Optimal Measurement of Coronary Flow and Microvascular Function in Animals and Humans

Article Cardiac & Cardiovascular Systems

Absolute coronary flow and microvascular resistance reserve in patients with severe aortic stenosis

Pasquale Paolisso et al.

Summary: In patients with severe aortic stenosis and non-obstructive coronary artery disease, the compensatory mechanism of increased resting flow maintains adequate perfusion at rest, but not during hyperaemia. Both coronary flow reserve (CFR) and microvascular resistance reserve (MRR) are significantly impaired.

HEART (2023)

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Article Cardiac & Cardiovascular Systems

Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA

Emanuele Gallinoro et al.

Summary: This study aimed to assess the reproducibility of bolus and continuous thermodilution in assessing coronary microvascular function. The results showed that continuous thermodilution demonstrated significantly less variability on repeated measurements than bolus thermodilution, indicating its higher reliability in evaluating coronary microvascular function.

EUROINTERVENTION (2023)

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Article Cardiac & Cardiovascular Systems

The Effect of Coronary Lesion Complexity and Preprocedural Revascularization on 5-Year Outcomes After TAVR

Lennert Minten et al.

Summary: This study aimed to investigate the association between the presence and complexity of coronary artery disease (CAD) and outcomes after transcatheter aortic valve replacement (TAVR). The study found that the presence of CAD and its anatomical complexity were significantly associated with worse 5-year outcomes after TAVR. However, angiography-guided percutaneous coronary intervention (PCI) did not improve outcomes, highlighting the need for further research into physiology-guided PCI.

JACC-CARDIOVASCULAR INTERVENTIONS (2022)

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Article Cardiac & Cardiovascular Systems

Microvascular Resistance Reserve for Assessment of Coronary Microvascular Function JACC Technology Corner

Bernard De Bruyne et al.

Summary: This study proposes microvascular resistance reserve (MRR) as a specific index for assessing coronary microvascular function, independent of autoregulation and myocardial mass, based on absolute values of coronary flow and pressure. The research found a strong correlation between continuous thermodilution-derived MRR and Doppler MRR, suggesting MRR as a specific, quantitative, and operator-independent metric for quantifying coronary microvascular dysfunction.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Optimal Measurement of Coronary Flow and Microvascular Function in Animals and Humans

相关参考文献

Absolute coronary flow and microvascular resistance reserve in patients with severe aortic stenosis

Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA

The Effect of Coronary Lesion Complexity and Preprocedural Revascularization on 5-Year Outcomes After TAVR

Microvascular Resistance Reserve for Assessment of Coronary Microvascular Function JACC Technology Corner

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