☆ 4.8 Review

Cu-related agents for cancer therapies

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Nanoscience & Nanotechnology

siRNA-Based Carrier-Free System for Synergistic Chemo/Chemodynamic/RNAi Therapy of Drug-Resistant Tumors

Yifan Jiang et al.

Summary: The study introduces a carrier-free Cu-siMDR-CDDP system that combines siRNA, CDDP, and Cu2+ to deactivate and release drugs in the tumor microenvironment, targeting drug-resistant cancer cell mechanisms. This system demonstrates synergistic chemo/chemodynamic RNA interference therapy in vivo.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Transferrin Protein Corona-Modified CuGd Core-Shell Nanoplatform for Tumor-Targeting Photothermal and Chemodynamic Synergistic Therapies

Xiangyu Qi et al.

Summary: A novel protein corona-modified nanoplatform has been developed for tumor-targeting photothermal and chemodynamic synergistic therapy. The nanoplatform exhibits high photothermal conversion efficiency and excellent stability. It shows strong chemodynamic therapy ability and can induce cancer cell death. Additionally, it can accurately diagnose cancer, making it a promising candidate for photothermal and chemodynamic synergistic theranostics.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction

Sagang Koo et al.

Summary: The study presents a heterogeneous chemodynamic therapy (CDT) system based on copper-iron peroxide nanoparticles for synergistic therapy in the tumor microenvironment (TME). The system demonstrates excellent tumor therapeutic efficacy by enhancing hydroxyl radical production through a highly efficient catalytic loop. It also generates O-2 and exhibits TME-responsive T-1 magnetic resonance imaging contrast enhancement.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy

Ke Li et al.

Summary: A Cu-TCPP(Fe) MOF-based nanosystem incorporating Au nanoparticles and RSL3 is reported in this study, which can universally suppress the antiferroptotic pathway in tumor cells and amplify ferroptotic damage. The nanosystem exhibits enzyme-like activities and can inhibit the antioxidant mechanisms involved in ferroptosis.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Biodegradable Metal-Organic-Framework-Gated Organosilica for Tumor-Microenvironment-Unlocked Glutathione-Depletion-Enhanced Synergistic Therapy

Yuanyuan Ma et al.

Summary: This study achieved targeted delivery of cisplatin using biocompatible and biodegradable hollow mesoporous organosilica (HMOS) nanoparticles by blocking the pores with a bimetallic Zn2+/Cu2+ co-doped metal-organic framework (MOF). The MOF decomposes in the acidic tumor microenvironment to release cisplatin for chemotherapy, while the released Cu2+ depletes intracellular glutathione (GSH) and catalyzes the decomposition of intratumoral H2O2 into highly toxic •OH for chemodynamic therapy. The reduced GSH also protects the •OH from scavenging, enhancing the chemodynamic therapy effect.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic /Immunotherapy

Man Wang et al.

Summary: A TME-responsive nanosystem was engineered in this study to enhance reactive oxygen species production in the tumor microenvironment for cancer starvation, chemodynamic, and immunotherapy, which was achieved through combining natural enzymes and nanozymes. Furthermore, the enhanced oxidative stress by the nanosystem facilitated antitumor immune responses and effectively inhibited tumor growth and metastasis when combined with PD-L1 antibody for synergistic therapy.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Yao Lu et al.

Summary: Disulfiram (DSF) has been used as an alcoholism drug for 70 years and has recently gained attention for its anticancer activity. However, the oral delivery of DSF in clinical settings has not yielded satisfactory outcomes, calling for a deeper understanding of its mechanisms and limitations. This review provides a critical summary of the molecular biological anticancer mechanisms of DSF/Cu2+ and explains the challenges of oral DSF delivery in clinical oncology. It also highlights recent advances in DSF/Cu2+ delivery strategies and emerging treatment regimens for cancer therapy.

BIOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy

Jiahui Li et al.

Summary: A glycol nanomedicine utilizing a metal-coordination supramolecular self-assembly strategy was developed, which demonstrated successful drug target delivery and release monitoring. Enhanced anti-cancer efficiency was achieved through synergistic therapy of chemotherapy and chemodynamic therapy. This technology may have significant applications in drug tracking and combined cancer therapy.

CHEMICAL COMMUNICATIONS (2022)

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Article Engineering, Environmental

TME-responded Full-biodegradable nanocatalyst for mitochondrial calcium Overload-induced hydroxyl radical bursting cancer treatment

Wensheng Xie et al.

Summary: Mitochondrial calcium ions (Ca2+) overload has been identified as a potential strategy for effective cancer treatment. Inspired by this, the researchers successfully developed a degradable nanocatalyst that can respond to the tumor microenvironment and generate toxic radicals to kill tumor cells. Both in vitro and in vivo evaluations demonstrated the efficient anti-tumor effect of this nanocatalyst.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Inorganic & Nuclear

Discovery of thirteen cobalt(II) and copper(II) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance in vitro and in vivo

Ya-Ting Chen et al.

Summary: In this study, 13 transition metal complexes were synthesized and characterized. Two novel complexes exhibited strong cytotoxic activities against A549/DDP cancer cells, inducing apoptosis and autophagy via the mitochondria! dysfunction pathway. These complexes also showed pronounced and selective activity against A549/DDP xenografts in vivo.

DALTON TRANSACTIONS (2022)

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Article Pharmacology & Pharmacy

Two birds with one stone: Copper metal-organic framework as a carrier of disulfiram prodrug for cancer therapy

Qingqing Pan et al.

Summary: The study developed a novel copper-based nanoscale metal-organic framework (MOF) loaded with a disulfiram prodrug and copper ions, combined with glucose oxidase, for enhanced chemo-chemodynamic therapy against tumors. This self-activated system generated highly cytotoxic Cu(CDTC)2 in situ for tumor-specific chemotherapy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy

Meixu Chen et al.

Summary: The FDA-approved drug Disulfiram has been found to have potent antitumor therapeutic effect by generating Cu(DTC)2, but its poor tumor selectivity and lack of sufficient endogenous Cu2+ concentration within the tumor site hinder its application. A GSH-responsive coordination nanoparticles (Cu-IXZ@DSF) was established to achieve selective triggered tumor in situ Cu(DTC)2 generation for antitumor therapy, showing good biosafety and excellent antitumor effect via endoplasmic reticulum stress (ERS) and reactive oxygen species (ROS) generation pathway. This nanocarrier provides a specific-triggered antitumor Cu(DTC)2 generation for DSF-based chemotherapy with high therapeutic effect and biosafety, showing great potential of treating cancer.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Copper-Based Metal-Organic Framework Overcomes CancerChemoresistance through Systemically Disrupting DynamicallyBalanced Cellular Redox Homeostasis

Jia Liu et al.

Summary: This study presents a copper/catechol-based metal-organic framework that disrupts the redox homeostasis in drug-resistant cancer cells, leading to increased cellular oxidative stress and selective cytotoxicity. The framework effectively inhibits in vivo drug-resistant tumor growth and improves survival rates in tumor-bearing mice.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Biochemistry & Molecular Biology

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

Sebastiano Masuri et al.

Summary: Copper, as an endogenous metal ion, plays a significant role in the development of anti-tumoral agents. Copper complexes have been found to have multi-factorial anti-cancer properties. This study focuses on the anti-cancer properties of mixed Cu(II) complexes with different auxiliary ligands and discusses their mechanisms of action.

MOLECULES (2022)

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Review Biotechnology & Applied Microbiology

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Yicheng Jiang et al.

Summary: Recent studies have shown that imbalanced copper homeostasis can affect tumor growth, causing irreversible damage. Copper can induce various forms of cell death, such as apoptosis and autophagy, through mechanisms involving reactive oxygen species accumulation, proteasome inhibition, and antiangiogenesis. This review highlights the antitumor mechanisms of copper, the development of biomaterials and nanotechnology incorporating copper, and the clinical applications of novel copper complexes.

NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

Near-Infrared II Plasmonic Phototheranostics with Glutathione Depletion for Multimodal Imaging-Guided Hypoxia-Tolerant Chemodynamic-Photocatalytic-Photothermal Cancer Therapy Triggered by a Single Laser

Beibei Shan et al.

Summary: This study presents an all-in-one phototheranostic platform based on dpGCS NCs for combined CDT, PCT, and PTT therapies triggered by a single NIR-II laser. The platform demonstrates remarkable therapeutic efficacy in both in vitro and in vivo experiments, achieving complete inhibition of tumor growth, providing a distinctive paradigm for the development of NIR-II phototheranostic platforms.

SMALL (2022)

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Article Medicine, Research & Experimental

Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy

Yuxuan Xiong et al.

Summary: This study developed an intelligent nanoplatform that can activate chemodynamic therapy specifically in tumor tissues and provide photoacoustic imaging and amplified combined therapy. The nanoplatform releases therapeutic drugs through interactions with the tumor microenvironment and induces intratumoral oxidative stress. Additionally, the nanoplatform exhibits good biosafety.

