidase-like CoOOH nanoflakes

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JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Biochemical Research Methods

Switchable fluorescence of MoS2 quantum dots: a multifunctional probe for sensing of chromium(VI), ascorbic acid, and alkaline phosphatase activity

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Carbon dots prepared from Litchi chinensis and modified with manganese dioxide nanosheets for use in a competitive fluorometric immunoassay for aflatoxin B-1

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MICROCHIMICA ACTA (2018)

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Strategy for In Situ Imaging of Cellular Alkaline Phosphatase Activity Using Gold Nanoflower Probe and Localized Surface Plasmon Resonance Technique

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ANALYTICAL CHEMISTRY (2018)

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Article Nanoscience & Nanotechnology

Poly(thymine)-Templated Selective Formation of Copper Nanoparticles for Alkaline Phosphatase Analysis Aided by Alkyne Azide Cycloaddition Click Reaction

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ACS APPLIED NANO MATERIALS (2018)

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VS2 quantum dot label-free fluorescent probe for sensitive and selective detection of ALP

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ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)

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A MnO2 nanosheets-o-phenylenediamine oxidative system for the sensitive fluorescence determination of alkaline phosphatase activity

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ANALYTICAL METHODS (2018)

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Dual-readout aptasensing of antibiotic residues based on gold nanocluster-functionalized MnO2 nanosheets with target-induced etching reaction

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Formation of Hierarchical In2S3-CdIn2S4 Heterostructured Nanotubes for Efficient and Stable Visible Light CO2 Reduction

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Determination of the activity of alkaline phosphatase based on the use of ssDNA-templated fluorescent silver nanoclusters and on enzyme-triggered silver reduction

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MICROCHIMICA ACTA (2017)

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Competitive photometric and visual ELISA for aflatoxin B1 based on the inhibition of the oxidation of ABTS

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MICROCHIMICA ACTA (2017)

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An enzyme-induced Au@Ag core-shell nanoStructure used for an ultrasensitive surface-enhanced Raman scattering immunoassay of cancer biomarkers

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NANOSCALE (2017)

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Sandwich-type microRNA biosensor based on magnesium oxide nanoflower and graphene oxide-gold nanoparticles hybrids coupling with enzyme signal amplification

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Article Chemistry, Analytical

Colorimetric and SERS dual-readout for assaying alkaline phosphatase activity by ascorbic acid induced aggregation of Ag coated Au nanoparticles

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SENSORS AND ACTUATORS B-CHEMICAL (2017)

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Article Chemistry, Analytical

Sensitive and selective colorimetric assay of alkaline phosphatase activity with Cu(II)-phenanthroline complex

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TALANTA (2017)

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Novel turn-on fluorescent detection of alkaline phosphatase based on green synthesized carbon dots and MnO2 nanosheets

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Nitrogen-Doped Porous Carbon-ZnO Nanopolyhedra Derived from ZIF-8: New Materials for Photoelectrochemical Biosensors

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Rapid and Reliable Detection of Alkaline Phosphatase by a Hot Spots Amplification Strategy Based on Well-Controlled Assembly on Single Nanoparticle

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Article Biophysics

Chemical redox modulated fluorescence of nitrogen-doped graphene quantum dots for probing the activity of alkaline phosphatase

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BIOSENSORS & BIOELECTRONICS (2017)

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Article Biochemical Research Methods

Fluorescence turn-on detection of alkaline phosphatase activity based on controlled release of PEI-capped Cu nanoclusters from MnO2 nanosheets

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A novel multiple signal amplifying immunosensor based on the strategy of in situ-produced electroactive substance by ALP and carbon-based Ag-Au bimetallic as the catalyst and signal enhancer

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Review Biophysics

Recent advances in DNA-based electrochemical biosensors for heavy metal ion detection: A review

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BIOSENSORS & BIOELECTRONICS (2017)

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MnO2 nanosheets as an artificial enzyme to mimic oxidase for rapid and sensitive detection of glutathione

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Au nanoparticles/hollow molybdenum disulfide microcubes based biosensor for microRNA-21 detection coupled with duplex-specific nuclease and enzyme signal amplification

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Enhanced Photoelectrochemical Method for Sensitive Detection of Protein Kinase A Activity Using TiO2/g-C3N4, PAMAM Dendrimer, and Alkaline Phosphatase

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Facile colorimetric assay of alkaline phosphatase activity using Fe(II)-phenanthroline reporter

