☆ 4.7 Article

Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives

CHINESE CHEMICAL LETTERS (2024)

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Laura Golusda et al.

Summary: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract. This study utilized very small superparamagnetic iron oxide nanoparticles (VSOPs) in magnetic resonance imaging (MRI) to detect intestinal inflammation in mouse models. The results suggest that VSOPs can serve as a potential contrast agent for early non-invasive diagnosis of IBD, depending on the hyaluronic acid content.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Pharmacology & Pharmacy

Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system

Sang Hoon Lee et al.

Summary: This study developed a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for targeted oral delivery of therapeutic antibodies. The system showed favorable drug carrier properties and exhibited pH-dependent drug release, leading to effective treatment of ulcerative colitis.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Chemistry, Multidisciplinary

Ultrathin Hafnium Disulfide Atomic Crystals with ROS-Scavenging and Colon-Targeting Capabilities for Inflammatory Bowel Disease Treatment

Ruoyao Li et al.

Summary: This study explores the use of tannic acid capped hafnium disulfide nanosheets as high-performance anti-inflammatory agents for the targeted therapy of inflammatory bowel disease. These nanosheets can effectively eliminate reactive oxygen and nitrogen species, downregulate pro-inflammatory factors, and have excellent targeting capability to inflamed colon. They can be excreted via kidney and hepatointestinal systems.

ACS NANO (2022)

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Editorial Material Medicine, General & Internal

In active UC, upadacitinib induced and maintained remission

Geoffrey M. Forbes

ANNALS OF INTERNAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Ozanimod: A Review in Ulcerative Colitis

Julia Paik

Summary: Ozanimod is the first sphingosine-1-phosphate receptor (S1PR) modulator approved for the treatment of moderately to severely active ulcerative colitis. It has shown effectiveness in inducing and maintaining remission in adults with this condition, with manageable or transient adverse events. This expands the treatment options for patients with ulcerative colitis.

DRUGS (2022)

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Article Biochemistry & Molecular Biology

Oral delivery of curcumin via multi-bioresponsive polyvinyl alcohol and guar gum based double-membrane microgels for ulcerative colitis therapy

Yan Hu et al.

Summary: In this study, a new oral drug delivery system was developed using multi-bioresponsive microgels loaded with anti-inflammatory drug curcumin. The microgels exhibited good bio-responses and sustained-release properties, and specifically accumulated in the colon tissue to alleviate the symptoms of ulcerative colitis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Chemistry, Multidisciplinary

Spheroplexes: Hybrid PLGA-cationic lipid nanoparticles, for in vitro and oral delivery of siRNA

Danielle Campiol Arruda et al.

Summary: This study developed a novel lipid-polymer hybrid nanoparticle called Spheroplexes for efficient siRNA delivery. The nanoparticles consist of a hydrophobic PLGA matrix surrounded by a lipid envelope adopting a lamellar structure, in which the siRNA is complexed. The Spheroplexes were shown to be stable and more efficient than siRNA lipoplexes for delivering siRNA to cultured cells.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Multidisciplinary Sciences

In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis

Xinyan Zhou et al.

Summary: This study presents a therapy for ulcerative colitis based on a multitargeted genetic circuit, which effectively targets multiple pathogenic genes and pathways in male mice with induced or spontaneous genetic colitis.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Two-birds-one-stone colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis

Jiaxin Zhang et al.

Summary: This study developed a chitosan-modified poly(lactic-co-glycolic acid) nanoparticle system for co-delivering patchouli alcohol and simvastatin to the inflamed colonic epithelium, aiming to remodel the immune microenvironment and alleviate colonic fibrosis in ulcerative colitis treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance One Stone Four Birds Effect of Rhein on Ulcerative Colitis

Shanshan Qi et al.

Summary: This study developed a polysaccharide-based nanodelivery system with pH/ROS sensitivity and mucosal adhesion to load the ulcerative colitis (UC) treatment candidate, Rhein (RH). The system showed stable gastric release and colon-specific targeting. In vivo experiments demonstrated that the system effectively reduced inflammation, repaired colonic mucosal barrier, and regulated intestinal microflora.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Medicine, Research & Experimental

Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis

Caifang Gao et al.

Summary: Turmeric-derived nanovesicles (TNVs) showed promising anti-inflammatory effects by restoring damaged intestinal barrier, regulating gut microbiota, and reshaping macrophage phenotype.

THERANOSTICS (2022)

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Review Materials Science, Biomaterials

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

Sunni Chen et al.