THERANOSTICS (2022)

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Article Engineering, Biomedical

A Facile and Universal Method for Preparing Polyethylene Glycol-Metal Hybrid Nanoparticles and Their Application in Tumor Theranostics

Zefeng Chen et al.

Summary: This study proposes a novel approach for the transport of metal ions using polyethylene glycol. By a simple synthesis method, 31 different metal ion-based nanoparticles were successfully synthesized and demonstrated their potential for cancer theranostics.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

Biomimic Binding Affinity Gradients Triggered GSH-Response of Core-Shell Nanoparticles for Cascade Chemo/Chemodynamic Therapy

Qinghua Wang et al.

Summary: The biomimetic copper-ion mediated GSH-responsive nanomedicine exploits the gradient copper-binding strengths between polydopamine and GSH to release chemotherapeutic drugs specifically in tumor cells, achieving cascade anticancer effects. This multilevel anticancer system demonstrates efficient tumor inhibition with minimal systemic toxicity, presenting a new bioinspired GSH-responsive strategy for developing stimuli-responsive structures.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

Copper (alpha)/cis-platinum-loaded nanogels as an adjuvant potentiate disulfiram's antitumor efficacy

Yu Geng et al.

Summary: This study presents a new strategy to enhance the anticancer activity of disulfiram (DSF) by using nanogels to deliver metal ions to tumors. The nanogels, developed with the ability to chelate copper ions or cis-platinum (CDDP), effectively delivered a high concentration of metal ions to the tumor, resulting in potent in vitro and in vivo anticancer activity of separately administered DSF.

BIOMATERIALS SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Engineering 2D Cu-composed metal-organic framework nanosheets for augmented nanocatalytic tumor therapy

Shangwen Zhuang et al.

Summary: In this study, Cu-based two-dimensional metal-organic framework nanosheets were utilized as a catalytic nanocatalyst to trigger a Fenton-like reaction by GSH and H2O2 in tumor cells, resulting in enhanced ROS production and accumulation, and inducing cell apoptosis and tumor inhibition.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Materials Science, Biomaterials

Biocompatible 2D Cu-TCPP Nanosheets Derived from Cu2O Nanocubes as Multifunctional Nanoplatforms for Combined Anticancer Therapy

Le Gao et al.

Summary: In this study, 2D Cu-tetrakis(4-carboxyphenyl) porphyrin (TCPP) nanosheets were prepared and used as a nanoplatform for loading Pt and Au nanoparticles (NPs), resulting in multifunctional Cu2O/Cu-TCPP/(Pt-Au) nanomedicines. These nanomedicines showed superior anticancer effects through multiple therapeutic modes, including the production of reactive oxygen species and modulation of the tumor hypoxia environment.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

One-Pot Synthesis of Customized Metal-Phenolic-Network-Coated AIE Dots for In Vivo Bioimaging

Changhuo Xu et al.

Summary: A facile and universal strategy for preparing metal-phenolic-network (MPN)-coated AIE dots with high encapsulation efficiency is reported. The assembled core-shell MPN-coated AIE dots exhibit bright emission and can be readily tuned by varying the incorporated AIEgens. These nanocomposites can be used for various imaging applications.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy

Tingting Wang et al.

Summary: This study demonstrates the significant improvement of immunotherapy efficacy for glioblastoma (GBM) by modulating the tumor immunosuppressive microenvironment (TIME) through novel all-in-one biomimetic nanoparticles. By remodeling the TIME, these nanoparticles activate immune responses, decrease tumor infiltration, and reduce the expression of PD-L1 on tumor cells. Modulating the TIME shows potential as a significant strategy to enhance immunotherapy for GBM and other cold tumors.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting

Xiangyu Chen et al.

Summary: This study investigated the treatment efficiency of Cu-Cy based X-PDT under clinical conditions, using a clinical linear accelerator and deep-seated tumor models. The results showed that Cu-Cy nanoparticles had low toxicity in cells at a low concentration, and Cu-Cy mediated X-PDT can inhibit cell proliferation and migration in a dose-dependent manner. Furthermore, this therapy inhibited the growth of deep-seated tumors in mice and rabbits without obvious toxicities. These findings suggest that Cu-Cy NPs have a promising clinical application prospect in X-PDT.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Watson-Crick Base Pairing-Inspired Laser/GSH Activatable miRNA-Coordination Polymer Nanoplexes for Combined Cancer Chemo-Immuno-Photothermal Therapy

Jiulong Zhang et al.

Summary: In this study, a versatile noncationic miRNA vector was developed for cancer immunotherapy. The vector can reverse the tumor immunosuppressive microenvironment by downregulating the expression of IDO1. The multifunctional nano-complex not only inhibits tumor growth but also shows remarkable therapeutic effects on distant tumors.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Open-Source and Reduced-Expenditure Nanosystem with ROS Self-Amplification and Glutathione Depletion for Simultaneous Augmented Chemodynamic/Photodynamic Therapy

Miaomiao Chen et al.

Summary: This study developed a CaO2-based nanosystem with ROS self-amplification and GSH-depletion abilities, significantly improving the synergistic photodynamic and chemodynamic therapy for cancer.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy

Xiao Zheng et al.

Summary: In this study, a dual closed-loop strategy was developed using a rational material design to enhance the efficacy of cancer immunotherapy by catalyzing lactate depletion and immune response. This strategy effectively inhibited tumor growth, providing a promising treatment modality for cancer immunotherapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Two-Dimensional MXene-Originated In Situ Nanosonosensitizer Generation for Augmented and Synergistic Sonodynamic Tumor Nanotherapy

Min Zhang et al.

Summary: This study reports the fabrication of two-dimensional (2D) nanosonosensitizers/nanocatalysts for in situ generation of nanosonosensitizers, which respond to the tumor microenvironment. The nanosonosensitizers showed enhanced sonodynamic therapy (SDT) efficacy due to in situ generation of TiO2 nanosonosensitizers and enhanced ROS production. The combination of SDT and chemodynamic therapy demonstrated synergistic therapeutic effects both in vitro and in vivo.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme

Changyu Cao et al.

Summary: In this study, a nanozyme resembling cytochrome c oxidase was demonstrated for nanocatalytic cancer therapy. By loading a bioreductive predrug, it simultaneously achieved starvation, ferroptosis, and chemical therapy, resulting in significant tumor elimination and increased survival rate in tumor-bearing mice.

ADVANCED MATERIALS (2022)

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Article Chemistry, Physical

A metal ion-drug-induced self-assembly nanosystems for augmented chemodynamic and chemotherapy synergetic anticancer therapy

Dong-Hui Zhao et al.

Summary: This study demonstrates the assembly of CCD nanoparticles to respond to the tumor microenvironment, achieving enhanced chemodynamic therapy effects. The CCD NPs show excellent biocompatibility and synergistic anti-tumor ability, effectively inhibiting tumor growth.

CARBON (2022)

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Article Chemistry, Physical

A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy

Hailong Tian et al.

Summary: A novel cascaded copper-based metal-organic framework therapeutic nanocatalyst was reported for amplified hepatocellular carcinoma therapy by integrating a COX-2 inhibitor and a chemotherapeutic agent to trigger ferroptosis-mediated therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Physical

pH-responsive aminotriazole doped metal organic frameworks nanoplatform enables self-boosting reactive oxygen species generation through regulating the activity of catalase for targeted chemo/chemodynamic combination therapy

Junliang Dong et al.

Summary: This study demonstrates the rational integration of chemotherapy and CDT via functional metal-organic frameworks. The pH-responsive MAF carrier showed high drug load and uniform size, making it a promising candidate for targeted drug delivery in cancer therapy. Additionally, the use of enzyme inhibitors as ligands in constructing functional MOFs provides a feasible strategy for regulating enzyme activity and enhancing CDT efficacy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Pharmacology & Pharmacy

Biosynthesis of folic acid appended PHBV modified copper oxide nanorods for pH sensitive drug release in targeted breast cancer therapy

Swati Singh et al.

Summary: Multifunctional nanoplatforms as nanocarriers have the potential to improve cancer treatment by achieving greater therapeutic effect in delivering anticancer drugs to tumors. In this study, a pH-sensitive CuO-PTX@PHBV-PEG-FA nanosystem was successfully developed by loading the drug PTX and CuO nanoparticles into PHBV nanospheres, which showed promising anticancer effects in vitro.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Multidisciplinary Sciences

DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems

Yawen You et al.

Summary: This study reports on a DNA-based biocompatible, highly efficient, and precisely targeted copper nanocatalyst, which exhibits excellent catalytic activity and achieves efficient prodrug activation and antitumor effects in cancer cells.

NATURE COMMUNICATIONS (2022)

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Article Engineering, Biomedical

Metabolic Intervention Nanoparticles for Triple-Negative Breast Cancer Therapy via Overcoming FSP1-Mediated Ferroptosis Resistance

Jie Yang et al.