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Gold Nanoparticles Deposited Polyaniline-TiO2 Nanotube for Surface Plasmon Resonance Enhanced Photoelectrochemical Biosensing

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Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: a new approach to magnetic sensing

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ANALYST (2016)

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Naked-eye sensitive detection of alkaline phosphatase (ALP) and pyrophosphate (PPi) based on a horseradish peroxidase catalytic colorimetric system with Cu(II)

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Multicolor ELISA based on alkaline phosphatase-triggered growth of Au nanorods

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ANALYST (2016)

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A sensitive fluorescence biosensor for alkaline phosphatase activity based on the Cu(II)-dependent DNAzyme

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ANALYTICA CHIMICA ACTA (2016)

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Invoking Direct Exciton-Plasmon Interactions by Catalytic Ag Deposition on Au Nanoparticles: Photoelectrochemical Bioanalysis with High Efficiency

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Alkaline Phosphatase Tagged Antibodies on Gold Nanoparticles/TiO2 Nanotubes Electrode: A Plasmonic Strategy for Label-Free and Amplified Photoelectrochemical Immunoassay

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Fluorescence Immunoassay System via Enzyme-Enabled in Situ Synthesis of Fluorescent Silicon Nanoparticles

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ANALYTICAL CHEMISTRY (2016)

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Highly sensitive visual detection of Avian Influenza A (H7N9) virus based on the enzyme-induced metallization

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A plasmonic colorimetric strategy for biosensing through enzyme guided growth of silver nanoparticles on gold nanostars

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Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers

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Article Biophysics

Switchable fluorescence of gold nanoclusters for probing the activity of alkaline phosphatase and its application in immunoassay

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Turn-On Colorimetric Platform for Dual Activity Detection of Acid and Alkaline Phosphatase in Human Whole Blood

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Rapid detection of Salmonella using a redox cycling-based electrochemical method

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Plasmonic ELISA based on the controlled growth of silver nanoparticles

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A fluorescent ELISA based on the enzyme-triggered synthesis of poly (thymine)-templated copper nanoparticles

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A novel signal-on photoelectrochemical biosensor for detection of 5-hydroxymethylcytosine based on in situ electron donor producing strategy and all wavelengths of light irradiation

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A hierarchical charge transport cascade based on W-Bi2S3/poly(thiophenyl-3-boronic acid) hybrid for robust photoelectrochemical analysis of subgroup J of avian leukosis virus

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Photoelectrochemical immunosensor for microRNA detection based on gold nanoparticles-functionalized g-C3N4 and anti-DNA:RNA antibody

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Fluorescence turn-on sensing of ascorbic acid and alkaline phosphatase activity based on graphene quantum dots

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Sensitive detection of ascorbic acid and alkaline phosphatase activity by double-channel photoelectrochemical detection design based on g-C3N4/TiO2 nanotubes hybrid film

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Sensitive and selective determining ascorbic acid and activity of alkaline phosphatase based on electrochemiluminescence of dual-stabilizers-capped CdSe quantum dots in carbon nanotube-nafion composite

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Iodine-Mediated Etching of Gold Nanorods for Plasmonic ELISA Based on Colorimetric Detection of Alkaline Phosphatase

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Sensitive and direct electrochemical detection of double-stranded DNA utilizing alkaline phosphatase-labelled zinc finger proteins

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ANALYST (2015)

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An electrochemical microRNAs biosensor with the signal amplification of alkaline phosphatase and electrochemical-chemical-chemical redox cycling

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ANALYTICA CHIMICA ACTA (2015)

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Target-Induced Nano-Enzyme Reactor Mediated Hole-Trapping for High-Throughput Immunoassay Based on a Split-Type Photoelectrochemical Detection Strategy

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Highly sensitive detection of sequence-specific DNA with morpholino-functionalized magnetic microspheres

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ANALYTICAL METHODS (2015)

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CoOOH Nanosheets with High Mass Activity for Water Oxidation

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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A novel signal-on strategy for M.SssI methyltransfease activity analysis and inhibitor screening based on photoelectrochemical immunosensor

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A signal on photoelectrochemical biosensor for assay of protein kinase activity and its inhibitor based on graphite-like carbon nitride, Phos-tag and alkaline phosphatase

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Review Chemistry, Multidisciplinary

Photoelectrochemical bioanalysis: the state of the art

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Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical-chemical-chemical redox cycling

