A Qualitative Assessment of a Training and Communication Intervention on Antibiotic Prescription Practices Among Health Workers and Outpatients at Public Health Facilities in Uganda

Qualitative assessment of healthcare providers' prescription of and patients' adherence to antibiotics informed training and communication (T & C) for the Antimicrobial Resistance (AMR) Diagnostic Use Accelerator clinical trial in Uganda, indirectly reducing AMR through adherence messages to intervention arm participants. Background Antibiotic prescribing practices are 1 of the contributing causes of antimicrobial resistance (AMR). The study explored the key drivers and barriers to adherence to prescribing instructions among healthcare workers and outpatient attendees with the aim of developing a training and communication intervention to improve adherence to prescription. Methods Prior to randomized trials at 3 health centers in Uganda (Aduku, Kihihi, and Nagongera), a pre-intervention qualitative assessment was conducted to explore behavioral drivers for adherence to prescriptions and the communication of adherence messages. Based on the findings, a training and communication package was developed for healthcare workers and patients at Day 0 of the trial. During the trial's Day 7 patient follow-up, in-depth interviews were conducted to further investigate adherence behaviors. Results Five main themes were identified that acted as drivers or barriers to prescription adherence. Key drivers included: drug availability at health facility, health worker knowledge, and communication to patients. Barriers included: care-seeker use of treatment resorts and an inability by care-seeker to buy drugs. Conclusions The T & C appeared to influence both health workers' and patients' behavior and improve adherence to prescription. The adapted T & C should be considered a toolkit to improve antibiotic use across health facilities accompanied with appropriate guidelines to mitigate AMR.

Automated summary

This study aimed to improve healthcare providers' prescription of antibiotics and patients' adherence through training and communication, ultimately reducing antibiotic resistance in Uganda. A qualitative assessment was conducted to explore the drivers and barriers to adherence and develop an intervention package. The study found that the training and communication influenced behavior and improved prescription adherence, suggesting its potential as a toolkit for improving antibiotic use.