Summary: In this study, Cu-SF(RSV) NPs were used to overcome ferroptosis resistance in TNBC cells by intervening in metabolic pathways and generating oxidative stress to amplify the effect of ferroptosis, providing a promising therapeutic platform for clinical TNBC treatment.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

An Intelligent Nanovehicle Armed with Multifunctional Navigation for Precise Delivery of Toll-Like Receptor 7/8 Agonist and Immunogenic Cell Death Amplifiers to Eliminate Solid Tumors and Trigger Durable Antitumor Immunity

Yanyun Hao et al.

Summary: Intelligent nanovehicles accurately deliver drugs to tumor cells and dendritic cells, reducing tumor burden through immunogenic cell death and generating long-term immune protection.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Materials Science, Biomaterials

GSH-Responsive and Hypoxia-Activated Multifunctional Nanoparticles for Synergetically Enhanced Tumor Therapy

Chunyang Liu et al.

Summary: This study proposes a strategy for synergistic cancer treatment by integrating reactive oxygen species (ROS)-based chemodynamic therapy (CDT) and photodynamic therapy (PDT) using metal-coordinated multifunctional nanoparticles (NPs). These NPs, triggered by Cu2+, can induce a cascade of combinational therapeutic reactions in the tumor microenvironment, achieving hyperthermia, GSH elimination, Cu+-mediated center dot OH generation, and hypoxia-triggered chemotherapeutic effects. The results suggest the great potential of these Cu-ICG/TPZ NPs in enhancing tumor treatment.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Materials Science, Biomaterials

A Multifunctional Nanoplatform Based on Fenton-like and Russell Reactions of Cu, Mn Bimetallic Ions Synergistically Enhanced ROS Stress for Improved Chemodynamic Therapy

Wei Ma et al.

Summary: This study developed a nanoplatform based on two-dimensional metal-organic frameworks for improved chemodynamic therapy (CDT). The nanoplatform combined bimetallic CDT, glutathione consumption, tumor targeting, and mitochondrial targeting. The nanoplatform showed high efficiency in generating reactive oxygen species and achieved a significant tumor suppression effect.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Pharmacology & Pharmacy

A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers

Paul Rocchi et al.

Summary: This study developed a multimodal ultrasmall nanoparticle, CuPRiX, for cancer treatment. CuPRiX nanoparticles can prevent tumor cell dissemination and metastasis by depleting copper in tumors, and they also increase the sensitivity of tumors to radiotherapy.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Platinum-copper alloy nanoparticles armored with chloride ion transporter to promote electro-driven tumor inhibition

Tong Chen et al.

Summary: This study combines Pt/Cu alloy nanoparticles with chloride ion transporter (CIT) for electrodynamic therapy (EDT)-based combinational therapy. Under an electric field, PtCu3 NPs induce the generation of oxidative species, transform endogenous H2O2 into center dot OH, and consume intracellular glutathione (GSH). With the aid of CIT, extracellular chloride ion (Cl-) is transported into cells, significantly promoting the generation of oxidative species. Additionally, CIT delivery internally increases lysosomal pH, disrupting cellular autophagy and weakening treatment resistance.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Analytical

Application of Self-Assembly Nanoparticles Based on DVDMS for Fenton-Like Ion Delivery and Enhanced Sonodynamic Therapy

Jinqiang Liu et al.

Summary: Sonodynamic therapy (SDT) induces cancer cell death through reactive oxygen species (ROS) mediated pathway. The combination of SDT and chemodynamic therapy (CDT) has become a research hotspot in tumor therapy. Self-assembly nanotechnology can be applied to modify sonosensitizers in order to improve their efficiency.

BIOSENSORS-BASEL (2022)

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Article Nanoscience & Nanotechnology

Engineering Metal-Organic Framework Hybrid AIEgens with Tumor-Activated Accumulation and Emission for the Image-Guided GSH Depletion ROS Therapy

Ming-Jie Dong et al.

Summary: A metal-organic framework (MOF) hybrid AIEgen theranostic platform has been designed, which shows exciting potential for application in cancer phototheranostics. It successfully achieves tumor-activated bright emission, enhanced reactive oxygen species (ROS) generation, high tumor accumulation, and minimized ROS depletion. This platform can selectively kill tumors with excellent efficacy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

CuS Nanoparticles-Loaded and Cisplatin Prodrug Conjugated Fe(III)-MOFs for MRI-Guided Combination of Chemotherapy and NIR-II Photothermal Therapy

Sufeng Qiang et al.

Summary: In this study, a versatile cisplatin prodrug-conjugated therapeutic platform was constructed based on ultrasmall CuS-modified Fe(III)-metal-organic frameworks (MIL-88) for tumor-specific enhanced synergistic chemo-/phototherapy. The platform successfully inhibited tumor growth and avoided direct drug-induced side effects.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Weijun Xu et al.

Summary: Cuproptosis is a newly recognized regulated cell death mechanism that shows promise in cancer treatment. A novel copper/iron hybrid hollow metal organic framework (HaMOF) is developed for synergistic anticancer therapy by amplifying oxidative stress and disrupting copper/iron metabolism. The bimetallic hollow nanoplatform induces potent ferroptosis and cuproptosis, and efficiently suppresses tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Physical

Copper-based metal-organic frameworks for biomedical applications

Ju-E Cun et al.

Summary: This article reviews the applications of copper-based metal-organic frameworks (Cu-MOFs) in the field of biomedicine and discusses their future development prospects. The article introduces the synthesis methods and strategies of Cu-MOFs and summarizes their recent advances in cancer treatment, bacterial inhibition, biosensing, biocatalysis, and wound healing.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2022)

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Article Engineering, Environmental

MOF-derived CuS@Cu-MOF nanocomposites for synergistic photothermal-chemodynamic-chemo therapy

Peng Geng et al.

Summary: In this study, CuS@Cu-MOF nanocomposites were successfully prepared as multifunctional nanoagents with simultaneous bioimaging and photothermal/chemodynamic/drug-delivering functions. The nanoagents showed increased NIR photoabsorption and high thermal conversion efficiency for photothermal therapy, as well as Fenton-like reaction feature for chemodynamic therapy. The drug (DOX) could be efficiently encapsulated into the nanoagents and exhibited rapid release in an acidic environment for chemotherapy. The nanoagents demonstrated excellent imaging-guided multi-model therapy effects on tumors, with no noticeable side effects.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Oncology

Relationship between copper and immunity: The potential role of copper in tumor immunity

Fu Cheng et al.

Summary: Copper ions are essential for the development and function of the immune system. Both copper deficiency and elevated copper levels have been linked to various diseases, including immune system disorders and tumor development. Recent studies have also revealed the role of copper ions in regulating tumor immunity through gene expression.

FRONTIERS IN ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence

Wentao Dang et al.

Summary: In this study, 3D printed hydrogel scaffolds incorporating Gel-SA-CuO were developed for efficient inhibition of postoperative liver cancer recurrence. CuO nanoparticles released Cu2+ to produce ROS and served as photothermal agents to generate heat, enhancing the tumor inhibition through Fenton-like reaction and inducing ferroptosis via GSH depletion.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Chemotherapy Mediated by Biomimetic Polymeric Nanoparticles Potentiates Enhanced Tumor Immunotherapy via Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

Yunqi Guo et al.

Summary: Reported is a nanomedicine formulation based on nanoparticles, which can release drugs on the surface of tumors, effectively inhibit tumor growth, and enhance the function of immune cells.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy

Yuzhi Xu et al.

Summary: Cuproptosis, a copper-dependent form of regulated cell death, offers great opportunities for cancer treatment. In this study, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], is developed for starvation-augmented cuproptosis and photodynamic synergistic therapy. In vivo experimental results show its effectiveness in inhibiting tumor growth.

ADVANCED MATERIALS (2022)

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Article Engineering, Environmental

Photoactive polymers-decorated Cu-Al layered double hydroxide hexagonal architectures: A potential non-viral vector for photothermal therapy and co-delivery of DOX/pCRISPR

Milad Ashrafizadeh et al.

Summary: In this study, Cu-Al layered double hydroxide (LDH) nanoparticles decorated with different forms of poly(phenylenediamine) were fabricated and used for the co-delivery of the drug doxorubicin (DOX) and plasmid CRISPR (pCRISPR). The pH-responsive nanocarriers exhibited high drug release in an acidic environment and showed promising cargo delivery in MEF-7 and HEK-293 cells. The study also assessed the potential usage of the cell-imprinted technique to enhance cellular internalization and demonstrated the biocompatibility and anti-cancer activity of LDH nanostructures.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Inorganic & Nuclear

Water soluble transition metal [Ni(II), Cu(II) and Zn(II)] complexes of N-phthaloylglycinate bis(1,2-diaminocyclohexane). DNA binding, pBR322 cleavage and cytotoxicity

Salman Khursheed et al.

Summary: In this study, a series of complexes were synthesized to investigate the effect of metal ions in analogous ligand scaffolds on DNA binding and cytotoxic response. The copper(II) complex showed the highest anticancer activity among the complexes tested.

