☆ 4.8 Review

Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Engineering, Biomedical

An oral ratiometric NIR-II fluorescent probe for reliable monitoring of gastrointestinal diseases in vivo

Tuanwei Li et al.

Summary: This study presents a single-component NIR-II ratiometric molecular nanoprobe (LC-1250 NP) for early monitoring of gastrointestinal diseases via oral administration. LC-1250 NP shows stable fluorescence in the 1250 nm long-pass channel before and after disease detection, but exhibits enhanced fluorescence in the 1150 nm short-pass channel in the diseased gastrointestinal environment due to the activation of LC-1250 molecules by H2O2. The ratio of fluorescence signals (F1150SP/F1250LP) linearly increases with the concentration of H2O2, providing accurate mapping of the diseased areas and reliable evaluation for the progress of gastroenteritis.

BIOMATERIALS (2023)

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Review Chemistry, Inorganic & Nuclear

Engineering of BODIPY-based theranostics for cancer therapy

Zhiqiang Mao et al.

Summary: In recent years, BODIPY-based theranostics have been increasingly utilized in cancer therapy with remarkable success. By modifying the chemical structure, the optical imaging and phototherapy properties of BODIPY-based dyes can be well-balanced and tailored. Additionally, molecular/nanoparticle engineering allows versatile functionalities and improved tumor-targeting ability, enhancing the therapeutic efficacy and minimizing side effects. This review focuses on the applications of BODIPY-based theranostics in tumor therapy, including fluorescence-guided chemotherapy, photodynamic therapy, photothermal therapy, and multi-modal imaging-guided therapies.

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Chemistry, Analytical

Revealing the Phase Separation in ER Membranes of Living Cells and Tissues by In Situ NIR Ratiometric Imaging

Minggang Tian et al.

Summary: Studying the phase separation of ER membranes is crucial for understanding the fundamental biology of ER. However, NIR ratiometric imaging of ER phase behaviors has not been explored in living cells and diverse tissues. In this study, we developed a polarity-responsive NIR fluorescent probe to visualize the phase behavior in ER membranes and revealed different phase behaviors in different tissues.

ANALYTICAL CHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

The Chemistry of Organic Contrast Agents in the NIR-II Window

Jing Mu et al.

Summary: Optical imaging is a non-invasive method with high resolution and sensitivity. Researchers have focused on developing contrast agents with near-infrared absorption or emission to improve imaging quality. This review summarizes recent advances in organic luminescent and photoacoustic materials and discusses their imaging performance and potential applications.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Biomedical

Advanced NIR ratiometric probes for intravital biomedical imaging

Haoying Huang et al.

Summary: Near-infrared (NIR) fluorescence imaging technology has been extensively used in biomedical imaging, with recently developed ratiometric fluorescent probes providing more accurate detection feedback. These probes can be applied in various fields in vivo biological imaging, such as molecular detection, pH and temperature measurement, drug delivery monitoring and treatment evaluation.

BIOMEDICAL MATERIALS (2022)

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Article Biochemistry & Molecular Biology

A near-infrared, colorimetric and ratiometric fluorescent sensor with high sensitivity to hydrogen peroxide and viscosity for solutions detection and imaging living cells

Daili Liu et al.

Summary: NCR is a near-infrared fluorescent sensor capable of detecting H2O2 and viscosity with high sensitivity. It has the potential to be a practical tool for monitoring H2O2 level in biological processes, and has been successfully used to detect exogenous and endogenous H2O2 in living cells.

BIOORGANIC CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Esterases as emerging biocatalysts: Mechanistic insights, genomic and metagenomic, immobilization, and biotechnological applications

Hamza Rafeeq et al.

Summary: Esterase enzymes play a significant role in the industrial enzymes market and have diverse applications in various sectors. Utilizing genomic techniques, researchers extract and utilize esterases for their beneficial activities.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

Activatable fluorescent probes for in situ imaging of enzymes

Xiaofeng Wu et al.

Summary: This article summarizes the methods for in situ imaging of enzymes using activatable fluorescent probes, and proposes that fluorescent probes with both activatable and in situ properties will facilitate high-resolution studies of enzymes in living systems.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Inorganic & Nuclear

Recent advances in multifunctional fluorescent probes for viscosity and analytes

Xiaopeng Yang et al.

Summary: Viscosity plays a crucial role in biological systems and its abnormality is closely related to the development of diseases in cellular microenvironment. Fluorescence imaging, with its excellent sensitivity, non-invasive detection, high selectivity and real-time imaging, has become a powerful tool for monitoring local microviscosity and analytes changes in living cells. This review focuses on the design strategies, spectral performance, and biological applications of multifunctional probes for simultaneous detection of viscosity and analytes, and proposes new ideas to overcome the limitations of existing probes.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Chemistry, Inorganic & Nuclear

Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Ji-Ting Hou et al.

Summary: Hypochlorous acid is an endogenously produced reactive oxygen species that plays a crucial role in various diseases. Sulfur-based fluorescent probes for HOCl have shown excellent performance in terms of rapid reaction rate, high selectivity, and sensitivity, which are essential for better understanding the role of HOCl in chemical biology.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Chemistry, Applied

An ESIPT-based NIR-emitting ratiometric fluorescent probe for monitoring hydrogen peroxide in living cells and zebrafish

Miao Chen et al.

Summary: HBQ-B is a NIR-emitting ratiometric fluorescent probe designed to detect H2O2 with specificity and a linear relationship. It can be used for imaging intracellular H2O2 in various types of cells and monitoring the dynamics of H2O2 level changes during zebrafish development.

DYES AND PIGMENTS (2022)

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Article Cell Biology

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Helmut Sies et al.

Summary: This article discusses the key issues associated with identifying the physiological roles of oxidants, with a focus on H2O2 and O-2(.-). The article emphasizes the need for more precise measurement of oxidants and specific identification of their signaling targets. It also highlights the importance of inter-organellar communication and the contribution of environmental exposures. Development of tools for real-time detection and quantification of individual oxidants is crucial for achieving these goals.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Article Chemistry, Analytical

Smart dual-response probe reveals an increase of GSH level and viscosity in Cisplatin-induced apoptosis and provides dual-channel imaging for tumor

Shumin Feng et al.

Summary: In this study, a dual-responsive fluorescence probe MGV was developed for simultaneous detection of mitochondrial GSH and viscosity. MGV showed a selective ratiometric response to GSH and distinct fluorescence enhancement as viscosity increases. The probe exhibited low cytotoxicity and good mitochondrial-targeting ability, and was successfully applied for dual-channel imaging of cancer cells/tumors. This work provides new insights and methods for apoptosis and tumor imaging.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Constructing a NIR fluorescent probe for ratiometric imaging viscosity in mice and detecting blood viscosity in folliculitis mice and peritonitis mice

Linlin Zhu et al.

