期刊
CLINICAL NEUROPHYSIOLOGY
卷 154, 期 -, 页码 100-106出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2023.06.024
关键词
Neuromuscular junction; Pyridostigmine; Muscle electrical activation; Fatigability; Spinal muscular atrophy
The study investigates the electrophysiological basis of pyridostigmine enhancement of endurance performance in patients with spinal muscular atrophy. The results show that pyridostigmine improves the low-threshold motor unit function in upper extremity muscles, reducing muscle fatigue.
Objective: To investigate the electrophysiological basis of pyridostigmine enhancement of endurance performance documented earlier in patients with spinal muscular atrophy (SMA). Methods: We recorded surface electromyography (sEMG) in four upper extremity muscles of 31 patients with SMA types 2 and 3 performing endurance shuttle tests (EST) and maximal voluntary contraction (MVC) measurements during a randomized, double blind, cross-over, phase II trial. Linear mixed effect models (LMM) were used to assess the effect of pyridostigmine on (i) time courses of median frequencies and of root mean square (RMS) amplitudes of sEMG signals and (ii) maximal RMS amplitudes during MVC measurements. These sEMG changes over time indicate levels of peripheral muscle fatigue and recruitment of new motor units, respectively. Results: In comparison to a placebo, patients with SMA using pyridostigmine had fourfold smaller decreases in frequency and twofold smaller increases in amplitudes of sEMG signals in some muscles, recorded during ESTs (p < 0.05). We found no effect of pyridostigmine on MVC RMS amplitudes. Conclusions: sEMG parameters indicate enhanced low-threshold (LT) motor unit (MU) function in upperextremity muscles of patients with SMA treated with pyridostigmine. This may underlie their improved endurance. Significance: Our results suggest that enhancing LT MU function may constitute a therapeutic strategy to reduce fatigability in patients with SMA.
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