Decarboxylative Amination with Nitroarenes via Synergistic Catalysis

In this paper, we have developed a decarboxylative amination of carboxylic acids with nitroarenes for the synthesis of secondary amines. The protocol is performed at mild conditions without the use of noble metals as catalysts. A wide range of structurally diverse secondary amines could be obtained in good yields (up to 94%) with good functional group tolerance. This transformation shows good to excellent selectivity, avoiding the generation of over alkylated byproducts.

Automated summary

In this paper, a mild and noble-metal-free method for the synthesis of secondary amines has been developed, which involves the decarboxylative amination of carboxylic acids with nitroarenes. This transformation provides structurally diverse secondary amines in good yields (up to 94%) with good functional group tolerance.