期刊
COORDINATION CHEMISTRY REVIEWS
卷 493, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2023.215278
关键词
Selenium; Fluorescent probes; Biomedical application
Selenium is essential for human health and its regulation of selenoproteins is crucial. However, the lack of tools for in situ monitoring of selenium species hinders its development in bio-analysis. Thus, fluorescent probes that can specifically recognize and respond to selenium species show promise for studying its biological actions.
Selenium (Se) is of fundamental importance to human health as an essential trace element, mainly through regulation of selenoproteins (SePs). Therefore, monitoring Se transformation in living systems and revealing cellular functions of SePs are of great significance for diverse disease treatment. However, the lack of probing tools for in situ monitoring of Se species severely hinders its development in bio-analysis. Thus, the discovery of fluorescent probes with specific recognition and responses to SePs/Se-containing species are promising for investigating the biological actions of Se. Herein, we summarized the chemical properties of various active Se species and discussed the rational design of basic structures of fluorescent probes for Se species and their biomedical applications. We also highlighted the key findings on fluorescent probes for Se species inside living systems, and proposed a network for rational design and biomedical applications of fluorescent probes for biological Se-containing substances.
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