DALTON TRANSACTIONS (2022)

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Article Materials Science, Biomaterials

One-pot fabrication of a polydopamine-based nanoplatform for GSH triggered trimodal ROS-amplification for cancer therapy

Qinghua Wang et al.

Summary: This study presents a cancer-specific oxidative stress amplification nanomedicine that increases oxidative stress within cancer cells, induces cancer cell apoptosis, and significantly inhibits tumor growth.

BIOMATERIALS SCIENCE (2022)

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Article Materials Science, Biomaterials

A triphenylphosphine coordinated cinnamaldehyde-derived copper(I) Fenton-like agent with mitochondrial aggregation damage for chemodynamic therapy

Zhaoguo Hong et al.

Summary: A new metal complex CDT agent was developed to efficiently induce oxidative damage and generate large amounts of hydroxyl radicals, leading to cell death, with excellent tumor growth inhibition capability shown in in vivo experiments.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Inorganic & Nuclear

Sparfloxacin - Cu(II) - aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

Qi-Yan Liu et al.

Summary: Two new copper(II) complexes of sparfloxacin were synthesized and displayed good antitumor activity by inducing apoptosis through DNA damage and loss of mitochondrial functions.

DALTON TRANSACTIONS (2022)

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Article Chemistry, Inorganic & Nuclear

Cyclam with a phosphinate-bis(phosphonate) pendant arm is a bone-targeting carrier of copper radionuclides

Lucia Pazderova et al.

Summary: Ligands combining a bis(phosphonate) group with a macrocycle can serve as metal isotope carriers for imaging and treating bone metastases. The negative effect of bis(phosphonate) pendant arms on complex formation can be mitigated by using a suitable spacer. The newly synthesized H(5)te1P(BP) ligand showed high selectivity to Cu-II and formed the Cu-II complex quickly. It also exhibited resistance to acid hydrolysis and effective adsorption on hydroxyapatite.

DALTON TRANSACTIONS (2022)

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Article Chemistry, Multidisciplinary

Programmed self-assembly of enzyme activity-inhibited nanomedicine for augmenting chemodynamic tumor nanotherapy

Ling Chang et al.

Summary: This study reports a multilayered nanostructure with rapid glutathione response characteristics, which can enhance the efficiency of chemodynamic therapy and comprehensively inhibit tumor metabolic activity through exchanging with glutathione in tumor cells.

NANOSCALE (2022)

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Article Chemistry, Inorganic & Nuclear

Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(i) coordinated cluster for enhanced chemodynamic therapy

Xin You et al.

Summary: A tetra-nuclear copper coordinated cluster with triphenylphosphine modification was constructed to enhance chemodynamic therapy (CDT). The increased number of metal centers resulted in more copper accumulation inside bladder cancer cells, leading to the generation of more ·OH and inducing more significant apoptosis via a Fenton-like reaction, thereby improving the tumor inhibition effect and enhancing the efficiency of CDT.

DALTON TRANSACTIONS (2022)

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Article Chemistry, Inorganic & Nuclear

A bioinspired redox-modulating copper(II)-macrocyclic complex bearing non-steroidal anti-inflammatory drugs with anti-cancer stem cell activity

Alice Johnson et al.

Summary: This study reports a biologically stable copper(II) complex that effectively kills breast cancer cells and breast cancer stem cells, while exhibiting low toxicity towards non-cancerous cells. Mechanistically, the complex induces breast cancer stem cell death by elevating intracellular reactive oxygen species and inhibiting cyclooxygenase-2 activity.

DALTON TRANSACTIONS (2022)

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Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

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Article Chemistry, Multidisciplinary

Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition

Nicolo Zuin Fantoni et al.

Summary: A series of copper(II) artificial metallo-nucleases (AMNs) were reported, demonstrating their DNA damaging properties and in-vitro cytotoxicity against human-derived pancreatic cancer cells. Among these, the Cu-DPA-DPPZ complex showed the strongest DNA binding and intercalation effects, exhibiting promising anticancer activity surpassing the clinical platinum(II) drug oxaliplatin in in-vitro results.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Carrier-free nanodrugs for safe and effective cancer treatment

Sena Karaosmanoglu et al.

Summary: The clinical applications of many anti-cancer drugs are limited by their hydrophobic nature, leading to the development of carrier-based nanoparticles. However, these strategies often fail to efficiently encapsulate drugs and may cause toxicity problems in the long term. Therefore, elegantly designed strategies for carrier-free nanodrugs, including simple self-assembly and chemical modifications, are desired for high quality, stability, and performance.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Biotechnology & Applied Microbiology

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui et al.

Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.

NATURE BIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Endogenous Copper for Nanocatalytic Oxidative Damage and Self-Protection Pathway Breakage of Cancer

Yuedong Guo et al.

Summary: This study focuses on using endogenous copper ions as a source of Fenton-like agents in cancer treatment, to disrupt the intrinsic protection pathway of cancer cells and induce apoptosis through catalytic oxidative damage reactions. The nanocatalyst shows excellent biosafety and enhanced therapeutic efficacy by simultaneously targeting cancer cell self-protection mechanisms and inducing oxidative damage.

ACS NANO (2021)

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Article Engineering, Biomedical

Intelligent MoS2-CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy

Fan Jiang et al.

Summary: The MoS2-CuO nanoplatform designed in this study integrates multimodal imaging and therapeutic functions for cancer treatment. It is capable of enhancing antitumor efficacy through a combination of photothermal therapy, chemodynamic therapy, and immunotherapy, while also generating strong antitumor immune responses for effectively eliminating primary and metastatic tumors.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Incorporation of β-Alanine in Cu(II) ATCUN Peptide Complexes Increases ROS Levels, DNA Cleavage and Antiproliferative Activity**

Julian Heinrich et al.

Summary: The study demonstrates that replacing Gly with β-Ala in the ATCUN structure can reactivate ROS production and increase oxidative cleavage activity towards DNA. Modifications with Lys residues play a role in enhancing DNA affinity and increasing nuclease activity. The β-Ala2 complexes exhibit higher cytotoxicity, possibly due to increased cellular uptake.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Article Engineering, Multidisciplinary

ROS generation/scavenging modulation of carbon dots as phototherapeutic candidates and peroxidase mimetics to integrate with polydopamine nanoparticles/GOx towards cooperative cancer therapy

Girum Getachew et al.

Summary: This study demonstrates the regulation of the reactive oxygen species (ROS) scavenging or generation ability of carbon dots (CDs) by incorporating heteroatoms, leading to the creation of novel nanocomposites with efficient therapeutic effects in both photodynamic therapy and chemodynamic therapy. The multifunctional nanocomposites show satisfactory photothermal conversion efficiencies, high ROS yield, and good biocompatibility, offering potential for enhanced cancer therapy through a combination of different treatment modalities.

COMPOSITES PART B-ENGINEERING (2021)

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Article Pharmacology & Pharmacy

Novel nanoformulated diethyldithiocarbamate complexes with biosynthesized or green chemosynthesized copper oxide nanoparticles: An in vitro comparative anticancer study

Marwa M. Abu-Serie et al.

Summary: Developing soluble and stable nanoformulation of antitumor copper complex CD is desired. CD nanoparticles were successfully formulated using bacterially and green chemically prepared copper oxide nanoparticles. Chemical CO NPs showed higher homogeneity and outperformed Bio CD NPs in terms of anticancer efficacy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation

Michael Grasso et al.

Summary: Studies show that copper (Cu) serves as an intracellular signaling mediator by connecting to the amplitude of mitogen-activated protein kinase signaling through direct interaction with kinases MEK1 and MEK2, influencing cell proliferation. The Cu chaperone CCS provides fidelity within a complex biological system, facilitating appropriate installation of Cu within the MEK1 kinase active site to modulate kinase activity.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Nanoscience & Nanotechnology

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Jianping Liu et al.

Summary: A novel trifunctional LDH nanosystem was developed for combined photochemotherapy of skin cancer by releasing drugs in an acid-triggered manner and generating heating and reactive oxygen species upon laser irradiation, which nearly eradicated tumor tissues with minimal side effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Applied

Aptamer targeted red blood cell membrane-coated porphyrinic copper-based MOF for guided photochemotherapy against metastatic breast cancer

Monireh Falsafi et al.

Summary: This study developed a nano metal-organic framework coated with red blood cell membrane and loaded with doxorubicin for targeted chemo and photodynamic therapy, showing enhanced toxicity against breast cancer cells. The fabricated nanostructures demonstrated effective synergistic chemo and photodynamic therapy, potentially serving as a potent platform for dual therapy in clinic.

MICROPOROUS AND MESOPOROUS MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Copper-Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T-Cell Infiltration

Yuxiang Wang et al.

Summary: The use of Cu-based nanoscale coordination polymers in combination with radiation therapy can induce potent ICD, leading to enhanced dendritic cell maturation and promotion of anti-tumor T-cell infiltration, which can potentiate the efficacy of checkpoint blockade immunotherapies against primary and metastatic tumors.

