期刊
MEDICINAL RESEARCH REVIEWS
卷 36, 期 6, 页码 1080-1126出版社
WILEY
DOI: 10.1002/med.21400
关键词
ischemic stroke; mesenchymal stem cells; induced pluripotent stem cells; mechanisms of stem cell therapy; noninvasive imaging
资金
- Fonds Wetenschappelijk Onderzoek [G0A7514N, G089213N, G029112N, 12D8516N, 1508015N]
- Bijzonder Onderzoeksfonds [BOF15DOC04]
Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据