Summary: By designing and synthesizing a new fluorescent probe NileTPE, the study achieved viscosity ratiometric imaging in vitro, ratiometric imaging viscosity in mice for the first time, and detection of blood viscosity in mice with peritonitis and folliculitis. Importantly, this effective method only requires 10 μL of blood, providing a more accurate tool for non-invasive diagnosis of viscosity-related diseases.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

A quinoline-coumarin near-infrared ratiometric fluorescent probe for detection of sulfur dioxide derivatives

Feng-Ting Liu et al.

Summary: Sulfur dioxide derivatives are crucial in various applications such as food preservation, antibacterial properties, and antioxidants. This study presents the development of a new near-infrared fluorescence probe, CQC, for detecting SO2 derivatives. The probe has a large Stokes shift, high energy transfer efficiency, and high sensitivity towards HSO3- /SO32- detection.

ANALYTICA CHIMICA ACTA (2022)

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Article Oncology

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Activating the Keap1-Nrf2 antioxidant program promotes migration, invasion, metastasis, and metabolic stress resistance in PDAC. The cystine transporter SLC7A11 is identified as a druggable target downstream of the MCU-Nrf2 axis.

CANCER RESEARCH (2022)

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Article Chemistry, Applied

Engineering an ESIPT-based fluorescent probe for dual-channel (Vis/NIR) ratiometric monitoring of intracellular sulfur dioxide by single wavelength excitation

Haixian Ren et al.

Summary: ESIPT-based probes with dual emission and large stokes shift can quantify analytes through dual channel imaging without the need for two lasers. This study successfully developed a near-infrared SO2 probe based on the ESIPT mechanism, which can ratiometrically visualize SO2 levels in water and cells under 460 nm excitation.

DYES AND PIGMENTS (2022)

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Article Chemistry, Multidisciplinary

Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology

Haoying Huang et al.

Summary: This study demonstrates the precise detection of all-phases peripheral vascular disease (PVD) using a novel multiplexed NIR-II fluorescence imaging technology. The imaging method provides high-resolution functional and morphological analysis and accurately grades PVD with multi-parameter molecular detection, which can be used for preventive measures against diabetic foot ulcer.

NANO TODAY (2022)

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Review Chemistry, Multidisciplinary

Activated supramolecular nano-agents: From diagnosis to imaging-guided tumor treatment

Jingjing Han et al.

Summary: This review discusses the application of supramolecular well-ordered nanomaterials in phototherapy, focusing on how to overcome the limitations of phototherapy through improved fabrication of photosensitizers, modulation of environmental conditions, and enhancement of depth penetration. By gaining a better understanding of the programmed activated mechanism of supramolecular assembly, it is possible to develop simpler and more environmentally friendly strategies for targeted tumor therapy and improve clinical treatment outcomes.

NANO TODAY (2022)

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Article Chemistry, Analytical

A unique probe enables labeling cell membrane and Golgi apparatus and tracking peroxynitrite in Golgi oxidative stress and drug-induced liver injury

Shumin Feng et al.

Summary: This study reports a Golgi-targetable fluorescence probe for the detection of peroxynitrite. The probe exhibits low cytotoxicity, high sensitivity and selectivity, and displays unique targeting properties in living cells. The probe can be used to monitor peroxynitrite in the Golgi and evaluate drug-induced liver injury.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Ratiometric detection and bioimaging of endogenous alkaline phosphatase by a NIR fluorescence probe

Yu-An Feng et al.

Summary: The newly designed NIR fluorescent probe SWJT-3 is capable of ratiometric determination of alkaline phosphatase (ALP) and can be used for both in vitro and in vivo detection. It is the first NIR and ratiometric fluorescent probe for imaging ALP in mice, with a large Stokes shift and low detection limit.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

A near-infrared fluorescent probe for ratiometric imaging peroxynitrite in Parkinson's disease modelY

Hao Kang et al.

Summary: Parkinson's disease is a common neurodegenerative disease that causes great pain and economic burden. Peroxynitrite (ONOO-) plays a significant role in the development of Parkinson's disease, but effective detection methods are currently lacking. This study design a highly sensitive and selective near-infrared ratiometric fluorescent probe to track ONOO- and successfully observe its changes in a Parkinson's disease model.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Multidisciplinary

Cardiolipin-Targeted NIR-II Fluorophore Causes ?Avalanche Effects? for Re-Engaging Cancer Apoptosis and Inhibiting Metastasis

Hui Bian et al.

Summary: A designed dye DUT850 has shown potential for targeted chemo-phototheranostic application. By specifically recognizing and binding to cardiolipin, DUT850 induces physiological disruptions that inhibit tumor metastasis and activate cancer cell apoptosis. This work offers a promising approach for cancer therapy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Biophysics

NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications

Chonglu Li et al.

Summary: Due to their low toxicity, high synthetic repeatability, and simplicity of chemical modification, organic NIR-II fluorophores with a small-molecule framework have become the most attractive candidates for clinical translation. However, there are still many challenges that need to be addressed before they can be used in clinical settings, despite the wide usage of NIR-II fluorescence imaging technology in basic scientific research and preclinical practice throughout the past decade.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Agriculture, Multidisciplinary

Rational Construction of a Two-Photon NIR Ratiometric Fluorescent Probe for the Detection of Bisulfite in Live Cells, Tissues, and Foods

Jingcan Qin et al.

Summary: In this study, a novel ratiometric fluorescent probe based on a D-pi-A-A structure was developed. The probe displayed good selectivity and high sensitivity towards bisulfite in aqueous solution. It exhibited excellent two-photon fluorescence properties and was successfully used for fluorescence imaging of bisulfite in MCF-7 cells and rat liver tissues. Furthermore, the probe showed potential for practical application in measuring bisulfite content in real food samples.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Chemistry, Analytical

Real-time screening of hydrazine by a NIR fluorescent probe with low cytotoxicity in living cells and its multiple applications: Optimization using Box-Behnken Design

Serkan Erdemir et al.

Summary: This research reports a new fluorescence and colorimetric sensing method for detecting N2H4 with high selectivity and low cytotoxicity, and it can visualize the distribution of N2H4 in cells. In addition, several practical applications have been successfully established.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

H-aggregation of heptamethine cyanine dye induced by Smiles rearrangement for fluorescence sensing of biological species: A near-infrared ratiometric fluorescent assay for esterase

Jiajia Li et al.