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Article Electrochemistry

Photoelectrochemical biosensor for highly sensitive detection of microRNA based on duplex-specific nuclease-triggered signal amplification

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JOURNAL OF SOLID STATE ELECTROCHEMISTRY (2015)

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Article Nanoscience & Nanotechnology

High-Resolution Colorimetric Assay for Rapid Visual Readout of Phosphatase Activity Based on Gold/Silver Core/Shell Nanorod

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ACS APPLIED MATERIALS & INTERFACES (2014)

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A Plasmonic Nanosensor for Immunoassay via Enzyme-Triggered Click Chemistry

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ACS NANO (2014)

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Ultrasensitive Electroanalysis of Low-Level Free MicroRNAs in Blood by Maximum Signal Amplification of Catalytic Silver Deposition Using Alkaline Phosphatase-Incorporated Gold Nanoclusters

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A novel electrochemical immunosensor based on dual signal amplification of gold nanoparticles and telomerase extension reaction

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ANALYTICAL METHODS (2014)

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A facile method for detection of alkaline phosphatase activity based on the turn-on fluorescence of resorufin

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ANALYTICAL METHODS (2014)

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Signal-on photoelectrochemical biosensor for microRNA detection based on Bi2S3 nanorods and enzymatic amplification

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Effective signal-on photoelectrochemical immunoassay of subgroup J avian leukosis virus based on Bi2S3 nanorods as photosensitizer and in situ generated ascorbic acid for electron donating

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Photoelectrochemical biosensing platform for microRNA detection based on in situ producing electron donor from apoferritin-encapsulated ascorbic acid

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Toward therapeutic effects evaluation of chronic myeloid leukemia drug: Electrochemical platform for caspase-3 activity sensing

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Probing phosphatase activity using redox active nanoparticles: A novel colorimetric approach for the detection of enzyme activity

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Electrochemical Immunosensor for Staphylococcal Enterotoxin B (SEB) Based on Platinum Nanoparticles-Modified Electrode Using Hydrogen Evolution Inhibition Approach

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ELECTROANALYSIS (2014)

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Article Electrochemistry

Electrochemical-chemical-chemical redox cycling triggered by thiocholine and hydroquinone with ferrocenecarboxylic acid as the redox mediator

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ELECTROCHIMICA ACTA (2014)

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Article Chemistry, Analytical

Ascorbic acid-triggered electrochemical-chemical-chemical redox cycling for design of enzyme-amplified electrochemical biosensors on self-assembled monolayer-covered gold electrodes

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Aptamer-aided target capturing with biocatalytic metal deposition: an electrochemical platform for sensitive detection of cancer cells

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Ultrasensitive electrochemical strategy for trace detection of APE-1 via triple signal amplification strategy

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Multi-labeled functionalized C60 nanohybrid as tracing tag for ultrasensitive electrochemical aptasensing

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Electrochemical Aptamer Sensor for Thrombin Detection Based on Au Nanoneedle and Enzymatic Ascorbic Acid Oxidization

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Electrochemical immunosensor for the detection of tumor necrosis factor a based on hydrogel prepared from ferrocene modified amino acid

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Simultaneous electrochemical detection of multiple tumor markers based on dual catalysis amplification of multi-functionalized onion-like mesoporous graphene sheets

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Article Chemistry, Analytical

In Situ Enzymatic Ascorbic Acid Production as Electron Donor for CdS Quantum Dots Equipped TiO2 Nanotubes: A General and Efficient Approach for New Photoelectrochemical Immunoassay

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A sensitive enzyme-catalytic nanogold-resonance scattering spectral assay for alkaline phosphate

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In situ enzymatic silver enhancement based on functionalized graphene oxide and layer-by-layer assembled gold nanoparticles for ultrasensitive detection of thrombin

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Ultrasensitive DNA detection based on coulometric measurement of enzymatic silver deposition on gold nanoparticle-modified screen-printed carbon electrode

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Optimization of Phosphatase- and Redox Cycling-Based Immunosensors and Its Application to Ultrasensitive Detection of Troponin I

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In-situ produced ascorbic acid as coreactant for an ultrasensitive solid-state tris(2,2′-bipyridyl) ruthenium(II) electrochemiluminescence aptasensor

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High-sensitive electrochemical detection of point mutation based on polymerization-induced enzymatic amplification

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Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

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