期刊
CLINICAL CANCER RESEARCH
卷 29, 期 17, 页码 3253-3255出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-23-1194
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This article discusses the 5-year update of the pivotal trial CheckMate-238 and provides context to its results considering limited survival data, neoadjuvant therapy, next-generation biomarkers, and novel immunotherapy combinations.
The results of CheckMate-238 led to the original FDA approval of anti-PD-1 therapy in high-risk, resectable melanoma. In this CCR Translations, we discuss the 5-year update of this pivotal trial and contextualize its results in the face of limited survival data, neoadjuvant therapy, next-generation biomarkers, and novel immunotherapy combinations.
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