Summary: Oral colon-targeted delivery systems (OCDSs), which offer enhanced efficacy and reduced side effects, have gained significant attention in the treatment of colon and non-colon diseases. Chitosan, a biopolymer with great biocompatibility and sensitivity to colonic flora, serves as an ideal biomaterial for OCDS construction. This review provides a detailed overview of the preparation of chitosan-based delivery systems and summarizes recent research findings on its application in nutritional and biomedical fields, shedding light on the future development of OCDSs.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Applied

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Dominik Rotrekl et al.

Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.

CARBOHYDRATE POLYMERS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Magnetic resonance colonography with intestine-absorbable nanoparticle contrast agents in evaluation of colorectal inflammation

Xue Dong et al.

Summary: Enema with Gd-FITC-SLNs may be beneficial for diagnosing and differentiating acute and chronic UC, and can provide comparable or superior results to intravenous Gd-DTPA administration.

EUROPEAN RADIOLOGY (2021)

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Article Gastroenterology & Hepatology

Safety and Efficacy of Anti-TNF Therapy in Older Adults with Ulcerative Colitis: A New Path Forward

Adam S. Faye et al.

GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia

Shu-Chen Wei et al.

Summary: The incidence and prevalence of ulcerative colitis (UC) in some Asian countries have increased significantly in the last four decades, though generally lower than in the West. As the prevalence rises, overall healthcare costs will also increase. Different Asian countries face unique challenges in utilizing available resources and selecting from emerging treatment options to benefit their populations.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Immunology

Macrophage-Biomimetic Nanoparticles Ameliorate Ulcerative Colitis through Reducing Inflammatory Factors Expression

Zhengshuo Li et al.

Summary: The study developed a safe and effective nano-delivery system targeting S100A9, which significantly improved the therapeutic efficacy in an ulcerative colitis mouse model by reducing S100a9 and other cytokines to achieve immunomodulatory and suppressive effects.

JOURNAL OF INNATE IMMUNITY (2021)

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Article Biochemical Research Methods

Small intestinal sampling capsule for inflammatory bowel disease type detection and management

Sina Nejati et al.

Summary: A battery-free smart capsule has been designed to target sample inflammatory biomarkers in the small intestine, providing a non-invasive method to differentiate types of inflammatory bowel disease. This innovative technology offers a promising solution for improving IBD diagnosis and treatment strategies by assessing inflammation biomarkers throughout the digestive tract.

LAB ON A CHIP (2021)

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Article Chemistry, Multidisciplinary

Optotheranostic Nanosystem with Phone Visual Diagnosis and Optogenetic Microbial Therapy for Ulcerative Colitis At-Home Care

Meihui Cui et al.

Summary: A study developed an optotheranostic nanosystem for self-diagnosis and long-acting mitigation of ulcerative colitis (UC). The system utilized smartphone optical sensing for disease prescreening and an optogenetic engineered bacteria system for real-time intervention. Treatment with IL-10-secreting EcN effectively suppressed intestinal inflammatory response and protected intestinal mucosa in UC mice.

ACS NANO (2021)

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Review Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

Hiroshi Nakase et al.

Summary: Inflammatory bowel disease (IBD) encompasses chronic or remitting/relapsing inflammatory diseases of the intestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD). The etiology of IBD involves disease susceptibility genes, environmental factors, and intestinal bacteria. Optimal management depends on evidence-based interventions tailored by physicians.

JOURNAL OF GASTROENTEROLOGY (2021)

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Article Chemistry, Medicinal

Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon

Hamid A. Bakshi et al.

Summary: The prevalence of colon-associated diseases has risen, making the development of effective treatments challenging. Researchers have found that gut microbiota metabolism could offer a potential method for targeted drug delivery. Utilizing drug delivery systems to modulate microbiota will help in developing a new generation of therapies leveraging human gut microflora metabolism.

PHARMACEUTICALS (2021)

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Review Gastroenterology & Hepatology

Breaking the therapeutic ceiling in drug development in ulcerative colitis

Dahham Alsoud et al.

Summary: This article discusses the limitations of therapeutic efficacy in ulcerative colitis treatment, the shortcomings of current strategies, and proposes solutions for improving therapeutic outcomes.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Nanoscience & Nanotechnology

Oral Core-Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Xiao Wang et al.