Summary: This study developed a novel near-infrared probe Cy-NE based on heptamethine cyanine dyes for esterase detection. The probe exhibited a large fluorescence change upon sensing procedure, which allowed for accurate detection of esterase activity in cells and animals.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Fe2+ imaging in ferroptosis and drug-induced liver injury with a ratiometric near-infrared fluorescent probe

Shumin Feng et al.

Summary: Recently, the detection of ferrous ion (Fe2+) in live organisms has gained significant attention due to its vital role in life and its association with ferroptosis and several diseases. In this study, a novel NIR ratiometric fluorescent probe NRF-Fe2+ based on a fluorescence resonance energy transfer (FRET) system using the N-oxide chemistry is reported. The probe exhibits high selectivity and sensitivity for Fe2+ with significant ratiometric fluorescence changes, making it suitable for imaging both exogenous and endogenous Fe2+ in cells with low cytotoxicity. The probe is also successfully applied for imaging Fe2+ in mice and monitoring the level changes of Fe2+ in ferroptosis and drug-induced liver injury.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Spectroscopy

Rational design of a FRET-based ratiometric fluorescent probe with large Pseudo-Stokes shift for detecting Hg2+ in living cells based on rhodamine and anthracene fluorophores

Qian Zhang et al.

Summary: In this study, a novel fluorescent probe 1 based on rhodamine and anthracene groups was designed and synthesized for the selective, sensitive, and ratiometric detection of Hg2+ using the FRET mechanism. The probe exhibited a fast response time and a visible color change, and it was successfully used for cell imaging of Hg2+ detection. The mechanism of Hg2+ detection by probe 1 was verified through various experimental techniques.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Pharmacology & Pharmacy

An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Molecule Reveals Zn2+ Micro-Dynamics During Drug-Induced Organelle Ionic Disorder

Hongbao Fang et al.

Summary: Researchers designed and synthesized a ratiometric fluorescent probe for detecting zinc ions under endoplasmic reticulum (ER) stress. The probe allows for quantitative and reversible detection of exogenous zinc ions, as well as observation of zinc ion level changes under ER stress. It also has near-infrared imaging capability, providing a basis for further animal model research and potential visualization and treatment of ER stress-related diseases through zinc ion regulation.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Analytical

An effective benzothiazole-indandione D-p-A fluorescent sensor for ratiometric detection of hydrazine: Its solvatochromism properties and applications in environmental samples and living cells

Mehmet Oguz et al.

Summary: This article introduces a ratiometric fluorescent probe based on the ICT mechanism for detecting hydrazine. The probe exhibits high sensitivity and selectivity, with the ability to detect hydrazine within approximately 2.0 minutes. Additionally, the probe demonstrates solvatochromism, indicating a high sensitivity to medium polarity. By constructing a portable smartphone platform, the probe is successfully applied to water samples, bioimaging, and environmental monitoring, suggesting significant potential applications.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Analytical

Rational Design of a Near-Infrared Ratiometric Probe with a Large Stokes Shift: Visualization of Polarity Abnormalities in Non-Alcoholic Fatty Liver Model Mice

Yaogeng Ma et al.

Summary: Tracking liver polarity using noninvasive and dynamic imaging techniques is crucial for understanding non-alcoholic fatty liver (NAFL). A novel near-infrared fluorescent probe called Cy-Mp was developed, which emits at NIR wavelengths with high photostability and a large Stokes shift. Cy-Mp exhibits a ratiometric response to polarity, enabling accurate analysis of intracellular polarity. In vivo studies demonstrated that Cy-Mp can accumulate in the liver and diagnose NAFL by detecting decreased polarity.

ANALYTICAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

A highly selective probe for ratiometric imaging peroxynitrite in living cells and in vivo

Jia-Qi Xu et al.

Summary: In this study, a ratiometric fluorescent probe JQ-2 was developed for detecting ONOO-. JQ-2 showed a rapid response and high selectivity, and could emit signals in two channels for visualizing ONOO- in vitro and vivo.

BIOORGANIC CHEMISTRY (2022)

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Review Chemistry, Inorganic & Nuclear

Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Xinyu Liu et al.

Summary: Near-infrared fluorescence imaging has gained attention in biomedical research due to its high sensitivity and specificity. Near-infrared II (NIR-II) fluorescence imaging further enhances the imaging effect by reducing tissue absorption, scattering, and autofluorescence. Organic small molecule fluorophores have shown promising potential as fluorescent probes. This review summarizes the latest progress in organic small molecule fluorescent probes for NIR-II imaging, including molecular structure, performance improvement methods, probe delivery in organisms, and their applications in biological imaging and tumor therapy.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Reactive sulfur and selenium species in the regulation of bone homeostasis

Annie K. Gilbert et al.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Environmental Sciences

Design of a ratiometric near-infrared fluorescent probe with double excitation for hydrazine detection in vitro and in vivo

Tengteng Zhang et al.

Summary: A new near-infrared ratiometric fluorescent probe (Ac-HY) was designed for rapid and sensitive detection of hydrazine. The probe exhibited high selectivity and sensitivity, making it suitable for various applications in environmental sciences and biological systems.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Chemistry, Analytical

Mitochondria targeted and immobilized ratiometric NIR fluorescent probe for investigating SO2 phytotoxicity in plant mitochondria

Xiaodong Chen et al.

Summary: We developed a novel ratiometric NIR fluorescent probe for highly sensitive and selective detection of SO2 derivatives in plant mitochondria. The probe can not only target into the mitochondria but also immobilize in the mitochondria to continue detecting SO2 derivatives even when the mitochondrial membrane potential is collapsed by high concentration of SO2 derivatives. It has been successfully used to monitor high concentration of SO2 derivatives in the plant mitochondria when the plant is suffering from SO2 phytotoxicity, indicating that the interaction of SO2 derivatives with plant mitochondria could be an important mechanism for SO2 phytotoxicity.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Water-soluble improved NIR ratiometric fluorescent probe for specific imaging sulfur dioxide in cancer cell membranes and living mice

Tao Liu et al.

Summary: The comprehensive understanding of the mechanism between gas messenger molecules and cell membrane microenvironment is important for basic biology research. In this study, a ratiometric probe CMCB based on coumarin and indole sulfonate platform was designed and synthesized, which showed good targeting and near-infrared emission on cell membranes. The probe exhibited low detection limit, high selectivity, and specificity for targeting cell membranes.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Spectroscopy

Selective visualization of cyanide in food, living cells and zebrafish by a mitochondria targeted NIR-emitting fluorescent probe

Zhenming Dong et al.

Summary: In this study, a mitochondria-targeted near-infrared fluorescent probe BTC was designed for ratiometric monitoring of cyanide in the environment and food samples. BTC exhibited high selectivity and low detection limit for cyanide, and was capable of naked-eye colorimetric detection. Furthermore, BTC enabled real-time tracking and imaging of cyanide in the mitochondria of cells and zebrafish.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

Fast and sensitive near-infrared ratiometric fluorescent probe with a self-immolative spacer for imaging of endogenous alkaline phosphatase activity in cells and in vivo

Lin Wang et al.