SMALL (2021)

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Article Engineering, Biomedical

Multishell Nanoparticles with Linkage Mechanism for Thermal Responsive Photodynamic and Gas Synergistic Therapy

Jiawei Zhu et al.

Summary: A linkage mechanism strategy utilizing thermal controllable multishell nanoparticles is proposed for combining photodynamic therapy (PDT) and NO-based gas therapy. This strategy achieves precise release and synergy of treatments, overcoming premature gas release and presenting effective antitumor efficiencies with the guidance of fluorescence and photoacoustic imaging.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Dual Size/Charge-Switchable Nanocatalytic Medicine for Deep Tumor Therapy

Wencheng Wu et al.

Summary: A dual size/charge-switchable nanocatalytic medicine triggered by ultrasound was developed for deep solid tumor therapy by catalyzing ROS generation, with the negatively charged liposome outer-layer enabling prolonged blood circulation and enhanced tumoral accumulation, while the positively charged Fenton-like catalyst Cu-LDH released under US stimulation demonstrated enhanced intratumoral penetration.

ADVANCED SCIENCE (2021)

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Article Multidisciplinary Sciences

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Divya Ramchandani et al.

Summary: Copper chelation reduces TNBC metastasis by inactivating Complex IV in sensitive SOX2/OCT4+ cells, showing potential to enrich patient populations in next-generation therapeutic trials.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Nanomedicine Enables Drug-Potency Activation with Tumor Sensitivity and Hyperthermia Synergy in the Second Near-Infrared Biowindow

Weiwei Liu et al.

Summary: DSF@PEG-HCuSNPs were designed to achieve in situ formation of cytotoxic Cu(DTC)(2) in the tumor microenvironment, enhancing DSF-based chemotherapy through NIR-II-induced photonic hyperthermia. The high photothermal conversion efficiency of DSF@PEG-HCuSNPs in the NIR-II biowindow significantly induced photonic hyperthermia to eliminate cancer cells.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Breaking the Redox Homeostasis: an Albumin-Based Multifunctional Nanoagent for GSH Depletion-Assisted Chemo-/Chemodynamic Combination Therapy

Kaicheng Liang et al.

Summary: By developing novel nanoagents that can disrupt redox homeostasis for tumor therapy, a multifunctional albumin-based nanoagent was successfully developed in this study. By depleting glutathione (GSH) to assist chemotherapy and chemodynamic therapy, this method increases oxidative stress and enhances therapeutic effects.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Intracellular Bottom-up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX-2 Inactivation

Liandong Feng et al.

Summary: A new treatment strategy involving Cu-meloxicam complexes encapsulated by human serum albumin for intracellular bottom-up synthesis of CuS nanodots has been developed, which effectively eliminates tumors and inhibits inflammation induced by photothermal damage. The therapy demonstrates promising results for precise cancer treatment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Cancer-Cell-Activated in situ Synthesis of Mitochondria-Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Yuanbo Wang et al.

Summary: This study presents a cancer-cell-activated photosensitizer synthesis strategy to selectively synthesize efficient PS with mitochondria-targeting capability for potent cancer-cell-specific ablation under light irradiation, ensuring high specificity and safety for post-treatment.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Self-Assembly of Copper-DNAzyme Nanohybrids for Dual-Catalytic Tumor Therapy

Congzhi Liu et al.

Summary: A novel hybrid nanostructure was developed in this study, delivering DNAzyme and Cu2+ to cancer cells for combinational therapy. The system demonstrated significant antitumor effects in tumors through catalytic cleavage of VEGFR2 mRNA and chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Biotechnology & Applied Microbiology

Second near-infrared photothermal-amplified immunotherapy using photoactivatable composite nanostimulators

Haitao Sun et al.

Summary: A composite nanostimulator (CNS) was developed for spatiotemporally controlled release of second near-infrared (NIR-II) photothermal-mediated immune agents, achieving efficient suppression of tumor growth and prevention of metastasis in mouse models.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Co-delivery of nanoparticle and molecular drug by hollow mesoporous organosilica for tumor-activated and photothermal-augmented chemotherapy of breast cancer

Haixian Zhang et al.

Summary: This study proposed a therapeutic construction with high biosafety and efficiency for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo, achieving remarkable results in tumor elimination.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells

Ssu-Yu Chen et al.

Summary: DSF-Cu+/Cu2+ complex induces cytotoxicity in oral epidermoid carcinoma cells but not in human gingival epithelial cells. It affects cell cycle, cell proliferation, and ROS levels.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

Hailong Tian et al.

Summary: The study developed a novel Cu-MOF-199 nanoplatform integrating vitamin K3, which modulates endogenous H2O2 and GSH levels to amplify the effect of chemodynamic therapy, effectively inhibiting tumor growth with minimal side effects in vivo.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Review Engineering, Biomedical

Transitional Metal-Based Noncatalytic Medicine for Tumor Therapy

Wencheng Wu et al.

Summary: Nanocatalytic medicine is a promising strategy for cancer therapeutics that generates toxic agents within tumors through catalytic reactions. Transitional metal-based nanocatalytic medicines show significant catalytic activity and clinical potential, but face obstacles and challenges in design and clinical application.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Multidisciplinary Sciences

A tumor microenvironment-induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

Shulong Wang et al.

Summary: The study found that the GSH level significantly increases in tumor tissues, thus it can be used as an endogenous molecule for diagnosing and treating tumors. The Fe-Cu@PANI nanoparticles prepared in the study utilize the tumor microenvironment-induced properties to activate tumor photoacoustic imaging and photothermal therapy in vivo, enhancing the efficiency of treatment.

SCIENCE ADVANCES (2021)

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Review Engineering, Biomedical

Biological applications of copper-containing materials

Peng Wang et al.

Summary: Copper is an essential trace element in the human body, impacting health through enzyme and protein functions. Researchers are increasingly focusing on developing novel copper-containing biomaterials with unique properties for cardiovascular protection, bone healing, and antibacterial effects. These materials also show potential in wound healing, cancer treatment, PET imaging, and radiotherapy applications.

BIOACTIVE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Mutual Benefit between Cu(II) and Polydopamine for Improving Photothermal-Chemodynamic Therapy

Wen-Xin Zhang et al.

Summary: This study demonstrates the synergistic effect of Cu(II)-doped PDA loaded on HMSNs in combining photothermal therapy and chemodynamic therapy for tumor treatment. PDA contributes to improved photothermal performance and enhanced therapeutic effect of CDT.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Autophagy-Dependent Apoptosis Induced by Apoferritin-Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells

Kai Xiong et al.

Summary: This study presents a therapeutic copper polypyridine complex encapsulated in a natural nanocarrier, apoferritin, which shows higher cytotoxicity towards drug-resistant cancer cells compared to noncancerous cells. The compound triggers cell autophagy-dependent apoptosis, leading to cell death. Injection of this nanodrug conjugate into a mouse model with multidrug-resistant colon tumor results in a strong inhibition of tumor growth.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

H2O2 Self-Supplying and GSH-Depleting Nanoplatform for Chemodynamic Therapy Synergetic Photothermal/Chemotherapy

Zhimei Xiao et al.

Summary: This study proposed an intelligent nanoplatform that induces the depletion of GSH and self-supply of H2O2 in tumor cells to enhance the efficacy of chemodynamic therapy (CDT). Through various mechanisms, the integration of chemotherapy, photothermal therapy, and CDT was realized.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal-Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator

Yu Sun et al.

Summary: The study demonstrates the development of tumor microenvironment-responsive nanoparticles for synergistic sono-chemodynamic therapy, which can generate free radicals in an oxygen-independent manner and increase treatment efficacy. This innovative approach offers a promising strategy for antitumor therapy under hypoxic conditions.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Multifunctional CuO/Cu2O Truncated Nanocubes as Trimodal Image-Guided Near-Infrared-III Photothermal Agents to Combat Multi-Drug-Resistant Lung Carcinoma

Munusamy Shanmugam et al.

Summary: In this study, a versatile plasmonic CuO/Cu2O truncated nanocube-based theranostic nanomedicine was developed to address multidrug resistance and deep tissue photoactivation problems. This nanomedicine acts as a triple modal near-infrared fluorescence imaging agent, sensitizes the formation of singlet oxygen, and absorbs long NIR light for photothermal therapeutic effects on drug-resistant lung tumors. The findings show that H69AR lung cancer cells do not develop drug resistance to this nanomedicine.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Mixed-Metal MOF-Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species-Augmented Synergistic Therapy

Yue Cheng et al.

Summary: This study proposes a trimodality therapy using a mixed-metal MOF composite for synergistic photothermal therapy, photodynamic therapy, and chemodynamic therapy. The composite with hollow structures efficiently integrates multiple functions to enhance treatment efficacy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy

Linping Zhao et al.