Summary: The study successfully loaded magnolol into core-shell zein-based nanoparticles with chondroitin sulfate coating and embedded them into hydrogel microspheres, forming a system named Mag@CS-Zein NPsinMPs. This drug delivery system exhibited good macrophage-targeting and sustained drug release capabilities.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents

Surajit Das

Summary: Utilization of pectin in colon-specific delivery systems shows promise, especially in combination with other materials/polymers. Smartly designed pectin-based multi-particulate carriers have potential for successful colon-specific release of payload, but more clinical trials are needed to validate this idea.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives

Aline Martins dos Santos et al.

Summary: Colon-targeted oral drug delivery is a promising approach for treating intestinal diseases, though it faces challenges that require advanced strategies and the use of micro- and nanoparticles for localized therapy. Polysaccharides-based nano-in-microparticulate systems have key properties and advantages for effective colon-specific oral delivery, showing potential for targeted therapy within the colon.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Pharmacology & Pharmacy

Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

Peng Liu et al.

Summary: Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful symptoms and high risks of cancerization. There is no curative therapy for IBD at present, so the development of targeted drug delivery systems for the inflamed areas is highly advocated.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

Murtada A. Oshi et al.

Summary: A novel colon-targeted drug delivery system composed of CsA crystals-loaded, Eudragit S 100-coated alginate microparticles (CsAc-EAMPs) was developed to minimize systemic side effects and enhance therapeutic efficacy of CsA in treating UC. CsAc-EAMPs exhibited high drug loading capacity and sustained drug release profile, showing enhanced anti-inflammatory activity in a mouse model of DSS-induced colitis, suggesting its promising potential as a drug delivery system for UC therapy.

PHARMACEUTICS (2021)

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Article Gastroenterology & Hepatology

Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial

Taku Kobayashi et al.

Summary: This study compared outcomes of patients with ulcerative colitis in remission who continued infliximab treatment versus those who discontinued it, showing that maintenance of remission was significantly more common in patients who continued infliximab. The study suggests caution when considering discontinuing infliximab, taking into account the risk of relapse and efficacy of re-treatment.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Ciclosporin or Infliximab as Rescue Therapy in Acute Glucorticosteroid-Refractory Ulcerative Colitis: Systematic Review and Network Meta-Analysis

Brigida Barberio et al.

Summary: The study found that both ciclosporin and infliximab were superior to placebo in terms of improving treatment response and avoiding colectomy in patients with acute glucocorticosteroid-refractory ulcerative colitis, with no significant differences in efficacy or safety between the two within 1 year.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Medicine, Research & Experimental

Colon tissue-accumulating mesoporous carbon nanoparticles loaded with Musca domestica cecropin for ulcerative colitis therapy

Lun Zhang et al.

Summary: MDC@MCNs improved colonic injury in UC mice significantly by ameliorating colonic epithelial cells damage, inhibiting inflammation and oxidative stress, enhancing colonic tight junctions, and regulating intestinal flora.

THERANOSTICS (2021)

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Article Gastroenterology & Hepatology

Oral Targeted Delivery by Nanoparticles Enhances Efficacy of an Hsp90 Inhibitor by Reducing Systemic Exposure in Murine Models of Colitis and Colitis-Associated Cancer

Mei Yang et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Chemistry, Physical

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Yonghyun Lee et al.

NATURE MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Macrophage-based nanotherapeutic strategies in ulcerative colitis

Jiaxin Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Enhanced Transport of Shape and Rigidity-Tuned α-Lactalbumin Nanotubes across Intestinal Mucus and Cellular Barriers

Cheng Bao et al.

NANO LETTERS (2020)

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Article Multidisciplinary Sciences

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

Nobuyuki Kakiuchi et al.

NATURE (2020)

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Article Chemistry, Multidisciplinary

Acid-resistant ROS-responsive hyperbranched polythioether micelles for ulcerative colitis therapy

Haitong Shi et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Gastroenterology & Hepatology

Lactic Acid Bacteria Isolated From Korean Kimchi Activate the Vitamin D Receptor-autophagy Signaling Pathways

Rong Lu et al.

INFLAMMATORY BOWEL DISEASES (2020)

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Article Biochemistry & Molecular Biology

Nanogels of a Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Release Behavior, Gastrointestinal Distribution, and Systemic Absorption

Haiyan Zhou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response

Mouna Rahabi et al.

CELL REPORTS (2020)

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Review Gastroenterology & Hepatology

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

Azucena Salas et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Small molecule oral targeted therapies in ulcerative colitis

Uday N. Shivaji et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Biochemistry & Molecular Biology

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

Sho Kitamoto et al.