Summary: A novel near-infrared ratiometric fluorescent probe was designed for capturing ALP activity, featuring fast response, good water solubility, large Stokes shift, and low detection limit. The probe was successfully applied to monitor variations in endogenous ALP activity in zebrafish.

TALANTA (2022)

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Article Multidisciplinary Sciences

Orthogonally-tunable and ER-targeting fluorophores detect avian influenza virus early infection

Taewon Kang et al.

Summary: In this study, a stress-responsive molecular probe was developed for fast detection of avian influenza virus infection at the single-cell level.

NATURE COMMUNICATIONS (2022)

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Review Chemistry, Inorganic & Nuclear

Aggregation-induced emission fluorophores towards the second near- infrared optical windows with suppressed imaging background

Jun Qian et al.

Summary: This review discusses the use of fluorescence bioimaging in the second near-infrared (NIR-II) region to visualize deep bioinformation in real time with high sensitivity. The focus is on the design of AIE molecules with ultra-bright NIR-IIa or NIR-IIb emission and their applications in bioimaging. The review also highlights the development prospects and current challenges in this field.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Chemistry, Inorganic & Nuclear

Mitochondria-targeted smart AIEgens: Imaging and therapeutics

Haidong Li et al.

Summary: Mitochondria, as the main energy source of cells, play important roles in the regulation of physiology and diseases. Aggregation-induced emission luminogens (AIEgens) have become a research hotspot due to their unique properties, and can be used to dynamically monitor mitochondrial behaviors and effectively kill tumors through regulating cell death pathways. This review provides systematic information on the working mechanism of aggregation-induced emission, design principles of mitochondria-targeted AIEgens, examples of AIEgens for imaging and detecting bio-species in mitochondria, and their biomedical applications.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Hui Li et al.

Summary: Near-infrared (NIR) fluorophores have great potential in tumor imaging and therapy, but non-targeting dyes suffer from low selectivity. Therefore, extensive research efforts have been devoted to developing NIR fluorophores that specifically target tumors, resulting in significant progress.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Materials Science, Multidisciplinary

A novel windmill-shaped AIE-active pyrrolopyrrole cyanine: design, synthesis and efficient hydrazine detection

Lingyun Wang et al.

Summary: In this study, we developed a windmill-shaped pyrrolopyrrole cyanine dye (PPCy-TBE) with aggregation-induced emission (AIE) characteristics, which exhibited highly sensitive and selective detection of hydrazine. The dye also showed extended absorption and emission maxima in the near-infrared region. The detection mechanism involved acrylonitrile cleavage and B-N bond cleavage by hydrazine, resulting in smaller conjugated molecules. The PPCy-TBE-loaded film was capable of detecting hydrazine gas in a colorimetric and ratiometric fluorescence turn on mode.

JOURNAL OF MATERIALS CHEMISTRY C (2022)

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Review Chemistry, Multidisciplinary

Recent advances in small-molecule fluorescent probes for studying ferroptosis

Ya-Lin Qi et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death involved in the development and progression of various diseases. Small-molecule fluorescent probes have been used to study ferroptosis by tracking biomolecules or microenvironment-related parameters in vitro and in vivo.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Materials Science, Biomaterials

Rational engineering of biomimetic flavylium fluorophores for regulating the lysosomal and mitochondrial localization behavior by pH-induced structure switch and application to fluorescence imaging

Liping Wang et al.

Summary: This study proposed a pH-induced structure switch strategy for regulating the localization behavior of fluorescent probes in lysosomes and mitochondria. A series of cationic flavylium derivatives with tunable structure switch ability were synthesized. The results showed that the localization behavior of the dyes was closely related to their structure switch ability, providing a feasible strategy for lysosomal and mitochondrial targeting.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

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Review Chemistry, Multidisciplinary

Fluorine-18 Radiolabelling and Photophysical Characteristics of Multimodal PET-Fluorescence Molecular Probes

Mitchell A. Klenner et al.

Summary: PET-fluorescence imaging is an emerging field that combines positron emission tomography and fluorescence imaging techniques, utilizing probes containing fluorophores and radioisotopes to provide complementary information. Different fluorine-18 labelled PET-fluorescence probes have been classified into four groups based on the implemented fluorophore, with a systematic comparison of their properties to aid future endeavors in PET-fluorescence chemistry.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Review Chemistry, Multidisciplinary

The Path to Controlled Delivery of Reactive Sulfur Species

Xiang Ni et al.

Summary: Reactive sulfur species (RSS) play regulatory roles in many physiological and pathological processes, and efforts have been made to develop unique RSS releasing compounds or in situ RSS generation systems to overcome technical difficulties in studying these RSS. The research group developed a series of novel H2S donors by exploring stable molecular entities triggered by biologically relevant factors, which led to the discovery of new RSS donors for biological applications.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging

Dan Cheng et al.

Summary: Drug-induced acute liver injury (DIALI) is a significant challenge, and molecular optical probes are considered potent tools for its detection. Existing challenges include signal errors and limitations in clinical applications.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Article Chemistry, Analytical

Construction of NIR and Ratiometric Fluorescent Probe for Monitoring Carbon Monoxide under Oxidative Stress in Zebrafish

Wen-Li Jiang et al.

Summary: A ratiometric near-infrared fluorescent probe CP-CO based on a coumarin-benzopyran fluorophore for imaging CO was developed with high sensitivity and enhancement ratio. The probe was successfully applied for ratiometric monitoring of cellular endogenous and exogenous CO levels, as well as fluorescence imaging in zebrafish using two-photon excitation.Moreover, CP-CO visualized the upregulation of CO under lipopolysaccharide-induced oxidative stress in a zebrafish model, showcasing its excellent ability in elucidating CO function in related biological events.

ANALYTICAL CHEMISTRY (2021)

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Review Chemistry, Inorganic & Nuclear

Recent advances in reaction-based fluorescent probes for the detection of central nervous system-related pathologies in vivo

Ya-Lin Qi et al.

Summary: Imaging biomarkers related to CNS is crucial for studying mental illnesses, with fluorescence imaging being considered as an effective and non-invasive tracking tool. In recent years, an increasing number of fluorescent probes have been proposed for tracking molecules in CNS, providing new possibilities for future medical research.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Chemistry, Applied

Synthesis of a NIR fluorescent dye and its application for rapid detection of HSO3- in living cells

Qiang Zhang et al.

