4.5 Article

Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide-Modified Analogues

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Total synthesis and chemical stability of pseudouridimycin

Christopher F. Cain et al.

Summary: We report the chemical synthesis of pseudouridimycin (1), an antimicrobial natural product that selectively inhibits bacterial RNA polymerase. Intramolecular hydroxamate bond scission was found to be a major decomposition pathway for 1 in aqueous buffer. Replacement of the hydroxamate bond with a tertiary amide resulted in a conformational isostere resistant to degradation. These findings lay the foundation for the design and synthesis of analogues with improved chemical stability and biological activity.

CHEMICAL COMMUNICATIONS (2022)

Article Chemistry, Organic

δ-Azaproline and Its Oxidized Variants

Yassin M. Elbatrawi et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

Article Chemistry, Organic

N-Hydroxy peptides: solid-phase synthesis and β-sheet propensity

Matthew P. Sarnowski et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Mechanisms of antibiotics inhibiting bacterial RNA polymerase

Hamed Mosaei et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Chemistry, Organic

Total Synthesis of L-156,373 and an oxoPiz Analogue via a Submonomer Approach

Yassin M. Elbatrawi et al.

ORGANIC LETTERS (2018)

Article Biochemistry & Molecular Biology

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase

Sonia I. Maffioli et al.

Article Chemistry, Multidisciplinary

Peptide N-Amination Supports β-Sheet Conformations

Matthew P. Sarnowski et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Medicinal

A novel N-terminal degradation reaction of peptides via N-amidination

Yoshio Hamada

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Biotechnology & Applied Microbiology

Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763

Alexander Pesic et al.

JOURNAL OF ANTIBIOTICS (2014)

Review Biotechnology & Applied Microbiology

Resistance to rifampicin: a review

Beth P. Goldstein

JOURNAL OF ANTIBIOTICS (2014)

Article Biochemistry & Molecular Biology

Oligo(N-alkoxy glycines): Trans Substantiating Peptoid Conformations

Peter A. Jordan et al.

BIOPOLYMERS (2011)

Article Biochemistry & Molecular Biology

Structures of RNA polymerase-antibiotic complexes

Mary X. Ho et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)

Review Pharmacology & Pharmacy

Progress in targeting bacterial transcription

Philippe Villain-Guillot et al.

DRUG DISCOVERY TODAY (2007)