CELL (2020)

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Article Chemistry, Multidisciplinary

Natural -lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

Chunhua Yang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Biomedical

Colitis-targeted hybrid nanoparticles-in-microparticles system for the treatment of ulcerative colitis

Muhammad Naeem et al.

ACTA BIOMATERIALIA (2020)

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Review Food Science & Technology

Dietary fiber-based colon-targeted delivery systems for polyphenols

Hsi-Yang Tang et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

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Article Medicine, General & Internal

Ulcerative colitis

Taku Kobayashi et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Biochemistry & Molecular Biology

Natural proteins and polysaccharides in the development of micro/nano delivery systems for the treatment of inflammatory bowel disease

Brijesh M. Shah et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Novel β-1,3-d-glucan porous microcapsule enveloped folate-functionalized liposomes as a Trojan horse for facilitated oral tumor-targeted co-delivery of chemotherapeutic drugs and quantum dots

Xiaonan Li et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Medicine, Research & Experimental

Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine

Tianlei Sun et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE(2)-mediated M2 macrophage polarization

Xiaocang Cao et al.

THERANOSTICS (2020)

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Review Pharmacology & Pharmacy

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

Niranjan G. Kotla et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Gastroenterology & Hepatology

Appropriate Therapeutic Drug Monitoring of Biologic Agents for Patients With Inflammatory Bowel Diseases

Konstantinos Papamichael et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Pharmacology & Pharmacy

Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel disease

Mahira Zeeshan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Gastroenterology & Hepatology

A blood-based prognostic biomarker in IBD

Daniele Biasci et al.

GUT (2019)

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Article Biochemistry & Molecular Biology

Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis

Souvik Mohanta et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

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Review Cell Biology

Advances in therapeutic applications of extracellular vesicles

Oscar P. B. Wiklander et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide

Matthew T. Henke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Surgery

Prospective cohort study of appendicectomy for treatment of therapy-refractory ulcerative colitis

M. E. Stellingwerf et al.

BRITISH JOURNAL OF SURGERY (2019)

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Review Pharmacology & Pharmacy

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

Susan Hua

FRONTIERS IN PHARMACOLOGY (2019)

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Review Pharmacology & Pharmacy

Yeast-inspired drug delivery: biotechnology meets bioengineering and synthetic biology

Chinnu Sabu et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Medicine, General & Internal

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis A Randomized Clinical Trial

Samuel P. Costello et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Review Gastroenterology & Hepatology

New biologics and small molecules in inflammatory bowel disease: an update

Joao Sabin et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2019)

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Review Biochemistry & Molecular Biology

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Daniel E. Murphy et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Gastroenterology & Hepatology

Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-α-Directed Therapy for Inflammatory Bowel Disease

James D. Lewis et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2018)

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Article Chemistry, Applied

Degradation studies of modified inulin as potential encapsulation material for colon targeting and release of mesalamine

Michael Walz et al.

CARBOHYDRATE POLYMERS (2018)

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Review Biochemistry & Molecular Biology

Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease

Yilin Guo et al.

MOLECULES (2018)

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Review Pharmacology & Pharmacy

Advances in rectal drug delivery systems

Trusha J. Purohit et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2018)

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Review Gastroenterology & Hepatology

Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation

Zhao-Hua Shen et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Engineering, Biomedical

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Wei Li et al.

BIOMATERIALS (2018)

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Article Microbiology

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course

Melanie Schirmer et al.

CELL HOST & MICROBE (2018)

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Review Immunology

Role of biologics and biosimilars in inflammatory bowel disease: current trends and future perspectives

Prashanth Rawla et al.

JOURNAL OF INFLAMMATION RESEARCH (2018)

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Article Gastroenterology & Hepatology

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

Marcus Harbord et al.

JOURNAL OF CROHNS & COLITIS (2017)

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Article Medicine, General & Internal

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

Siew C. Ng et al.

LANCET (2017)

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Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

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Article Materials Science, Multidisciplinary

Bioinspired yeast microcapsules loaded with self-assembled nanotherapies for targeted treatment of cardiovascular disease

Xiangjun Zhang et al.

MATERIALS TODAY (2017)

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Article Biotechnology & Applied Microbiology

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Bo Xiao et al.

MOLECULAR THERAPY (2017)

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Article Chemistry, Multidisciplinary

Engineered biomimetic nanovesicles show intrinsic anti-inflammatory properties for the treatment of inflammatory bowel diseases

Claudia Corbo et al.

