4.7 Article

A mathematical algorithm to harmonize measurements for thyroid-stimulating hormone between instruments

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CLINICA CHIMICA ACTA
卷 548, 期 -, 页码 -

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ELSEVIER
DOI: 10.1016/j.cca.2023.117513

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Thyroid-stimulating hormone (TSH); Determination; Comparability; Conversion; Mathematical algorithm

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The developed mathematical algorithm allows for harmonizing TSH measurements between different instruments, enabling comparability of TSH data across laboratories.
Background: Thyroid-stimulating hormone (TSH) is measured differently between diagnostic units using different devices, which makes cross-comparisons challenging. Here, we have developed a mathematical algorithm to harmonize TSH measurements between 2 instruments, the Abbott ISR2000 and the Siemens ADVIA Centaur XP.Methods: Applying the principle of the maximum allowable error between the standard curve and real signal values, the minimum number of comparison samples required for TSH hormone detection was calculated for both instruments. Next, a mathematical algorithm describing the relationship between TSH standard curves from both instruments was established. The algorithm was then tested on sample measurements from both instruments, with signals transformed to Siemens ADVIA Centuar XP-type data. Finally, test results were assessed where the relative error was 1/2 TEa). After algorithmic transformation, the average percentage error was reduced to 7.93% (<1/2 TEa).Conclusions: Our algorithm enables TSH measurements across different instruments to be comparable, and provides a method to harmonize TSH data between laboratories that utilize different instrumentation.

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