期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202302919
关键词
pyrrolo[2,1-b][3]benzazepines; pyrido[2,1-a]isoquinolines; pyrrolo[2,1-a]isoquinolines; microwave irradiation; sigmatropic rearrangement
In this study, 1-substituted 1-ethynyl-2-vinyldi- and tetrahydroisoquinolines were successfully subjected to [3,3]-sigmatropic rearrangement under microwave irradiation at 150 degrees Celsius in toluene, in the presence of nucleophiles (DMAP, triphenylphosphine and tetrahydrothiophene), yielding pyrrolo[2,1-b][3]benzazepines with good yields. The replacement of toluene with acetonitrile directed the rearrangement towards the formation of 7,11b-dihydro-6H-pyrido[2,1-a]isoquinolines.
Under microwave (MW) irradiation at 150 degree celsius in toluene and in the presence of nucleophiles (DMAP, triphenylphosphine and tetrahydrothiophene) 1-substituted 1-ethynyl-2-vinyldi- and tetrahydroisoquinolines undergo [3,3]-sigmatropic rearrangement providing pyrrolo[2,1-b][3]benzazepines in good yields. The replacement of toluene with acetonitrile directs the rearrangement towards the formation of 7,11b-dihydro-6H-pyrido[2,1-a]isoquinolines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据