Summary: BAOA, a novel fluorescent probe, was designed for rapid and sensitive detection of HSO3- in both industrial and biological settings. It also demonstrated targeting capabilities within cells.

DYES AND PIGMENTS (2021)

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Article Chemistry, Inorganic & Nuclear

Tracking Labile Copper Fluctuation In Vivo/Ex Vivo: Design and Application of a Ratiometric Near-Infrared Fluorophore Derived from 4-Aminostyrene-Conjugated Boron Dipyrromethene

Hongxia Xu et al.

Summary: A novel ratiometric sensor, BDPS1, was developed to detect labile copper fluctuations in animals, showing an effective design rationale for NIR ratiometric sensors for copper tracking in vivo/ex vivo. The use of BDPS1 allowed for tracking of copper changes in mice and revealed distinct labile copper increases in different organs following injection of the therapeutic agent CUTX-101.

INORGANIC CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells

Hongbao Fang et al.

Summary: The study introduced a new method (Zn-STIMO) for tracking zinc ions in multiple organelles using structured illumination microscopy and a single zinc ion fluorescent probe. By developing a new zinc ion fluorescent probe and combining it with SIM imaging technology, the study successfully achieved morphology-correlated organelle identification in living cells.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

A Study on Hypoxia Susceptibility of Organ Tissues by Fluorescence Imaging with a Ratiometric Nitroreductase Probe

Sourav Sarkar et al.

Summary: This study investigated the hypoxia susceptibility of different organ tissues by detecting nitroreductase, finding that the kidney was notably susceptible to hypoxia due to the renal medulla. The probe used in the study features practical properties for studying nitroreductase activity and hypoxia-associated biological processes.

ACS SENSORS (2021)

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Article Oncology

In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification

Jinghang Xie et al.

Summary: Prostate cancer is a common malignancy with limited tools for prognostic risk stratification. This study identified MetAP2 as a potential early-risk stratifier and developed a novel MetAP2-activated PET imaging tracer for monitoring MetAP2 activity in vivo, which may offer new opportunities for noninvasive risk assessment and therapeutic monitoring in prostate cancer patients.

CANCER RESEARCH (2021)

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Review Engineering, Environmental

Fluorescent probe for mercury ion imaging analysis: Strategies and applications

Yue Wang et al.

Summary: This article reviews recent advances in fluorescent probes for Hg2+ analysis, focusing on different response modes and design strategies, highlighting their applications in environmental detection and in vivo analysis. Challenges and prospects for fluorescent probes are proposed to guide new design strategies and applications expansion in the future.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Analytical

Near-infrared ratiometric fluorescence imaging of lysosomal polarity in live cells and in vivo

Xijuan Chao et al.

Summary: Changes in lysosomal polarity are important indicators of cell status in physiological and pathological processes, and can be used as markers for cancer detection. The DCM-ML probe is highly sensitive to polarity, making it a potential tool for cancer cell diagnosis and real-time monitoring of cell and zebrafish processes. Its development could contribute to research on lysosome-related physiological and pathological processes.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

A near-infrared ratiometric fluorescent probe for selectively tracking human cytochrome P450 3A5 in living cells and tumor-bearing mice

Hefang Ji et al.

Summary: Two novel enzyme-activatable near-infrared ratiometric fluorescent probes, Hcy-Br and Hcy-Cl, were designed and synthesized to measure the activity of CYP3A5 in complex biological systems. These probes were successfully used to monitor endogenous CYP3A5 activity in living cells and tumor-bearing mice, representing a potential tool for investigating the function of CYP3A5 in drug metabolism and pathologic processes.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

Xiao Liu et al.

Summary: A new dual-stimulus responsive near-infrared reversible ATP-pH probe has been developed for fluorescence and photoacoustic ratiometric imaging of tumors, effectively reducing cumulative response after intravenous injection and suitable for in vivo imaging.

ANALYTICAL CHEMISTRY (2021)

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Article Electrochemistry

Rational Design of A NIR Ratiometric Fluorescent Probe with Large Stokes Shift for Sulfite Detection

Yali Cui et al.

Summary: Sulfite (SO3 (2-)), as an important reactive sulfur in the food industry and various physiological processes, requires an effective detection method. Inspired by the effect of electron-donating or electron-withdrawing groups on fluorescence emission spectrum shift, this study designed and synthesized cyanine-based fluorescent probes BBHy and NBHy. NBHy, with large Stokes shift and fluorescence intensity change in the presence of SO3 (2-), showed superior recoveries for SO3 (2-) detection in food samples and living cells through dual-channel fluorescence imaging, confirming the feasibility of the probe design.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2021)

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Article Biochemistry & Molecular Biology

Ratiometric Near-Infrared Fluorescent Probes Based on Hemicyanine Dyes Bearing Dithioacetal and Formal Residues for pH Detection in Mitochondria

Yunnan Yan et al.

Summary: Ratiometric near-infrared fluorescent probes (AH(+) and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The probes display ratiometric fluorescent responses to pH changes through the protonation and deprotonation of a hydroxy group in hemicyanine dyes, with experimentally determined pKa values.

MOLECULES (2021)

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Article Chemistry, Analytical

Ratiometric and reversible detection of endogenous SO2 and HCHO in living cells and mice by a near-infrared and dual-emission fluorescent probe

Mengzhao Wang et al.

Summary: A novel NIR dual-emission fluorescent probe (BCou-BP) was developed for the detection of SO2 and FA with ratiometric detection ability and fast response time. The probe successfully visualized the dynamic change of endogenous mitochondrial SO2 and FA in living cells and mice. Endogenous FA could restore the fluorescence at 694 nm of BCou-BP due to the capture of SO2 from decomposition of the adduct BCou-BP-SO3H.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

A novel 100% aqueous solution near-infrared ratiometric fluorescent CN-probe based on 1,4-dihydropyridines, with a large fluorescent emission peak shift

Longqi Xue et al.

Summary: A fluorescent probe based on 1,4-dihydropyridines was designed and synthesized in this experiment to detect CN-. The probe showed outstanding properties and a super large fluorescent emission peak shift. The reaction mechanism was studied using various methods.

TALANTA (2021)

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Article Chemistry, Medicinal

A bioluminescent probe for in vivo imaging of pyroglutamate aminopeptidase in a mouse model of inflammation

Shilong Hu et al.

Summary: In this study, a bioluminescence probe (PBL) was designed and synthesized for detecting the activity of PGP, providing a powerful tool for studying physiological and pathological processes involving PGP. In vivo imaging in a mouse model of inflammatory liver disease demonstrated the excellent sensitivity and selectivity of the probe.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

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Review Chemistry, Inorganic & Nuclear

Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis

Van-Nghia Nguyen et al.

