4.3 Article

Validation of a touchscreen probabilistic reward task for mice: A reverse-translated assay with cross-species continuity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task

Ann M. Iturra-Mena et al.

Summary: Blunted reward learning and reward-related activation in the corticostriatal-midbrain circuitry are linked to anhedonia and depression. This study used event-related potentials and spectral analyses to identify the electrophysiological signatures of reward learning in rats. The findings suggest that these approaches could be used to evaluate novel therapeutics targeting anhedonia.

NEUROPSYCHOPHARMACOLOGY (2023)

Article Clinical Neurology

Nociceptin Receptor Antagonism Modulates Electrophysiological Markers of Reward Learning

Ann M. Iturra-Mena et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2023)

Article Neurosciences

Early life stress in male mice blunts responsiveness in a translationally-relevant reward task

Erin E. Hisey et al.

Summary: Early-life stress has long-lasting impacts on the brain, increasing the risk of psychiatric illnesses. By modeling human early-life stress in mice, researchers have identified biomarkers that are relevant to mood and anxiety disorders, which can potentially improve treatment and prevention strategies.

NEUROPSYCHOPHARMACOLOGY (2023)

Article Neurosciences

A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Brian D. Kangas et al.

Summary: Exposure to early-life adversity leads to blunted response biases in the Probabilistic Reward Task (PRT) and decreased sucrose preference, indicating anhedonic-like phenotypes. The unpredictability of maternal care during early life is identified as a key driver of reward sensitivity deficits, highlighting the importance of maternal signals in shaping reward circuitry. The PRT is established as a powerful tool to assess the impact of early-life adversity on reward circuitry across different species.

NEUROPSYCHOPHARMACOLOGY (2022)

Article Psychology, Clinical

Toward a Quantification of Anhedonia: Unified Matching Law and Signal Detection for Clinical Assessment and Drug Development

Oanh T. Luc et al.

Summary: Anhedonia, the loss of pleasure from previously rewarding activities, is a core symptom of several neuropsychiatric conditions. New research has integrated quantitative frameworks to develop metrics for assessing anhedonia, leading to a more translational approach for treatment development. The Probabilistic Reward Task has been utilized to evaluate reward responsiveness and has shown consistency across diverse clinical populations and laboratory animals, providing potential for accelerated treatment development.

PERSPECTIVES ON BEHAVIOR SCIENCE (2021)

Article Clinical Neurology

Translational Assessments of Reward Responsiveness in the Marmoset

Lisa M. Wooldridge et al.

Summary: The study validated a touchscreen-based probabilistic reward task for marmosets, showing that ketamine, but not phencyclidine, produced dose-related increases in response bias without reducing task discriminability. These findings provide important information for the development of medications to counter anhedonia.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Article Psychiatry

Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms

James F. Cavanagh et al.

Summary: This study presented evidence from three paradigms showing similar electrophysiological signals between humans and mice in tasks related to effortful motivation, reinforcement learning, and cognitive control. These findings provide insights for translating preclinical research findings into clinical settings using electrophysiology.

TRANSLATIONAL PSYCHIATRY (2021)

Article Psychiatry

Empirical validation of a touchscreen probabilistic reward task in rats

Brian D. Kangas et al.

TRANSLATIONAL PSYCHIATRY (2020)

Letter Biotechnology & Applied Microbiology

The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development

Andrew D. Krystal et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Biochemical Research Methods

Sucrose preference test for measurement of stress-induced anhedonia in mice

Meng-Ying Liu et al.

NATURE PROTOCOLS (2018)

Article Neurosciences

Investigating dopamine and glucocorticoid systems as underlying mechanisms of anhedonia

Steven J. Lamontagne et al.

PSYCHOPHARMACOLOGY (2018)

Review Behavioral Sciences

Touchscreen technology in the study of cognition-related behavior

Brian D. Kangas et al.

BEHAVIOURAL PHARMACOLOGY (2017)

Review Behavioral Sciences

Assessing anhedonia in depression: Potentials and pitfalls

Sakina J. Rizvi et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Substance Abuse

Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers

Alyssa L. Peechatka et al.

DRUG AND ALCOHOL DEPENDENCE (2015)

Article Psychology, Clinical

Co-Occurring Depressive and Substance Use Disorders in Adolescents: An Examination of Reward Responsiveness During Treatment

Kathryn D. Boger et al.

JOURNAL OF PSYCHOTHERAPY INTEGRATION (2014)

Article Neurosciences

Reduced Reward Learning Predicts Outcome in Major Depressive Disorder

Elske Vrieze et al.

BIOLOGICAL PSYCHIATRY (2013)

Editorial Material Psychiatry

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

Thomas Insel et al.

AMERICAN JOURNAL OF PSYCHIATRY (2010)

Article Psychiatry

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Diego A. Pizzagalli et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2008)

Article Psychology, Biological

Empirical validation of a procedure to correct position and stimulus biases in matching-to-sample

Brian D. Kangas et al.

JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR (2008)

Review Pharmacology & Pharmacy

Assessing antidepressant activity in rodents: recent developments and future needs

JF Cryan et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2002)