Mo@PANI-catalyzed oxidative deoximation reaction

Deoximation is an important transformation in synthetic industry. It can be employed in protection, characterization and purification of the carbonyls, and in the synthesis of ketones from non-carbonyl molecules. In the field, oxidative deoximation reaction can utilize the driving force caused by the oxidation process so that the reaction can occur under relatively mild conditions. Recently, we designed and prepared polyaniline-supported molybdenum (Mo@PANI) just by immersing PANI into the EtOH/H 2 O solution of MoCl 5 . The material was successfully applied as the efficient catalyst for oxidative deoximation reactions, which were performed in ethanol using H 2 O 2 as the clean oxidant. The substrate scope of the reaction was wide. It could be applied on heterocycle-containing substrates, making this protocol preferable for pharmaceutical intermediate synthesis. Since Mo is a necessary trace element for both animals and plants, this method is environment-friendly and is suitable for large-scale preparation. This work as the first example of Mo-catalyzed oxidative deoximation reaction may inspire novel ideas for both catalyst design and synthetic process development.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Deoximation is an important transformation in synthetic industry, which can protect, characterize and purify carbonyl compounds, and synthesize ketones from non-carbonyl molecules. Recently, we designed and prepared a molybdenum catalyst supported by polyaniline, which was successfully applied in ethanol for deoximation reactions with a wide substrate scope, making it advantageous for pharmaceutical intermediate synthesis.