Summary: A self-delivery oxidative stress amplifier has been developed for chemotherapy sensitized immunotherapy, which can accelerate tumor cell death by breaking intracellular redox homeostasis. The amplifier is able to effectively accumulate in tumor tissues and trigger immunogenic cell death through GSH-responsive drug release.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Tumor microenvironment responsive biomimetic copper peroxide nanoreactors for drug delivery and enhanced chemodynamic therapy

Shengxin Hou et al.

Summary: A new type of nano-Fenton catalyst was developed to release H2O2 in the tumor microenvironment and combine with chemotherapy drugs, effectively improving the therapeutic effect of tumors. This new strategy provides a new direction for enhancing chemodynamic therapy and synergistic treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Pharmacology & Pharmacy

Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death

Xuejia Kang et al.

Summary: The CDL therapy combines CuS NP, DQ prodrug, and NIR laser to effectively kill cancer cells through ROS amplification cascade and Cu(DDC)2 chemotherapy, while ensuring tumor-specificity and reducing systemic toxicity through NIR light-triggered nontoxic-to-toxic transition. Additionally, the therapy has the potential to induce immunogenic cell death and elicit antitumor immunity.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer

Jianping Liu et al.

Summary: A novel nanomedicine has been developed for combination breast cancer therapy, which shows high efficacy in nearly eliminating tumors with minimal side effects.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Metal-coordinated nanomedicine for combined tumor therapy by inducing paraptosis and apoptosis

Rongrong Zheng et al.

Summary: COMBO is a Cu2+-coordinated morusin/doxorubicin biological organizer that can be disassembled by glutathione to combat cellular resistance to apoptosis through the joint action of paraptosis and apoptosis, exhibiting low system toxicity in tumor therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Metal Phenolic Network-Integrated Multistage Nanosystem for Enhanced Drug Delivery to Solid Tumors

Yuhao Gao et al.

Summary: Metal-phenolic networks have been utilized to develop a unique core-satellite nanosystem for enhanced solid tumor treatment, with the disassembly triggered by light leading to improved outcomes in tumor-bearing mice.

SMALL (2021)

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Article Biotechnology & Applied Microbiology

NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy

Li Zhang et al.

Summary: The novel smart nanogenerator APCZ was synthesized for combined cancer therapy, showing promising GSH-depleting ability and photothermal performance. By releasing CuS nanoparticles in situ, it achieved chemodynamic therapy and also allowed for photodynamic therapy through decomposition of AIPH. With enhanced therapeutic effects in both hypoxic and normoxic conditions, complete eradication of tumors was achieved after 14 days of treatment. Additionally, APCZ demonstrated feasibility as a contrast agent for photoacoustic imaging, showcasing its potential for efficient diagnosis and treatment of deep-seated and hypoxic tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy

Ya-Nan Hao et al.

Summary: The study developed a novel core-shell nanostructure, Cu-MOF/GOD@HA, to enhance the efficiency of chemodynamic therapy by increasing H2O2 concentration and targeting cancer cells.

NANOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

Modulation of Intracellular Copper Levels as the Mechanism of Action of Anticancer Copper Complexes: Clinical Relevance

Maria Babak et al.

Summary: Copper plays a crucial role in cellular growth and development and its imbalance can lead to toxicity. This review explores the mechanisms of intracellular copper balance interference in tumor development and progression, and discusses the potential of using copper-depleting and copper-overloading conditions for improved patient outcomes. Additionally, the advantages of pre-formed copper complexes in comparison to in situ formed complexes are highlighted.

BIOMEDICINES (2021)

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Article Oncology

Novel nanoformulation of disulfiram with bacterially synthesized copper oxide nanoparticles for augmenting anticancer activity: an in vitro study

Marwa M. Abu-Serie et al.

Summary: A novel nanocomplex of DS-CuO NPs was prepared, showing high stability and potent selective anticancer activity against human breast, lung, and liver cancer cells with low inhibitory concentration. This nanocomplex exhibited better anticancer effect and cellular uptake, as well as prooxidant effect-mediated apoptosis and anti-metastatic potential. These findings suggest that the novel nanocomplex may improve the therapeutic index of the conventional DS-Cu complex and warrant further investigation for future clinical applications.

CANCER NANOTECHNOLOGY (2021)

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Article Chemistry, Physical

Creating Structural Defects of Drug-Free Copper-Containing Layered Double Hydroxide Nanoparticles to Synergize Photothermal/Photodynamic/Chemodynamic Cancer Therapy

Luyao Sun et al.

Summary: A nanoplatform based on LDH nanoparticles has been developed for combined breast cancer therapy without traditional anticancer drugs, utilizing photothermal/photodynamic/chemodynamic therapy. By enhancing photothermal transduction and singlet-oxygen generation, the nanoplatform effectively inhibits tumor growth with low doses of Cu and ICG under mild laser irradiation.

SMALL STRUCTURES (2021)

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Article Materials Science, Biomaterials

Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy

Min Liu et al.

Summary: The study developed a nanoplatform for specific chemodynamic/metal-ion therapy, which could release silver at the tumor site and generate highly toxic hydroxyl radicals through the degradation of external MOFs triggered by Cu2+-reduced glutathione. The combined treatment of CDT with metal-ion therapy showed excellent inhibition of tumor cell growth.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Inorganic & Nuclear

Metal-organic framework-encapsulated nanoparticles for synergetic chemo/chemodynamic therapy with targeted H2O2 self-supply

Ruixue Cui et al.

Summary: The study introduces a novel drug delivery system CDZH, capable of targeted release of chemotherapy drugs and H2O2 supply in acidic tumor microenvironment, showing excellent chemo/chemodynamic synergistic therapy capability.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Inorganic & Nuclear

Two novel chiral tetranucleate copper-based complexes: syntheses, crystal structures, inhibition of angiogenesis and the growth of human breast cancer in vitro and in vivo

Xiao-Xiao Hou et al.

Summary: The novel chiral tetranucleate copper(ii)-based complex TNCu-A exhibits potent anti-cancer activity both in vitro and in vivo by inhibiting angiogenesis, inducing apoptosis in cells, and suppressing tumor growth.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Inorganic & Nuclear

Novel {Cu4} and {Cu4Cd6} clusters derived from flexible aminoalcohols: synthesis, characterization, crystal structures, and evaluation of anticancer propertiest

Khushboo Iman et al.

Summary: Two new copper clusters, {Cu-4} and {Cu4Cd6}, with polydentate aminoalcohol ligands, were synthesized and exhibited significant cytotoxicity towards human cervical and lung cancer cells. The high-nuclearity cluster {Cu4Cd6} showed better anticancer activity compared to the tetranuclear cluster {Cu-4}, indicating the role of high nuclearity and additional Cd metal in enhancing intracellular production of ROS.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Inorganic & Nuclear

Identification of potent anticancer copper(II) complexes containing tripodal bis[2-ethyl-di(3,5-dialkyl-1H-pyrazol-1-yl)]amine moiety

Salah S. Massoud et al.

Summary: A series of heteroleptic copper(II) complexes were synthesized and evaluated for their cytotoxicity. Complexes 1 and 2 showed the highest efficacy against human cancer cells, inducing apoptosis by increasing ROS production.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Multidisciplinary

A Cu2+ doped mesoporous polydopamine Fenton nanoplatform for low-temperature photothermal therapy

Yuanyuan Chen et al.

Summary: The Cu2+ doped CuPDA nanoplatform combines photothermal, chemodynamic, and NIR laser therapies, effectively inhibiting cancer cell proliferation under mild conditions and showing improved efficacy in chemodynamic therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Inorganic & Nuclear

Anticancer activity of a new copper(ii) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models

Lucia M. Balsa et al.

Summary: The study presents a copper-hydrazone complex with anticancer activity against human breast cancer cells on 2D and 3D models, showing higher efficacy than cisplatin. Molecular docking and dynamics simulations revealed CuHL's interaction with DNA, inducing cell programmed death and genotoxic effects. The compound also decreased breast cancer stem cell population and overcame cisplatin's efficacy on multicellular spheroids.

DALTON TRANSACTIONS (2021)

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Article Materials Science, Biomaterials

Self-assembled Au4Cu4/Au25 NCs@liposome tumor nanotheranostics with PT/fluorescence imaging-guided synergetic PTT/PDT

Xinyu Liu et al.

Summary: The study successfully assembled a cancer theranostic nanoplatform with dual-imaging, dual-phototherapy, and laser-responsiveness to tumor microenvironment, which effectively improves treatment outcomes and reduces side effects.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Inorganic & Nuclear

Copper chloride complexes with substituted 4′-phenyl-terpyridine ligands: synthesis, characterization, antiproliferative activities and DNA interactions

Jiahe Li et al.

Summary: In this study, eleven copper chloride coordination compounds were synthesized and their antiproliferative activities against tumor cells and interactions with DNA were investigated. The compounds demonstrated higher antiproliferative activities compared to cisplatin, with compound 6 showing the best anti-proliferation activity. The results suggest that the compounds' ability to form hydrogen bonds plays a key role in their binding with biological macromolecules and exhibiting high antiproliferative activity.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Multidisciplinary

Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles

Hongzhi Qiao et al.