NANOSCALE (2017)

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Review Gastroenterology & Hepatology

Current and emerging therapeutic targets for IBD

Markus F. Neurath

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Multidisciplinary Sciences

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Koji Atarashi et al.

SCIENCE (2017)

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Article Gastroenterology & Hepatology

Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis

Samin Zamani et al.

GUT PATHOGENS (2017)

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Review Chemistry, Applied

Alginate microparticles as oral colon drug delivery device: A review

Lissette Aguero et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Applied

Starch-based nanocapsules fabricated through layer-by-layer assembly for oral delivery of protein to lower gastrointestinal tract

Yiping Zhang et al.

CARBOHYDRATE POLYMERS (2017)

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Review Gastroenterology & Hepatology

Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis

Sawan Bopanna et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2017)

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Review Immunology

Mechanisms and consequences of Jak-STAT signaling in the immune system

Alejandro V. Villarino et al.

NATURE IMMUNOLOGY (2017)

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Review Pharmacology & Pharmacy

Size-dependent nanoparticulate drug delivery in inflammatory bowel diseases

John Youshia et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

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Article Engineering, Biomedical

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

Mingzhen Zhang et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Qixiong Zhang et al.

BIOMATERIALS (2016)

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Article Chemistry, Applied

Amidated pectin/sodium carboxymethylcellulose microspheres as a new carrier for colonic drug targeting: Development and optimization by factorial design

Hytham H. Gadalla et al.

CARBOHYDRATE POLYMERS (2016)

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Editorial Material Multidisciplinary Sciences

Inflammatory bowel disease

Richard Hodson

NATURE (2016)

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Review Pharmacology & Pharmacy

Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review

Nidhi et al.

SAUDI PHARMACEUTICAL JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

Katharina Maisel et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Review Nanoscience & Nanotechnology

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

Susan Hua et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Review Oncology

Chronic ulcerative colitis and colorectal cancer

Gerhard Rogler

CANCER LETTERS (2014)

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Article Chemistry, Applied

Electrosprayed inulin microparticles for microbiota triggered targeting of colon

Arvind K. Jain et al.

CARBOHYDRATE POLYMERS (2014)

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Article Gastroenterology & Hepatology

Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

Bo Xiao et al.

GASTROENTEROLOGY (2014)

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Review Biotechnology & Applied Microbiology

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

Vladimir P. Torchilin

NATURE REVIEWS DRUG DISCOVERY (2014)

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Review Pharmacology & Pharmacy

pH- and ion-sensitive polymers for drug delivery

Takayuki Yoshida et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

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Article Gastroenterology & Hepatology

Geographical variability and environmental risk factors in inflammatory bowel disease

Siew C. Ng et al.

GUT (2013)

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Article Medicine, General & Internal

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

Brian G. Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Review Pharmacology & Pharmacy

The oral delivery of peptides and proteins: established versus recently patented approaches

Louise Rosenmayr-Templeton

PHARMACEUTICAL PATENT ANALYST (2013)

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Review Pharmacology & Pharmacy

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

Laura M. Ensign et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Review Pharmacology & Pharmacy

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

Bo Xiao et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

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Review Immunology

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

John J. O'Shea et al.

IMMUNITY (2012)

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Review Gastroenterology & Hepatology

Ulcerative colitis as a progressive disease: The forgotten evidence

Joana Torres et al.

INFLAMMATORY BOWEL DISEASES (2012)

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Article Medicine, General & Internal

Ulcerative colitis

Ingrid Ordas et al.

LANCET (2012)

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Review Pharmacology & Pharmacy

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

Morteza Mahmoudi et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

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Meeting Abstract Chemistry, Multidisciplinary

A novel oral colon-targeting drug delivery system based on resistant starch acetate

Ling Chen et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Review Pharmacology & Pharmacy

Biodegradation, biodistribution and toxicity of chitosan

T. Kean et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

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Review Immunology

The regulation of IL-10 production by immune cells

Margarida Saraiva et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Daniel N. Frank et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Dectin-1 and its role in the recognition of β-glucans by macrophages

J Herre et al.

MOLECULAR IMMUNOLOGY (2004)

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Review Multidisciplinary Sciences

Inflammation and cancer

LM Coussens et al.

NATURE (2002)

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Article Immunology

Dectin-1 is a major β-glucan receptor on macrophages

GD Brown et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

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Review Gastroenterology & Hepatology

Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs

SG Nugent et al.

GUT (2001)

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Article Immunology

Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)

BM Wittig et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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