Oxide-supported metal catalysts for anaerobic NAD plus regeneration with concurrent hydrogen production

We report SiO2-supported monometallic Pt, Pd, Au, Ni, Cu and Co catalysts for proton-driven NAD(+) regeneration, co-producing H-2. All metals are fully selective to NAD(+) where the order of turnover frequencies (Pt > Pd > Cu > Au, Ni and Co) coincides with those otherwise observed in electrochemical hydrogen evolution reactions. This has revealed that NADH is capable of converting the metal sites into a cathode without an external potential and the NADH to NAD(+) reaction involves transferring electron and hydrogen atom separately. Electron-deficient Pt delta+ (on CeO2) enhances TOF and the heterogeneous Pt/CeO2 catalyst is recyclable without losing any activity/selectivity.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

SiO2-supported monometallic Pt, Pd, Au, Ni, Cu and Co catalysts are used for proton-driven NAD(+) regeneration and H-2 production. All metals show full selectivity to NAD(+), with turnover frequency order matching that of electrochemical hydrogen evolution reactions. The study reveals that NADH can convert metal sites into a cathode without an external potential and the NADH to NAD(+) reaction involves separate electron and hydrogen atom transfer.