Summary: Boron-dipyrromethene (BODIPY) platforms are versatile candidates for constructing fluorescent probes, playing a significant role in physiological processes and early cancer diagnosis. The continuous advancement in design and utilization of ROS/RNS fluorescent probes in recent years has contributed to reducing cancer-related deaths.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Biochemical Research Methods

Colorimetric and Ratiometric Fluorescence Detection of HSO3- With a NIR Fluorescent Dye

Wenjie Liu et al.

Summary: Bisulfite (HSO3-) is widely used in food and industry, bringing convenience to human life but also posing serious health risks. The probe PBI was designed and synthesized to selectively detect HSO3- through nucleophilic addition reaction, with the ability to quantitatively detect and visually identify HSO3-. It was successfully applied to fluorescent imaging of HSO3- in living cells.

JOURNAL OF FLUORESCENCE (2021)

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Article Chemistry, Multidisciplinary

Activatable Rare Earth Near-Infrared-II Fluorescence Ratiometric Nanoprobes

Ziqiang Sun et al.

Summary: Efficient lanthanide-doped downshifting nanoparticles were successfully designed with minimized energy loss, demonstrating strong near-infrared-II fluorescence emissions. A novel ratiometric nanoprobe was fabricated for rapid and sensitive detection of peroxynitrite in vivo, showing great potential for biomedical applications.

NANO LETTERS (2021)

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Article Chemistry, Analytical

A ratiometric near-infrared fluorescent probe with a large emission peak shift for sensing and imaging hypochlorous acid

Meng He et al.

Summary: Diabetes can lead to delayed wound healing, and monitoring the role of HOCl in the healing process is crucial. The new fluorescent probe CX-MTC shows excellent selectivity and high sensitivity towards HOCl.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

A cyanine-derived NIR molecular rotor for ratiometric imaging of amyloid-β aggregates

Xueluer Mu et al.

Summary: A cyanine-derived NIR molecular rotor Mu1 with ratiometric signal is introduced, showing significant enhancement in fluorescence ratio in the presence of insulin fibrils. This sensor may be promising for early detection of AD, as the enhancement in fluorescence ratio is due to restricted rotation and conformational factors.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Near-infrared ratio fluorescent sensor for the study of PGP-1 in inflammation and tumor mice

Ting Cao et al.

Summary: Research has found that the designed probe TP-1 for PGP-1 detection is more accurate, revealing the association between PGP-1 and inflammation and tumors, providing important clues for further study of disease mechanisms.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Multidisciplinary

Ratiometric Detection of Hypochlorous Acid in Brain Tissues of Neuroinflammation and Maternal Immune Activation Models with a Deep-Red/Near-Infrared Emitting Probe

Kyeong Hwan Kim et al.

Summary: Fluorescent probes with practicality are crucial for investigating ROS-associated neurological disorders, such as neuroinflammation and MIA in mice models. This study found that the level of hypochlorous acid in the brain tissues of neuroinflammatory and MIA model mice was significantly higher compared to normal brain tissue.

ACS SENSORS (2021)

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Article Chemistry, Multidisciplinary

Acidic pH-Activatable Visible to Near-Infrared Switchable Ratiometric Fluorescent Probe for Live-Cell Lysosome Targeted Imaging

Ayan Mukherjee et al.

Summary: In this study, a pH-activatable fluorescent dye was designed and synthesized, which can switch from visible to near-infrared spectrum under acidic conditions and be controlled by pH. The properties of this fluorescent dye were monitored using NMR, UV/vis, and fluorescence spectroscopies. The dye showed promising performance in live cell lysosomal imaging and has potential applications.

ACS SENSORS (2021)

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Review Chemistry, Multidisciplinary

Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions

Junling Yin et al.

Summary: The microenvironment within specific organelles plays a vital role in cellular processes and physiological functions. Monitoring and understanding the variations in the microenvironment is essential for identifying disease development. Progress has been made in developing fluorescent probes to study the microenvironment within specific cellular regions, but comprehensive research on small-molecule fluorescent chemosensors for cellular microenvironments is still needed.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Analytical

Construction of a near-infrared fluorescent probe for ratiometric imaging of peroxynitrite during tumor progression

Zan Li et al.

Summary: In this study, a reliable near-infrared ratiometric fluorescent biosensor CDMS was designed and constructed for real-time monitoring of ONOO- fluctuations in tumor progression. The probe demonstrated excellent performance in cellular imaging and in vivo visualization of ONOO- in tumor pathological progression, showing great potential for tumor diagnosis and therapy.

ANALYST (2021)

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Article Chemistry, Multidisciplinary

AIE plus ESIPT activity-based NIR Cu2+ sensor with dye participated binding strategy

Jie Jiang et al.

Summary: A novel activity-based Cu2+ fluorescent probe with multidentate binding sites was synthesized, functioning through chelation with Cu2+ and specifically triggering hydrolysis of the probe to release near-infrared emission with AIE + ESIPT properties. The probe was capable of ratiometric imaging of Cu2+ in living HeLa cells.

CHEMICAL COMMUNICATIONS (2021)

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Review Chemistry, Multidisciplinary

Small-molecule fluorescence-based probes for interrogating major organ diseases

Hai-Hao Han et al.

Summary: This tutorial review discusses the importance of chemical tools in real-time monitoring of organ function and visualization of organ-related processes at the cellular level in biological research. It highlights the potential of small-molecule fluorescent probes in advancing the understanding of organ-related diseases and emphasizes the need for probes with high sensitivity, low limit of detection, fast response times, and appropriate biocompatibility.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Fluorescence imaging of pathophysiological microenvironments

Shan Wang et al.

Summary: Abnormal microenvironments play a significant role in various pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. Fluorescence imaging has emerged as a powerful tool for tracking changes in pathophysiological microenvironments, offering promising prospects for future development and application in fluorescent probes.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Materials Science, Biomaterials

A ratiometric near-infrared fluorescent probe based on a novel reactive cyanine platform for mitochondrial pH detection

Shulin Wan et al.

Summary: In this study, four fluorescent probes with different structures were synthesized for the detection and study of mitochondrial pH. These probes exhibited varying fluorescence properties under different conditions, with probe D showing potential applications through the detection of pH changes in HeLa cells and Drosophila melanogaster first-instar larvae.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared Ratiometric Two-Photon Probe for pH Measurement in Human Stomach Cancer Tissue

Vinayak Juvekar et al.

Summary: Stomach cancer is a global health issue with high incidence and mortality rates. The development of the HCC1 probe allows for quantitative analysis of pH in live cells and human stomach tissues, showing promising results for in situ pH-related studies and cancer research.

ACS APPLIED BIO MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

Luling Wu et al.

