期刊
MEDICINE
卷 95, 期 30, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000003973
关键词
recursive feature elimination; region of interest; schizophrenia; support vector machine; voxel-based morphometry
资金
- National Natural Science Foundation of China (NSFC) [31400845, 81571333]
- Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase)
- Guangdong Natural Science Foundation [S2012040007743, 2015A030313800]
- Fundamental Research Funds of Central Universities under South China University of Technology [2013ZM046, 2015ZZ042]
- Medical Research Foundation of Guangdong [A2012523]
- Science and Technology Program of Guangdong [2013B021800027]
- Science and Technology Program of Guangzhou [2013J4100096, 2014Y2-00062, 201501010260]
- Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital [GBH2014-ZD04, GBH2014-QN06]
Structural abnormalities in schizophrenia (SZ) patients have been well documented with structural magnetic resonance imaging (MRI) data using voxel-based morphometry (VBM) and region of interest (ROI) analyses. However, these analyses can only detect group-wise differences and thus, have a poor predictive value for individuals. In the present study, we applied a machine learning method that combined support vector machine (SVM) with recursive feature elimination (RFE) to discriminate SZ patients from normal controls (NCs) using their structural MRI data. We first employed both VBM and ROI analyses to compare gray matter volume (GMV) and white matter volume (WMV) between 41 SZ patients and 42 age- and sex-matched NCs. The method of SVM combined with RFE was used to discriminate SZ patients from NCs using significant between-group differences in both GMV and WMV as input features. We found that SZ patients showed GM and WM abnormalities in several brain structures primarily involved in the emotion, memory, and visual systems. An SVM with a RFE classifier using the significant structural abnormalities identified by the VBM analysis as input features achieved the best performance (an accuracy of 88.4%, a sensitivity of 91.9%, and a specificity of 84.4%) in the discriminative analyses of SZ patients. These results suggested that distinct neuroanatomical profiles associated with SZ patients might provide a potential biomarker for disease diagnosis, and machine-learning methods can reveal neurobiological mechanisms in psychiatric diseases.
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