期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 33, 页码 7108-7111出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01854d
关键词
-
资金
- FP7 EU project (InnovaBalt)
- FP7 EU project (Dynano)
1-N-Alkylated-6-sulfamoyl saccharin derivatives were prepared and assayed as carbonic anhydrase inhibitors (CAIs). During X-ray crystallographic experiments an unexpected hydrolysis of the isothiazole ring was evidenced which allowed us to prepare highly potent enzyme inhibitors with selectivity for some isoforms with medical applications.
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