Summary: This tutorial review explores recent advances in the design, construction, and application of two-photon excited fluorescence (TPEF)-based small-molecule probes, discussing advantages, two-photon fluorophores, design strategies, and various applications including photodynamic therapy.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Analytical

Noninvasive ratiometric fluorescence imaging of γ-glutamyltransferase activity using an activatable probe

Zheng Huang et al.

Summary: The study presents a GGT-activatable ratiometric fluorescent probe for evaluating GGT levels in different tumor cells, enabling the detection and study of GGT-positive tumor tissues.

ANALYST (2021)

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Review Chemistry, Multidisciplinary

Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease

Liqian Gao et al.

Summary: Parkinson's disease is a neurodegenerative disease with complex pathological processes and remains difficult to treat. Developing new tools for early diagnosis and treatment, including the use of fluorescent probes to monitor pathological features, is crucial.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The Disposal of Reactive Carbonyl Species through Carnostne Conjugation. What We Know Now

Ettore Gilardoni et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Spectroscopy

Highly selective ratiometric fluorescent probes for the detection of Fe3+ and its application in living cells

Chunqing Li et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

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Article Chemistry, Analytical

Near-infrared ratiometric probe with a self-immolative spacer for rapid and sensitive detection of alkaline phosphatase activity and imaging in vivo

Xueyan Zhang et al.

ANALYTICA CHIMICA ACTA (2020)

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Review Chemistry, Medicinal

Recent advances with alkaline phosphatase isoenzymes and their inhibitors

Dana M. Zaher et al.

ARCHIV DER PHARMAZIE (2020)

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Article Chemistry, Analytical

Turn-on visible and ratiometric near-infrared fluorescent probes for distinction endogenous esterases and chymotrypsins in live cells

Jiemin Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

An ultra-fast, NIR, mitochondria-targeted fluorescent probe for sulfur dioxide based on benzopyrylium and its imaging of in living cells

Tao Li et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Spectroscopy

Development of a new ratiometric probe with near-infrared fluorescence and a large Stokes shift for detection of gasotransmitter CO in living cells

Enbo Zhou et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

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Article Chemistry, Applied

A novel coumarin-based ratiometric near-infrared fluorescence probe for hypochlorous acid in living cells

Jing Nie et al.

DYES AND PIGMENTS (2020)

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Article Optics

A ratiometric and near-infrared fluorescent probe for discrimination of Cys/Hcy/GSH in aqueous solution and its intracellular imaging in living cells

Jin Bai et al.

JOURNAL OF LUMINESCENCE (2020)

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Article Chemistry, Analytical

Imaging Hg2+-Induced Oxidative Stress by NIR Molecular Probe with Dual-Key-and-Lock Strategy

Xiaopeng Yang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo

Lina Huang et al.

CHINESE CHEMICAL LETTERS (2020)

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Review Chemistry, Inorganic & Nuclear

Fluorescent sensors for the detection of hydrazine in environmental and biological systems: Recent advances and future prospects

Xiang-Yang Zhang et al.

COORDINATION CHEMISTRY REVIEWS (2020)

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Article Chemistry, Applied

Mitochondrial-targeted near-infrared dual mode fluorescent dyes with large Stokes shift for detection of hypochlorous acid and its bioimaging in cell and mice

Yongfei Huang et al.

DYES AND PIGMENTS (2020)

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Article Chemistry, Applied

A new near-infrared ratiometric fluorescent probe based on quinoline-fused rhodamine dye for sensitive detection of cysteine and homocysteine in mitochondria

Yating Yu et al.

DYES AND PIGMENTS (2020)

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Article Chemistry, Multidisciplinary

Visible to Near-Infrared Emission Ratiometric Fluorescent Probe for the Detection of Vanin-1 In Vivo

Jing Qian et al.

ACS SENSORS (2020)

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Review Chemistry, Inorganic & Nuclear

Recent progress in the design principles, sensing mechanisms, and applications of small-molecule probes for nitroreductases

Ya-Lin Qi et al.

COORDINATION CHEMISTRY REVIEWS (2020)

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Article Chemistry, Analytical

Construction of a multi-signal near-infrared fluorescent probe for sensing of hypochlorite concentration fluctuation in living animals

Xiangpeng Lin et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

A novel hepatocyte-targeting ratiometric fluorescent probe for imaging hydrogen peroxide in zebrafish

Wen-Li Jiang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Spectroscopy

A colorimetric and near-infrared ratiometric fluorescent probe for hydrazine detection and bioimaging

Cuiyan Wu et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

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Article Chemistry, Multidisciplinary

Multifunctional Near-Infrared Fluorescent Probes with Different Ring-Structure Trigger Groups for Cell Health Monitoring and In Vivo Esterase Activity Detection

Jiemin Wang et al.

ACS SENSORS (2020)

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Article Materials Science, Multidisciplinary

Synthesis, fluorescence property and cell imaging of a perylene diimide-based NIR fluorescent probe for hypochlorite with dual-emission fluorescence responses

Huan-ren Cheng et al.

MATERIALS ADVANCES (2020)

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Article Chemistry, Analytical

A near-infrared fluorescent probe for ratiometric sensing of SO2 in cells and zebrafish

Mengya Lv et al.

ANALYST (2020)

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Article Materials Science, Biomaterials

A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model

Jiao Lu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Analytical

Accurately monitoring of sulfur dioxide derivatives in agricultural crop leaf tissues by a novel sensing system

Qian Chen et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Analytical

A FRET-based near-infrared ratiometric fluorescent probe for detection of mitochondria biothiol

Lu Wang et al.

TALANTA (2020)

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Review Nanoscience & Nanotechnology

Rational Design of Ratiometric Near-Infrared Aza-BODIPY-Based Fluorescent Probe for in Vivo Imaging of Endogenous Hydrogen Peroxide

Wenle Mao et al.

ACS APPLIED BIO MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Synthetic ratiometric fluorescent probes for detection of ions

Sang-Hyun Park et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

Mingwang Yang et al.

CHEMICAL SCIENCE (2020)

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Article Chemistry, Applied

A novel ratiometric near-infrared fluorescent probe for monitoring cyanide in food samples

Lingliang Long et al.

FOOD CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

Hong-Wen Liu et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

A novel near-infrared turn-on and ratiometric fluorescent probe capable of copper(II) ion determination in living cells

Ziya Aydin et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

A novel near-infrared ratiometric fluorescent probe for SO2 detection with a large emission shift

Shaohui Han et al.

NEW JOURNAL OF CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Rational modulation of coumarin-hemicyanine platform based on OH substitution for higher selective detection of hypochlorite

Jin-Shuai Lan et al.

