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Article
Cardiac & Cardiovascular Systems
Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure?
Satyam Sarma et al.
Summary: Exercise intolerance is a common symptom in patients with heart failure with preserved ejection fraction (HFpEF), which is believed to be caused by a marked rise in pulmonary capillary wedge pressure (PCWP). This study investigated the effect of nitroglycerin on PCWP and exercise capacity in patients with HFpEF. The results showed that nitroglycerin successfully reduced PCWP during exercise, but did not improve peak oxygen uptake. These findings suggest that reducing PCWP alone is not sufficient to enhance exercise capacity in patients with HFpEF.
CIRCULATION (2023)
Article
Cardiac & Cardiovascular Systems
Factors Contributing to Exercise Intolerance in Patients With Atrial Fibrillation
Adrian D. Elliott et al.
Summary: Reduced exercise capacity in atrial fibrillation (AF) patients is associated with elevated left ventricular filling pressure and reduced chronotropic response rather than rhythm status. Subjectively reported exercise intolerance is not a sensitive assessment of reduced exercise capacity.
HEART LUNG AND CIRCULATION (2021)
Article
Medicine, General & Internal
Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure The GALACTIC Randomized Clinical Trial
Nikola Kozhuharov et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)