Summary: By constructing ATP-responsive nanoparticles containing CTND and siRNA, the release of which in cancer cells can enhance therapeutic efficacy and terminate resistance of B16F10 melanoma cells to CTND.

CHEMICAL SCIENCE (2021)

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Article Materials Science, Biomaterials

Biodegradable copper-metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H2O2 accumulation

Xiangyu Meng et al.

Summary: This study introduces a novel nanofiber drug carrier that inhibits tumor hypoxia and promotes H2O2 accumulation, achieving chemo/chemodynamic synergistic therapy and significantly suppressing tumor growth. The method also enhances efficacy by increasing ROS accumulation and cutting off energy supply.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Inorganic & Nuclear

NIR-triggered biodegradable MOF-coated upconversion nanoparticles for synergetic chemodynamic/photodynamic therapy with enhanced efficacy

Man Zou et al.

Summary: A new nano-composite UCZRF was designed to release photosensitizer and metal ions specifically in the tumor microenvironment, effectively enhancing the efficiency of ROS generation, and thus strengthening the anti-tumor effects of CDT and PDT.

INORGANIC CHEMISTRY FRONTIERS (2021)

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Article Nanoscience & Nanotechnology

Conjugated Polymer Nanoparticles Based on Copper Coordination for Real-Time Monitoring of pH-Responsive Drug Delivery

Jiatong Li et al.

Summary: Metal coordination-driven composite systems with excellent stability and pH-responsive ability show potential for specific drug delivery in physiological conditions. pH-responsive nanoparticles, PPEIDA-Cu-DOX CPNs, constructed in this study exhibit high drug loading, efficient drug release monitoring, and lower toxicity to normal cells, demonstrating feasibility for cancer treatment.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Inorganic & Nuclear

Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities

Nazanin Kordestani et al.

Summary: The study on the anticancer activity of copper complexes against different tumor cell lines revealed that complexes with a 2-pycolylamine-type motif were more cytotoxic and induced reactive oxygen species. Among the complexes, Cu(Cl-2-L-1)NO3 was identified as the most promising candidate for additional biological applications.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Inorganic & Nuclear

Influence of anchoring moieties on new benzimidazole-based Schiff base copper(ii) complexes towards estrogen dependent breast cancer cells

Anup Paul et al.

Summary: The two newly synthesized copper(II) compounds exhibit significant in vitro cytotoxic effects, particularly showing pronounced inhibitory effects on the proliferation of the breast cancer cell line MCF-7. Through various biological studies, the effective antiproliferative mechanism of compound 1 on breast cancer cells has been confirmed.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Multidisciplinary

CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy

Guilong Zhang et al.

Summary: The nanoplatform enhances mimic-peroxidase activity by self-supplying Cu(I), effectively inhibits tumor growth, and improves MRI contrast performance.

MATERIALS HORIZONS (2021)

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Article Chemistry, Multidisciplinary

Polarity control of DNA adsorption enabling the surface functionalization of CuO nanozymes for targeted tumor therapy

Yingcai Meng et al.

Summary: By functionalizing CuO nanozyme with DNA, targeted delivery and selective tumor destruction were achieved. A specific DNA sequence designed for stable adsorption on the CuO surface allowed passive accumulation into tumor tissue during in vivo circulation, specific recognition of tumor cells, resulting in significant nanocatalytic tumor suppression in tumor xenograft mice models with no noticeable cytotoxicity.

MATERIALS HORIZONS (2021)

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Article Chemistry, Multidisciplinary

A PDA-DTC/Cu-MnO2 nanoplatform for MR imaging and multi-therapy for triple-negative breast cancer treatment

Xiaochun Hu et al.

Summary: A multi-functional nanoplatform (PDA-DTC/Cu-MnO2) was developed for MR imaging-guided multi-therapy (CDT, PTT, and chemotherapy) in cancer treatment. Both in vitro and in vivo results confirmed the biocompatible nanoplatform's ability to significantly induce tumor cell death and inhibit tumor growth.

CHEMICAL COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Tingting Hu et al.

Summary: This study has developed a novel tumor therapy nanoplatform by integrating acid-enhanced photothermal therapy and pH-responsive chemodynamic therapy, which almost eliminates tumor tissue in vivo with low-dose drug injection.

CHEMICAL SCIENCE (2021)

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Article Chemistry, Inorganic & Nuclear

Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action

Diogo Sequeira et al.

Summary: The newly developed Cu(I) complexes show potential in targeting resistant cells, with complex 8 showing high cytotoxic potential against colorectal cancer and low cytotoxicity towards healthy cells. The complexes can induce cell death via an oxidative mechanism, trigger apoptosis and autophagy, and exhibit cytostatic potential. Further exploration using in vivo animal models is recommended.

DALTON TRANSACTIONS (2021)

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Article Materials Science, Biomaterials

NIR-II light triggered nitric oxide release nanoplatform combined chemo-photothermal therapy for overcoming multidrug resistant cancer

Jin Wang et al.

Summary: In this study, a novel nano-drug delivery system was designed to overcome multidrug resistance cancer by releasing nitric oxide, chemotherapeutic drugs, and photothermal therapy, showing superior therapeutic effects and diversified treatment modalities.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

Localized NIR-II photo-immunotherapy through the combination of photothermal ablation and in situ generated interleukin-12 cytokine for efficiently eliminating primary and abscopal tumors

Xinyi Lin et al.

Summary: A novel photothermal agent and gene co-delivery nanoparticle (CSP) has been explored for localized tumor NIR-II PTT and in situ immunotherapy through local generation of IL-12 cytokine, showing great gene transfection efficiency, outstanding NIR-II PTT effect, and excellent therapeutic outcomes. This in situ joint therapy modality significantly induces systemic immune responses to efficiently eliminate possible metastatic lesions, providing a safer and more efficient alternative strategy for future photo-immunotherapy.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu-Al layered double hydroxides

Zhengdi Wang et al.

Summary: This study designed Ce-doped Cu-Al layered double hydroxide (CAC-LDH) nanosheets loaded with indocyanine green (ICG) as a Fenton-catalyst and photothermal agent for synergistic chemodynamic therapy (CDT) and photothermal therapy (PTT) in cancer treatment. The results demonstrated the potential of ICG/CAC-LDH as an integrated agent for dual-modal imaging and synergistic CDT/PTT.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Multidisciplinary

Copper nanoclusters: designed synthesis, structural diversity, and multiplatform applications

Ani Baghdasaryan et al.

Summary: Atomically precise metal nanoclusters have unique molecular-like properties, which offer opportunities for constructing novel nanomaterials with rich absorption, luminescence, and magnetic properties. Copper nanoclusters, in particular, have shown promising applications in catalysis and biomedicine. Despite the discovery of numerous copper nanoclusters with atomic precisions over the past few decades, there are still many unanswered questions and challenges to be addressed.

NANOSCALE (2021)

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Review Materials Science, Biomaterials

State-of-the-art advances of copper-based nanostructures in the enhancement of chemodynamic therapy

Ya-Nan Hao et al.

Summary: Chemodynamic therapy (CDT) is a novel strategy for treating tumors by inducing tumor cell death through the generation of reactive oxygen species (ROS). Copper-based nanostructures have received significant attention for their use in CDT, in conjunction with other therapies such as photothermal therapy, photodynamic therapy, and sonodynamic therapy for synergistic treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Inorganic & Nuclear

Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes

Marlene Mathuber et al.

Summary: The encapsulation of copper (II) complexes of triapine and COTI-2 into liposomes showed promising results in enhancing stability, slow drug release, and reduced cytotoxicity in in vitro and in vivo studies, especially for Cu-triapine. This nanoformulation represents an important step towards increasing the plasma half-life time and tumor targeting properties of anticancer thiosemicarbazones.

DALTON TRANSACTIONS (2021)

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Article Chemistry, Multidisciplinary

In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS-Mediated Anticancer Therapy

Ling Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Boosting H2O2-Guided Chemodynamic Therapy of Cancer by Enhancing Reaction Kinetics through Versatile Biomimetic Fenton Nanocatalysts and the Second Near-Infrared Light Irradiation

Tingting Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy

Xiaoyan Zhong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications

Hendrik Naatz et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition

Bowen Yang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A RuII Polypyridyl Alkyne Complex Based Metal-Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

Xiaochun Hu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

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Review Chemistry, Multidisciplinary

Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy

Anne McMahon et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR-Driven Photothermal Cancer Therapy

Yangziwan Weng et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Fusiform-Like Copper(II)-Based Metal-Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

Zhao Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Near-Infrared Light Dual-Promoted Heterogeneous Copper Nanocatalyst for Highly Efficient Bioorthogonal Chemistry in Vivo

Yawen You et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Engineering a Therapy-Induced Immunogenic Cancer Cell Death Amplifier to Boost Systemic Tumor Elimination

Bei Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Metal-Organic Framework Assisted and Tumor Microenvironment Modulated Synergistic Image-Guided Photo-Chemo Therapy

Yuanbo Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Copper-Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification

Wencheng Wu et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy

Yixin Zhang et al.