CHEMICAL COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Recent Advances in the Development of Optical Imaging Probes for γ-Glutamyltranspeptidase

Zhiliang Luo et al.

CHEMBIOCHEM (2019)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide, reactive sulfur species and coping with reactive oxygen species

Kenneth R. Olson

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Chemistry, Multidisciplinary

Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery

Shoujun Zhu et al.

ADVANCED MATERIALS (2019)

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Review Biochemistry & Molecular Biology

Reactive sulfur species (RSS): persulfides, polysulfides, potential, and problems

Nathanael Lau et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2019)

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Review Chemistry, Multidisciplinary

Metal Ions in Alzheimer's Disease: A Key Role or Not?

Yan Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Review Chemistry, Multidisciplinary

An Endeavor in the Reaction-Based Approach to Fluorescent Probes for Biorelevant Analytes: Challenges and Achievements

Subhankar Singha et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Vanin 1: Its Physiological Function and Role in Diseases

Roberta Bartucci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Chemistry, Analytical

Recent progress in the development of small-molecule fluorescent probes for the detection of hydrogen peroxide

Da-Jun Zheng et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Review Immunology

Calcium signalling in T cells

Mohamed Trebak et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Recent Progress in Small-Molecule Near-IR Probes for Bioimaging

Jun-Bin Li et al.

TRENDS IN CHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Fluorogenic probes for disease-relevant enzymes

Junji Zhang et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detection and Molecular Imaging

Sen Ye et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Review Chemistry, Multidisciplinary

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Xiaolin Huang et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HCLO) in wounded tissues

Zhiqiang Mao et al.

CHEMICAL SCIENCE (2018)

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Review Geriatrics & Gerontology

Oxidative stress, aging, and diseases

Ilaria Liguori et al.

CLINICAL INTERVENTIONS IN AGING (2018)

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Article Chemistry, Multidisciplinary

A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine

Qiuyu Gong et al.

ADVANCED SCIENCE (2018)

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Review Pharmacology & Pharmacy

Human carboxylesterases: a comprehensive review

Dandan Wang et al.

ACTA PHARMACEUTICA SINICA B (2018)

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Review Chemistry, Analytical

Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems

Xiaoyun Jiao et al.

ANALYTICAL CHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Zinc in Cellular Regulation: The Nature and Significance of Zinc Signals

Wolfgang Maret

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Nutrition & Dietetics

Chemical tools for detecting Fe ions

Tasuku Hirayama et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2017)

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Review Chemistry, Multidisciplinary

Fluorescent chemosensors: the past, present and future

Di Wu et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Review Chemistry, Multidisciplinary

Ratiometric Fluorescent Probes for the Detection of Reactive Oxygen Species

Diana Andina et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

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Article Toxicology

Development of sulfanegen for mass cyanide casualties

Steven E. Patterson et al.

COUNTERMEASURES AGAINST CHEMICAL THREATS (2016)

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Article Pharmacology & Pharmacy

S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

Katalin Modis et al.

PHARMACOLOGICAL RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

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TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Review Materials Science, Multidisciplinary

Ratiometric mechanosensitive fluorescent dyes: design and applications

Mark A. Haidekker et al.

JOURNAL OF MATERIALS CHEMISTRY C (2016)

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Article Biochemistry & Molecular Biology

Pros and Cons of Current Approaches for Detecting Peroxynitrite and Their Applications

Xingmiao Chen et al.

Biomedical Journal (2016)

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Article Cell Biology

Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates

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AUTOPHAGY (2015)

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Review Chemistry, Multidisciplinary

Fluorescence imaging of metal ions implicated in diseases

Xuhong Qian et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Review Chemistry, Multidisciplinary

Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules

Min Hee Lee et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Review Chemistry, Multidisciplinary

Design strategies of fluorescent probes for selective detection among biothiols

Li-Ya Niu et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Review Biochemistry & Molecular Biology

Enzymes: principles and biotechnological applications

Peter K. Robinson

UNDERSTANDING BIOCHEMISTRY: ENZYMES AND MEMBRANES (2015)

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Article Biochemistry & Molecular Biology

Role of the Vnn1 pantetheinase in tissue tolerance to stress

Philippe Naquet et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2014)

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The regulation of iron transport

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BIOFACTORS (2014)

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Carbon monoxide - physiology, detection and controlled release

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Review Chemistry, Multidisciplinary

Fluorescent Sensors for Measuring Metal Ions in Living Systems

Kyle P. Carter et al.

CHEMICAL REVIEWS (2014)

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Review Chemistry, Multidisciplinary

Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

Zhiqian Guo et al.

CHEMICAL SOCIETY REVIEWS (2014)

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Review Chemistry, Multidisciplinary

Recent progress in the development of fluorometric and colorimetric chemosensors for detection of cyanide ions

Fang Wang et al.

CHEMICAL SOCIETY REVIEWS (2014)

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Review Oncology

Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review

Imen Belhadj Slimen et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2014)

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Review Biochemistry & Molecular Biology

Alkaline Phosphatase: An Overview

Ujjawal Sharma et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2014)

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Review Chemistry, Multidisciplinary

FRET-Based Small-Molecule Fluorescent Probes: Rational Design and Bioimaging Applications

Lin Yuan et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Article Oncology

Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer

Emmet McCormack et al.

CANCER RESEARCH (2013)

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Review Chemistry, Multidisciplinary

Energy transfer cassettes based on organic fluorophores: construction and applications in ratiometric sensing

Jiangli Fan et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Chemistry, Multidisciplinary

Thiol-addition reactions and their applications in thiol recognition

Caixia Yin et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Chemistry, Multidisciplinary

Recent progress in luminescent and colorimetric chemosensors for detection of thiols

Hyo Sung Jung et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Biochemistry & Molecular Biology

Peroxynitrite, a Stealthy Biological Oxidant

Rafael Radi

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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The Linkage Between Coenzyme A Metabolism and Inflammation: Roles of Pantetheinase

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Review Chemistry, Multidisciplinary

Fluorescent chemodosimeters using mild chemical events for the detection of small anions and cations in biological and environmental media

Jianjun Du et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Pharmacogenetic biomarkers: cytochrome P450 3A5

Iain A. M. MacPhee

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Endogenous generation of sulfur dioxide in rat tissues

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

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Sensors and regulators of intracellular pH

Joseph R. Casey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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SO2 Inhalation Contributes to the Development and Progression of Ischemic Stroke in the Brain

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Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding

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CELL (2008)

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Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing and signaling

Elizabeth A. Veal et al.

MOLECULAR CELL (2007)

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Fluorescent probes for proteolysis: Tools for drug discovery

J Neefjes et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

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Review Chemistry, Analytical

Peroxynitrite biochemistry: formation, reactions and detection

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