CHINESE CHEMICAL LETTERS (2020)

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Review Pharmacology & Pharmacy

The combination of disulfiram and copper for cancer treatment

Hong Li et al.

DRUG DISCOVERY TODAY (2020)

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Article Chemistry, Multidisciplinary

Augmenting Tumor-Starvation Therapy by Cancer Cell Autophagy Inhibition

Bowen Yang et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

Peijing An et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

Haifeng Yuan et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Nanocomposite with Dual Cell-Tissue Penetration for Deep Tumor Chemo-Phototherapy

Xueting Pan et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Yite Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Copper Single-Atom Catalysts for Tumor Parallel Catalytic Therapy

Xiangyu Lu et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H2O2

Rui Cao et al.

CHINESE CHEMICAL LETTERS (2020)

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Review Materials Science, Biomaterials

Recent Advances in Combination of Copper Chalcogenide-Based Photothermal and Reactive Oxygen Species-Related Therapies

Yi Zhao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Materials Science, Multidisciplinary

Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy

Fan Jiang et al.

SCIENCE CHINA-MATERIALS (2020)

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Article Biology

A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy

Lulu Zhou et al.

COMMUNICATIONS BIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Light-Responsive Core-Shell Nanoplatform for Bimodal Imaging-Guided Photothermal Therapy-Primed Cancer Immunotherapy

Wei Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Biodegradable Quantum Composites for Synergistic Photothermal Therapy and Copper-Enhanced Chemotherapy

Han-Xiao Tang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Colorectal Tumor Microenvironment-Activated Bio-Decomposable and Metabolizable Cu2O@CaCO3Nanocomposites for Synergistic Oncotherapy

Mengyu Chang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu2+Nanoassemblies

Shan Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Biodegradable Poly(gamma-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy

Ming Zhang et al.

BIOMATERIALS (2020)

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Article Medicine, Research & Experimental

Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as a Drug Self-Delivery System for Highly Robust and Specific Cancer Therapy

Ying Peng et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Oncology

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

Florida Voli et al.

CANCER RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Phosphorus dendrimer-based copper(II) complexes enable ultrasound-enhanced tumor theranostics

Yu Fan et al.

NANO TODAY (2020)

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Review Chemistry, Inorganic & Nuclear

Copper sulphide based heterogeneous nanoplatforms for multimodal therapy and imaging of cancer: Recent advances and toxicological perspectives

Ajinkya N. Nikam et al.

COORDINATION CHEMISTRY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancerin vivo

Wenmin Zhang et al.

SCIENCE CHINA-CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Haozhe He et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

A Metal-Polymer Hybrid Biomimetic System for use in the Chemodynamic-Enhanced Photothermal Therapy of Cancers

Lingdan Kong et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Smart Porous Core-Shell Cuprous Oxide Nanocatalyst with High Biocompatibility for Acid-Triggered Chemo/Chemodynamic Synergistic Therapy

Hongshuai Wu et al.

SMALL (2020)

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Article Cell Biology

Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26

Chun Jin et al.

CELL DEATH & DISEASE (2020)

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Review Chemistry, Multidisciplinary

The Coppery Age: Copper (Cu)-Involved Nanotheranostics

Caihong Dong et al.

ADVANCED SCIENCE (2020)

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Review Oncology

The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

Pierre Lelievre et al.

CANCERS (2020)

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Article Nanoscience & Nanotechnology

Endogenous H2S-Activable Liposomal Nanoplatform for Synergistic Colorectal Tumor Ablation at Mild Apparent Temperature

Jingyan Sun et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Copper-Chalcogenide-Based Multimodal Nanotheranostics

Hao Zhang et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

An Intelligent Biomimetic Nanoplatform for Holistic Treatment of Metastatic Triple-Negative Breast Cancer via Photothermal Ablation and Immune Remodeling

Yuanyuan Cheng et al.

ACS NANO (2020)

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Article Materials Science, Biomaterials

A porous material excited by near-infrared light for photo/chemodynamic and photothermal dual-mode combination therapy

Mingdi Sun et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Inorganic & Nuclear

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

Eva A. Enyedy et al.

DALTON TRANSACTIONS (2020)

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Article Medicine, Research & Experimental

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Beibei Shan et al.

THERANOSTICS (2020)

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Article Chemistry, Multidisciplinary

Therapeutic iminoboronate-based polymersomes with a Cu(ii)-mediated Fenton reaction-enhanced ROS-response

Ruidong Cheng et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Inorganic & Nuclear

New copper(i) complexes selective for prostate cancer cells

Joao Franco Machado et al.

DALTON TRANSACTIONS (2020)

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Article Engineering, Biomedical

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Kai Zhang et al.

BIOMATERIALS (2020)

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Article Chemistry, Inorganic & Nuclear

Cu(II)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis

Ming Liu et al.

DALTON TRANSACTIONS (2020)

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Article Chemistry, Multidisciplinary

A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy

Hongshuai Wu et al.

NANOSCALE (2020)

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Article Chemistry, Inorganic & Nuclear

Two novel chiral tetranucleate copper-based complexes: crystal structures, nanoparticles, and inhibiting angiogenesis and the growth of human breast cancer by regulating the VEGF/VEGFR2 signal pathway in vitro

Pei-Lu Zhang et al.

DALTON TRANSACTIONS (2020)

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Article Chemistry, Inorganic & Nuclear

Adipato bridged novel hexanuclear Cu(II) and polymeric Co(II) coordination compounds involving cooperative supramolecular assemblies and encapsulated guest water clusters in a square grid host: antiproliferative evaluation and theoretical studies

Hiren Nath et al.

DALTON TRANSACTIONS (2020)

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Article Chemistry, Inorganic & Nuclear

Thiosemicarbazone(s)-anchored water soluble mono- and bimetallic Cu(ii) complexes: enzyme-like activities, biomolecular interactions, anticancer property and real-time live cytotoxicity

Nithya Balakrishnan et al.

DALTON TRANSACTIONS (2020)

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Article Chemistry, Multidisciplinary

An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(ii) complex, leading to prompt cell apoptosis via photoactivation of a prodrug

Amrita Chaudhuri et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Materials Science, Biomaterials

Post-synthesis strategy to integrate porphyrinic metal-organic frameworks with CuS NPs for synergistic enhanced photo-therapy

Xiaochun Hu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

N-Oxide polymer-cupric ion nanogels potentiate disulfiram for cancer therapy

Yin Zhong et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Inorganic & Nuclear

Homo- and heteroleptic trimethoxy terpyridine-Cu(ii) complexes: synthesis, characterization, DNA/BSA binding, DNA cleavage and cytotoxicity studies

Surbhi Jain et al.

DALTON TRANSACTIONS (2020)

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Article Chemistry, Inorganic & Nuclear

Octahedral copper(II)-diimine complexes of triethylenetetramine: effect of stereochemical fluxionality and ligand hydrophobicity on CuII/CuI redox, DNA binding and cleavage, cytotoxicity and apoptosis-inducing ability

Mitu Sharma et al.

DALTON TRANSACTIONS (2020)

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Article Materials Science, Biomaterials

Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

Lina Gao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Materials Science, Biomaterials

Synthesis, modification and bioapplications of nanoscale copper chalcogenides

Baofeng Yun et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Medicine, Research & Experimental

Tumor reoxygenation for enhanced combination of radiation therapy and microwave thermal therapy using oxygen generation in situ by CuO nanosuperparticles under microwave irradiation

Zengzhen Chen et al.

THERANOSTICS (2020)

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Article Materials Science, Biomaterials

Tumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy

Wentao Wan et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

Oxyhemoglobin nano-recruiter preparation and its application in biomimetic red blood cells to relieve tumor hypoxia and enhance photodynamic therapy activity

Xianqing Shi et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Medicine, Research & Experimental

Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Peng Mi

THERANOSTICS (2020)

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Article Chemistry, Multidisciplinary

A Biocompatible Heterogeneous MOF-Cu Catalyst for In Vivo Drug Synthesis in Targeted Subcellular Organelles

Faming Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Engineering, Biomedical

Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer

Ping Zhou et al.

BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis

Yu Fan et al.

NANO LETTERS (2019)

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Article Nanoscience & Nanotechnology

Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity

Tingting Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy

Chao Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Inorganic & Nuclear

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Copper(II) complexes of functionalized 2,2′:6′,2-terpyridines and 2,6-di(thiazol-2-yl)pyridine: structure, spectroscopy, cytotoxicity and catalytic activity

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Novel mitochondria targeted copper(II) complexes of ferrocenyl terpyridine and anticancer active 8-hydroxyquinolines showing remarkable cytotoxicity, DNA and protein binding affinity

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Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2-xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

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Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G-Quadruplex Telomeric DNA by an Anticancer Copper-Acridine-ATCUN Complex

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Copper induces cellular senescence in human glioblastoma multiforme cells through downregulation of Bmi-1

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Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay

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